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| Research progress of microRNA in prevention and treatment of femoral head necrosis |
| YU Changsui1 ZHANG Xiaofeng2 XU Xilin2 YU Zhongbao3 WANG Shuren4 WANG Zhengchun1 PENG Yufei4 CHEN Weiheng5 |
1.School of Graduates, Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150040, China;
2.The Third Department of Orthopedics, the Second Hospital Affiliated to Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150001, China;
3.Yu Zhongbao Chinese Medicine Clinic of Kuandian Manchu Autonomous County, Liaoning Province, Kuandian 118200, China;
4.The Second Department of Orthopedics, the First Hospital Affiliated to Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150040, China;
5.The Third Department of Orthopedics, Wangjing Hospital of China Academy of Chinese Medical Science, Beijing 100102, China |
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Abstract microRNAs (miRNAs) belongs to a small RNA of non-protein coding families, and is involved in many physiological and pathological processes. They are about 22 nucleotides long and have specific expression in human tissues or cells. One group of miRNAs has been shown to play a fundamental role in gene regulation in various kinds of orthopedics diseases, such as bone tumors, osteoarthritis, and rheumatoid arthritis. The study of miRNA in osteonecrosis of the femoral head can help to understand the pathogenesis of the disease more clearly. The main cause of osteonecrosis of the femoral head is the destruction of femoral head blood supply, and the main symptoms are bone and muscle dysfunction. The recent studies show that microRNA plays an important role in the regulation of microcirculation of osteonecrosis of the femeral head, local microcirculation dysfunction caused by other diseases and bone cells apoptosis. In this paper, the related research results of microRNA and osteonecrosis of the femoral head in recent years are analyzed and summarized, and the prospect of microRNA in the prevention and treatment of osteonecrosis of the femoral head is also looked forward.
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