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2017 Vol. 14, No. 27
Published: 2017-09-25
 
 
4 Virtual screening of novel dual inhibitors of HIV reverse transcriptase and integrase
XIAO Zeyun1 LI Kai1,2 LI Aixiu1,3 WANG Xiaohui4 LIU Yongqing5
Objective To create the pharmacophore of 3-OH HEPT derivatives of dual inhibitors against HIV non-nucleoside reverse transcriptase inhibit or binding pocket and integrase [RT(NNRTI)/IN], filter traditional Chinese medicine database (TCMD) with the pharmacophore, and find novel dual inhibitors of HIV. Methods Based on the known 3-OH HEPT derivatives against HIV RT(NNRTI)/IN, the pharmacophore was created. TCMD was filtered with the pharmacophore and Lipinski's five rules. Results The pharmacophore of six features was created. 16 molecules which matched five out of the six features were hit by searching from texting database, and the detection rate was 100%. 229 compounds were hit when used the pharmacophore of six features and Lipinski's five rules to filter TCMD, which contained compounds that were known inhibitors of HIV. Conclusion The pharmacophore and the screening strategy lay a good foundation for further studies.
2017 Vol. 14 (27): 4-7,20 [Abstract] ( 267 ) HTML (1 KB)  PDF (951 KB)  ( 202 )
8 Effect of Dark Plum Sprays on radiation-induced submandibular gland damage of rats
CHEN Qianyi LI Bixia YE Jingyun ZHANG Jiapeng YE Qianqing CHEN Guanlin CHEN Peiyi
Objective To observe the influence of Dark Plum Sprays on radiation-induced submandibular gland damage of rats. Methods According to the random number table, a total of 30 healthy Wistar male rats aged 6-7 weeks were divided into normal group (NG), untreated group (UG), high-dose Dark Plum Sprays group (HG), medium-dose Dark Plum Sprays group (MG), low-dose Dark Plum Sprays group (LG), each group had 6 rats. The rats were given one-time 18 Gy irradiation locally on the submandibular glands. 14 days later, saliva was collected to calculate the salivary flow rate and detected the biochemical indexes. After that, submandibular glands were draw out. Morphology examination was assessed by HE staining. Results 14 days after administration, the average body weights in UG, HG, MG, LG groups were significantly lower than those in the NG group (P < 0.05). The salivary flow rate, Na+, K+, Na+/K+ in UG, HG, MG, LG groups were lower than those in the NG group, but there were no statistically significant differences (P > 0.05). The cells of the Wistar rats in the NG group were regularly arranged, and there were no obviously pathological changes. The cells in UG group presented inflammatory infiltration and the collagen fibrils demonstrated fibrosis with significant hyperplasia. The submandibular gland cells of UG, HG, MG, LG groups had radioactive damage after irradiation. However, the submandibular gland cells of HG group was less atrophy, inflammatory and more cytoplasm secretion than UG. The restoration of submandibular gland cells in HG group were better than UG, but failed to return to normal. Conclusion High-dose Dark Plum Sprays may repair the pathomorphism of submandibular gland cells after radioactive damage, but relevant mechanisms need to be further explored.
2017 Vol. 14 (27): 8-11 [Abstract] ( 230 ) HTML (1 KB)  PDF (878 KB)  ( 167 )
12 Application of RP-HPLC in determination of the three main kinds of components in the extract of Psoralea corylifolia
LI Jianmei1 ZHOU Fan2 Xirali·TURSUN1 LI Zhijian1▲ CAO Chunyu3▲
Objective To determine psoralen, isopsoralen and bakuchiol from the extract of Psoralea corylifolia by RP-HPLC. Methods The contents of paoralen, isopsoralen and bakuchiol were determined on the Epic C18 (250 mm×4.6 mm, 5 μm) column, with methanol: water in gradient elution manner. The flow rate was 1.0 mL/min, the column temperature was maintained at 30℃, and the detection wavelength was set up at 250 nm. Results The linear ranges of paoralen, isopsoralen and bakuchiol were 0.0563-0.3379, 0.0523-0.3139 and 0.1280-0.7680 μg (r=0.9999). The average recovery of paoralen, isopsoralen and bakuchiol were 100.66%, 100.43% and 99.41%, RSD were 1.77%, 1.45% and 1.63% (n=6). Conclusion The method is convenient, accurate sensitive and repeatable, and can be used in the content control method of psoralen, isopsoralen and bakuchiol in extract of Psoralea corylifolia.
2017 Vol. 14 (27): 12-15 [Abstract] ( 365 ) HTML (1 KB)  PDF (760 KB)  ( 112 )
16 Primary study on HBx transfection in inducing the multidrug resistance of hepatocellular carcinoma cell line Bel-7404
LIN Songting CHEN Zhengyi ZHONG Wenzhou
Objective To study the effects of HBx transfection on proliferation, cell cycle, and multidrug resistance of hepatocellular carcinoma cell line Bel-7404, and to investigate the possible mechanism of HBx transfection in inducing the multidrug resistance of liver cancer. Methods Human hepatocellular carcinoma cell line Bel-7404 was transfected, and the cells were divided into three groups according to the transfection conditions, which were transfected HBx cell group (Bel-7404-HBx group), transfected cell group with empty vector (Bel-7404-con group) and blank cells group (Bel-7404 group). The expression of HBx RNA in all groups was detected by real-time PCR. The expression of HBx, Notch-1 and multi-drug resistance protein (MRP) in all groups was detected by Western blot, the cell proliferation activity and multidrug resistance in all groups were determined by CCK-8, and the cell growth cycle was analyzed by flow cytometer. Results PCR amplified gel electrophoresis showed that HBx fragments were detected in Bel-7404-HBx group, while no HBx mRNA expression could be found in the other two groups; Western blot indicated that the protein band (HBx protein) was detected in the Bel-7404-HBx group, while no expression was found in Bel-7404 group and Bel-7404-con group. Furthermore, compared with Bel-7404 group and Bel-7404-con group, the cell proliferation in Bel-7404-HBx group was increased significantly (P ＜ 0.05); compared with Bel-7404 group and Bel-7404-con group, the protein expression of Notch-1 and MRP in Bel-7404-HBx group was increased significantly; the results of cell cycle showed that, compared with Bel-7404 group and Bel-7404-con group, the number of cells in G0/G1 phase was decreased significantly (P ＜ 0.05), which was significantly increased in S phase (P ＜ 0.01), while there was no significant differences in G2/M phase (P ＞ 0.05); multidrug resistance experiments showed that, compared with Bel-7404 group and Bel-7404-con group, the resistance index of Mitomycin, Adriamycin, 5-Fluorouracil, Cisplatin and Oxaliplatin in the Bel-7404-HBx group was increased significantly (P ＜ 0.05 or P ＜ 0.01). Conclusion Bel-7404 cells transfected by HBx may induce overexpression of Notch-1 and MRP, leading to the increase of multiplication capacity of hepatocellular carcinoma cell line Bel-7404 and the occurrence of multidrug resistance.
2017 Vol. 14 (27): 16-20 [Abstract] ( 288 ) HTML (1 KB)  PDF (814 KB)  ( 169 )
21 Simultaneous determination of seven C21 steroidal saponins in Cortex periplocae extract by quantitative analysis of multi-components by single-marker
LI Ruixue1 WU Fei1,2,3 ZHANG Jiquan1,2 FENG Yi1,2
Objective To establish a high performance liquid chromatography method for quantitative analysis of seven C21 steroidal saponins in Cortex periplocae extract by quantitative analysis of multi-components by single-marker. Methods The high performance liquid chromatography analysis was performed on a Capcell Pak C18 column with the detection wavelength at 263 nm. The mobile phase was water containing 0.2% formic acid and acetonitrile in the gradient mode. Periploside C (PSA) was used as the internal marker to establish relative correction factors between PSA and periploside K (PSK), periploside R (WJ53), periploside E (WJ521), periploside D (PSD), periploside Q (WJ33), periploside O (WJ32), and the relative correction factors would be used in the calculation of their contents. The result of quantitative analysis of multi-components by single-marker was compared with external standard method, so as to verify the accuracy of quantitative analysis of multi-components by single-marker. Results The relative correction factors between PSA and PSK, WJ53, WJ521, PSD, WJ33, WJ32 was 0.867, 0.867, 0.847, 0.994, 0.922 and 1.029, respectively. The content values calculated by correction factors and measured values of external standard method did not show significant differences. Conclusion The established quantitative analysis of multi-components by single-marker method is feasible, accurate, simple and can be used as a method for the determination of multi-component indexes in the extract of Cortex periplocae.
2017 Vol. 14 (27): 21-24 [Abstract] ( 235 ) HTML (1 KB)  PDF (774 KB)  ( 133 )
25 The behavior study on the increase of susceptibility to epilepsy in Wistar rats by β-amyloid protein
ZHAO Juan1 ZHANG Yanmei2 ZHENG Naizhi1
Objective To study the effects of β-amyloid protein (Aβ) on the pathogenesis of epilepsy (EP). Methods 40 male Wistar rats were divided into Aβ1-42 + PILO group, Aβ1-42 group, PBS + PILO group and PBS group by random number table, with 10 rats in each group. The former two groups were called Aβ1-42 model group and the later PBS control group. Aβ1-42 and same volume PBS were injected into the hippocampal CA3 region of Wistar rats in Aβ1-42  model group and PBS control group by stereotaxic apparatus respectively, and the Morris water maze test was observed after 2 weeks. Escape latency, the percentage of swimming time in the target quadrant and the number of times of crossing the platform were recorded. After the AD model was successfully made, the rat model of chronic EP was established by intraperitoneal injection of LI-PILO. The latency of EP, degree of seizure and mortality of rats were recorded according to Racine grading criteria. Results One rat died in Aβ1-42  model group and the PBS control group. The results of Morris water maze test showed that compared with the PBS control group, the escape latency of the Aβ1-42  model group was longer (P < 0.01), the proportion of swimming time in the target quadrant was shorter (P < 0.05), and the number of crossing the platform was also significantly reduced (P < 0.05). It indicated that the AD model was successfully prepared. Preparation of rats EP model: The latency of EP in Aβ1-42 + PILO group was significantly shorter (P < 0.01), and the degree of seizure was more severe (P < 0.05), compared with PBS + PILO group, according to Racine grading criteria. The mortality of rats in Aβ1-42 + PILO group was significantly increased compared with PBS + PILO group (P < 0.05). Conclusion It can lead to the impaired hippocampus-related learning and memory function by injection of Aβ1-42 in hippocampal CA3 region of rats. The existing of Aβ increasing the susceptibility to EP in the rats, which indicates that Aβ plays a facilitation role in the occurrence of EP.
2017 Vol. 14 (27): 25-28,36 [Abstract] ( 229 ) HTML (1 KB)  PDF (812 KB)  ( 182 )
29 Effects of bone mesenchymal cells transplantation on number of CD4+CD25+Treg cells of peripheral blood in atherosclerotic rats
ZHANG Yuan1 ZHANG Quan2 MENG Chun2
Objective To explore the effect on the number of CD4+CD25+regulatory T cells in the peripheral blood of the rats with AS after the mesenchymal stem cells transplanted into them and the effects of the two cells on the related inflammatory factors and AS. Methods  90 male Wistar rats were divideinto two groups: the normal diet group (30 rats) and the high-fat diet group (60 rats), and the high-fat diet group were divide into the control group (30 rats) and the transplanted group (30 rats). MSCS suspension (1×106 cells dissolved in 200 μL PBS) were injected into the transplanted group via the tail vein, while the control group were given 200 μL PBS. TC, TG, HDL-C, and LDL-C were analyze by automatic biochemical analyzer,  the levels of hs-CRP and IL-6 in peripheral blood serum were measurated by ELISA and the level of CD4+CD25+Foxp3 Treg cells were observed by flow cytometry and the histological changes were observed by hematoxyli eosin stain. Results The histological analysis showed that the model of atherosclerosis was formed sucessfully. The blood lipid and inflammatory factors of control group were than the normal diet group（P < 0.05). The levels of blood lipid and inflammatory factors the transplanted group decreased after 4 weeks (P < 0.05), and the number of CD4+CD25+ regulatory T cells and CD4+CD25+Foxp3 increased（P < 0.05）. Conclusion The transplantation of BMMSCs to Wistar rats with AS can increase the number of CD4+CD25+regulatory T cells, promote the expression of Foxp3, and decline blood lipid and inflammatory factors, thus providing a new idea to restrain the occurrence and development of AS and stabilize the plaques.
2017 Vol. 14 (27): 29-32,47 [Abstract] ( 248 ) HTML (1 KB)  PDF (1536 KB)  ( 300 )
33 Study on chemical constituents from stems and leaves of Sedum aizoon L.
HAN Wei1 LI Mingxiao2 LYU Chongning2 HAO Yimeng2 LU Jincai2
Objective To study the chemical constituents in the stems and leaves of Sedum aizoon L. Methods The stems and leaves of Sedum aizoon L. was extracted with 70% ethyl alcohol to give ethanol extracts, which was further diluted by H2O and extracted with petroleum ether, chloroform, EtOAc and n-BuOH, respectively. They were isolated and purified by silica gel column chromatography, Sephadex LH-20 gel column chromatography and high performance liquid chromatography methods. The structures were elucidated based on the physic-chemical characters and spectral analysis. Results Nine compounds were obtained from n-BuOH extracts of 70% ethyl alcohol extracts from stems and leaves of Sedum aizoon L., which was kaempferol-3-O-β-D-glucopyranoside (1), myricetin-3-O-α-L-arabinopyranoside (2), quercetin-3-O-α-L-arabinopyranoside (3), herbacetin-3-O-α-L-arabinopyranoside (4), woodorien (5), vanilloloside (6), benzy-1-O-β-D-glucopyranoside (7), benzylethyl-O-β-D-glucopyranoside (8), benzylethyl-O-β-D-xylopyranosyl-(1→2)-O-β-D-glucopyranoside (9), respectively. Conclusion Compound 4 is a new compound, which has not yet been reported. Compounds 6-9 are isolated from genus Sedum for the first time.
2017 Vol. 14 (27): 33-36 [Abstract] ( 267 ) HTML (1 KB)  PDF (815 KB)  ( 82 )
37 Research progress of collateral circulation in cerebral infarction by TCM and western medicine
CHEN Yunbo1 MA Min1 CHEN Zhaobang2
Cerebral infarction has become one of the three diseases in China, it is the one of the common diseases of the nervous system with high morbidity and mortality. In recent years, the influencing factors of collateral circulation, evaluation and treatment methods, and interventional research of traditional Chinese medicine, which gradually enrich the understanding of collateral circulation, so that the treatment of cerebral infarction has increased by an important means,the mortality and disability degree of the patients were obviously decreased.
2017 Vol. 14 (27): 37-39,61 [Abstract] ( 231 ) HTML (1 KB)  PDF (645 KB)  ( 76 )
40 Research progress of combination drugs of antidepressants
YUAN Jie1 GAO Jing2 XIAO Jian2 LI Jinhao2 WANG Ning2 WANG Jing3
Depression is a common affective disorder disease, the application of antidepressants can improve the symptoms of depression significantly, which is the main way to treat depression in clinical practice currently. A reasonable addition of other drugs on the basis of antidepressants can significantly improve the cure rate of depression, so the combination of drugs is commonly used in the treatment of clinicians. This article systematically expounds the status of antidepressant drugs in combination, for the rational use of combined drug regimen provides new basis.
2017 Vol. 14 (27): 40-43 [Abstract] ( 320 ) HTML (1 KB)  PDF (637 KB)  ( 169 )
44 Recent advances in the study of glucagon like peptide -2
MA Li′na BI Huimin GAO Ling
Glucagon like peptide-2 (GLP-2) is a recently discovered gastrointestinal specific growth factor, with a variety of intestinal regulatory function, including: promoting growth, nutrient digestion and absorption of the intestinal mucosa, increasing intestinal blood flow, improving intestinal barrier function, and promoting the repair of intestinal mucosa damage and healing. In view of the above features, GLP-2 has clinical value in many intestinal diseases such as short bowel syndrome and inflammatory bowel disease. GLP-2 plays a biological role by acting on glucagon like peptide-2 receptors (GLP-2R). Recent experiment data suggest that GLP-2 has a beneficial effect on glucose metabolism, especially for conditions related to increased energy intake. In this paper, the generation, secretion, metabolism and physiological functions of GLP-2 are summarized, and the latest research progress of GLP-2 physiological function is discussed.
2017 Vol. 14 (27): 44-47 [Abstract] ( 204 ) HTML (1 KB)  PDF (636 KB)  ( 188 )
48 Research progress of microRNA in prevention and treatment of femoral head necrosis
YU Changsui1 ZHANG Xiaofeng2 XU Xilin2 YU Zhongbao3 WANG Shuren4 WANG Zhengchun1 PENG Yufei4 CHEN Weiheng5
microRNAs (miRNAs) belongs to a small RNA of non-protein coding families, and is involved in many physiological and pathological processes. They are about 22 nucleotides long and have specific expression in human tissues or cells. One group of miRNAs has been shown to play a fundamental role in gene regulation in various kinds of orthopedics diseases, such as bone tumors, osteoarthritis, and rheumatoid arthritis. The study of miRNA in osteonecrosis of the femoral head can help to understand the pathogenesis of the disease more clearly. The main cause of osteonecrosis of the femoral head is the destruction of femoral head blood supply, and the main symptoms are bone and muscle dysfunction. The recent studies show that microRNA plays an important role in the regulation of microcirculation of osteonecrosis of the femeral head, local microcirculation dysfunction caused by other diseases and bone cells apoptosis. In this paper, the related research results of microRNA and osteonecrosis of the femoral head in recent years are analyzed and summarized, and the prospect of microRNA in the prevention and treatment of osteonecrosis of the femoral head is also looked forward.
2017 Vol. 14 (27): 48-51 [Abstract] ( 245 ) HTML (1 KB)  PDF (635 KB)  ( 268 )
52 Study on the relationship between the spleen deficiency syndrome and antibacterial drugs using in children
LIU Meiying CHI Rongxiang SUN Congling SHAO Shang HAN Feng▲
 Spleen deficiency syndrome is one of the most common syndromes in pediatric clinic, and children are susceptible to get infectious diseases. The antibacterial drugs use are one of the most in pediatric clinic, children with spleen deficiency are more susceptible to infection, and the use of antibacterial drugs can cause spleen deficiency. From the past understanding and the current research of spleen deficiency syndrome, and the situation of antibacterial drugs use, this paper try to investigate the relationship between the spleen deficiency syndrome of children and the antibacterial drugs use, and in order to guide rational administration and clinical differentiation.
2017 Vol. 14 (27): 52-55 [Abstract] ( 276 ) HTML (1 KB)  PDF (633 KB)  ( 82 )
56 Advances in the study of early renal impairment in hypertension
HAO Yongzhe1 CHENG Wenjun2
The end-stage renal disease is the third disease caused by high blood pressure, closely after primary glomerular disease and diabetic nephropathy, moreover, renal impairment in hypertension has close relationship with death rate of patients, so it attracts great attention of researchers. This article sums up mechanism of hypertensive renal impairment and early detection and treatment. The aim of this article is to prevent and delay the occurrence and development of hypertensive renal damage.
2017 Vol. 14 (27): 56-61 [Abstract] ( 272 ) HTML (1 KB)  PDF (715 KB)  ( 123 )
62 The advance of the use of Pre-S1 antigen in the diagnosis and therapy of hepatitis B virus infection
HUANG Lili WU Yulin
Pre-S1 antigen is a membrane protein which is located at the surface of hepatitis B virus (HBV) particle. Recently，a lot of studies suggested Pre-S1 antigen could be detected in blood and used as a marker of the early infection of HBV. The detection of Pre-S1 antigen is highly consistent with the detection of HBV-DNA and HBeAg to be the supplement and reference. The clearance time and continuing positive of Pre-S1 antigen could respectively indicate the prognosis of the infection of HBV. Therefore, Pre-S1 antigen could be used as an important tool for the diagnosis and therapy of hepatitis B virus infection. In this study, we will summarize the structure and function of Pre-S1 antigen and it clinical use in liver diseases associated with hepatitis B virus infection.
2017 Vol. 14 (27): 62-65 [Abstract] ( 225 ) HTML (1 KB)  PDF (695 KB)  ( 105 )
66 Research progress of novel serine protease Corin in cardiovascular disease
FENG Muqiang YU Chaopin ZHAO Zuofang QIN Yalu DU Xi
Corin is a recently discovered Ⅱ type transmembrane serine protease, which is produced in cardiomyocytes, and let cardioascular active peptide precursor enzyme converte  to bioactive peptide. Corin plays an important role in reducing blood volume, regulating fluid balance, controlling blood pressure and improving heart function, which is a kind of new biomarkers of heart failure. More and more studies have found that Corin is not only related to heart failure, but also related to the development of hypertension, coronary heart disease and other cardiovascular diseases.
2017 Vol. 14 (27): 66-69 [Abstract] ( 309 ) HTML (1 KB)  PDF (636 KB)  ( 196 )
70 Analysis of current situation and influence factors of empowerment level of patients with chronic obstructive pulmonary disease
CAI Shubin YE Jiarong LI Jiqiang
Objective To investigate the current situation of empowerment level of patients with chronic obstructive pulmonary disease (COPD) at stable phase and to analyze the influence factors. Methods Totally 192 COPD patients at stable phase accepting treatment in Traditional Chinese Medical Hospital of Guangdong Province from November 2016 to March 2017 were selected to finish self-designed general situation investigation questionnaire and client empowerment scale (CES). Single factor analysis and regression analysis were carried out with PASW 18.0 software. Results CES scores of COPD patients at stable phase were from 44 to 187 points, with the average score of (107.31±31.93) points, which was in or below the medium level. Confidence in disease control, role cognition and participation in medical decision-making were the three dimensions with lowest scores. Regression analysis results showed that age, education background, course of disease, pulmonary function degree and dyspnea degree were influence factors of empowerment level (P < 0.05), and they together could explain 31.4% of the variance variability amount. Conclusion Empowerment level of COPD patients at stable phase is relatively low, and the patients especially lack capability in disease control, role cognition and participation in medical decision-making. Age, education background, course of disease, pulmonary function degree and dyspnea degree are influence factors of empowerment level.
2017 Vol. 14 (27): 70-73,100 [Abstract] ( 280 ) HTML (1 KB)  PDF (802 KB)  ( 131 )
74 Emotional labor of standardized training of resident doctors and its influence on patient-physician relationship in 3-A-grade hospitals in Wuhan
XU Weiming1,2 LIANG Yun3 GUO Haiyan2
Objective To investigate the emotional labor of standardization training of resident doctors and its influence on the patient-physician relationship in 3-A-grade hospitals in Wuhan. Methods Standardization training of resident doctors in three 3-A-grade hospitals in Wuhan who were willing to participate were investigated by Diefendorff (2005) emotional labor strategy scale and DDPRQ-10 scale by use of self-administered questionnaire survey platform from January to February in 2017. Results A total of 82 doctors participated in the survey. Compared with neutral attitude, natural acting and deep acting of these doctors were more high (P < 0.05). And emotional labor scores were not significantly differences among different sex, age and hospitals (P ＞ 0.05), except surface acting score was significant difference between different sex(P < 0.05). Patient-physician relationship of these doctors was more fragile compared with neutral attitude (P < 0.05). There was a significantly negative but weak correlation among deep acting of emotional labor with the subjective and objective view of patient-physician relationship and the total score of patient-physician relationship (P < 0.05, r < 0.5). Conclusion The most frequently adopted strategy by doctors in 3-A-grade hospital in Wuhan is deep acting and natural acting. Emotional labor may indirectly influence patient-physician relationship through other factors.
2017 Vol. 14 (27): 74-77 [Abstract] ( 212 ) HTML (1 KB)  PDF (402 KB)  ( 154 )
78 Study on characteristics of prediabetes blood lipid in middle-aged and elderly population
GUO Caihong LU Xin WANG Ruiqing AN Yan ZU Fei GUO Baoying ZHANG Jing
Objective To investigate the characteristics of blood lipid in prediabetes in middle-aged and elderly population. Methods From January 2014 to December 2016 admitted to Department of Endocrinology of Beijing Aerospace Hospital in elderly patients with prediabetes of 270 cases as research objects. The relevant examination after admission was perfected. According to the blood glucose test results, all patients were divided into fasting glucose group (IFG) group (n=50), impaired glucose tolerance (IGT) group (n=120) and IFG+IGT group (n=100). The blood lipid levels of 3 groups were measured. The patients were given corresponding treatment, for 3 consecutive years of follow-up after lipid levels, blood lipid levels and blood lipid among 3 groups and the prevalence of abnormal outcome after 3 years. Results There was no significant difference among 3 groups in the level of LDL-C before intervention (P ＞ 0.05). TC, TG levels in IFG＋IGT group were higher than those in IFG group and IGT group before intervention (P < 0.05). The levels of high-density lipoprotein (HDL-C) in IFG+IGT group and IGT group were lower than those in IFG group before intervention (P < 0.05). The incidence of hyperglycemia in IFG+IGT group was significantly higher than that in IFG group and IGT group before intervention (P < 0.05). The incidence of hyperglycemia in IGT group was significantly higher than that in IFG group before intervention (P < 0.05). There was no significant difference in the levels of TC, TG, HDL-C and LDL-C among three groups (P > 0.05). Conclusion In the middle-aged and elderly people, prediabetes is often associated with different levels of lipid metabolism abnormalities. The monitoring of TG levels can predict the changes of patients' condition, guide clinical treatment and improve the prognosis of patients.
2017 Vol. 14 (27): 78-80 [Abstract] ( 235 ) HTML (1 KB)  PDF (335 KB)  ( 71 )
81 Effect of head-low and hip-high position in the treatment of upper ureteral calculi
ZHOU Rongsheng HAN Conghui ZHOU Xiangju ZANG Guanghui FAN Tao MA Weiming PANG Kun▲
Objective To research clinical effect between head-low hip-high position and traditional position in the treatment of upper ureteral calculi. Methods 70 patients with upper ureteral calculi treated with ureteroscopic holmium laser lithotripsy from January 2013 to January 2016 in Xuzhou Central Hospital were selected. The patients were divided into two groups: head-low hip-high position ureteroscopic holmium laser lithotripsy group (experimental group, 35 cases) and traditional position holmium laser lithotripsy group (control group, 35 cases) according to random number table method. Operation time, postoperative hospital stay, stones up, surgical complications and gravel success between two groups were compared. Results There was no significant difference on baseline data in addition to body mass index between two groups (P > 0.05). There were no significant difference between two groups in operation time, postoperative hospital stay, surgical complications, stone uptake (P > 0.05). The success rate of crushed stone in experimental group was higher than that in control group (P < 0.05). Conclusion For the treatment of upper ureteral calculi, the success rate of head-low hip-high position is higher than that of traditional position without the improvement of other complications.
2017 Vol. 14 (27): 81-84 [Abstract] ( 213 ) HTML (1 KB)  PDF (392 KB)  ( 227 )
85 The effect of microvascular invasion on prognosis in renal cell carcinoma
ZHANG Yuanjie LI Guohao CHEN Lin WU Ding GUO Yonglian▲
Objective To investigate the effect of microvascular invasion (MVI) on prognosis in renal cell carcinoma (RCC). Methods The clinical data of patients with RCC which be collected from January 2002 to June 2014 in Central Hospital of Wuhan were analyzed. 51 patients (T1-T3, without renal vein or inferior vena cava invasion) with MVI confirmed by pathology and the same number patients without MVI were enrolled in this study. Disease free survival (DFS) and cancer specific survival (CSS) were analyzed by Kaplan-Meier. Prognostic factors of patients with MVI were analyzed by Cox's model. Results 5-year CSS rate of patients with or without MVI were 86% and 84%. There were no obviously difference of CSS and DFS between two groups（P > 0.05）. But the tumor grade and TNM staging were confirmed to be the prognostic factors of CSS, and the relative risk (RR) value were 3.535 and 2.219 (P > 0.05). It was also showed that tumor grade and TNM staging were prognostic factors of DFS, and RR value were 7.333 and 2.029 (P < 0.05). Conclusion MVI appear to have no effect on prognosis in localized RCC patients. Higher grade and TNM staging are related to the poor prognosis.
2017 Vol. 14 (27): 85-88 [Abstract] ( 203 ) HTML (1 KB)  PDF (479 KB)  ( 145 )
89 Clinical effect of arthroscopic surgery for rotator cuff injuries in the elderly
DAI Haifeng1 LI Jia1 WANG Zhihui1 LIU Feng2 XU Cong1▲
Objective To investigate the difference of curative effect between arthroscopic surgery and conservative treatment for rotator cuff injury in patients over 65 years. Methods From May 2011 to June 2014, in Department of Joint Surgery, Affiliated Hospital of Chengde Medical College, 50 patients with rotator cuff injuries were selected, the patients were divided into two groups according to patients' treatment willingness, 30 cases treated with arthroscopy or shoulder arthroscopy were selected as operation group, and 20 cases treated conservative method were selected as conservation group. The pain visual analogue scale (VAS), American shoulder and elbow surgeons (ASES) and shoulder joint score system  in California University (UCLA) were compared, and the recovery of shoulder function after surgery were also evaluated. Results All patients were followed up for 24-36 months. No complication such as infection, incision not healing, secondary crack were observed. There was no significant difference in shoulder function scores between the operation group and the conservation group before treatment (P > 0.05); the shoulder joint function in two groups at the last follow-up significantly improved compared with before treatment, and this in operation group was bwtter than that in conservation group, the difference were statistically significant (P < 0.05). Conclusion Arthroscopic surgery to repair rotator cuff injuries in patients over the age of 65 years can improve function and pain relief.
2017 Vol. 14 (27): 89-92 [Abstract] ( 329 ) HTML (1 KB)  PDF (598 KB)  ( 161 )
93 Clinical curative effect analysis research of the autologous PRP in spinal tuberculosis bone fusion surgical treatment
LI Zeqing1 TANG Baoming1 TAN Jun2 ZHONG Hao1 LI Zhaowei1▲
Objective To discuss clinical application and curative effect of  autologous platelet rich plasma (PRP) in spinal tuberculosis bone fusion surgical treatment. Methods From March 2013 to March 2016, in Qinghai University Affiliated Hospital, 32 patients with spinal tuberculosis who were all from Qinghai area were selected. Patients given autologous PRP mixture with artificial bone in spinal tuberculosis were selected as PRP group (16 cases), patients with artificial bone in spinal tuberculosis were selected as none-PRP group (16 cases). The bone transplanted fusion time, operation time, treatment time, intraoperative blood loss, postoperative Oswestry index (ODI), VAS score, CRP, ESR after 1 week to 2 months, complication incidence of patients were recorded and analyzed. Results All the patients' spinal tuberculosis in PRP group and none-PRP group were cured. The bone fusion time, average operation time the average time of treatment, postoperative 1 weeks to 2 months hs-CRP, ESR value, and complication rate in PRP group were shorter or lower than those in none-PRP group, ODI scores in PRP group was higher than that in none-PRP group, the differences were statistically significant (P < 0.05). The amount of bleeding and postoperative pain VAS score (not including donor) in two groups were compared, the differences were not statistically significant (P > 0.05). Conclusion Autologous PRP and artificial bone mixture compares with ilium in spinal tuberculosis after grafting bone fusion has obvious advantages. Its application not only shortens the operation time, but also effectively avoid the donor bone pain and other complications. Most notably, the PRP-artificial bone can substantially shorten the time of bone graft fusion and provide an effective and reasonable treatment for spinal tuberculosis.
2017 Vol. 14 (27): 93-96 [Abstract] ( 328 ) HTML (1 KB)  PDF (814 KB)  ( 180 )
97 Clinical effect of Shenggu Decoction combined with modified core decompression and osteotomy on early treatment of femoral head necrosis
HE Kaiyi1 YI Shenghui2 QIN Gang1 DU Mindong1 CHEN Jing1 HUANG Xiaohua1 ZENG Ping1
Objective To explore the clinical effect of Shenggu Decoction combined with core decompression and bone grafting in the treatment of early femoral head necrosis. Methods From May 2014 to April 2016, in First Affiliated Hospital of Guangxi University of Chinese Medicine, 60 patients with early femoral head necrosis were selected, according to random number table, they were divided into two groups, with 30 cases in each group, the control group was given modified core decompression and bone graft treatment, the observation group was given Shenggu Decoction based on control group. The clinical efficacy, hip function score and imaging evaluation before and after treatment were observed. Results The total effective rate of the observation group was significantly higher than that of the control group (P < 0.05), the imaging scores of the two groups were significantly improved after treatment (P < 0.05), the hip function scores were significantly improved (P < 0.05), and improvement of the observation group was better than that of the control group (P < 0.05). Conclusion Shenggu Decoction combined with modified core decompression and bone grafting treatment of early femoral head necrosis can not only improve the patients' hip function and imaging performance, but also  improve the quality of life of patients.
2017 Vol. 14 (27): 97-100 [Abstract] ( 223 ) HTML (1 KB)  PDF (603 KB)  ( 177 )
101 Relationship of bone density with sCD163 in diabetic osteoporosis
CHEN Aibao1 ZENG Guoqing1 GONG Qi2 YANG Xuehong1 MU Jihong1
Objective To investigate the correlation of the bone mineral density (BMD) in patients with type 2 diabetes mellitus with sCD163. Methods From January 2015 to April 2016, in 425th Hospital of PLA, 82 patients with type 2 diabetes mellitus were selected as DM group, DM group was divided into osteoporotic DM group (45 cases) and non-osteoporotic DM group (37 cases), at the same time, 30 healthy persons were enrolled as the control group. BMD of lumbar span (L1-L4) was measured with dual energy X-ray absorptiometry, the levels of FPB and HbA1c were analysed by automatic biochemistry analyzer. The serum level of sCD163 was detected by ELISA. Results The levels of FGP, HbA1c, sCD163 in DM group were significantly higher than those in control group (P < 0.05). The BMD in DM group was significantly lower than that in control group (P < 0.05). The level of sCD163 in osteoporotic DM group was significantly higher than that in non-osteoporotic DM group (P < 0.05), and the level of BMD more declined in osteoporotic DM group than that in non-osteoporotic DM group (P < 0.05). Furthermore, the result of Pearson correlation analysis indicated that BMD was negatively correlated with sCD163 (r = -0.880, P < 0.05). Logistic regression analysis indicated that in DM patients sCD163 was the risk factor for osteoporosis (OR = 1.490, P < 0.05). Conclusion The increased level of sCD163 is related to the osteoporosis in DM.
2017 Vol. 14 (27): 101-104 [Abstract] ( 171 ) HTML (1 KB)  PDF (613 KB)  ( 216 )
105 Clinical results of external fixator pinning in anterior process of calcaneus combined with open reduction and internal fixation for treatment of instable ankle fracture
LIU Chang ZHANG Haisen PEI Baojing SU Ke WANG Qinghai BAI Yuming LI Longjie
Objective To investigate clinical effect of the external fixator pinning in anterior process of calcaneus combined with open reduction and internal fixation in treatment of instable trimalleolar fracture of the ankle. Methods From January 2012 to December 2015, in Central Hospital of Cangzhou City, the clinical data of 23 patients with instable trimalleolar fracture of the ankle treated by the external fixator pinning in anterior process of calcaneus combined with open reduction and internal fixation were retrospectively analyzed. All cases were closed fractures with posterior subluxation of the talus. All patients had posterior malleolar fragments involving the tibial articular surface ≥25%. According to Lauge-Hansen classification, 9 cases were with pronation external rotation type Ⅳ, 14 cases with supination and external rotation type Ⅳ. External fixator was relaxed for once per week after operation 4 weeks in order to exercise motion of ankle. At postoperative fellow-up, outcomes were measured by clinical scores and serial radiographic analysis. Results The operation time was (59.5±21.4) min, intraoperative blood loss was (101.5±33.7) mL, and length of stay was (11.5±3.3) d. Regarding complications, one cases (4.3%) had postoperative superficial inflammatory reaction around fibular incision, they healed well afer surgery treatment. There was no occurrence of injury fo blood vessels or nerves. The incidence of perioperative complications was 4.3%. All patients were followed up for mean (15.8±4.3) months. All fractures were healed without loss of reduction. For Lowa ankle score and VAS score, there was not significant different during postoperative follow-up points (P > 0.05). At the last follow-up, Lowa ankle score and VAS score were (86.9±5.4), (2.7±0.6) scores. According to the Maryland score, the good rate of the curative effect was 91.3%. Conclusion Clinical results of the external fixator pinning in anterior process of calcaneus combines with open reduction and internal fixation in treatment of instable trimalleolar fracture of the ankleare is good. The complication rate is low. This is an alternative method in the treatment ofinstable trimalleolar fracture of the ankle.
2017 Vol. 14 (27): 105-108 [Abstract] ( 206 ) HTML (1 KB)  PDF (641 KB)  ( 216 )
109 Clinical effect of treating Denis typeⅡ sacral fracture with iliac fixation
DONG Hui1 RAN Jian2 WANG Jianyuan1 YAN Guoliang1 CUI Xiaozhou1
Objective To observe the clinical effect of treating of Denis typeⅡ fracture of the sacrum with iliac fixation. Methods From October 2015 to October 2016, in 474 Hospital of PLA, 83 patients with Denis typeⅡ sacral fracture were selected, according to the operation method, they were divided into routine group 42 cases (treated with traditional surgery) and iliopsoas group 41 cases (treated with iliolumbar fixation ). The operation time, fracture healing time, sacral function recovery time and total clinical efficiency rate of two groups were analyzed and compared. Results The operation time, fracture healing time, sacral function recovery time of iliopsoas group were shorter than those of routine group, the differences were statistically significant (P < 0.05). The total clinical efficiency rate of iliopsoas group were higher than that of routine group, the difference was statistically significant (P < 0.05). Conclusion For patients with sacral fractures of Denis typeⅡ, the operative time, fracture healing time, sacral function recovery time and total clinical efficiency rate of iliacolumbar fixation are significantly better than those of traditional surgical treatment, it can shorten the recovery time and hospitalization time, it is worth to clinical popularity, promotion.
2017 Vol. 14 (27): 109-111 [Abstract] ( 241 ) HTML (1 KB)  PDF (584 KB)  ( 97 )
112 The effect of embryo culture media on the birthweight and length of newborns
JIANG Yiqun WANG Shanshan XU Zhipeng ZHANG Ningyuan▲
Objective To investigate the effect of two commercial embryo culture media (Cook，Vitrolife) on the birthweight and length of newborns after fresh embryo transfer in IVF/ICSI. Methods The data of 1441 patients conceived through IVF/ICSI in Reproductive Medicine Center, the Affiliated Drum Tower Hospital of Nanjing University Medical School from August 2014 to December 2015 were analyzed retrospectively. According to the fetal number and embryo culture media, these patients were divided into two groups: singletons group and twins group, both the two groups included Cook and Vitrolife subgroups. The birthweight and length of newborns were compared in singletons and twins groups. Results There were no significant differences in birthweight and length of the newborns between the Cook and Vitrolife subgroups in singletons group (P > 0.05); while there were no significant differences in birthweight and length between the Cook and Vitrolife subgroups in twins group (P > 0.05). Conclusion It can be concluded that embryos cultured in Cook and Vitrolife media after fresh cleavage embryo transfer do not affect the birthweight and length of newborns.
2017 Vol. 14 (27): 112-115 [Abstract] ( 212 ) HTML (1 KB)  PDF (436 KB)  ( 134 )
116 Effect of different oxygen concentrations on brain damage in neonatal asphyxiation recovery
GU Yufang ZENG Guixiang MENG Li HUANG Chunyu JIANG Ningning
Objective To discuss the clinical effects of different oxygen concentrations during neonatal asphyxiation recovery. Methods 120 full-term newborns with asphyxia treated in the Sixth People's Hospital of Nanning City from February 2016 to February 2017 were selected. The newborns were randomly divided into the air resuscitation group, low concentration oxygen group and high concentration oxygen group, each group had 40 cases. The air resuscitation group was treated with air resuscitation, high concentration oxygen group was treated with 100% oxygen resuscitation, and low concentration oxygen group was treated with 30% oxygen resuscitation. The time of began to cry and spontaneous breathing establishment, Apgar scores at different time after birth, recovery success rate and recovery safety of the three groups were compared. Results There were statistically significant differences in the time of began to cry and the time of spontaneous breathing establishment among the three groups (P < 0.05), of which the air resuscitation group and low concentration oxygen group were all shorter than the high concentration oxygen group, with statistically significant differences (P < 0.05), the low concentration oxygen group were shorter than the air resuscitation group, but no statistically significant differences (P > 0.05). There were statistically significant differences in Apgar scores at different time after birth among the three groups (P < 0.05), of which the air resuscitation group and low concentration oxygen group were higher than the high concentration oxygen group, with statistically significant differences (P < 0.05), the low concentration oxygen group were higher than the air resuscitation group, but no statistically significant differences (P > 0.05). The incidence of neonatal brain injury of the air resuscitation group and low concentration oxygen group were lower than those of the high concentration oxygen group, with statistically significant differences (P < 0.05), while the low concentration oxygen group was lower than the air resuscitation group, but no statistically significant difference (P > 0.05). The successful rate of recovery was 100.00% in three groups. The incidence of oxygen poisoning of the air resuscitation group and low concentration oxygen group were lower than those of the high concentration oxygen group, with statistically significant differences (P < 0.05), while the low concentration oxygen group was lower than the air resuscitation group, but no statistically significant difference (P > 0.05). Conclusion During the course of neonatal asphyxia resuscitation, 30% oxygen resuscitation is effective, which can achieve better recovery effect, effectively reduce brain damage and avoid the emergence of oxygen poisoning. It is a more safe and effective recovery program.
2017 Vol. 14 (27): 116-119 [Abstract] ( 256 ) HTML (1 KB)  PDF (432 KB)  ( 122 )
120 The changes of coagulation in patients with amniotic fluid embolism
YUE Yongfei FENG Yiqi▲ WANG Yun WANG Xiaoyan
Objective To investigate the blood transfusion treatment and the changes of coagulation function in patients with amniotic fluid embolism (AFE). Methods The data of 10 cases of patients with AFE treated in Suzhou Hospital Affiliated to Nanjing Medical University from January 2011 to March 2017 were analyzed retrospectively. The changes of infusion of erythrocyte suspension, plasma, prothrombin, platelet and coagulation function were analyzed. Results In this study, 10 cases of AFE patients had suffered from disseminated intravascular coagulation (DIC). In 24 hours after AFE, the average amount of bleeding was (4065.6±1008.0) mL, the infusion of red blood cell suspension was (16.6±7.2) U, the infusion of plasma was (2450.0±1250.3) mL, the infusion of cold precipitation was (8.4±7.3) U, the infusion of fibrinogen was (4.6±2.4) g, only two patients were infused with platelets. Coagulation index had rapid changes within 2 hours of AFE, the indicators were restored in 24 hours to normal levels after improving coagulation function. Time of prothrombin returned to normal levels in about 8 hours, which was the fastest. Fibrin degradation products and D-dimer recovery in about 24 hours, which were the slowest. The amount of platelets maintained at 50×109/L after AFE, which could ensure the normal blood clotting needs and returned to normal levels in about 72 hours, but the recovery was also slower. Conclusion Coagulation index had rapid changes within 2 hours of AFE, the timely infusion of blood components can improve DIC and coagulation return to normal in about 24 hours.
2017 Vol. 14 (27): 120-123,131 [Abstract] ( 170 ) HTML (1 KB)  PDF (921 KB)  ( 195 )
124 Effect of psychological intervention on idiopathic tinnitus
XU Jing1,2 YAN Dan1 PAN Gangqiang2 SHEN Li2 YU Lu2
Objective To investigate the role of psychological intervention in treatment of idiopathic tinnitus and provide the theoretical basis for clinical application. Methods From December 2015 to December 2016, 66 patients with idiopathic tinnitus in Huangshi Love & Health Hospital were selected and divided into control group and observation group by random number table, with 33 cases in each group. Both groups were treated by routine treatment (drug therapy, intratympanic injection, hyperbaric oxygen). Additionally, the observation group was combined with psychological intervention (acclimatization, cognitive, masking, implied). Hamilton anxiety scale (HAMA) and Hamilton depression scale (HAMD) examinations were taken before and after treatment. The effective rates of two groups were compared at the end of 2-week treatment and 2 months after treatment，respectively. Results In observation group, the HAMA score and HAMD score after treatment were lower than those before treatment (P < 0.05). But there was no significant difference in control group (P > 0.05). Before treatment, there was no difference in HAMA score and HAMD score between two groups (P > 0.05). After treatment, the HAMA score and HAMD score in the observation group were significantly lower than those in the control group (P < 0.05). The effective rate of the observation group was significantly higher than that of the control group both at the end of 2-week treatment and 2 months after treatment (P < 0.05). Conclusion Psychological intervention in the conventional treatment of idiopathic tinnitus can reduce anxiety and depression and improve therapeutic effect.
2017 Vol. 14 (27): 124-127 [Abstract] ( 247 ) HTML (1 KB)  PDF (497 KB)  ( 107 )
128 The correlation between metabolic syndrome and dry eye syndrome in middle-aged and elderly community-dwelling residents in Beijing
ZHANG Jing1 MA Xiao2▲ YIN Baiding3 TU Dahong3
Objective To analyze the pathogenic correlation between metabolic syndrome (MetS) and dry eye syndrome (DES). Methods 1738 adults age 40 or older from Huichengmen Community of Haidian District, Beijing were involved to complete DES questionnaires combined with laboratory tests, anthropometric measures and slit-lamp examinations. Results Morbidities of MetS and DES was 32% and 24.7% respectively. The incidences in female patients were significantly higher than those in male (P < 0.05). Logistic regression analysis indicated that hyperglycemia and hyperlipidemia were independent risk factors for MetS after correcting ages, smoking, drinking and education level. Conclusion Positive correlation was observed between MetS and DES. Hyperglycemia and hyperlipidemia were the independent risk factors for MetS.
2017 Vol. 14 (27): 128-131 [Abstract] ( 230 ) HTML (1 KB)  PDF (516 KB)  ( 146 )
132 Application value of antibiotics combined with Vitamin C in recurrent oral ulcer
CHEN Jinfen
Objective To evaluate the application of antibiotics combined with Vitamin C in patients with recurrent oral ulcer. Methods 90 patients with recurrent oral ulcer from April 2015 to July 2016 in 174 Hospital of PLA were divided into control group and study group by random number table, with 45 cases in each group. The control group was treated by conventional symptomatic treatment, control related factors, relieve tension, saline mouthwash, metronidazole; besides, the study group was treated by Ceftriaxone Sodium + Vitamin C, which were treated for 2 weeks. Serum cytokines, immune function and hemorheological indexes were measured before and after treatment. The clinical efficacy and complications were also compared. Results Compared with before treatment, levels of serum IL-2, IL-8, TNF-α and CRP were decreased, levels of CD3+, CD4+, CD4+/CD8+ were increased and level of CD8+ was decreased, whole blood viscosity, plasma viscosity, whole blood reduced viscosity and erythrocyte aggregation index decreased in two groups 2 weeks after treatment (P < 0.05). Compared with the control group, in the study group, levels of IL-2, IL-8, TNF-α and CRP were significantly lower (P < 0.05), levels of CD3+, CD4+, CD4+/CD8+ were higher, and level of CD8+ was lower, and whole blood reduced viscosity and erythrocyte aggregation index were lower (P < 0.05), the effective rate in the control group was lower than the study group (P < 0.05). Conclusion The combination of antibiotics and Vitamin C is effective in the treatment of recurrent aphthous ulcer. It can improve the inflammation and hemorheological indexes and improve the immune function.
2017 Vol. 14 (27): 132-135 [Abstract] ( 203 ) HTML (1 KB)  PDF (470 KB)  ( 68 )
136 Influence of combined medication of Dioctahedral Smectite, Mannitol and Activated Carbon for the effect and anxiety-depression of patients with paraquat poisoning 
CHEN Zhihong1,2 GUO Yan2 WANG Xingang3,4 LIU Wei1,4
Objective To investigate the influence of combined medication of Dioctahedral Smectite, Mannitol and Activated Carbon for the effect and anxiety-depression of patients with paraquat poisoning. Methods Eighty-six cases of patients with paraquat poisoning admitted to No.169 Hospital of PLA (Xiangnan Hospital Affiliated to Hu′nan Normal University) from June 2014 to June 2016 were selected and divided into two groups by random number table, with 43 cases in each group. The control group was given routine treatment, the observation group was given combined medication of Dioctahedral Smectite, Mannitol and Activated Carbon on the basis of control group. The course of both groups was 7 days. The therapeutic effects, the occurrence time of pulmonary fibrosis, respiratory failure and multiple organ dysfunction syndrome (MODS) of the two groups were compared, and the indexes of liver function [aspartate aminotransferase (AST), alanine transaminase (ALT)] and scores of anxiety and depression of the two groups before and after treatment were compared. Results The total effective rate of observation group (62.79%) was higher than that of control group (32.56%), with statistically significant difference (P ＜ 0.05). The occurrence time of pulmonary fibrosis, respiratory failure and MODS in observation group was later than those of control group, with statistically significant differences (all P ＜ 0.05). After treatment, the levels of AST, ALT in the two groups were all lower than those before treatment, which of observation group were lower than those of control group (all P ＜ 0.05). After treatment, the scores of anxiety and depression in both groups were all lower than those before treatment, which of observation group were lower than those of control group, the differences were all statistically significant (all P ＜ 0.05). Conclusion Combined medication of Dioctahedral Smectite, Mannitol and Activated Carbon for patients with paraquat poisoning has good curative effect, which can improve the symptoms of anxiety and depression. It has important research significance.
2017 Vol. 14 (27): 136-139 [Abstract] ( 249 ) HTML (1 KB)  PDF (519 KB)  ( 175 )
140 Effect of Dexamethasone on postoperative delirium and cognitive dysfunction in elderly patients with joint replacement surgery
LYU Xuewen HUANG Wen DONG Shuhua▲
Objective To study the effect of Dexamethasone on postoperative delirium and cognitive dysfunction in elderly patients with joint replacement surgery. Methods Two hundred and twenty-five elderly patients with joint replacement surgery [≥65 years old, American Society of Anesthesiologists (ASA) Ⅱ-Ⅲ grade] in the First Affiliated Hospital of Chengdu Medical College from September 2015 to December 2016 were selected. These patients were divided into low dose of Dexamethasone group (group D1), high dose of Dexamethasone group (group D2) and control group (group C) by random number table, with 75 cases in each group. One hour before operation, group D1 was given intravenous injection of Dexamethasone 10 mg, group D2 was given intravenous injection of Dexamethasone 20 mg, group C was given intravenous injection of equal quantity of normal saline. The confusion assessment method-Chinese revision (CAM-CR), mini-mental state examination (MMSE) and visual analogue scale (VAS) were used to evaluate postoperative delirium, postoperative cognitive dysfunction and postoperative pain of the patients respectively. Results After operation for 1, 3, 7 days, the scores of CAM-CR in group D1 and D2 were all lower than those of group C, and the scores of MMSE were all higher than those of group C, with statistically significant differences (all P ＜ 0.01), while there were no significant differences of VAS scores compared with those of group C (P ＞ 0.05). There were no significant differences of the scores of CAM-CR, MMSE and VAS after operation for 1, 3, 7 days between group D1 and D2 (all P ＞ 0.05). After operation for 1, 3, 7 days, the incidence of postoperative delirium and cognitive dysfunction were all lower than those of group C, with statistically significant differences (all P ＜ 0.05), while there were no significant differences of the incidence of postoperative delirium and cognitive dysfunction after operation for 1, 3, 7 days between group D1 and D2 (P ＞ 0.05). Conclusion Application of Dexamethasone before operation can reduce the incidence of postoperative delirium and postoperative cognitive dysfunction in elderly patients underwent joint replacement surgery.
2017 Vol. 14 (27): 140-143 [Abstract] ( 237 ) HTML (1 KB)  PDF (539 KB)  ( 102 )
144 Meta-analysis of efficacy and safety of Rituximab combined with CHOP regimen in the treatment of diffuse large B-cell lymphoma in Chinese population
ZHU Hui1 LI Peihan2 JIN Jian1
Objective To systematically review the efficacy and safety of Rituximab combined with CHOP for treating diffuse large B-cell lymphoma (DLBCL) of Chinese population. Methods From January 2005 to June 2017, the Chinese Journal Full-text Database, VIP, PubMed, EMBase, Medline and Cochrance Library were retrieved to collect the randomized controlled trials (RCT) of Rituximab combined CHOP (treatment group) comparing with single CHOP (control group) for treating DLBCL. After the quality evaluation and information collection of clinical studies with inclusion criteria, RevMan 5.3 software was conducted for Meta-analysis. Results There were totally 27 RCTs involving 2134 patients. Meta-analysis results showed that the complete remission rate (OR = 2.13, 95%CI: 1.77-2.57, P ＜ 0.01); response rate (OR = 3.06, 95%CI: 2.40-3.91, P ＜ 0.01); survival rate (OR = 2.40, 95%CI: 1.89-3.04, P ＜ 0.01) in the treatment group were significantly higher than those of control group, with significant differences. In the subgroup analysis, the complete remission rate (OR = 2.30, 95%CI: 1.80-2.95, P ＜ 0.01), total efficiency (OR = 3.41, 95%CI: 2.51-4.63, P ＜ 0.01) in different courses had statistically significant differences; the complete remission rate (OR = 2.24, 95%CI: 1.84-2.72, P ＜ 0.01), total efficiency (OR = 3.06, 95%CI: 2.40-3.91, P ＜ 0.01) in different CHOP drugs had statistically significant differences. Conclusion Rituximab combined with CHOP in the treatment of DLBCL has good curative effect and safety. Due to the limitation of research quality, the conclusion remains to be further verified.
2017 Vol. 14 (27): 144-152 [Abstract] ( 239 ) HTML (1 KB)  PDF (3093 KB)  ( 248 )
153 Effect of Huoxue Yishen Decoction combined with western medicine in the treatment of chronic glomerulonephritis
CHU Xu CHU Xiulin
Objective To evaluate the clinical curative effect of Huoxue Yishen Decoction combined with western medicine in the treatment of chronic glomerulonephritis. Methods Eighty-six patients with chronic glomerulonephritis treated in Xushui People's Hospital of Baoding City from July 2014 to August 2016 were selected as research objects, and they were divided into two groups according to random number table method. 43 patients in the control group were treated with conventional therapy, and 43 patients in the combined group received conventional therapy + Huoxue Yishen Decoction. Before treatment and after treatment for 2 months, the TCM syndrome scores and the levels of serum creatinine (Scr) and blood urea nitrogen (BUN) between the two groups were compared, and the therapeutic effects of the two groups were evaluated. Results Compared with before treatment, the TCM syndrome scores in the two groups after treatment were decreased significantly, and the TCM syndrome score of combined group after treatment was significantly lower than that of control group, the differences were statistically significant (P ＜ 0.05). Compared with before treatment, the levels of Scr and BUN in the two groups after treatment were decreased significantly, and the levels of Scr and BUN in combined group after treatment were significantly lower than those in control group, the differences were statistically significant (P ＜ 0.05). The total effective rate of combined group was higher than that of control group, the difference was statistically significant (P ＜ 0.05). Conclusion Huoxue Yishen Decoction combined with western medicine in the treatment of chronic glomerulonephritis can significantly improve the clinical efficacy, relieve the clinical symptoms of patients, and promote the recovery of renal function.
2017 Vol. 14 (27): 153-156 [Abstract] ( 235 ) HTML (1 KB)  PDF (462 KB)  ( 129 )
157 Clinical efficacy of cardiac rehabilitation of integrated Chinese and western medicine in the treatment of patients with chronic heart failure
CHEN Yanqiao ZHANG Chengying CHEN Shaojun LI Jiangke
Objective To observe the clinical efficacy of cardiac rehabilitation of integrated Chinese and western medicine in the treatment of patients with chronic heart failure. Methods One hundred patients with chronic heart failure hospitalized in Traditional Chinese Medicine Hospital of Beijing Huairou from January 2015 to January 2016 were selected and divided into treatment group and control group by random number table, with 50 cases in each group. The control group was treated by conventional western medicine therapy, on basis of which, the treatment group was added with cardiac rehabilitation of integrated Chinese and western medicine. Before treatment and after treatment for 6 months, the cardiac function classification of New York Heart Association (NYHA), 6-min walking test (6MWT) and the efficacy of traditional Chinese medicine (TCM) symptoms between two groups were compared. Results The total effective rate of cardiac function (84.0%), TCM symptoms (90.0%) in the treatment group were all higher than those of control group (70.0%, 80.0%), with statistically significant differences (all P ＜ 0.05). After treatment, 6MWT in both groups were all increased more than those before treatment, and the improvement in the treatment group was more remarkable, with statistically significant difference (P ＜ 0.05). Conclusion Cardiac rehabilitation of integrated Chinese and western medicine can significantly improve the cardiac function, exercise tolerance and TCM symptoms of patients with chronic heart failure.
2017 Vol. 14 (27): 157-160 [Abstract] ( 189 ) HTML (1 KB)  PDF (468 KB)  ( 199 )
161 Exploration on the acupotomy therapy for knee osteoarthritis from the characteristics of aponeurotic system and bowstring
LIU Jianmin1,2 LIU Jing3
According to the discourse and interpretation of ancient classics for aponeurotic system, this paper analyzes the relationship of knee osteoarthritis and aponeurotic system theory deeply, and realizes that the characteristics of aponeurotic system and bowstring mechanics of knee maintain the normal physiological function of knee joint. When the aponeurotic system is damaged, nodular lesions will be appeared in the following lines, especially in the "knot" and "conglobulation" parts of aponeurotic system, which leads to the pain and dysfunction of lesion site. Based on the characteristics of aponeurotic system and bowstring mechanics, combining with the revelation of the understanding of modern medicine and biomechanics for knee osteoarthritis, this paper explores the advantage and mechanism of acupotomy in the treatment of knee osteoarthritis, it is considered that acupotomy in the treatment of knee osteoarthritis guided by the characteristics of aponeurotic system and bowstring of knee joint can reflect the holism concept of Chinese medicine and equal importance of muscles and bones. On the one hand, it enriches the theory of traditional Chinese medicine in the treatment of knee osteoarthritis, on the other hand, it provides a new idea for improving the clinical effect of acupotomy in the treatment of knee osteoarthritis.
2017 Vol. 14 (27): 161-164 [Abstract] ( 199 ) HTML (1 KB)  PDF (497 KB)  ( 130 )
165 Data mining of Acupotomy in treating lumbar spinal stenosis
LYU Haoyuan1 ZHANG Yanji2 XIAO Qiangbing1,3,4 CHEN Minxing5 ZHU Tianjiao1 SONG Hu1
2017 Vol. 14 (27): 165-168,172 [Abstract] ( 265 ) HTML (1 KB)  PDF (1126 KB)  ( 163 )
169 Design and application of needle-knife and yuandun needle
ZHOU Jianbin1 LU Ying2 LI Kaiping2
Professor Zhu Hanzhang invented a kind of sharp separating needle named needle-knife. His patent for invention "series of closed surgical needles" includes 12 types of needles. Needle-knife includes a needle, needle body and needle handle. Flat gourd-shaped or trapezoid handle of needle-knife is parallel to the blade line. The body of needle-knife is a cylinder. The different shape of the head of needle made various types of needle-knife. Professor Zhou Jianbin invented the blunt separation needle named yuandun needle. Yuandun needle includes a needle body and needle handle. The body of yuandun needle is long cone-shaped and the head is round-shaped. The handle of yuandun needle is bamboo-shaped. The treatment of acupotomy and yuandun needle therapy was based on body bowstring mechanical anatomy system and "mesh theory" of pathological framework of chronic soft tissue injury from Professor Zhang Tianmin. The cutting ways of acupotomy includes longitudinal dredging method, transverse dissection method, insert cutting method, stripping of bone surface method, permeability stripping method. Yuandun needle therapy includes parallel stab method and oblique stab method. The advantage of acupotomy is the ability to loosen soft tissue effectively and the defect is that it may damage normal human tissue. The advantage of yuandun needley is that it can safely loosen soft tissue and the defect is the limitation of treatment that cannot penetrate the dense connective tissue. Professor Zhou Jianbin invented tong needle, which can meanwhile sharp separate and blunt separate. Tong needle plays the advantages of needle-knife and yuandun needle and avoids the defects of needle-knife and yuandun needle.
2017 Vol. 14 (27): 169-172 [Abstract] ( 234 ) HTML (1 KB)  PDF (568 KB)  ( 216 )
173 Data analysis of clinical transfusion in obstetrics
YAO Jie1 REN Wei1 YAN Yu1 CHEN Jinmei1 REN Yanli1 GAO Yan1 ZHANG Shujian2 ZHAO Zheng2
Objective To provide evidence-based medical basis to improve the blood supply ability and safety stock level of blood transfusion in Department of Obstetrics, Xuanwu Hospital, Capital Medical University ("our hospital" for short) by analyzing clinical blood use and other data of blood transfusion for nearly 6 years. Methods Retrospective study was conducted by our hospital to analyze the data about clinical blood use of 15 498 obstetrical patients from January 2011 to December 2016, including component blood transfusion quantity, blood transfusion rate, massive blood transfusion rate, supreme value of massive blood transfusion and clinical information of massive blood transfusion patients. Results 229 of 15 498 patients had received blood transfusion, with the rate of 1.48%. Transfusion quantity, blood transfusion rate and massive blood transfusion annually decreased from 2011 to 2014, fell to 177 U, 0.70% and 0.03% in 2014. Since 2015, the index started to rise and reached 501 U, 2.28% and 0.40% by 2016. 29 patients had received red blood cell infusion more than 10 U. The supreme value of red blood cell infusion was 42 U in 2012, 24 U in 2015 and 20 U in 2016 respectively. Conclusion The transfusion quantity, blood transfusion rate and massive blood transfusion of blood transfusion department annually decreased from 2011 to 2014. An increase followed in 2015 and 2016. It Indicated an increase risk of clinic blood use and a decrease in supreme value of massive blood transfusion. The blood transfusion department should perform preoperative blood preparation in cooperation with the obstetrics to ensure the obstetrical medical safety.
2017 Vol. 14 (27): 173-176 [Abstract] ( 205 ) HTML (1 KB)  PDF (614 KB)  ( 111 )
177 Cultivation of scientific research thinking in medical students
LI Bo1 DONG Chunling2 YU Weixian1 GUO Xiaodong1 LI Baoquan1 LI Daowei1 SUN Hongchen1
The essence of scientific research thinking is a thinking model to actively identify and solve problems. The cultivation of scientific research thinking is the most important part in scientific research training. The tutors should pay more attention to the cultivation of medical students' scientific research thinking during the training of scientific research, instruct these students to complete the conversion of passive thinking to active thinking, and to establish critical, creative and inferential thinking.
2017 Vol. 14 (27): 177-180 [Abstract] ( 648 ) HTML (1 KB)  PDF (597 KB)  ( 194 )
181 The present situation and development prospect of China′s palliative care
WANG Kai1 WANG Xinhong2 WANG Songmei2
Palliative care can keep dignity for the dying people, help them face death calmly, improve their life quality in the final stage of life through relieving physical and mental pain. China′s palliative care is still in an embryonic stage, and is facing the problems of the transformation of social ideology and the lack of relevant institutions and personnel. Currently, in the serious situation of increasing aging population, to help dying people and their families to accept palliative care, many efforts needs to be done to introduce the corresponding laws and regulations of palliative care, universal ethics education, improve the medical environment, recruit and train professional service personnel. Thus vigorously promote the development of palliative care.
2017 Vol. 14 (27): 181-184 [Abstract] ( 836 ) HTML (1 KB)  PDF (598 KB)  ( 269 )
185 Coping strategy of health insurance financial management in hospital transition period under total health insurance prepaid
GAO Li
Beijing has carried out total medical insurance prepaid policy in city hospitals since 2011. Hospitals′medical insurance income proportion increased year by year as appointed medical institutions. Therefore, it has become an urgent task for hospitals to ensure the smooth operation of hospital medical insurance financial management, especially when the hospital needs to gradually transform from integrated to specialized hospital. Higher requirements are put forward for the management, in order to fit for quota insurance and cope with shifting events. This article mainly from the definition of the total medical insurance prepaid to put forward the influence and challenge of hospital medical insurance financial management during the transformation period. The hospital should meet the requirements and construct financial management coping strategies such as the financial accounting of medical insurance types by strengthening the total amount of the medicare budget, keeping budget in balance with cost and optimizing HIS system data
2017 Vol. 14 (27): 185-188 [Abstract] ( 272 ) HTML (1 KB)  PDF (640 KB)  ( 112 )
189 Internet oriented cross hospital shared big data information security protection mechanism research
ZHANG Xinzhi
Health care as one of the key areas which is related to people's livelihood causes widespread concern of the whole society. In order to advance into the objective needs of big data Era, internet based cross hospital electronic case data sharing is in response to the national call for more data run away, fewer people to run errands advocate. This paper gives a detailed analysis of the overall goal of across hospital shared big data exchange, safety supervision, the problems of talent cultivation, especially points out that the block chain technology should strengthen the independent research and development for the medical industry. As it is conceivable that block chain technology will change the global medical industry in the near future, more attention should be paid so as not to miss the opportunity to apply block chaining technology to form a series of the medical industry state information security standards and technical norms as soon as possible. It also will be crucial to seize the commanding heights of the application of information technology in this medical field, which will provide a space for the future development and make the real realization of information security technology for the medical industry to provide fast, convenient service escort.
2017 Vol. 14 (27): 189-192 [Abstract] ( 231 ) HTML (1 KB)  PDF (597 KB)  ( 430 )
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