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Analysis on the medication rules of traditional Chinese medicine in the treatment of male infertility based on data mining |
GAO Rong1 LIU Jianguo2 GUO Bin1 MIAO Xiaoguang1 |
1.The First Clinical Medical College, Shaanxi University of Chinese Medicine, Shaanxi Province, Xianyang 712046, China;
2.Department of Andrology, Shaanxi Provincial Hospital of Chinese Medicine, Shaanxi Province, Xi’an 710003, China
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Abstract Objective To explore the medication rules of traditional Chinese medicine in the treatment of male infertility based on data mining. Methods The empirical prescriptions for male infertility treatment using traditional Chinese medicine published in China National Knowledge Infrastructure, VIP, Wanfang Data, Chinese Biomedical Literature databases from their inception to December 2021 were collected and sorted out. The database was screened and established on the Traditional Chinese Medicine Inheritance Assistant Platform (V2.5), and relevant data mining technologies such as basic information statistics, frequency analysis, and association rule analysis were used to analyze medical records, explore their medication rules, and explore new prescriptions. Results A total of 114 prescriptions were screened, involving 160 single traditional Chinese medicine. Frequency analysis results showed that Cuscutae Semen, Lycii Fructus, Rehmanniae Radix Praeparata, Epimedii Folium, Astragali Radix, Dioscoreae Rhizoma, Corni Fructus, Rubi Fructus, Poria, Angelicae Sinensis Radix ranked top ten in the frequency of drug use. The medicinal natures were mainly warm and plain. The main medicinal flavour was sweet, followed by pungent and bitter, and the channel tropism was mainly kidney and liver channels. A total of 55 common drugs combinations, 11 drugs association rules, and seven potential new prescriptions were obtained. Conclusion The basic treatment of male infertility with traditional Chinese medicine is to tonify kidney and essence, and to promote blood circulation for removing blood stasis, invigorate spleen for promoting diuresis.
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