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2023 Vol. 20, No. 5
Published: 2023-02-15
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Medication rule mining of traditional Chinese medicine for dysmenorrhea based on Ancient and Modern Medical Records Cloud Platform
LYU Shuzhen1 JU Yuanhong2 XU Jingwen1 SHAO Qi3 GAO Zhiming1 MU Dongmei4
DOI: 10.20047/j.issn1673-7210.2023.05.01
Objective To explore the medication rules of traditional Chinese medicine for dysmenorrhea based on Ancient and Modern Medical Records Cloud Platform (V2.3.5). Methods The medical records of traditional Chinese medicine for dysmenorrhea collected in Ancient and Modern Medical Records Cloud Platform (V2.3.5) from the inception to October 2021 were retrieved to construct the database of traditional Chinese medicine data. The Ancient and Modern Medical Records Cloud Platform (V2.3.5) and Gephi (V0.9.2) were used to conduct medication statistics, compatibility analysis, cluster analysis, and complex network analysis of traditional Chinese medicine. Results A total of 200 medical records prescriptions were included in this study, involving 246 flavours of drugs, and Angelicae Sinensis Radix was the most frequently used. The medicinal natures were mainly warm, and the medicinal flavours were mainly pungent, sweet, and bitter, which were mainly returned to the liver, spleen, and heart channels. The drug compatibility of “Angelicae Sinensis Radix-Paeoniae Radix Alba” appeared more; five groups of traditional Chinese medicine cluster combinations were obtained. Core drugs included Angelicae Sinensis Radix, Paeoniae Radix Alba, Corydalis Rhizoma, Glycyrrhizae Radix Et Rhizoma, Chuanxiong Rhizoma, etc. Conclusion The treatment of dysmenorrhea by traditional Chinese medicine is mainly based on the medicine of regulating menstruation and relieving pain, removing blood for removing blood stasis, moistening intestines and defecating bowels, tonifying blood and activating blood circulation, supplemented by the medicine of soothing liver and relieving depression, regulating qi and spreading middle, nourishing yin and tonifying kidney, paying attention to both deficiency and excess, treating both manifestation and root cause of disease.
2023 Vol. 20 (5): 4-8,13 [
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Study on the protective mechanism of Bakuchiol against Streptozotocin induced diabetic cardiomyopathy in rats
KANG Yongjian1 ZHENG Quanyou2 WANG Xi3▲
DOI: 10.20047/j.issn1673-7210.2023.05.02
Objective To investigate the protective mechanism of Bakuchiol against Streptozotocin induced diabetic cardiomyopathy in rats. Methods Forty-five 8-week-old SPF male SD rats, weighing 180-220 g, were randomly divided into control group, diabetes mellitus group, and Bakuchiol group, with 15 rats in each group. After four weeks of high sugar and fat diet (HFD), the diabetes mellitus group and Bakuchiol group were injected intraperitoneal with Streptozotocin (50 mg/kg) every day. After four weeks of normal diet, the control group was injected intraperitoneally with the same amount of normal saline every day, all the three groups were injected continuously for three days. One week after intraperitoneal injection of Streptozotocin, the three groups were orally given glucose (2 g/kg) on an empty stomach for 12 h, and blood glucose values were recorded at 0, 30, 60, 90, and 120 min. The diabetes mellitus group and Bakuchiol group were considered to be successful in modeling with random blood glucose ≥16.7 mmol/L, the two groups continued to be fed HFD for eight weeks, and the Bakuchiol group was also given Bakuchiol (60 mg/kg) gavage for eight weeks. The control group continued the normal diet for eight weeks. After the intervention, the cardiac function was detected by small animals ultrasound, the heart tissue was taken for hematoxylin-eosin staining and Masson staining, the myocardial apoptosis index was detected by TUNEL staining, and the expression level of myocardial apoptosis related proteins was detected by Western blotting. Results Hematoxylin-eosin staining and Masson staining showed that the myocardial arrangement was disordered in the diabetes mellitus group and the perivascular collagen fibers increased significantly, while the myocardial disorder was improved in the Bakuchiol group and the perivascular collagen fibers decreased significantly. Left ventricular ejection fraction, left ventricular short axis shortening rate, and Bcl-2 levels in diabetes mellitus group were lower than those in control group, while the area under the blood glucose curve, myocardial apoptosis index, Cleaved caspase-3/caspase-3, and Bax expression level in model group were higher than those in control group, the differences were highly statistically significant (P＜0.01). Left ventricular ejection fraction, left ventricular short axis shortening rate in Bakuchiol group were higher than those in diabetes mellitus group, while the area under the blood glucose curve, myocardial apoptosis index, Cleaved caspase-3/caspase-3, Bcl-2, and Bax expression level in Bakuchiol group were lower than those in diabetes mellitus group, the differences were statistically significant (P＜0.05 or P＜0.01). Conclusion Bakuchiol treatment can Significantly reduce streptozotocin induced diabetic cardiomyopathy in rats, inhibit apoptosis signal, reduce myocardial cell apoptosis, and improve cardiac function.
2023 Vol. 20 (5): 9-13 [
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CiteSpace visual analysis of depression research in traditional Chinese medicine
HE Chenhao1 WANG Xinyuan1 SUN-FU Tongyu1 WANG Feng1 TAN Xi2
DOI: 10.20047/j.issn1673-7210.2023.05.03
Objective To explore the general situation and analyze the hot topics and research fronts of depression research in traditional Chinese medicine. Methods CNKI was used as the database, the literature sources of “SCI source Periodicals”, “EI source Periodicals”, “Peking University core”, “CSSCI” and “CSCD”, and the retrieval formula was “SU= depression AND SU= traditional Chinese medicine”, the retrieval period was from October 1991 to October 2021 and the search time was October 2021. Visual charts were drawn by CiteSpace software to analyze research hotspots and development trends. Results A total of 585 literatures were retrieved, the research on depression in traditional Chinese medicine showed an increasing trend, but the analysis showed that the cooperation among institutions was scattered; hot topics could be clustered into four categories:“traditional Chinese medicine syndrome”, “traditional Chinese medicine therapy”, “clinical research”, and “classification of depression”; prominent topics focus on “Meihe Qi”, “traditional Chinese medicine syndrome”, and “classification of depression”. Conclusion From 1991 to 2021, the cooperation of depression research in China is not close across institutions and fields. The research hotspots are traditional Chinese medicine syndrome, traditional Chinese medicine pathogenesis, traditional Chinese medicine therapy, clinical research, depression classification, etc. The research trend shows that the research fields focused on the characteristics of traditional Chinese medicine, the research method pay attention to the combination of traditional Chinese medicine theory and modern technology, the research content includes specific and details depression classification and other characteristics.
2023 Vol. 20 (5): 14-19 [
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Preparation and specificity analysis of monoclonal antibody against 6 kD early secretory antigenic target of Mycobacterium tuberculosis
NING Huanhuan1 REN Rui1 KANG Jian1 BAI Lu2 LU Yanzhi1 XIE Yanling2 ZHANG Fanglin1 BAI Yinlan1
DOI: 10.20047/j.issn1673-7210.2023.05.04
Objective To prepare a monoclonal antibody (mAb) against 6 kD early secretory antigenic target (ESAT-6) of Mycobacterium tuberculosis and to analyze its specificity. Methods ESAT-6 was purified by affinity chromatography and immunized mice with the protein. Splenocytes from ESAT-6 immunized mice were fused with myeloma cells, and hybridoma cell lines secreting mAb were screened. mAb was purified from ascites. The subclass and relative affinity of mAb were assayed by enzyme-linked immunosorbent assay. The specificity of the mAb was analyzed by Western blot. Results The hybridoma cell line secreting ESAT-6 antibody was obtained and mAb was purified. The subclass of ESAT-6 mAb was IgG1 with a relative affinity of 3.9×10-5. The mAb specifically recognizes ESAT-6 in Mtb. Conclusion The preparation of mAb against ESAT-6 lays a foundation for the application of ESAT-6 in the diagnosis and treatment of tuberculosis and its mechanism.
2023 Vol. 20 (5): 20-23 [
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Study on characteristics of acupuncture and moxibustion formulas for spastic cerebral palsy via association rules and complex network analysis
ZHANG Yidan MA Linghui MA Liangxiao ZHANG Zhou MU Jiedan SUN Tianyi QIAN Xu ZHANG Qinyong
DOI: 10.20047/j.issn1673-7210.2023.05.05
Objective To explore the study on characteristics of acupuncture and moxibustion formulas for spastic cerebral palsy via association rules and complex network analysis. Methods The clinical literatures on acupuncture and moxibustion for spastic cerebral palsy from CNKI, Wanfang Data, VIP, China Biomedical Literature Database, PubMed, and Web of Science were searched until May 2022. The Apriori algorithm was used to analyze the compatibility of core acupoints with association rules. The Gephi 0.9.6 software was used to analyze the core acupoint group and the characteristics of acupuncture and moxibustion through complex network. Results A total of 293 literatures were included, and 639 acupuncture and moxibustion prescriptions were extracted. The traditional acupoints with the highest relevance are zúsānlǐ-sānyīnjiāo, and the Jin’s Three-needling acupoints are Sishen-points, and the sensory area, balance area, movement area, and operation area of the foot in the Jiao’s head needle were consistent with each other. The core acupoint groups of the three types of complex network prescriptions mainly include bǎihuì, zúsānlǐ, sānyīnjiāo, hégǔ, qūchí, movement area, balance area, foot sensation area, yánglíngquán, temporal acupuncture, and moxibustion, etc. There are various acupuncture and moxibustion methods. Conclusion In the treatment of spastic cerebral palsy, acupuncture and moxibustion focus on the coordination of traditional acupoints with tou acupuncture and Jin’s Three-needling, mainly on the head acupoints targeted at the root of the lesion, and with the local selection of acupoints of the paralyzed limbs, so as to achieve the purpose of harmonization of form and spirit.
2023 Vol. 20 (5): 24-27,37 [
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Construction and verification of a prediction model for malnutrition risk in senile patients with severe cerebral apoplexy
LI Junzhuo YANG Wen LIU Guangwei▲ ZHANG Ruixin YANG Jiajia
DOI: 10.20047/j.issn1673-7210.2023.05.06
Objective To analyze the risk factors of malnutrition in senile patients with severe stroke, and to constructed the corresponding column graph model. Methods A total of 782 elderly patients with severe stroke in the intensive care Unit of Department of Neurology of the First Affiliated Hospital of Chongqing Medical University were selected as the research objects and divided into modeling group (547 cases) and validation group (235 cases). According to serum albumin level, patients were divided into malnutrition group and non-malnutrition group. The influencing factors of malnutrition were identified by logistic regression analysis, and the prediction model of malnutrition risk line graph was constructed. The prediction effect of the model was verified internally by Bootstrap method, and the model was verified externally by verification group data. Results There were statistically significant differences in age, history of chronic obstructive pulmonary disease, anemia, Charlson comorbidity index (CCI), Glasgow coma score (GCS), Barthel index, nutritional support, mechanical ventilation, neutrophil count, hematopoietic volume, proportion of fibrinogen, albumin, and total protein between the two groups (P＜0.05). Logistic regression analysis showed that age, CCI, GCS score, anemia, neutrophil count, total protein level, and nutritional support were independent influencing factors for malnutrition in senile patients with severe stroke (OR＞1, P＜0.05). The area under ROC curve of the constructed model was 0.858, and the internal verification results showed that the C-index was 0.851. The area under ROC curve of the verification group was 0.848. Conclusion The prediction effect of the column graph model constructed in this study is good, and it can provide reference for early clinical prediction of malnutrition risk in elderly patients with severe stroke.
2023 Vol. 20 (5): 28-32 [
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Research progress on genetic etiology and diagnosis and treatment of infantile spasms
NIE Lianghui WANG Shuai YANG Libin MA Rong CHEN Hanjiang RONG Ping
DOI: 10.20047/j.issn1673-7210.2023.05.07
Infantile spasms is a typical catastrophic epileptic encephalopathy, most of which are refractory epilepsy. Currently, the pathogenesis of infantile spasms is not fully clearly. In recent years, gene variants such as SCN2A, SCN8A, CDKL5, DEPDC5, STXBP1, GABRA, COL4A1/COL4A2, and CASK etc. have been gradually confirmed to be related to infantile spasms. Due to the specificity of clinical phenotypes caused by different gene mutations, western medicine treatment selects different therapeutic drugs with different targets for different pathogenesis. Traditional Chinese medicine, based on the constitution and disease characteristics of children, can also have certain curative effects by treating according to syndrome differentiation. Therefore, this article reviews the etiology and diagnosis and treatment of infantile spasms gene-related genetics in order to identify relevant gene mutations at an early stage and improve the efficiency of clinical diagnosis and treatment.
2023 Vol. 20 (5): 33-37 [
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Research progress of human body composition analysis in health management of chronic diseases
CAI Xiaolu1 ZHANG Jing2 ZHANG Yalan1 CHEN Zongtao1
DOI: 10.20047/j.issn1673-7210.2023.05.08
Chronic diseases, such as diabetes mellitus, hypertension, cardiovascular diseases, malignant tumors, and chronic respiratory diseases, seriously damage the health of individuals and groups. The composition of human body includes water, protein, body fat, inorganic salt, etc. The analysis of human body composition can comprehensively evaluate and dynamically monitor the nutritional risk of patients, guide the implementation of reasonable nutritional intervention and rehabilitation treatment, and it is of great significance to the prevention and treatment of chronic diseases. At present, physical measurement, densitometry, bioelectrical impedance method, and medical imaging technology can be used to measure the body composition in clinic, and the clinical treatment can be guided by the measured values such as body fat percentage, swelling index, and fat free tissue content. This paper reviews the composition of human body and its measurement methods, as well as the application effect in patients with chronic diseases, by consulting relevant literature at home and abroad, so as to provide theoretical basis for patients with chronic diseases to formulate effective health management intervention programs.
2023 Vol. 20 (5): 38-41,46 [
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Research progress of para-aortic prophylactic extended-field irradiation in locally advanced cervical cancer
WANG Yuanjing1 WU Yumei2
DOI: 10.20047/j.issn1673-7210.2023.05.09
Cervical cancer is the most common malignancy of the female reproductive system. Para-aortic prophylactic extended-field irradiation is recommended for locally advanced cervical cancer patients with positive common iliac or para-aortic lymph nodes. For patients with negative common iliac or para-aortic lymph nodes, the standard treatment is still pelvic radiotherapy with concurrent cisplatin-based chemotherapy. However, para-aortic lymph node metastasis is one of the common causes of treatment failure in locally advanced cervical cancer patients after chemo-radiotherapy. Currently, it is controversial whether to perform prophylactic extended-field irradiation for patients with high-risk factors of para-aortic lymph node metastasis. This article reviews the value of PET/CT in evaluating para-aortic lymph node metastasis of cervical cancer, the effectiveness and indications of prophylactic extended-field irradiation, hoping to provide an important reference for individualized precision radiotherapy for cervical cancer.
2023 Vol. 20 (5): 42-46 [
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Research progress of targeted diagnosis and treatment of colorectal cancer based on exosomal miRNA
WANG Yuting WANG Anqi LI Zhili LYU Zhengrong HUANG Chuyue FAN Zhimin
DOI: 10.20047/j.issn1673-7210.2023.05.10
MiRNA derived from circulating exosome regulate the development of colorectal cancer from both cell metabolism and tumor microenvironment aspects. In addition, exosomal miRNA has the potential to reflect the staging, therapeutic efficacy, chemotherapy resistance and recurrence risks of colorectal cancer. Based on its biological characteristics, we systematically reviewed that exosomal miRNA work as biomarkers for the diagnosis and prognosis of colorectal cancer, which were reported in related research, and we also summarized the mechanisms related to targeted treatment of colorectal cancer based on exsomal miRNA, in order to provide a theoretical basis for exosomal miRNA functioning as core biological markers and innovative therapeutic targets for colorectal cancer.
2023 Vol. 20 (5): 47-50 [
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Research progress on mechanism of electroacupuncture to relieve morphine tolerance
LI Li ZHANG Yu
DOI: 10.20047/j.issn1673-7210.2023.05.11
Owing to less toxic and side effects, simple and convenient operation and good efficacy, electroacupuncture has been widely used in clinic. Currently, the therapeutic efficacy of electroacupuncture in gastrointestinal diseases, neuropsychiatric diseases and various types of pain has been affirmed, and electroacupuncture also plays an important role in relieving morphine tolerance. The paper reviews previous studies on electroacupuncture and morphine tolerance and discusses the mechanism of relieving morphine tolerance in combination with the current mechanism of morphine tolerance, in order to solve the problem of morphine tolerance through the method of integrated traditional Chinese and western medicine.
2023 Vol. 20 (5): 51-54 [
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Characteristic analysis of chronic heart failure animal model based on data mining
HE Yixin1 WU Jianguang2
DOI: 10.20047/j.issn1673-7210.2023.05.12
Objective To analyzed the characteristic of chronic heart failure animal model based on data mining. Methods With “chronic heart failure” and “animal model” as the theme, the experimental literature on chronic heart failure were retrieved CNKI, Wanfang Database, and VIP Database from January 2011 to December 2021, and PubMed and SinoMed from January 2017 to April 2022. Animal species, modeling methods, positive medicine, and experimental observation indexs were summarized and analyzed in the literatures. Results A total of 201 valid literatures were screened. SD rats, Wistar rats, and C57BL/6 mice were mostly used for chronic heart failure modeling, male animals were used to model chronic heart failure; surgical methods such as ligation of the left anterior descending branch of coronary artery were used; Captopril was used as positive drug; the experimental indexes focus on serum biochemical indexes, inflammatory indexes, histopathological detection, cardiac function and structure, and hemodynamic indexes, etc. Conclusion At present, the success criteria, success rate, and mortality of chronic heart failure model are rarely mentioned, and most experimental tests tend to evaluate the treatment methods by serum biochemical indicators, inflammatory factors, and myocardial fibrosis indicators. It may be a new idea to establish an animal model reflecting the clinical characteristics of traditional Chinese medicine and western medicine in chronic heart failure, and to increase the experimental design related to metabolomics and exosomes of integrated of traditional and western medicine.
2023 Vol. 20 (5): 55-58,62 [
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Analysis of clinical characteristics and electrocardiogram features of De Winter syndrome without dynamic evolution
LIU Na LIU Dongsheng▲ ZHAO Xiuping ZHANG Tianhao SUN Yazhao LI Bin
DOI: 10.20047/j.issn1673-7210.2023.05.13
Objective To investigate the clinical characteristics and electrocardiogram features of De Winter syndrome without dynamic evolution. Methods A total of 24 cases of De Winter syndrome without dynamic evolution who were admitted to Cangzhou People’s Hospital, Hebei Province (“our hospital” for short) from January 2018 to January 2022 were selected as observation group, 95 cases of non-ST elevation myocardial infarction (NSTEMI) who previously criminal vessels were left anterior descending branch treated at the same time in our hospital were selected as control group. The laboratory monitoring indicators of two groups were compared, the electrocardiogram characteristics of observation group were observed and analyzed. Results There were no significant differences in total cholesterol, triglyceride, low density lipoprotein cholesterol, fasting blood glucose, creatinine, and the concentrations of potassium between two groups (P＞0.05). In observation group, the average J-point depression of thoracic guide was (2.67±1.52) mm, and the average T-wave amplitude of thoracic guide was (10.92±3.75) mm. A total of 14 cases (58.33%) had aVR lead elevation; 17 cases (70.83%) had low lead Ⅱ; 13 cases (54.17%) had low lead Ⅲ; 16 cases (66.67%) had low lead aVF. Electrocardiogram changes could be divided into two categories: one was no obvious change from beginning to end; the other was changed, but most of them change into T-wave flat or normal electrocardiogram. Conclusion The clinical characteristics of De Winter syndrome without dynamic evolution are basically equivalent to those of NSTEMI, and the electrocardiogram characteristics were basically the same as those of classic De Winter syndrome. Most patients returned to normal after surgery, and some cases remained unchanged.
2023 Vol. 20 (5): 59-62 [
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Clinical effect of electroacupuncture on gluteal nerve entrapment syndrome
HE Mingwei1 CAO Jing2 PANG Jinlei1 WANG Chengbin1 SUN Haiyan1 LIU Jinde2
DOI: 10.20047/j.issn1673-7210.2023.05.14
Objective To observe the efficacy and safety of electroacupuncture in the treatment of gluteal nerve entrapment syndrome. Methods A total of 80 patients with gluteal epithelial nerve entrapment syndrome treated in the Department of pain, Beijing Anzhen Hospital, Capital Medical University and North China Petroleum Administration General Hospital from May 2020 to May 2021 were divided into internal heat acupuncture group and internal heat acupuncture combined with electric acupuncture group (combined acupuncture group) according to random number table method, with 40 cases in each group. Each group was treated twice a week for two consecutive weeks, a total of four times. Visual analogue scale (VAS), Japanese Orthopaedic Association (JOA) score, interleukin (IL)-6, IL-8, and tumor necrosis factor (TNF) -α were compared before and after treatment between the two groups. Results The clinical effect of combination acupuncture group was better than that of internal heat acupuncture group, and the difference was statistically significant (P＜0.05). After treatment, VAS scores of the two groups were lower than before treatment, while that of the combined acupuncture group was lower than that of the internal heat acupuncture group; JOA score of two groups were higher than that before treatment, while that of the combination acupuncture group was higher than that of the internal heat acupuncture group, and the differences were statistically significant (P＜0.05). After treatment, serum IL-6, IL-8, and TNF-α in two groups were lower than before treatment, while those of combined injection group were lower than those of internal heat injection group, and the differences were statistically significant (P＜0.05). The incidence of adverse reactions in combination acupuncture group was lower than that in internal heat acupuncture group, and the difference was statistically significant (P＜0.05). Conclusion Compared with internal heat acupuncture, electroacupuncture combined with internal heat acupuncture is safe and effective in the treatment of patients with gluteal epithelial nerve entrapment syndrome, and can significantly improve clinical symptoms and daily activity ability of patients. The mechanism of action may be related to the reduction of IL-6, IL-8, and TNF-α levels.
2023 Vol. 20 (5): 63-66 [
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Clinical effect of Qishenhuanwu Capsules on Parkinson’s disease with qi and blood deficiency
WANG Wen1 QIU Zhixin1 ZHENG Jianbiao1 JING Haifang1 WANG Aiqing1 LIU Dongfang1 LI Ning1 WNAG Yingli2
DOI: 10.20047/j.issn1673-7210.2023.05.15
Objective To explore the clinical effect of Qishenhuanwu Capsules in treating Parkinson’s disease (PD) with Qi and blood deficiency. Methods A total of 100 PD patients with Qi and blood deficiency admitted to Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine from March 2020 to January 2022 were selected and divided into control group (conventional drug treatment, 50 cases) and experimental group (conventional drug treatment combined with Qishenhuanwu Capsules, 50 cases) by random number table method. The two groups were treated for a total of six weeks. The clinical effects, motor and non-motor symptoms before and after treatment, and related laboratory indicators were compared between the two groups. Results The clinical efficacy of the experimental group was better than that of the control group, and the difference was statistically significant (P＜0.05). After treatment, the scores of the Simple Intelligent Mental State Assessment Scale and the Montreal Cognitive Assessment Scale in the two groups were higher than before treatment, while those of the experimental group were higher than those of the control group, and the differences were statistically significant (P＜0.05). After treatment, PD rating scale Ⅲ and PD non-motor symptom questionnaire scores of the two groups were lower than before treatment, and those of the experimental group were lower than the control group, and the differences were statistically significant (P＜0.05). After treatment, serum insulin-like growth factor and β-amyloid 1-42 in two groups were higher than before treatment, while those of the experimental group were higher than those of the control group; homocysteine and C-reactive protein in the two groups were lower than before treatment, while those of the experimental group were lower than those of the control group, and the differences were statistically significant (P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05). Conclusion Qishenhuanwu Capsules can effectively improve motor and non-motor symptoms of PD patients with qi and blood deficiency, the effect is remarkable.
2023 Vol. 20 (5): 67-70,74 [
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Effect of upper limb robot combined with scalp acupuncture on upper limb motor function after stroke
CHEN Ruiquan XIAO Hongbo ZHU Zongjun CHEN Dongdong
DOI: 10.20047/j.issn1673-7210.2023.05.16
Objective To observe the effect of upper limb robot combined with scalp acupuncture on upper limb motor function after stroke. Methods From December 2020 to July 2021, 60 stroke patients who were hospitalized in the First Department of Acupuncture Rehabilitation, the First Affiliated Hospital of Anhui University of Chinese Medicine were selected, they were divided into control group and observation group according to the random number table method, with 30 cases in each group. The control group was treated with scalp acupuncture, and the observation group was given upper limb robot training on the basis of control group, treatment for three weeks. Fugl-meyer assessment (FMA), modified Barthel index (MBI), and active angle repositioning (AAR) before and after treatment were compared between two groups. Results After treatment, the scores of FMA and MBI in both groups were higher than those before treatment, and those of observation group were higher than those of control group (P＜0.05). AAR scores of 30° and 60° shoulder flexion in two groups were lower than those before treatment, and those of observation group were lower than those of control group (P＜0.05). Conclusion Upper limb robot combined with scalp acupuncture can significantly improve the upper limb motor function and the ability of daily living activities of stroke patient.
2023 Vol. 20 (5): 71-74 [
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Relationship between homocysteine, interleukin-6 and cognitive dysfunction after ischemic stroke
ZHANG Jianping1 LIN Wenjing1 SHI Yinhua2 LI Qing1 HAO Weihua3
DOI: 10.20047/j.issn1673-7210.2023.05.17
Objective To investigate the relationship between homocysteine (Hcy), interleukin-6 (IL-6) and cognitive dysfunction after ischemic stroke. Methods A total of 150 patients with ischemic stroke who visited Shijiazhuang People’s Hospital from December 2018 to December 2020 were included in the study, according to the results of the Montreal cognitive assessment scale score, the patients were divided into cognitive impairment group of 110 cases and control group of 40 cases. The gender, age, heart rate, total cholesterol, triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, Hcy, and IL-6 levels were collected and compared between the two groups, the correlation between Hcy level, IL-6 level and Montreal cognitive assessment scale (MoCA) score were analyzed. Results The levels of Hcy and IL-6 in cognitive dysfunction group were higher than those in control group, and the differences were statistically significant (P＜0.05). Hcy and IL-6 level were the influencing factors of cognitive dysfunction in ischemic stroke patients (F=25.225, P＜0.001). Regression equation: MoCA score of patients with ischemic stroke =1.091-0.239×Hcy-0.503×IL-6, R2 of the model was 0.135, and the adjusted R2 was 0.130. Conclusion Hcy level and IL-6 level are the influencing factors of cognitive dysfunction in ischemic stroke patients.
2023 Vol. 20 (5): 75-78 [
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Analysis of pulmonary infection and its influencing factors in patients with cerebral hemorrhage after tracheotomy
WANG Min ZHANG Xiumei QIN Lihui LI Jing YANG Li
DOI: 10.20047/j.issn1673-7210.2023.05.18
Objective To investigate the influencing factors of pulmonary infection in patients with cerebral hemorrhage after tracheotomy. Methods A total of 146 patients with cerebral hemorrhage admitted to the First Hospital of Handan City, Hebei Province from April 2020 to March 2022 were selected, all of whom underwent hematoma removal under general anesthesia. According to the condition of lung infection, the patients were divided into infected group and non-infected group, and the clinical characteristics of the two groups were compared to determine the influencing factors of lung infection. Results The pulmonary infection rate of 146 patients with cerebral hemorrhage was 21.92% (32/146). There were statistically significant differences in smoking history, malnutrition, chronic obstructive pulmonary disease, bleeding site, preoperative Glasgow coma scale score, tracheotomy time, and indwelling gastric tube ratio between the two groups (P＜0.05). Logistic regression results showed that malnutrition, bleeding site, preoperative Glasgow coma score, tracheotomy time, and indwelling gastric tube were risk factors for pulmonary infection (OR＞1, P＜0.05). Conclusion Patients with cerebral hemorrhage tracheotomy should strengthen nutrition, shorten the time of tracheotomy, strengthen the intervention of indwelling gastric tube and so on, and actively prevent and treat pulmonary infection.
2023 Vol. 20 (5): 79-81,89 [
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Relationship between vitamin A and E levels and pregnancy outcome in patients with gestational hypertension
YU Hongyun SUN Guiying DING Jianfen
DOI: 10.20047/j.issn1673-7210.2023.05.19
Objective To investigate the relationship between vitamin A and E levels and pregnancy outcomes in patients with gestational hypertension. Methods A total of 82 patients with gestational hypertension admitted to Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Jiangsu Province (“our hospital” for short) from March 2018 to April 2021 were selected as research group, in addition, 49 healthy pregnant women who underwent routine physical examination during the same period in our hospital were selected as control group. The serum vitamin A and E levels of control group and research group were compared; the research group was divided into poor pregnancy outcome group and good pregnancy outcome group according to pregnancy outcomes, the factors affecting pregnancy outcome were analyzed. The predictive value was evaluated by receiver operating characteristic curve. Results Serum vitamin A, E levels in research group were lower than those in control group, and the differences were statistically significant (P＜0.05). There were statistically significant differences in pre-pregnancy body mass index (BMI), disease severity, 24 h urinary protein quantity, blood uric acid, interleukin-6, serum vitamin A, and serum vitamin E between poor pregnancy outcome group and good pregnancy outcome group (P＜0.05). Pre-pregnancy BMI, disease severity, 24 h urinary protein quantity, serum vitamin A, and serum vitamin E were the influencing factors of adverse pregnancy outcome in pregnancy-induced hypertension patients (P＜0.05). The areas under the curve of serum vitamin A, E single and combined forecast were 0.734, 0.702, and 0.748, respectively. Conclusion Vitamin A and E levels are of great value in predicting adverse pregnancy outcomes in patients with gestational hypertension.
2023 Vol. 20 (5): 82-85 [
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Effect of Orff music therapy combined with repetitive transcranial magnetic stimulation on children with autism spectrum disorder
ZHANG Ling LIU Chunlei LONG Yajun ZHAO Sufen HUANG Yimeng LIU Chaoyu
DOI: 10.20047/j.issn1673-7210.2023.05.20
Objective To observe the effect of Orff music therapy combined with repetitive transcranial magnetic stimulation on children with autism spectrum disorder (ASD). Methods A total of 80 children with ASD who were admitted to Hunan Children’s Hospital from May to August 2021 were selected as the research objects, they were divided into control group (40 cases) and treatment group (40 cases) by random number table method. The control group received repetitive transcranial magnetic stimulation, and treatment group received Orff music therapy on the basis of control group. The autism treatment evaluation checklist scale (ATEC), children’s autism behavior checklist scale (ABC), and vestibular function scores were compared between two groups before and after treatment, the total occurrence of adverse reactions during treatment was observed in two groups. Results After treatment, the ATEC and ABC scores of two groups were decreased than those before treatment, vestibular function scores of two groups were increased than those before treatment; and the ATEC and ABC scores of treatment group were lower than those of control group, the vestibular function score was higher than that of control group (P＜0.05). There was no significant difference in the total incidence of adverse reactions between two groups (P＞0.05). Conclusion Orff music therapy combined with repetitive transcranial magnetic stimulation in the treatment of children with ASD is effective, can improve the clinical symptoms of children, and improve the state of comprehensive sensory disorders, and it is safe and reliable.
2023 Vol. 20 (5): 86-89 [
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Effect of Buzhong Yiqi Decoction on bone marrow suppression and quality of life in elderly patients with advanced digestive system malignant tumors
ZHU Minghui CAO Jing ZHOU Xi LI Yanfei▲
DOI: 10.20047/j.issn1673-7210.2023.05.21
Objective To explore the effect of Buzhong Yiqi Decoction on bone marrow suppression and quality of life in elderly patients with advanced digestive system malignant tumors. Methods Eighty-three elderly patients with advanced digestive system malignant tumor admitted to Jiangsu Provincial People’s Hospital from January 2019 to April 2022 were selected and divided into control group (41 cases, XELOX chemotherapy) and observation group (42 cases, XELOX chemotherapy + Buzhong Yiqi Decoction) by random number table method. The clinical efficacy of four weeks after chemotherapy and the myelosuppression of one week after chemotherapy were analyzed and compared between the two groups. The quality of life and immune level before and one week after chemotherapy were analyzed and compared between the two groups. The occurrence of adverse reactions during chemotherapy was recorded. Results At four weeks after chemotherapy, the curative effect of the observation group was better than that of the control group, the difference was statistically significant (P＜0.05). One week after chemotherapy, the incidence of grade Ⅱ and above myelosuppression rate in observation group was lower than that in control group, and the difference was statistically significant (P＜0.05). One week after chemotherapy, the Kanofsky performance status (KPS) score of control group was lower than that of control group before treatment, the KPS score of observation group was higher than that of observation group before treatment, and the levels of immunoglobulin (Ig) M, IgG, and IgA in both groups were higher than those before treatment, KPS score, IgM, IgG, and IgA in the observation group were higher than those in the control group, and the differences were statistically significant (P＜0.05). There were no significant differences in the incidence of nausea, vomiting, diarrhea, and alopecia between the two groups (P＞0.05). Conclusion Buzhong Yiqi Decoction can improve the clinical efficacy of elderly patients with advanced digestive system malignant tumors, reduce the degree of bone marrow suppression, greatly improve the quality of life and immune capacity of patients, and can be widely used in clinical treatment.
2023 Vol. 20 (5): 90-93,97 [
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Effect of permissive hypercapnia of CO2 artificial pneumothorax induced by single cavity tracheal intubation on coagulation, fibrinolysis, and lung function in esophageal cancer surgery
CHENG Yuanjian YI Chao LI Rui
DOI: 10.20047/j.issn1673-7210.2023.05.22
Objective To study the effect of permissive hypercapnia of CO2 artificial pneumothorax induced by single cavity tracheal intubation on coagulation, fibrinolysis, and lung function in esophageal cancer surgery. Methods A total of 108 patients with esophageal cancer expected to undergo laparoscopic thoracic surgery in Panzhihua Central Hospital of Sichuan Province from January 2020 to January 2022 were included as research objects, and they were divided into observation group and control group according to random number table method, with 54 patients in each group. In the observation group, the single lumen tracheal catheter was inserted orally, while in the control group, the left double-lumen bronchial catheter was inserted orally. The coagulation fibrinolytic indexes (coagulation response time [R], blood clot formation rate [K], plasminogen activator inhibitor-1 [PAI-1], tissue plasminogen activator [t-PA]) of the two groups were analyzed before surgery (T0), 60 min at the start of lung ventilation (T1), 30 min at the end of lung ventilation (T2), and one day after surgery (T3). Peak airway pressure and dynamic lung compliance were recorded, and compared between the two groups at each time point. Results In the observation group, R and K values at T1 and T2 were higher than those at T0, K value at T2 was lower than that at T1, and R and K values at T3 were lower than those at T1 and T2, R and K values at T1 and T2 in the observation group were higher than those in the control group at the same time point (P＜0.05). The levels of PAI-1 at T3 and t-PA at T1 in observation group were lower than those in control group at the same time point (P＜0.05). The peak airway pressures of two groups at T1, T2, and T3 were higher than those at T0, T2 and T3 were lower than T1, and T3 was lower than T2 (P＜0.05). The dynamic lung compliance at T1, T2, and T3 was lower than that at T0, T2 and T3 were higher than T1, and T3 was higher than T2 (P＜0.05). The peak airway pressures at T1, T2, and T3 in the observation group were lower than those in the control group at the same time points, and the dynamic lung compliance was higher than the control group at the same time points (P＜0.05). Conclusion Permissive hypercapnia of CO2 artificial pneumothorax has a protective effect on lung function in esophageal cancer surgery, which can reduce the occurrence of lung infection, but has certain influence on the coagulation and fibrinolytic function of patients, attention should be paid to preventing intraoperative bleeding.
2023 Vol. 20 (5): 94-97 [
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Effect of Shenqi Huayu Formula combined with transcatheter arterial chemoembolization in the treatment of patients with primary hepatocellular carcinoma
LU Dongyan YE Xiaowei
DOI: 10.20047/j.issn1673-7210.2023.05.23
Objective To evaluate the effect of Shenqi Huayu Formula combined with transcatheter arterial chemoembolization (TACE) in the treatment of patients with primary hepatocellular carcinoma (PHC). Methods Sixty patients with PHC admitted to the First Affiliated Hospital, Guangzhou University of Chinese Medicine from June 2020 to December 2021 were selected and divided into control group and treatment group by random number table method, with 30 cases in each group. Both groups received TACE and postoperative symptomatic treatment, and the treatment group was additionally given Shenqi Huayu Formula. The efficacy of solid tumor in the two groups after four weeks of treatment was evaluated according to the response evaluation criteria in solid tumor 1.1. Traditional Chinese medicine syndrome scores, quality of life- liver cancer scale scores, the levels of serum alpha-fetoprotein (AFP), interleukin (IL)-6, IL-1β, and tumor necrosis factor-α (TNF-α) were compared between the two groups before and four weeks after treatment. Results After four weeks of treatment, there was no significant difference in clinical efficacy between the two groups (P＞0.05). After four weeks of treatment, the scores of hypochondriac pain, abdominal distension, nausea and vomiting, anorexia, spiritlessness and fatigue, and total scores in two groups were lower than those before treatment, and the score of fever was higher than that before treatment, and all syndrome scores and total scores in the treatment group were lower than those in the control group (P＜0.05). After four weeks of treatment, physical function, mental function, symptoms scores, and total scores in both groups were higher than those before treatment, and the treatment group was higher than the control group (P＜0.05). After four weeks of treatment, the levels of serum AFP, IL-6, IL-1β, and TNF-α in two groups were lower than those before treatment, and the treatment group was lower than the control group (P＜0.05). Conclusion Shenqi Huayu Formula combined with TACE can effectively reduce the clinical symptoms of PHC patients, improve their quality of life, and reduce the levels of serum AFP and inflammatory factors.
2023 Vol. 20 (5): 98-101,110 [
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Self-disclosure status in patients with non-Hodgkin lymphoma undergoing chemotherapy and its association with perceived social support
YUAN Yun HU Yan WANG Ting
DOI: 10.20047/j.issn1673-7210.2023.05.24
Objective To explore self-disclosure in patients with non-Hodgkin lymphoma undergoing chemotherapy and analyze its association with perceived social support. Methods A total of 116 patients with non-Hodgkin lymphoma undergoing chemotherapy in the West China Hospital, Sichuan University from January to December 2021 were selected as the research subjects. Jourard self-disclosure questionnaire (JSDQ) was used to evaluate the patients’ self-disclosure, and the levels of self-disclosure of patients with different characteristics of non-Hodgkin lymphoma undergoing chemotherapy were compared. The perceived social support scale (PSSS) was used to evaluate the perceived social support status, the correlation between self-disclosure level and perceived social support was analyzed. Results JSDQ and PSSS scores of 116 patients with non-Hodgkin lymphoma were (106.58±6.39) and (49.25±8.41) points, respectively. Among them, 36 patients had low support status of PSSS, 39 patients had intermediate support status, and 41 patients had high support status. The JSDQ scores of non-Hodgkin lymphoma patients with different perceived social support status were statistically significant (P＞0.05). Correlation analysis showed that the level of self-disclosure was positively correlated with perceived social support in patients with non-Hodgkin lymphoma chemotherapy (r＞0, P＜0.05). Conclusion Overall self-disclosure and perceptive social support levels are low in patients with non-Hodgkin lymphoma undergoing chemotherapy, and perceptive social support was associated with self-disclosure.
2023 Vol. 20 (5): 102-105 [
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Effect of nutritional target support therapy with modified HB coefficient on the prognosis of patients with severe craniocerebral injury
GAO Tian1 WANG Wei1 GU Qin2 HUANG Peizan1 WANG Ling1 WANG Dan1 WANG Huibo3 LI Hailin4
DOI: 10.20047/j.issn1673-7210.2023.05.25
Objective To investigate the effect of nutritional target support therapy with modified Harris-Benedict (HB) coefficient on the prognosis of patients with severe craniocerebral injury (TBI). Methods A total of 87 severe TBI patients admitted to the Department of Neurosurgery, the First Affiliated Hospital of Nanjing Medical University, the Intensive Care Unit the Fourth Affiliated Hospital of Nanjing Medical University and the Gulou Hospital of Nanjing Medical University from September 2019 to June 2022 were selected. Resting energy expenditure (REE) was measured by respiratory indirect calorimetry (IC) method and HB method of nutritional support. The difference and correlation between the two methods were analyzed, and the linear regression equation of the two methods was obtained (namely improved HB coefficient method formula). In addition, 40 severe TBI patients admitted to the Fourth Affiliated Hospital of Nanjing Medical University from June 2022 to September were selected and they were divided into IC group and modified HB coefficient method group according to the random number table method, and the prognostic indicators of the two groups were compared. Results The REE values of severe TBI patients were measured by IC and HB coefficient method 316 times respectively within two weeks of nutritional support treatment. The REE values obtained by IC method were significantly higher than those obtained by HB coefficient method (P＜0.05); the modified HB coefficient regression equation based on IC method was Y = 0.68X+767.67 (unit: kJ/d, X was the REE calculated by HB coefficient method of severe TBI patients ). There was no significant difference in the the modified HB coefficient method group and IC method group (P＞0.05). Conclusion The HB coefficient method significantly underestimated the energy expenditure of severe TBI patients within two weeks of the course of the disease. The modified HB coefficient method by IC method can more accurately estimate the energy expenditure of severe TBI patients, and provide accurate and simple nutritional support for clinical practice.
2023 Vol. 20 (5): 106-110 [
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Clinicopathological features and genetics analysis of gastric adenocarcinoma from the fundic gland
ZHANG Xiaohong1 WANG Yu’e2 YANG Jing2 WANG Ye3 LIU Xiaojiang1 WANG Zhihui1 YAO Shaobo1
DOI: 10.20047/j.issn1673-7210.2023.05.26
Objective To investigate the clinicopathological features and genetic characteristics of gastric adenocarcinoma from the fundic gland. Methods From January 2017 to March 2022, seven cases in Linyi Tumor Hospital and two cases in Linyi Traditional Chinese Medicine Hospital of Shandong Province with adenocarcinoma from fundus gland were collected. The clinicopathological features were analyzed retrospectively, and immunohistochemical staining and next generation sequencing (NGS) were detected. Results Eight cases were diagnosed as gastric adenocarcinoma of fundus gland type (GA-FG), with the surface of the lesions covered by normal concave epithelium and low grade dysplasia below. One case was diagnosed as gastric adenocarcinoma of fundic gland mucosa type (GA-FGM) with mucosal structure disorder, neoplastic concave epithelium, and low-grade dysglandular mixed hyperplasia. No atrophy, intestinal metaplasia, and Helicobacter pylori infection were observed in the surrounding mucosa of seven GA-FG and one GA-FGM cases. Immunohistochemical staining showed that mucin (MUC) 6, pepsinogenⅠ, and H+/K+-adenosine triphosphatase (ATPase) were expressed in all the eight GA-FG cases, while MUC5AC was only expressed in normal concave epithelium. The tumor cells of one GA-FGM case expressed MUC6, MUC5AC, pepsinogenⅠand H+/K+-ATPase. The results of NGS detection showed that two GA-FG cases had GNAS missense mutations, and one GA-FGM case had BRAF and TP53 missense mutations. Conclusion GA-FG is a rare low-grade malignant tumor, which often infiltrates submucosa, but has a good prognosis in most cases, while GA-FGM has different clinicopathological characteristics and a slightly worse prognosis.
2023 Vol. 20 (5): 111-115 [
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Establishment of logistic regression model for predicting the risk of pulmonary complications in patients with gastric cancer after operation
WANG Fang1 ZHU Xiaosu2▲ WANG Lihua1
DOI: 10.20047/j.issn1673-7210.2023.05.27
Objective To explore the establishment of risk warning model and related factors of postoperative pulmonary complications in patients with gastric cancer, and to provide reference for clinical prevention. Methods Sixty patients with gastric cancer complicated with lung complications after surgery in the 904th Hospital of Joint Logistic Support Force of the Chinese People’s Liberation Army from May 2018 to May 2020 were selected as the case group and 60 patients with no lung complications after surgery during the same period were selected as the control group. The risk warning model system of lung complications was established by univariate and multivariate logistic regression models to analyze the risk factors of postoperative lung complications in patients with gastric cancer. Results The rates of smoking, laparotomy, surgical bleeding ≥300 ml, number of lymph nodes dissected ≥25, preoperative blood protein ＜35 g/L, combined with chronic obstructive pulmonary disease, combined with diabetes, and postoperative anastomotic fistula in case group were higher than those in control group, and the differences were statistically significant (P＜0.05). Logistic regression analysis results showed that smoking, laparotomy, number of lymph nodes dissected ≥25, preoperative blood protein ＜35 g/L, combined with combined with chronic obstructive pulmonary disease, diabetes, combined with and postoperative anastomotic fistula were independent risk factors for postoperative pulmonary complications in patients with gastric cancer (OR＞1, P＜0.05). Conclusion By establishing the risk early warning model of postoperative pulmonary complications in patients with gastric cancer, relevant risk factors can be effectively found, and targeted intervention measures can be proposed for the risk groups in clinic.
2023 Vol. 20 (5): 116-119 [
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Factors influencing the failure of high-flow cannula oxygen therapy in patients with acute moderate respiratory failure
HUANG Sheng YU Sun WANG Yilan XU Chunyang▲
DOI: 10.20047/j.issn1673-7210.2023.05.29
Objective To explore the factors influencing the failure of high-flow nasal cannula oxygen therapy (HFNC) for acute moderate respiratory failure. Methods Eighty patients with acute moderate respiratory failure admitted to Changshu First People’s Hospital from January 2021 to September 2021 were collected as research objects, and divided into successful group (43 cases) and failed group (37 cases) according to whether they were converted to non-invasive or tracheal intubation. The general data, prognosis, respiratory circulation index, and pulmonary ultrasound index of the two groups were compared, and the relevant influencing factors were analyzed. Results The lung ultrasound score (LUS) in the successful HFNC group was lower than that in the failed HFNC group, while the diaphragm excursion (DE) was higher than that in the failed HFNC group, and the differences were statistically significant (P＜0.05). Respiratory rate (RR) and mean arterial pressure (MAP) levels in successful HFNC group were lower than those in failed HFNC group, while heart rate (HR) and ROX index were higher than those in failed HFNC group, and the differences were statistically significant (P＜0.05). Logistic regression analysis showed that the increase of RR, MAP and LUS were independent risk factors for treatment failure of HFNC (OR＞1, P＜0.05); the increase of DE, HR, and ROX index were protective factors for treatment failure of HFNC (OR＜1, P＜0.05). Conclusion Lung ultrasound and respiratory circulatory related indexes are poor in patients with treatment failure of HFNC. The increase of RR, MAP and LUS are risk factors for treatment failure of HFNC, while the increase of DE, HR and ROX index are protective factor.
2023 Vol. 20 (5): 120-123 [
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Application effect of Linalopeptide combined with enteral nutrition solution on colonoscopy in patients with constipation type irritable bowel syndrome
CHEN Wenxiao HUANG Huifeng ZOU Jinyan WU Zhenxing HUANG Mengsha
DOI: 10.20047/j.issn1673-7210.2023.05.29
Objective To investigate the application effect of Linalopeptide combined with enteral nutrition solution on colonoscopy in patients with constipation type irritable bowel syndrome. Methods A total of 136 patients with constipation type irritable bowel syndrome who underwent colonoscopy in Taizhou First People’s Hospital from February 2020 to September 2021 were selected as the research objects. They were divided into control group (68 cases) and observation group (68 cases) by random number table method. The control group was given compound polyethylene glycol electrolyte powder before intestinal examination, and the observation group was given Linalopeptide on the basis of the control group. The intestinal cleanliness, spasm, pain, tolerance, and adverse reactions of the two groups were analyzed and compared. Results The score of intestinal cleanliness in the observation group was higher than that in the control group (P＜0.05). The scores of pain and spasm in the observation group were lower than those in the control group (P＜0.05). The tolerance of patients in the observation group was better than that in the control group (P＜0.05). The total incidence of adverse reactions in the observation group was lower than that in the control group (P＜0.05). Conclusion Linalopeptide combined with enteral nutrition solution has high cleanliness in colonoscopy in patients with constipation type irritable bowel syndrome, which is worthy of popularization and application.
2023 Vol. 20 (5): 124-127 [
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Discussion on the biological connotation of “theory of thicken intestine” based on intestinal mucus barrier and its application in the diagnosis and treatment of ulcerative colitis
XING Yunqi LI Junxiang ZHANG Wenji HAN Haixiao SUN Zhongmei YUAN Yali MAO Tangyou
DOI: 10.20047/j.issn1673-7210.2023.05.30
As a traditional Chinese medicine treatment method, “thicken intestine” appears many times in herbal medical related books and prescriptions, which mainly associated with intestinal diseases, such as bowel, diarrhoea, diuresis, and dysentery. However, due to the vague understanding of “thicken intestine” by most physician, it is generally called enhancing the function of intestine, which hindered the further development of the theory. It is not until the Qing Dynasty that some doctors gradually accurately understood the “thicken intestine” and believed that there is an inherent layer of “lipid membrane” or “ointment” in the intestine, which has the function of “protecting and guiding waste and making it go down”. The thinning of “lipid membrane” or “ointment” caused by damp heat or other reasons is the key pathogenesis of “putrid stool” and “bowel”, which is coupled with the damage of intestinal mucus barrier in modern medicine, the key pathogenesis of ulcerative colitis. Therefore, the corresponding treatment methods based on different pathogenesis of intestinal lipid membrane thinning should be adopted to “eliminate the source of damage, and the thin is thick”, so as to achieve the purpose of “thicken intestine” and finally treat ulcerative colitis, which is similar to the treatment of ulcerative colitis by reconstruction of mucus barrier function in modern medicine. By excavating the classic ancient books of traditional Chinese medicine, this paper traces and extendes the meaning of “theory of thicken intestine”, and deeply discusses its biological connotation from the perspective of intestinal mucus barrier, in order to provide new ideas and methods for the clinical treatment of ulcerative colitis.
2023 Vol. 20 (5): 128-132 [
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Professor Lü Wenliang’s experience in treating primary biliary cholangitis from liver and spleen
YU Yingying LYU Wenliang
DOI: 10.20047/j.issn1673-7210.2023.05.31
Primary biliary cholangitis is a chronic disease of intrahepatic cholestasis, with cirrhosis occurring as the disease progresses. There are problems such as immune non-response and relapse when reducing or stopping drugs. Based on years of clinical experience, Professor Lü Wenliang believes that the dysfunction of zang-fu organs such as liver, spleen, kidney is the basis of the disease, the liver and spleen are more important. Liver depression and spleen deficiency, damp-heat, poison, blood stasis, and deficiency internal knot are the core pathogenesis. On this basis, three important treatment principles are put forward: first is to soften liver and strengthen spleen, protect stomach qi; second is to clear damp detoxification and dispel evil; third is to eliminate stasis and dredge collaterals, reconcile qi and blood. Adapt to the physiological characteristics of zang-fu organs, adjust qi to make it peaceful, so as to prevent the progress of the disease. A medical case is attached in order to provide ideas and methods for traditional Chinese medicine treatment of primary biliary cholangitis.
2023 Vol. 20 (5): 133-136,141 [
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Analysis on the medication rules of traditional Chinese medicine compound prescriptions in the treatment of non-alcoholic fatty liver disease based on the national patent database
WEI Liuting1 HU Zhenbin2 GAO Songlin1 WEI Yuzhen2 ZHANG Jiazeng1 ZHANG Zhen1
DOI: 10.20047/j.issn1673-7210.2023.05.32
Objective To analyze the medication rules of national traditional Chinese medicine patent compound prescriptions in the treatment of non-alcoholic fatty liver disease (NAFLD) by data mining technology. Methods The traditional Chinese medicine compound prescriptions in the treatment of NAFLD in CNKI patent database and the Patent Search and Analysis System of the State Intellectual Property Office of China from inception to April 2022 were searched. Microsoft Excel software and Traditional Chinese Medicine Inheritance Computing Platform (V3.0) were used for drug frequency statistics, nature, flavour, channel tropism, association rules, and cluster analysis. Results Finally, a total of 93 prescriptions were included, with 241 traditional Chinese medicine. High frequency drugs included Salviae Miltiorrhizae Radix Et Rhizoma, Crataegi Fructus, Alismatis Rhizoma, Bupleuri Radix, Atractylodis Macrocephalae Rhizoma, and so on. The top four efficacies were supplementing deficiency drugs (mainly supplementing qi drugs), diuresis and diffusing dampness drugs, promoting blood circulation for removing blood stasis drugs, and clearing heat drugs. The four nature of drugs were mainly warm, slightly cold, and cold, and the five flavours were bitter, sweet, and pungent, mainly returning to the liver and spleen channels. A total of nine high-frequency couplet medicines, eight drug association rules were discovered, and three types of prescriptions were obtained by cluster analysis. Conclusion The traditional Chinese medicine patent compound prescriptions in the treatment of NAFLD is based on the basic methods of invigorating qi and invigorating spleen, and apply the method of dispersing liver and promoting qi, clearing heat and activating blood, removing dampness and turbidification, and so on.
2023 Vol. 20 (5): 137-141 [
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Analysis on the medication rules of traditional Chinese medicine in the treatment of male infertility based on data mining
GAO Rong1 LIU Jianguo2 GUO Bin1 MIAO Xiaoguang1
DOI: 10.20047/j.issn1673-7210.2023.05.33
Objective To explore the medication rules of traditional Chinese medicine in the treatment of male infertility based on data mining. Methods The empirical prescriptions for male infertility treatment using traditional Chinese medicine published in China National Knowledge Infrastructure, VIP, Wanfang Data, Chinese Biomedical Literature databases from their inception to December 2021 were collected and sorted out. The database was screened and established on the Traditional Chinese Medicine Inheritance Assistant Platform (V2.5), and relevant data mining technologies such as basic information statistics, frequency analysis, and association rule analysis were used to analyze medical records, explore their medication rules, and explore new prescriptions. Results A total of 114 prescriptions were screened, involving 160 single traditional Chinese medicine. Frequency analysis results showed that Cuscutae Semen, Lycii Fructus, Rehmanniae Radix Praeparata, Epimedii Folium, Astragali Radix, Dioscoreae Rhizoma, Corni Fructus, Rubi Fructus, Poria, Angelicae Sinensis Radix ranked top ten in the frequency of drug use. The medicinal natures were mainly warm and plain. The main medicinal flavour was sweet, followed by pungent and bitter, and the channel tropism was mainly kidney and liver channels. A total of 55 common drugs combinations, 11 drugs association rules, and seven potential new prescriptions were obtained. Conclusion The basic treatment of male infertility with traditional Chinese medicine is to tonify kidney and essence, and to promote blood circulation for removing blood stasis, invigorate spleen for promoting diuresis.
2023 Vol. 20 (5): 142-145,154 [
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Effect of warming needle moxibustion for secondary dysmenorrhea in cold coagulation and blood stasis type adenomyosis
ZHANG Yutong1 WANG Shilin1 SUN Yuanzheng2 YANG Dongxia3 SUN Yan4
DOI: 10.20047/j.issn1673-7210.2023.05.34
Objective To explore the clinical efficacy of warming needle moxibustion for secondary dysmenorrhea in cold coagulation and blood stasis type adenomyosis. Methods A total of 52 patients with secondary dysmenorrhea to adenomyosis in cold coagulation and blood stasis type who were treated in the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine from January to May 2022, and they were divided into control group and treatment group according to random number table method, with 26 cases in each group. The control group was treated with Shaofu Zhuyu Capsules, the treatment group was treated with warming needle moxibustion on the basis of the control group. Each course of treatment was seven days, all patients were treated for three courses. The scores of dysmenorrhea degree, traditional Chinese medicine symptoms, visual analog scale (VAS), and endometriosis quality of life assessment (EHP-5) were compared between the two groups. The clinical effect of the treatment group was better than that of the control group, the difference was statistically significant (P＜0.05). There were statistically significant differences in dysmenorrhea degree scores and traditional Chinese medicine symptom scores between the two groups at each time point after treatment (P＜0.05). The scores of dysmenorrhea degree and traditional Chinese medicine symptoms in the treatment group were lower than those in the control group at each time point, and the differences were statistically significant (P＜0.05). After three months of treatment, VAS and EHP-5 scores in two groups were lower than those before treatment, and those of the treatment group were lower than the control group, the differences were statistically significant (P＜0.05). Conclusion Warming needle moxibustion is effective in treating secondary dysmenorrhea in cold coagulation and blood stasis type adenomyosis. It can relieve pain and correct patients’ cold constitution, and the improvement degree is better than traditional Chinese patent medicine treatment.
2023 Vol. 20 (5): 146-149,159 [
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Explore the drug law of professor Wang Kungen in the treatment of gastric precancerous lesions based on data mining
CAI Lijun SHI Yihui HE Hui RUI Xiaowei MAO Xiangying FENG Tongfei WANG Kungen
DOI: 10.20047/j.issn1673-7210.2023.05.35
Objective To explore professor Wang Kungen’s prescription rules for the treatment of gastric precancerous lesions, based on the traditional Chinese medicine inheritance assistant platform. Methods Cases diagnosed as gastric precancerous lesions through gastroscopic pathology reports were collected from professor Wang Kungen’s clinic in Zhejiang Provincial Hospital of Chinese Medicine from December 2016 to December 2020. Prescription database was established, and conclusions were drawn from frequency analysis, association rules, complex system entropy clustering analysis, and other processing methods through tradition Chinese medicine inheritance assistance platform. Results A total of 130 outpatient cases were obtained, and 130 first-diagnosed prescriptions were obtained, involving 132 kinds of Chinese medicines. Among them, 25 Chinese medicines with a frequency of ＞20 times were obtained, drugs to bitter cold, mainly return to the spleen, stomach, liver meridian. The core prescriptions were Chinese thorowax root, turmeric root tuber, pinellia tuber, dried tangerine peel, indian bread, dandelion, golden thread, and four new prescriptions were obtained from entropy clustering. Conclusion The core drugs of professor Wang Kungen’s treatment of gastric precancerous lesions are Chinese thorowax root, turmeric root tuber, pinellia tuber, dried tangerine peel, indian bread, dandelion, and golden thread. The main therapeutic principle is to soothe liver and clear heat, regulate qi and stomach, and remove dampness and phlegm.
2023 Vol. 20 (5): 150-154 [
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Influence of Chinese herbal colon dialysis on intestinal “microecology” in patients of dampness-turbidity blood stasis syndrome with stage three to four chronic kidney disease
ZHANG Qian LI Tongxia▲ HUANG Xueying YAN Pu SHI Kaifeng WANG Xin HOU Hailing
DOI: 10.20047/j.issn1673-7210.2023.05.36
Objective To investigate the influence of Chinese herbal colon dialysis on intestinal “microecology” in patients of dampness-turbidity blood stasis syndrome with stage three to four chronic kidney disease. Methods One hundred and eight outpatients and inpatients from the Department of Nephroendocrinology, Wangjing Hospital of China Academy of Chinese Medical Sciences from April 2018 to August 2020 were selected and divided into control group and test group according to the district group, with 54 patients in each group. Both groups were given basic treatment, control group was given routine colon dialysis, and test group was given Chinese herbal colon dialysis, once every other day, for four weeks. Indoxyl sulfate, blood creatinine, urea nitrogen, estimated glomerular filtration rate (eGFR), serum endotoxin, D-lactic acid, Escherichia coli, Bifidobacterium of two groups were compared before and after treatment. Results Control group lost seven cases and test group lost five cases. Before treatment, there were no significant differences between the two groups in indoxyl sulfate, blood creatinine, urea nitrogen, and eGFR (P＞0.05). After treatment, the levels of indoxyl sulfate, blood creatinine, and urea nitrogen in the two groups were lower than those before treatment, and the eGFR in the two groups was higher than that before treatment, and the levels of indoxyl sulfate, blood creatinine, and urea nitrogen in test group were lower than those in control group, and the eGFR in test group was higher than that in control group, with statistically significant differences (P＜0.05). Before treatment, there were no significant differences between the two groups in serum endotoxin, D-lactic acid, and Escherichia coli (P＞0.05). After treatment, the serum endotoxin and D-lactic acid in the two groups were lower than those before treatment, and test group was lower than that control group, the differences were statistically significant (P＜0.05). After treatment, the number of Escherichia coli in test group was less than that before treatment and that in control group, the differences were statistically significant (P＜0.05). Before and after treatment, there was no significant difference in the inter-group and intra-group comparison of Bifidobacteria between the two groups (P＞0.05). Conclusion Chinese herbal colon dialysis can effectively reduce uremic toxin, improve the intestinal “microecology” of patients with chronic kidney disease, and delay the progression of renal function.
2023 Vol. 20 (5): 155-159 [
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Clinical effect of supporting qi and enriching blood and promoting diuresis and diffusing dampness method in the treatment of urinary retention after stroke
SUN Haiyan1 ZHAO Chunsheng2 TONG Fei1 JIA Rongyan1 DING Guangqian1
DOI: 10.20047/j.issn1673-7210.2023.05.37
Objective To investigate clinical effect of supporting qi and enriching blood and promoting diuresis and diffusing dampness method in the treatment of urinary retention after stroke. Methods One hundred and twenty-two patients with urinary retention after stroke admitted to Chengde Traditional Chinese Medicine Hospital, Hebei Province from January 2017 to September 2021 were selected and divided into reference group and observation group according to the random number table method, with 61 cases in each group. Reference group was given basic treatment and bladder function training, and observation group was given comprehensive treatment of supporting qi and enriching blood and promoting diuresis and diffusing dampness method on the basis of reference group. Both groups were treated for 14 days. Clinical effect, traditional Chinese medicine syndrome score, urination, bladder function score and specific stroke quality of life (SS-QOL) score between the two groups were compared. Results Clinical effect of observation group was better than that of reference group, the difference was statistically significant (P＜0.05). After treatment, the scores of hypoabdominal distension, micturition weakness and mental fatigue in the two groups were lower than those before treatment, and observation group was lower than that control group, the differences were statistically significant (P＜0.05). After treatment, the number of urination and average urine volume in the two groups were more than those before treatment, and the residual urine volume in the two groups was less than that before treatment, and the number of urination and average urine volume in observation group were more than those in reference group, and the residual urine volume in observation group was less than that in reference group, the differences were statistically significant (P＜0.05). After treatment, the bladder function score of the two groups was lower than that before treatment, and the SS-QOL score of the two groups was higher than that before treatment, and the bladder function score of observation group was lower than that of reference group, and the SS-QOL score of observation group was higher than that of reference group, the differences were statistically significant (P＜0.05). Conclusion The comprehensive treatment of supporting qi and enriching blood and promoting diuresis and diffusing dampness method in the treatment of urinary retention after stroke has a significant effect, and it can significantly improve bladder function.
2023 Vol. 20 (5): 160-163 [
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Exploration and practice on the construction of production management system in hospital preparation center
LIU Jiye LI Hongyan ZENG Weixin ZHANG Lei JIANG Dechun
DOI: 10.20047/j.issn1673-7210.2023.05.38
Hospital preparation production has a strict production process, from raw materials, intermediate products to the final preparation on the market are required to record the batch number, quantity, weight, time, personnel, equipment parameters, deviations, and other related data, which is the fundamental basis for ensuring the preparation quality. In this paper, taking Preparation Center of Beijing Shijitan Hospital, Capital Medical University (“our hospital” for short) as an example, a complete preparation production management system is established on the basis of the management procedures of preparation in medical institutions, and is applied to control the production process of preparation vitamin E cream in our hospital. Through the information means in the production management system, the data in each link of preparation production was effectively integrated and completely recorded, which effectively solved the problem of traceability, and finally realized the whole process management of preparation production and guarantees the quality of preparation.
2023 Vol. 20 (5): 164-167,184 [
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Effects of time-sensitive incentives on hope level and rehabilitation exercise compliance behavior in elderly patients with post-cerebral infarction hemiplegia
YAO Xiaoling CHEN Ping XIA Lei
DOI: 10.20047/j.issn1673-7210.2023.05.39
Objective To explore the effects of time-sensitive incentives on hope level and rehabilitation exercise compliance behavior in elderly patients with post-cerebral infarction hemiplegia. Methods A total of 106 elderly patients with post-cerebral infarction hemiplegia admitted to the Huaian First Hospital Affiliated to Nanjing Medical University from July 2019 to August 2020 were selected, and they were divided into control group and experimental group by random number table method, with 53 cases in each group. Both groups were given tertiary rehabilitation exercise, the control group was given routine nursing, and the experimental group was combined with time-effective incentive intervention. After six months of follow-up, hope level and compliance with rehabilitation exercise were compared between the two groups. Results There were six cases in the control group and four cases in the experimental were sheded. After six months of follow-up, the total scores of realistic and future attitudes, maintaining close relationships with others, adopting positive behaviors, and hope levels in both groups were higher than those before intervention, and those of the experimental group were higher than the control group (P＜0.05); the total scores of physical exercise, exercise effect monitoring, active advice seeking, and compliance in two groups were higher than those before intervention, and those of the experimental group were higher than the control group (P＜0.05); compliance of rehabilitation exercise in the two groups was better than that before intervention, and the experimental group was better than the control group (P＜0.05). Conclusion Timeliness incentive can promote the development of hope level in elderly patients with hemiplegia after cerebral infarction and improve the compliance behavior of rehabilitation exercise.
2023 Vol. 20 (5): 168-171 [
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Application value of early staged respiratory rehabilitation training in ICU patients with chronic obstructive pulmonary disease
SU Baoyan ZHONG Bohua YANG Ting
DOI: 10.20047/j.issn1673-7210.2023.05.40
Objective To analyze the value of applying early staged respiratory rehabilitation training in intensive care unit (ICU) patients with chronic obstructive pulmonary disease (COPD). Methods From March 2019 to January 2022, 120 patients with COPD in the ICU admitted to the First Affiliated Hospital of Guangxi Medical University were selected, and they were divided into control group and experimental group according to envelope random number table method, with 60 cases in each group. The control group received routine rehabilitation intervention, and the experimental group received early stage respiratory rehabilitation training intervention. Respiratory function, dyspnea, exercise tolerance, clinical indicators, and ventilator-related complications were compared between the two groups before intervention and two months after intervention. Results After two months of intervention, forced expiratory volume in 1 second (FEV1), percentage of forced vital capacity (FEV1/FVC), percentage of predicted value of FEV1 (FEV%), and six minutes walk test (6MWT) value increased, the values of FEV1, FEV1/FVC, FEV%, and 6MWT value in the experimental group were higher than those in the reference group, and the differences were statistically significant (P＜0.05). Medical research council scale (MRC) score decreased in both groups, and the experimental group was lower than the reference group, the differences were statistically significant (P＜0.05). Intubation time and ICU days of the experimental group were shorter than those of the reference group, and the difference was statistically significant (P＜0.05). The complication rate of experimental group was lower than that of reference group, and the difference was statistically significant (P＜0.05). Conclusion In the rehabilitation intervention of COPD patients in ICU, the effect of early stage respiratory rehabilitation training is significant, which is helpful to improve exercise tolerance and respiratory function.
2023 Vol. 20 (5): 172-175 [
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Application of workshop mode in training of operation skills of junior nurses
JI Xiaokang ZHENG Ting WU Xianshuai WANG Feiyan▲
DOI: 10.20047/j.issn1673-7210.2023.05.41
Objective To explore the application of workshop model in training of operation skills of junior nurses. Methods A total of 90 junior nurses who entered the emergency medicine department of Shanghai Sixth People’s Hospital from January 2019 to December 2021 were selected, and they were divided into control group and workshop group by convenience sampling method, with 45 nurses in each group. The control group adopted traditional nursing operation skills training mode, the workshop group adopted workshop mode. Training two times per week, two hours each time. The assessment scores of theoretical knowledge and operational skills, and comprehensive ability assessment scores of two groups were compared. The satisfaction of training effect in two groups were investigated by means of questionnaire. Results After training, the assessment scores of theoretical knowledge and operational skills in both groups were higher than those before training, and the workshop group was higher than control group (P＜0.05). The scores of communication and coordination ability, emergency handling ability, first aid cooperation ability, and work efficiency after training in workshop group were higher than control group (P＜0.05). The workshop group were more satisfied with training effect than control group (P＜0.05). Conclusion The workshop model used for junior nurses can strengthen training effect of their theoretical knowledge and operational skills, enhance the comprehensive ability of nurses, and improve training satisfaction.
2023 Vol. 20 (5): 176-179 [
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Influence of protective motivation intervention based on quantitative evaluation on cognition in patients with arrhythmia undergoing radiofrequ- ency ablation
ZHANG Jing ZHANG Haige CHENG Miaomiao GAO Nana▲
DOI: 10.20047/j.issn1673-7210.2023.05.42
Objective To explore the influence of the effect of protective motivation intervention based on quantitative evaluation on cognition in patients with arrhythmia undergoing radiofrequency ablation. Methods A total of 450 patients with arrhythmia treated by radiofrequency ablation in the Second Affiliated Hospital of Air Force Military Medical University, from January to December 2021 were selected as the research objects, and they were divided into control group and observation group by random number table method, with 225 cases in each group. The control group was treated with routine intervention, and the observation group was treated with protective motivation intervention based on quantitative evaluation. The cognitive level, self-care ability, and quality of life were compared between the two groups before intervention and one month after intervention. Results After intervention, scores of cognitive level (disease, treatment, rehabilitation, and social knowledge) in both groups were higher than before intervention, and the observation group were higher than the control group, the differences were statistically significant (P＜0.05). The scores of self-care ability (self-concept, health knowledge, and self-care skills, self-responsibility) in the two groups were higher than before intervention, and the observation group were higher than the control group, the differences were statistically significant (P＜0.05). Scores of all dimensions of quality of life (physical condition, illness, medical condition, general life, social/psychological condition, and working condition) in both groups were higher than those before intervention, and those of the observation group were higher than the control group, the differences were statistically significant (P＜0.05). Conclusion Protective motivation interventions based on quantitative evaluation can improve cognition, self-care, and quality of life in patients with arrhythmia undergoing radiofrequency ablation.
2023 Vol. 20 (5): 180-184 [
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Effect of TeamSTEPPS-based management model on safety attitude of nursing staff in operation rooms
XU Lizhen WANG Jingping LI Lihong▲
DOI: 10.20047/j.issn1673-7210.2023.05.43
Objective To explore the effect of TeamSTEPPS-based management model on safety attitude of nursing staff in operation rooms. Methods Forty-four operating room nursing staff in the Ninth People’s Hospital of Suzhou, Jiansu Province were selected as the research subjects. Implement routine safety training from January to June 2021 (before management), TeamSTEPPS was be applied for safety management on the basis of routine safety training from July to December 2021 (after management). The Chinese version of safety attitudes questionnaire (SAQ), and the reporting of adverse events scale (RoCAES) were used to assess the safety, and adverse event reporting attitudes of nursing staff in operation rooms before and after management, and the nursing quality and the incidence of adverse events were compared before and after management. Results After management, SAQ scores of operating room staff was higher than those before management (P＜0.05). After management, the latitude scores in RoCAES was higher than those before management (P＜0.05). The nursing quality score after management was higher than that before management (P＜0.05). The total incidence of adverse events after management was lower than that before management (P＜0.05). Conclusion The management mode based on TeamSTEPPS can improve the safety attitude and adverse event reporting attitude of operating room staff, improve the quality of care and effectively avoid nursing risk events.
2023 Vol. 20 (5): 185-188 [
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The function and innovation of “teacher inheritance+” in the training of modern traditional Chinese medicine talents by adopting multiple ideas
ZHUANG Yuan1 YAN Jun2 CHEN Yan3 BO Rongqiang1 AN Rongxian1 DING Xia3▲
DOI: 10.20047/j.issn1673-7210.2023.05.44
Since the founding of new China, the higher education of Chinese medicine has received unprecedented attention and enjoyed a thriving development. Teacher-inherited education and college education have become the leading education modes of modern traditional Chinese medicine talent cultivation and played major roles. However, after decades of practice, both of them showed their own limitations. Through comprehensive analysis of the respective advantages and disadvantages of the two talent training models, and on the basis of full consideration of the particularity of traditional Chinese medicine, this study clarified the role and irreplaceable position of teacher training in talent training. Nowadays, with the strong support of our government’s policies, traditional Chinese medicine universities have carried out exploration actively of “teacher-inheritance +” with multiple ideas and multiple ways, including the reform of teaching mode, the innovation of learning pathways through outpatient clinics, as well as innovation of inheritance concepts. Through the above initiatives, traditional Chinese medicine universities aimed to promote the high-quality integration of teacher-inherited education into college education, so as to cultivate more excellent traditional Chinese medicine doctors for the healthy China strategy.
2023 Vol. 20 (5): 189-192 [
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The present situation and countermeasures of the construction of faculty of Marxism in medical colleges in the new era
BIAN Feng YANG Juntao▲
DOI: 10.20047/j.issn1673-7210.2023.05.45
After a period of development, many achievements in both quantity and quality have been made in the construction of faculty of Marxism in medical colleges. It is of great significance to improve the quality of the construction of for strengthening the Party’s overall leadership, implementing the fundamental task of establishing morality and cultivating people and promoting the over all development of medical college students. According to the new requirements of the construction of faculty of Marxism in medical colleges in the new era, there are many problems in teachers team construction, faculties’quality, quality of teaching, discipline construction, scientific research and community service. Therefore, this paper puts forward measures to optimize discipline layout and innovate research methods, strengthen cross integration and increase the number of teachers, improve the teaching level and reform the teaching mode, improve the service ability and strengthen publicity and consultation.
2023 Vol. 20 (5): 193-196 [
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