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| Radiation- protective effect of thymoquinone in mice |
| HOU Qinlian DONG Yinping DONG Hui LI Deguan DU Liqing |
| Institute of Radiation Medicine, Peking Union Medical College Chinese Academy of Medical Sciences, Tianjing 300192, China |
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Abstract Objective To observe the protective effects of thymoquinone (TQ) against radiation injuries in mice. Methods C57BL/6J mice were randomly divided into three group (n=5): control group, irradiation group and irradiation + TQ group. The mice in the irradiation group and the irradiation + TQ group were accepted 7.5 Gy total body irradiation, and the mice in the control group was received sham irradiation. The irradiation + TQ group was administered orally the day before exposure (10 mg/kg), sustained administration for 3 days. The same volume normal saline was given to the mice in the control and irradiation group. Three days after irradiation, the samples were taken, and the indexes of spleen, lung, kidney, testes and liver of the mice were observed, and the contents of GSH, SOD and MDA in serum and liver tissues of each group were detected. Results Compared with the irradiation group, the GSH content in the liver tissues and SOD value in the serum in the irradiation + TQ group were increased, and the MDA level in the serum was decreased, with statistically significant difference (P < 0.05). Conclusion TQ can reduce radiation oxidation damage in the radiation mice, and it has certain protective effect on the radiation injury in mice.
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