肾细胞癌中微血管侵犯对于预后的影响

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Abstract Objective To investigate the effect of microvascular invasion (MVI) on prognosis in renal cell carcinoma (RCC). Methods The clinical data of patients with RCC which be collected from January 2002 to June 2014 in Central Hospital of Wuhan were analyzed. 51 patients (T1-T3, without renal vein or inferior vena cava invasion) with MVI confirmed by pathology and the same number patients without MVI were enrolled in this study. Disease free survival (DFS) and cancer specific survival (CSS) were analyzed by Kaplan-Meier. Prognostic factors of patients with MVI were analyzed by Cox's model. Results 5-year CSS rate of patients with or without MVI were 86% and 84%. There were no obviously difference of CSS and DFS between two groups（P > 0.05）. But the tumor grade and TNM staging were confirmed to be the prognostic factors of CSS, and the relative risk (RR) value were 3.535 and 2.219 (P > 0.05). It was also showed that tumor grade and TNM staging were prognostic factors of DFS, and RR value were 7.333 and 2.029 (P < 0.05). Conclusion MVI appear to have no effect on prognosis in localized RCC patients. Higher grade and TNM staging are related to the poor prognosis.

Key words： Renal cell carcinoma Microvascular invasion Prognosis Pathology

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	ZHANG Yuanjie LI Guohao CHEN Lin WU Ding GUO Yonglian▲

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ZHANG Yuanjie LI Guohao CHEN Lin WU Ding GUO Yonglian▲. The effect of microvascular invasion on prognosis in renal cell carcinoma[J]. 中国医药导报, 2017, 14(27): 85-88.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I27/85

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