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Explore the drug law of professor Wang Kungen in the treatment of gastric precancerous lesions based on data mining |
CAI Lijun SHI Yihui HE Hui RUI Xiaowei MAO Xiangying FENG Tongfei WANG Kungen |
The First Affiliated Hospital of Zhejiang Chinese Medical University Zhejiang Provincial Hospital of Chinese Medicine, Zhejiang Province, Hangzhou 310003, China
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Abstract Objective To explore professor Wang Kungen’s prescription rules for the treatment of gastric precancerous lesions, based on the traditional Chinese medicine inheritance assistant platform. Methods Cases diagnosed as gastric precancerous lesions through gastroscopic pathology reports were collected from professor Wang Kungen’s clinic in Zhejiang Provincial Hospital of Chinese Medicine from December 2016 to December 2020. Prescription database was established, and conclusions were drawn from frequency analysis, association rules, complex system entropy clustering analysis, and other processing methods through tradition Chinese medicine inheritance assistance platform. Results A total of 130 outpatient cases were obtained, and 130 first-diagnosed prescriptions were obtained, involving 132 kinds of Chinese medicines. Among them, 25 Chinese medicines with a frequency of >20 times were obtained, drugs to bitter cold, mainly return to the spleen, stomach, liver meridian. The core prescriptions were Chinese thorowax root, turmeric root tuber, pinellia tuber, dried tangerine peel, indian bread, dandelion, golden thread, and four new prescriptions were obtained from entropy clustering. Conclusion The core drugs of professor Wang Kungen’s treatment of gastric precancerous lesions are Chinese thorowax root, turmeric root tuber, pinellia tuber, dried tangerine peel, indian bread, dandelion, and golden thread. The main therapeutic principle is to soothe liver and clear heat, regulate qi and stomach, and remove dampness and phlegm.
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