抗抑郁药物的联合用药研究进展

Abstract
Figure/Table
References (36)
Related Citation (5)

Download: PDF (637 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Depression is a common affective disorder disease, the application of antidepressants can improve the symptoms of depression significantly, which is the main way to treat depression in clinical practice currently. A reasonable addition of other drugs on the basis of antidepressants can significantly improve the cure rate of depression, so the combination of drugs is commonly used in the treatment of clinicians. This article systematically expounds the status of antidepressant drugs in combination, for the rational use of combined drug regimen provides new basis.

Key words： Antidepressants Combination drugs Research progress Review

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	YUAN Jie1 GAO Jing2 XIAO Jian2 LI Jinhao2 WANG Ning2 WANG Jing3

Cite this article:

YUAN Jie1 GAO Jing2 XIAO Jian2 LI Jinhao2 WANG Ning2 WANG Jing3. Research progress of combination drugs of antidepressants[J]. 中国医药导报, 2017, 14(27): 40-43.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I27/40

[1] 沈渔邨.精神病学[M].5版.北京：人民卫生出版社，2009：559-561.
[2] Dennis CL，Dowswell T. Interventions（other than pharmacological，psychosocial or psychological）for treating antenatal depression [J]. Cochrane Database Syst Rev，2013，7（7）：6795-6802.
[3] Rush AJ，Trivedi MH，Stewart JW，et al. Combining medications to enhance depression outcomes（CO- MED）：acute and long- term outcomes of a single - blind randomized study [J]. Am J Psychiatry，2011，168（7）：689-701.
[4] Trivedi MH，Rush AJ，Wisniewski，et al. Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D：implications for clinical practice [J]. Am J Psychiatry，2006，163（1）：28-40.
[5] Thase ME. Antidepressant combinations：cutting edge psychopharmacology or passing fad?[J]. Curr Psychiatry Rep，2013，15（10）：403.
[6] Carpenter LL，Yasmin S，Price LH. A double-blind，placebo-controlled study of antidepressant augmentation with mirtazapine [J]. Biol Psychiatry，2002，51（2）：183-188.
[7] Blier P，Gobbi G，Turcotte JE. Mirtazapine and paroxetine in major depression：a comparison of monotherapy versus their combination from treatment initiation [J]. Eur Neuropsychopharmacol，2009，9（7）：457-465.
[8] 徐兵，陈梅，李智，等.米氮平片联合帕罗西汀片治疗女性重度抑郁症的临床研究[J].中国临床药理学杂志，2017， 33（3）：213-215.
[9] Lam RW，Wan DD，Cohen NL，et al. Combining antidepressants for treatment-resistant depression：a review [J]. J Clin Psychiatry，2002，63（8）：685-693.
[10] 叶秀红，唐贤祥.氟西汀联合氯米帕明治疗抑郁症疗效观察[J].浙江医学，2004，26（7）：547-548.
[11] 谭明刚.氟西汀联合阿米替林治疗抑郁症的疗效研究[J].中国全科医学，2002，5（4）：272-273.
[12] 徐丹.西酞普兰联合安非他酮对老年抑郁症患者的疗效观察[J].中国疗养医学，2016，25（5）：460-462.
[13] Bobo WV，Chen H，Trivedi MH，et al. Randomized comparison of selective serotonin reuptake inhibitor（escitalopram）monotherapy and antidepressant combination pharmacotherapy for major depressive disorder with melancholic features：a CO-MED report [J]. J Affect Disord，2011， 33（3）：467-476.
[14] Stewart JW，McGrath PJ，Blondeau C，et al. Combination antidepressant therapy for major depressive disorder：speed and probability of remission [J]. J Psychiatr Res，2014，52（3）：7-14.
[15] Pinel-Ríos FJ，Peuelas-Calvo I，Cerezo-Ramírez N，et al. Serotonin syndrome induced by a combination of venlafaxine and clomipramine. A case report [J]. Actas Esp Psiquiatr，2016，44（5）：193-202.
[16] Koga M，Kodaka F，Miyata H，et al. Symptoms of delusion：the effects of discontinuation of low-dose venlafaxine [J]. Acta Psychiatr Scand，2009，120（4）：329-331.
[17] Malhi GS，Ng F，Berk M，et al. Dual-dual action? Combining venlafaxine and mirtazapine in the treatment of depression [J]. J Psychiatry，2008，42（4）：346-349.
[18] Blier P，Ward HE，Tremblay P，et al. Combination of antidepressant medications from treatment initiation for major depressive disorder：a double-blind randomized study [J]. Am J Psychiatry，2010，167（3）：281-288.
[19] Decoutere L，De Winter S，Vander Weyden L，et al. A venlafaxine and mirtazapine-induced serotonin syndrome confirmed by de- and re-challenge [J]. Int J Clin Pharm，2012，34（5）：686-688.
[20] Thase ME. Introduction：new directions in the treatment of atypical depression [J]. J Clin Psychiatry，2006，67（12）：e18.
[21] Hudson AL，Lalies MD，Silverstone P. Venlafaxine enhances the effect of bupropion on extracellular dopamine in rat frontal cortex [J]. Can J Physiol Pharmacol，2012，90（6）：803-809.
[22] 韩继阳，战玉华，夏静，等.文拉法辛联合安非他酮与单用文拉法辛治疗非典型抑郁的对照研究[J].中国新药与临床杂志，2015，34（5）：382-385.
[23] Quante A，Regen F，Schindler F，et al. Quetiapine as combination treatment with citalopram in unipolar depression with prominent somatic symptoms：a randomised，double-blind，placebo-controlled pilot study [J]. Psychiatr Danub， 2013，25（3）：214-320.
[24] Karki SD，Masood GR. Combination risperidone and SSRI-induced serotonin syndrome [J]. Ann Pharmacother，2003，37（3）：388-391.
[25] Wang Y，Yang F，Liu YF，et al. Acetylsalicylic acid as an augmentation agent in fluoxetine treatment resistant depressive rats [J]. Neurosci Lett，2011，499（2）：74-79.
[26] Muller N，Schwarz MJ，Dehning S，et al. The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression：results of a double-blind，randomized，placebo controlled，add-on pilot study to reboxetine [J]. Mol Psychiatry，2006，11（7）：680-684.
[27] Ghanizadeh A，Hedayati A. Augmentation of citalopram with aspirin for treating major depressive disorder，a double blind randomized placebo controlled clinical trial [J]. Antiinflamm Antiallergy Agents Med Chem，2014，13（2）：108-111.
[28] Kilic FS，Ozatik Y，Kaygisiz B，et al. Acute antidepressant and anxiolytic effects of simvastatin and its mechanisms in rats [J]. Neurosciences（Riyadh），2012，17（1）：39-43.
[29] McFarland AJ，Anoopkumar-Dukie S，Arora DS，et al. Molecular mechanisms underlying the effects of statins in the central nervous system [J]. Int J Mol Sci，2014，15（11）：20607-20637.
[30] Khler O，Gasse C，Petersen L，et al. The Effect of Concomitant Treatment With SSRIs and Statins：A Population-Based Study [J]. Am J Psychiatry，2016，173（8）：807-815.
[31] Salagre E，Fernandes BS，Dodd S，et al. Statins for the treatment of depression：A meta-analysis of randomized，double-blind，placebo-controlled trials [J]. J Affect Disord，2016，200：235-242.
[32] Gougol A，Zareh-Mohammadi N，Raheb S，et al.Simvastatin as an adjuvant therapy to fluoxetine in patients with moderate to severe major depression：A double-blind placebo-controlled trial [J]. J Psychopharmacol，2015，9（5）：575-581.
[33] Ghanizadeh A，Hedayati A. Augmentation of fluoxetine with lovastatin for treating major depressive disorder，a randomized double-blind placebo controlled-clinical trial [J]. Depress Anxiety，2013，30（11）：1084-1088.
[34] Renshaw PF，Parsegian A，Yang CK，et al. Lovastatin potentiates the antidepressant efficacy of fluoxetine in rats [J]. Pharmacol Biochem Behav，2009，92（1）：88-92.
[35] Andrade C. Selective serotonin reuptake inhibitor drug interactions in patients receiving statins [J]. J Clin Psychiatry，2014，75（2）：5-9.
[36] Herbet M，Gawrońska-Grzywacz M，Izdebska M，et al. Impact of combined treatment with rosuvastatin and antidepressants on liver and kidney function in rats [J]. Exp Ther Med，2016，11（4）：1459-1464.