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2023 Vol. 20, No. 1 Published: 2023-01-05

	4	Construction of a nanoformulation with active targeting and preliminary study on its in vitro pharmacodynamics
		LIU Miao1 PENG Ying2 ZHOU Xingchen3
		DOI: 10.20047/j.issn1673-7210.2023.01.01
		Objective To construct an active targeting nanoformulation loaded with the chemotherapeutic Doxorubicin (DOX). Methods PLGA/DOX@PDA-PEG-FA nanoformulations were prepared by using polylactic acid-glycolic acid copolymer (PLGA), DOX, dopamine (DA), amino-modified polyethylene glycol folic acid (NH2-PEG-FA). Particle size, potential, drug loading, encapsulation efficiency, drug release characteristics were characterized, and cell uptake, biocompatibility, cytotoxicity were preliminarily discussed by fluorescence inverted microscope and thiazolyl blue (MTT) colorimetry. Results In this study, PLGA/DOX@PDA-PEG-FA nano-formulations were successfully prepared, which had an obvious core-shell structure with a particle size of about 120 nm, a shell thickness of about 18 nm, and ζ potential of -18.1 mV. The encapsulation efficiency and drug loading were 43.56% and 1.86%, respectively, and it had obvious sustained-release properties. MTT assay showed that the carrier material had good biocompatibility and the cytotoxicity was dose-dependent. Conclusion The nanocomposite prepared in this experiment has good biocompatibility and anti-tumor effect in vitro. The preparation provides a new idea for the wide application of PLGA and the effective reduction of adverse reactions of chemotherapy drugs.
		2023 Vol. 20 (1): 4-8 [Abstract] ( 10 ) HTML (1 KB) PDF (2112 KB) ( 232 )

	9	Analysis of medication rule of Puji Prescription in treating knee joint pain based on data mining
		MA Teng1 QU Wenjing1 CHEN Deqiang1 BI Rongxiu1 XIE Wenpeng2
		DOI: 10.20047/j.issn1673-7210.2023.01.02
		Objective To collect and analyze the clinical medication rule of Puji Prescription in the treatment of knee joint pain, so as to provide reference for the research and development of new traditional Chinese medicine prescription. Methods The prescription of Puji Prescription for the treatment of knee joint pain was selected, and SPSS 21.0 and IBM SPSS Modeler 18.0 were used for statistical and cluster analysis of drug frequency and drug properties (drug property, drug taste, and meridian transformation). Results A total of 136 prescriptions were included after screening, including 210 kinds of traditional Chinese medicines. The high frequency drugs were angelica sinensis, aconite, achyranthes bidentata, etc. The associated drug pairs were aconitate-achyrannosa radix and angelica Radix achyrannosa radix. The sexual flavor was mainly warm and xin, and the meridian was mainly returned to the liver, kidney, and spleen meridian. The efficacy was mainly to promote blood circulation, remove blood stasis and remove wind and dampness. Conclusion This study shows the medication rule of Puji Prescription for the treatment of knee joint pain, analyzes the pathogenesis of the treatment of knee joint pain, provides a reference for the clinical practice of traditional Chinese medicine for the treatment of knee joint pain, and lays a foundation for the clinical research and development of new prescriptions.
		2023 Vol. 20 (1): 9-12 [Abstract] ( 24 ) HTML (1 KB) PDF (1776 KB) ( 49 )

	13	Study of Compound Shelong Capsules on inhibiting Bax/Caspase-3 signaling pathway and reducing apoptosis in renal tissues of rats with membranous nephropathy
		JIA Shiyan1 ZHONG Qiming2 SI Ruihua1 FAN Xiaoyang2 YAN Wenyun1 LIU Guangzhen2
		DOI: 10.20047/j.issn1673-7210.2023.01.03
		Objective To investigat the effect of Compound Shelong Capsules on inhibiting Bax/Caspase-3 signaling pathway and reducing apoptosis in renal tissues of rats with membranous nephropathy. Methods Ten SPF male SD rats aged six weeks were selected as normal group, and the other 40 rats were injected with cationic bovine serum albumin (Alb) to construct the rat model of membranous nephropathy. They were divided into model group, Tripterygium Wilfordii Polyglycoside Tablets group, Compound Shelong Capsules low-dose and high-dose groups, with 10 rats in each group by random number table method. Except normal group and model group were given the same amount of normal saline, other groups were given the corresponding drug intragastric administration for four weeks. HE staining, Masson staining, transmission electron microscopy, and scanning electron microscopy were used to observe the pathological changes of renal tissues in each group; the contents of urinary microalbumin (mAlb), serum creatinine (SCr), triglyceride (TG), total cholesterol (TC), Alb, and total protein (TP) were compared among all groups; the apoptosis rate of renal tissues cells in each group was compared; the expression levels of Nephrin, Podocin, Bcl-2, Bax, and Caspase-3 mRNA in renal tissues of all groups were compared. Results Compared with normal group, the content of urinary mAlb in model group was increased (P＜0.05); the contents of serum Alb and TP were decreased, while the contents of TC, TG, and SCr were increased (P＜0.05). Compared with model group, the contents of urinary mAlb in Compound Shelong Capsules low-dose and high-dose groups was decreased (P＜0.05); the contents of serum Alb and TP were increased, while the contents of TC, TG, and SCr were decreased (P＜0.05). Compared with Compound Shelong Capsules low-dose group, the content of urinary mAlb in Compound Shelong Capsules high-dose group was decreased (P＜0.05); the contents of serum Alb and TP were increased, while SCr was decreased (P＜0.05). In the normal group, the structure of glomeruli was intact by HE staining; but no tissue fibrosis was observed by Masson staining. In model group, HE staining showed increased glomerular volume and vacuolar degeneration of renal tubules, accompanied by protein tubule type; Masson staining showed tissue fibrosis and blue collagen fiber tissue. Compared with model group, glomerular volume increased, tubular vacuolar degeneration and tissue fibrosis decreased in Compound Shelong Capsules low-dose and high-dose groups. In normal group, the structure of basement membrane was intact, and the structure of podocytes was normal; in model group, the glomerulus was edema, the basement membrane thickened, the foot process fused and widened, the structure of podocytes was seriously damaged, and cytoskeletal proteins were exposed; compared with model group, basilar membrane thickening was reduced and podocyte morphology and structure tended to be normal in Compound Shelong Capsules low-dose and high-dose groups. Compared with normal group, the apoptosis rate of renal tissues cells in model group was increased (P＜0.05); compared with model group, the apoptosis rate of renal tissues cells in Compound Shelong Capsules low-dose and high-dose groups was decreased (P＜0.05); compared with Compound Shelong Capsules low-dose group, the apoptosis rate of renal tissues in Compound Shelong Capsules high-dose group was decreased (P＜0.05). Compared with normal group, the expression levels of Nephrin, Podocin, and Bcl-2 mRNA in model group were decreased, the expression levels of Caspase-3 and Bax mRNA were increased, and Bcl-2/Bax ratio was decreased (P＜0.05). Compared with model group, the expression levels of Nephrin, Podocin, and Bcl-2 mRNA in Compound Shelong Capsules low-dose and high-dose groups were increased, the expression levels of Caspase-3 and Bax mRNA were decreased, and Bcl-2/Bax ratio was increased (P＜0.05). Compared with Compound Shelong Capsules low-dose group, the expression levels of Nephrin and Podocin mRNA in Compound Shelong Capsules high-dose group were increased, while Bcl-2/Bax ratio was increased (P＜0.05). Conclusion Compound Shelong Capsules can effectively improve albuminuria in rats with membranous nephropathy, significantly reduce renal pathological injury, and delay the progression of membranous nephropathy, the mechanism of which may be related to the inhibition of podocyte apoptosis.
		2023 Vol. 20 (1): 13-18,28 [Abstract] ( 22 ) HTML (1 KB) PDF (1856 KB) ( 214 )

	19	Discussion of effect of milkvetch root polysaccharides on osteoblast differentiation based on autophagy
		WANG Xiaolei1 WU Ye2 LIU Wenya1 HOU Yanhui1
		DOI: 10.20047/j.issn1673-7210.2023.01.04
		Objective To investigate the effect of milkvetch root polysaccharides on osteoblast differentiation and its related mechanism. Methods Osteoblasts were extracted from the skull of six SPF SD rats (half male and half female) aged one week and weight 15-30 g, and the cells were divided into control group and milkvetch root polysaccharides low, medium, and high dose groups, which were given 0, 0.006 1, 0.012 2, and 0.022 4 g/L milkvetch root polysaccharides for intervention culture, respectively. After 48 h, alkaline phosphatase and alizarin red staining were performed. The cells were transfected with autophagy fluorescent labeled virus, and the transfected cells were divided into control transfection group and milkvetch root polysaccharides low, medium, and high dose transfection groups. The corresponding concentration of milkvetch root polysaccharides was given for intervention culture, and the fluorescence intensity was observed under fluorescence microscope 24 h later. Then the autophagy inhibitor 3-methyladenine (3-MA) (10 mmol/L) and milkvetch root polysaccharides were used to intervene osteoblasts, which were divided into 3-MA group, 3-MA+milkvetch root polysaccharides low dose group, 3-MA+milkvetch root polysaccharides medium dose group, and 3-MA+milkvetch root polysaccharides high dose group. The effect of milkvetch root polysaccharides on the expression of osteogenic differentiation marker genes before and after inhibition autophagy was detected by PCR. Results The proportion of alizarin red staining mineralized area and alkaline phosphatase activity in milkvetch root polysaccharides low, medium, and high dose groups were higher than those in control group, and milkvetch root polysaccharides medium and high dose groups were higher than those in milkvetch root polysaccharides low dose group, and milkvetch root polysaccharides high dose group was higher than that in milkvetch root polysaccharides medium dose group (P＜0.05). The fluorescence intensity of milkvetch root polysaccharides low, medium, and high dose transfection groups were higher than those of control transfection group, and the milkvetch root polysaccharides medium and high dose transfection group were higher than those of milkvetch root polysaccharides low dose transfection group, and the milkvetch root polysaccharides high dose transfection group was higher than that of milkvetch root polysaccharides medium dose transfection group (P＜0.05). The gene expressions of Runt-related transcription factor 2 (RUNX2), bone sialoprotein (BSP), osteocalcin (OCN), and type Ⅰ collagen A1 (COL1A1) in milkvetch root polysaccharides low, medium, and high dose groups were higher than those in control group, and milkvetch root polysaccharides medium and high dose groups were higher than milkvetch root polysaccharides low dose group, milkvetch root polysaccharides high dose group was higher than milkvetch root polysaccharides medium dose group (P＜0.05). There were no significant differences in the expression of RUNX2, BSP, OCN, and COL1A1 in control group, 3-MA group, 3-MA+ milkvetch root polysaccharides low dose group, 3-MA+ milkvetch root polysaccharides medium dose group, and 3-MA+ milkvetch root polysaccharides high dose group (P＜0.05). Conclusion Milkvetch root polysaccharides can promote the differentiation of osteoblasts by increasing the level of autophagy.
		2023 Vol. 20 (1): 19-23 [Abstract] ( 21 ) HTML (1 KB) PDF (1398 KB) ( 43 )

	24	Study on the effect and mechanism of senile functional diarrhea treated by Sishen Pills based on brain-gut axis
		YIN Yue1 YIN Fangqin2 DU Hangshuai2 ZHANG Liqiong2
		DOI: 10.20047/j.issn1673-7210.2023.01.05
		Objective To observe and analyze the effects of Sishen Pills on the contents of 5-hydroxytryptamine (5-HT), substance P (SP), and glutathione peroxidase (GSH-Px) in senile functional diarrhea rats. Methods Forty SPF 12-month- old male SD rats with body weight (380±20) g were divided into blank group, model group, positive drug group, and Sishen Pills group by random number table method, with ten rats in each group. The rats were injected with hydrocortisone (25 mg/kg) and gavaged with senna leaf (0.45 g/ml) to create models. Body weight, body temperature, diarrhea index, urinary D-xylose excretion rate of rats were recorded. During administration period, the Sishen Pills group and positive drug group were given 0.183 g/ml Sishen Pills suspension, 1.523 mg/ml Piveronium Bromide suspension, respectively. The blank group and model group were given equal volume of normal saline. Continuous administration for 14 days. The contents of 5-HT, SP, and GSH-Px in hypothalamus and colon were observed. Results In Sishen Pills group, one died due to improper operation in the second week of modeling; in model group, one died due to stomach cold in the fourth week of modeling. There were nine rats in each Sishen Pills group and model group. Before and after administration, compared with blank group, body weight and body temperature were decreased, diarrhea index was increased, urinary D-xylose excretion rate was decreased in model group, and the differences were highly statistically significant (P＜0.01). After administration, compared with model group, body weight and body temperature were increased, diarrhea index was decreased, urinary D-xylose excretion rate was increased in Sishen Pills group, the differences were highly statistically significant (P＜0.01). Compared with blank group, the contents of 5-HT and SP in model group were increased, while the content of GSH-Px was decreased, and the differences were highly statistically significant (P＜0.01). Compared with model group, the contents of 5-HT and SP in Sishen Pills group were decreased, while the content of GSH-Px was increased, and the differences were highly statistically significant (P＜0.01). Conclusion Sishen Pills can effectively treat senile functional diarrhea of spleen-kidney-yang deficiency, its mechanism may be related to the regulation of the content and expression of 5-HT, SP, GSH-Px of brain-gut peptides in brain-gut axis.
		2023 Vol. 20 (1): 24-28 [Abstract] ( 23 ) HTML (1 KB) PDF (714 KB) ( 58 )

	29	Visualization analysis of benefit finding research at home and abroad based on CiteSpace
		DUAN Meiwen1 BI Qingquan1 WANG Mei2 YANG Shuhui1 CHEN Le1 YANG Jie1
		DOI: 10.20047/j.issn1673-7210.2023.01.06
		Objective To analyze the research status, hotspots and frontier trends in the field of benefit finding at home and abroad. Methods Literatures related to benefit finding were searched from Web of Science and Chinese National Knowledge Infrastructure databases from January 2000 to February 2022, and the visualization software CiteSpace was used for analysis. Results A total of 453 Chinese and 427 English literatures were included, and the annual publication outputs showed an upward trend generally. The United States published the most papers, the University of California and Anhui Medical University were the most active research institutions. Authors Antoni MH, Zhang Lanfeng and Liu Zhunzhun published the most frequenty. Foreign research hotspots were included Post-traumatic growth, quality of life, and breast cancer. In China, research hotspots fucused on influencing factors, nurses, breast cancer, qualitative research, and so on. Family caregivers, benefit finding scale and stroke were the frontiers of future research. Conclusion The research on benefit finding is gradually becoming an academic hotspots. Chinese scholars should learn from foreign advanced research results to enhance the depth and breadth of research in the field of benefit finding.
		2023 Vol. 20 (1): 29-32 [Abstract] ( 23 ) HTML (1 KB) PDF (1433 KB) ( 214 )

	33	Research progress on the mechanism and treatment of epicardial adipose tissue and diabetes mellitus
		GUO Zhendong1 TANG Hongxiu2 XIE Ping3
		DOI: 10.20047/j.issn1673-7210.2023.01.07
		Most people with diabetes are obese, presenting a low-grade proinflammatory state, and obesity increases insulin resistance and the risk of dyslipidemia, diabetes, and cardiovascular disease. At the same time, obesity can also lead to the thickening of epicardial adipose tissue (EAT), and there is increasing evidence that EAT is associated with an increased risk of diabetes. EAT is a kind of local deposit between myocardium and pericardium of viscera, and it is easy to measure visceral adipose tissue, its metabolic homeostasis plays an important role in the progression of diabetes. In recent years, new progress has been made in the research on the treatment strategy of diabetes and its influence on EAT. However, the exact role of EAT in the pathogenesis of diabetes needs further elucidation. In this paper, the molecular mechanism and therapeutic strategies of this disease are reviewed in order to provide clues for future research.
		2023 Vol. 20 (1): 33-39 [Abstract] ( 12 ) HTML (1 KB) PDF (705 KB) ( 142 )

	40	New progress in the study of markers for the early diagnosis of liver cancer
		CHEN Wenliang XU Ximing
		DOI: 10.20047/j.issn1673-7210.2023.01.08
		Hepatocellular carcinoma is one of the malignant tumors with the highest morbidity and mortality in our country, which poses a serious burden to society. Liver ultrasound and tumor marker alphafetoprotein (AFP) are the most widely used tests in the world. However, ultrasound and AFP have limited accuracy in the detection of early liver cancer. At present, many studies are looking for reliable biomarkers for the diagnosis of early liver cancer. Such biomarkers will help in the diagnosis of early liver cancer and ensure early detection, diagnosis, and treatment. This review summarizes the role of protein markers, gene markers (non-coding RNA and DNA methylation) as biomarkers in the identification of early liver cancer, and discuss their potential significance as biomarkers in the diagnosis of early liver cancer.
		2023 Vol. 20 (1): 40-44 [Abstract] ( 27 ) HTML (1 KB) PDF (576 KB) ( 245 )

	45	Progress of microRNA in osteosarcoma
		YANG Yan1 XU Yuansheng2 FU Danmei2 LIU Guoyin2▲
		DOI: 10.20047/j.issn1673-7210.2023.01.09
		MicroRNA (miRNA) is a class of small non-coding single-stranded RNA with a length of 22 nucleotides, which is mainly responsible for the regulation of gene post-transcriptional expression. Previous studies have confirmed that miRNA plays an important regulatory role in the pathophysiological processes of cell growth and development, differentiation, proliferation, and apoptosis. In recent years, studies have found that the abnormal expression of miRNA is closely related to the occurrence and development of osteosarcoma (OS), and regulation of miRNA can inhibit the progression of OS. In addition, studies have also shown that miRNA can be used as a marker of OS chemotherapy response and an important prognostic indicator of OS. Therefore, the role of miRNA in OS has become a hot research topic. In this paper, the research progress of miRNA in OS will be reviewed in order to provide theoretical basis for further research.
		2023 Vol. 20 (1): 45-48 [Abstract] ( 15 ) HTML (1 KB) PDF (419 KB) ( 41 )

	49	The mechanism and research progress of pyroptosis in arthritis
		YANG Qinglin1 XIE Ben1 YANG Dubin1 WANG Yikun1 QIN Qingqing1 WANG Yongping2
		DOI: 10.20047/j.issn1673-7210.2023.01.10
		Pyrodeath is a particular type of programmed cell death. It is regulated by the pyroporin family and is characterized by membrane perforation, cell swelling, and the release of a large number of pro-inflammatory factors. Relevant studies have shown that the key components of pyroptosis are closely related to the occurrence and development of rheumatoid arthritis, osteoarthritis, and gouty arthritis. This article mainly reviews the molecular mechanism of pyroptosis activation and its mechanism and progress in arthritis, aiming to provide reference for the related research of pyroptosis and arthritis.
		2023 Vol. 20 (1): 49-52,60 [Abstract] ( 36 ) HTML (1 KB) PDF (515 KB) ( 153 )

	53	Research progress of exosomes from different sources in osteoporosis
		CHEN Chao1 WANG Chunqing2
		DOI: 10.20047/j.issn1673-7210.2023.01.11
		Osteoporosis is the common disease caused by abnormal bone metabolism, and its main mechanism is reduced osteogenesis and enhanced osteoclast absorption. In recent years, a large number of studies have found that exosomes from different sources play an important role in osteoblast formation and proliferation, osteoclast differentiation and absorption, remodeling of bone microstructure and bone mineralization, tumor staging and metastasis, and bone microenvironment, especially in the field of osteoporosis, through their own or synergistic actions. Exosomes from different sources affect bone metabolism of target cells through osteogenic or osteoclastic metabolic pathways through miRNA in exosomes, and participate in the treatment of anti-osteoporosis and microinterpretation of diseases. Therefore, this article reviews the research progress of exosomes from different sources in osteoporosis, aiming to provide a new research direction for clinical treatment of osteoporosis.
		2023 Vol. 20 (1): 53-56 [Abstract] ( 20 ) HTML (1 KB) PDF (523 KB) ( 232 )

	57	Research progress of Curcumin and Resveratrol in the treatment of non-alcoholic fatty liver disease
		HE Yuhui1 ZHU Mingxing2 LIU Yueyang3 ZHAO Ruowei1 HUANG Mingqing1 SHI Hong4 ZHENG Yanfang1 LIN Yanxiang1
		DOI: 10.20047/j.issn1673-7210.2023.01.12
		Non-alcoholic fatty liver disease (NAFLD) is defined as liver disease characterized by fat accumulation caused by factors other than alcohol consumption. The pathogenesis of NAFLD is complex, including insulin resistance, mitochondrial dysfunction, intestinal flora disorder and other factors affecting the occurrence and development of NAFLD, and the activation of nuclear factor-κB signaling pathway and lipid overaccumulation may also be involved. Clinically, there is a lack of ideal drugs for NAFLD treatment, and the current treatment methods are mainly to reduce weight by regulating lifestyle and improve the components of metabolic syndrome to alleviate the disease. Curcumin and resveratrol, both polyphenols, have been found to be potential drugs for the treatment of NAFLD, and extensive experimental studies have been carried out. This paper systematically summarizes the research progress on the mechanism of curcumin and resveratrol in the treatment of NAFLD, providing theoretical basis for the subsequent treatment of NAFLD and the clinical application of curcumin and resveratrol.
		2023 Vol. 20 (1): 57-60 [Abstract] ( 23 ) HTML (1 KB) PDF (494 KB) ( 221 )

	61	Research progress on analgesic mechanism and application of transcutaneous electrical acupoint stimulation
		LI Yingsi1 FANG Juan1▲ CHEN Caiyi2 JIANG Jinguang3 WANG Meng3
		DOI: 10.20047/j.issn1673-7210.2023.01.13
		Pain is a kind of unpleasant feeling and emotional experience, which seriously harms the physical and mental health of patients. The effectiveness and scientific nature of acupuncture analgesia have been proved by many studies. As a means of acupuncture analgesia, transcutaneous electrical acupoint stimulation (TEAS) has become a hot spot in the field of acupuncture in recent years. TEAS can reduce pain sensitivity by activating the pain inhibition mechanism and promote the release of endogenous opioid peptides to exert analgesic effect, which can significantly improve pain and associated symptoms in patients. TEAS are widely used for a variety of acute and chronic pain, such as postoperative acute pain, chronic pain, cancer pain, etc. In this paper, the analgesic mechanism and clinical application of TEAS are reviewed in recent years, in order to provide reference for clinical analgesia of TEAS.
		2023 Vol. 20 (1): 61-64 [Abstract] ( 67 ) HTML (1 KB) PDF (548 KB) ( 133 )

	65	Research progress on molecular typing detection of endometrial cancer
		SHI Minjie1 XIE Baoguo2
		DOI: 10.20047/j.issn1673-7210.2023.01.14
		Endometrial cancer (EC) is a serious threat to women’s health. In recent years, with the influence of many factors such as economy and environment, EC is gradually developing towards higher incidence and younger trend, and has surpassed cervical cancer and ovarian cancer to become gynecological malignancy with the highest incidence rate in some developed European countries. At present, clinical studies on tumor have entered the age of molecular typing, which is closely related to the rapid development of molecular biological technology research. This paper reviews the challenges in the current classification system of endometrial carcinoma, the development of new molecular techniques to define and predict different molecular subtypes, and the potential applications of molecular typing.
		2023 Vol. 20 (1): 65-67,89 [Abstract] ( 25 ) HTML (1 KB) PDF (509 KB) ( 167 )

	68	Exploration on the integrated education of “medical functional disciplines” from the perspective of “three comprehensive education”
		ZHAO Shuang1 HUANG Yongyi1 WANG Ying1 HUANG Shiwen1 ZHANG Shengchang2▲
		DOI: 10.20047/j.issn1673-7210.2023.01.15
		Under the guidance of party branch construction, the fundamental task of cultivating virtues and cultivating people is implemented, and the integration of party construction and the construction and development of “medical function discipline” is explored, as well as the complementary integration mode of the respective features and highlights of “medical function discipline”. By participating in and holding discipline competitions, carrying out experimental skills training and scientific education, and then focusing on the ideological and political construction of the curriculum, expanding ways to develop ideas, and constantly improving the level of discipline education. Medical education should be centered on educating students and guided by improving the efficiency and quality of education and teaching, so as to let students have “early clinical practice”, “early scientific research”, and “early social practice”, improve students’ thinking ability, cultivate innovation and team spirit, promote the brand creation of party construction and discipline construction, truly realize the integrated development of disciplines, and help deepen the “three comprehensive education”.
		2023 Vol. 20 (1): 68-71 [Abstract] ( 12 ) HTML (1 KB) PDF (617 KB) ( 139 )

	72	Application on mind mapping in the teaching of history of traditional Chinese medicine based on heuristic teaching
		LI Dan1 GUO Hongwei2 ZHANG Hao2 YAN Zhaosheng1
		DOI: 10.20047/j.issn1673-7210.2023.01.16
		The history of traditional Chinese medicine is a compulsory basic course in traditional Chinese medicine major and related majors, which brings difficulties and challenges to teaching due to its strong comprehensive discipline, wide coverage of knowledge system and heavy task of training thinking ability. This paper analyzes the basic connotation of heuristic teaching and mind mapping, designs the fusion mode of the two, and explores the fusion approach between heuristic teaching and mind mapping. On this basis, with heuristic teaching as the guiding ideology, the mind map ping is applied to the teaching of history of traditional Chinese medical, and the teaching application of the fusion mode is discussed. This integration model can not only improve the quality and effect of the implementation of heuristic teaching, promote the construction of knowledge system and the development of thinking ability, cultivate the spirit of innovation and practical ability, but also provide an effective way for the teaching application of mind mapping, with a view to providing useful reference for promoting the teaching reform and providing more help for students in the future learning road.
		2023 Vol. 20 (1): 72-76 [Abstract] ( 20 ) HTML (1 KB) PDF (1492 KB) ( 280 )

	77	Application effect of problem-based teaching method combined with clinical path teaching mode in tumor teaching
		HU Songliu1 XU Jianyu2 LI Jian2 MA Jianli2 LIU Shanshan2▲
		DOI: 10.20047/j.issn1673-7210.2023.01.17
		Objective To investigate the influence of problem based learning (PBL) teaching mode combined with clinical pathway (CP) teaching mode on the assessment results of interns in cancer teaching. Methods A total of 100 clinical undergraduate interns who practiced in Harbin Medical University Cancer Hospital from February 2019 to April 2021 were divided into group A and group B by random number table method, with 50 cases in each group. The group A was given the CP teaching mode, and the group B was given the PBL teaching method combined with the CP teaching mode. Both groups were taught for three weeks. The recruitment situation of the two groups, the results of various assessments, the survey results of the recognition of various questions, and the satisfaction of teaching methods after three weeks of teaching, the scores of critical thinking and communication skills before and after three weeks of teaching were compared. Results After three weeks of teaching, the theoretical scores, operational ability, case analysis scores, and total scores of group B were higher than those of group A (P＜0.05). After three weeks of teaching, the proportion of recognition of ①-⑦ in group B was higher than that in group A (P＜0.05), the satisfaction of teaching method in group B was better than that in group A (P＜0.05). Compared with before teaching, after three weeks of teaching, Chinese version of critical thinking disposition inventory score and communication ability score of both groups were increased, and group B was higher than group A (P＜0.05). Conclusion The PBL teaching method combined with the CP teaching mode helped to improve the appraisal performance of interns, critical thinking ability, communication ability, and further improve their recognition of various problems, moreover, interns were highly satisfied with this teaching mode, and the teaching effect is significant.
		2023 Vol. 20 (1): 77-80 [Abstract] ( 19 ) HTML (1 KB) PDF (546 KB) ( 49 )

	81	Application of objective structured clinical examination in pharmaceutical care assessment of clinical pharmacists of traditional Chinese medicine
		ZHANG Weifeng1 LI Ying1 LIN Menglu1 CAO Kang1 GUO Yanyan2 GAO Jiarong1
		DOI: 10.20047/j.issn1673-7210.2023.01.18
		At present, the examination of Chinese medicine clinical pharmacists in China is mostly in the form of theoretical examinations, case reports, and bedside consultations, while there are some certain limitations to it. The objective structured clinical examination (OSCE) can simulate real clinical scenarios and assess the comprehensive abilities of clinical pharmacists, such as pharmacy professionalism, communication skills, and practical skills, and is being introduced into the assessment of clinical pharmacists. In this paper, the specific process of pharmaceutical care assessment for clinical pharmacists in the First Affiliated Hospital of Anhui University of Chinese Medicine in September 2021 was taken as an example to explore the application of OSCE in pharmaceutical care assessment for clinical pharmacists and establish an OSCE assessment model for clinical pharmacists of traditional Chinese medicine. And the application content, effect, standardized patients, sample question bank, feedback, and need to improve and other aspects of the assessment are analyzed. Although the OSCE model finally established has some shortcomings and needs to be improved, the overall effect is good. It can comprehensively examine the comprehensive ability of students and promote the improvement of the comprehensive quality of students and the quality of clinical teaching. It is an effective model for the assessment and evaluation of pharmaceutical care of clinical pharmacists of traditional Chinese medicine, and it is worth promoting.
		2023 Vol. 20 (1): 81-84,102 [Abstract] ( 21 ) HTML (1 KB) PDF (938 KB) ( 103 )

	85	Reflection and exploration on the development of medical education in colleges and universities
		YANG Yuchun
		DOI: 10.20047/j.issn1673-7210.2023.01.19
		At present, the discipline layout of medical education is not balanced, and the external return rate and social service ability still need to be improved. Through perspective of the discipline structure of medical education, to clarify the discipline logic of social service function of medical education, based on the social needs, to clarify the connotation and methods of medical education innovation in colleges and universities. In the future, medical education in primary and secondary schools should be regarded as an effective way to expand social service of medical discipline, lead the construction of professional system of health education in colleges and universities by interdisciplinary logic, update the knowledge system of traditional medical education by the view of great health, expand the scope of social service, and guide the scientific and professional medical education by the methodology of discipline integration.
		2023 Vol. 20 (1): 85-89 [Abstract] ( 19 ) HTML (1 KB) PDF (749 KB) ( 195 )

	90	Clinical characteristics of anti-tuberculosis drug-induced liver injury in patients with simple pulmonary tuberculosis and pulmonary tuberculosis combine with HIV infection
		LU Nihong LIU Honglu SUN Yaping CHEN Yangjun YANG Yan DU Yingrong▲
		DOI: 10.20047/j.issn1673-7210.2023.01.20
		Objective To analyze the clinical characteristics of anti-tuberculosis drug-induced liver injury (ATB-DILI) in patients with simple pulmonary tuberculosis and pulmonary tuberculosis combine with human immunodeficiency virus (HIV) infection. Methods Clinical data of 128 patients with ATB-DILI pulmonary tuberculosis admitted to Kunming Third People’s Hospital from January 2019 to January 2021 were retrospectively analyzed. Among them, 76 patients with simple pulmonary tuberculosis were classified as group A, and 52 patients with pulmonary tuberculosis combine with HIV infection were classified as group B. General data and clinical data of two groups were collected; the severity of ATB-DILI in two groups was analyzed; the occurrence time of ATB-DILI in two groups was recorded. Results Globulin in group B was lower than that in group A (P＜0.05). There were no statistical significances in aspartate aminotransferase, alanine aminotransferase, gamma glutamyl transpeptidase, lactate dehydrogenase, alkaline phosphatase, total protein, albumin, total bilirubin, direct bilirubin, indirect bilirubin, and total bile acid between two groups (P＞0.05). The difference of ATB-DILI degree between two groups was statistically significant (P＜0.05). There was statistical significance in the occurrence time of ATB-DILI between two group (P＜0.05). Conclusion Low protein status is one of the factors for ATB-DILI in patients with pulmonary tuberculosis combine with HIV infection, and ATB-DILI appears earlier in patients with pulmonary tuberculosis combine with HIV infection. Adjusting nutritional status and early application of hepatoprotective drugs may have certain clinical value in preventing ATB-DILI.
		2023 Vol. 20 (1): 90-93 [Abstract] ( 20 ) HTML (1 KB) PDF (500 KB) ( 81 )

	94	Effects of Flubiprofen Axetil on postoperative analgesia and cognitive function in cirrhotic patients
		LIU Ying1 WANG Lu2 ZHANG Xuedi3 YAN Jiawei3 YANG Jingru1 WANG Liwei1
		DOI: 10.20047/j.issn1673-7210.2023.01.21
		Objective To study the effects of Flubiprofen Axetil on postoperative analgesia and cognitive function in cirrhosis patients. Methods A total of 60 cirrhosis patients who underwent surgical treatment in Xuzhou Central Hospital of Jiangsu Province from July 2020 to December 2021 were selected. According to the random number table method, they were divided into observation group and control group, with 30 cases in each group. Before the surgery, the observation group was given 20 mg Flurbiprofen Axetil, followed by intravenous controlled analgesia pump (Flurbiprofen Axetil 2.00 mg/kg+Desoxine 0.50 mg/kg+ Paronosetron 0.15 mg, plus normal saline to 100 ml); control group was given an intravenous analgesic pump (Desoxine 0.50 mg/kg+ Paronosetron 0.15 mg, plus normal saline to 100 ml). The scores of mini-mental state examination (MMSE) were compared between two groups at 24 h preoperative (T1), 24 h postoperative (T3), and 48 h postoperative (T4); visual analog scale (VAS) scores at 12 h postoperative (T2), T3, and T4 were compared between two groups; the levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were compared between two groups before surgery (Ta), after surgery (Tb) and T3, and the occurrence of adverse reactions within 48 h after surgery were recorded between two groups. Results There were no significant differences in the scores of MMSE at T1, T3, and T4 between two groups (P＞0.05). The scores of VAS at T2, T3, and T4 of observation group were lower than those of control group, and the differences were statistically significant (P＜0.05). There were no significant differences in the levels of IL-6 and TNF-α at Ta, Tb, and T3 between two groups (P＞0.05). There was no significant difference in the incidence of POCD between two groups within 48 h after surgery (P＞0.05). There was no significant difference in the total incidence of adverse reactions between two groups within 48 h after surgery (P＞0.05). Conclusion Flubiprofen Axetil and its combination of Desosxin are satisfactory for postoperative analgesia and can reduce postoperative pain in cirrhosis patients. No effect of Flulofenen Axetil on cognitive function and inflammation level in cirrhosis patients are observed.
		2023 Vol. 20 (1): 94-97,110 [Abstract] ( 26 ) HTML (1 KB) PDF (630 KB) ( 102 )

	98	Effect of AIDET communication mode combined with acceptance commitment therapy on patients undergoing percutaneous coronary stenting
		KANG Wei1 LI Hui2▲ NIU Qin2
		DOI: 10.20047/j.issn1673-7210.2023.01.22
		Objective To investigate the effect of AIDET communication mode combined with acceptance commitment therapy on patients undergoing percutaneous coronary stenting. Methods A total of 65 patients underwent percutaneous coronary stenting in the First Affiliated Hospital of Xinjiang Medical University from June to December 2019 were selected as the research subjects, and the patients were divided into the control group (32 cases) and the observation group (33 cases) according to the random number table method. The control group received routine psychological nursing and education, and the observation group received AIDET communication mode combined with acceptance commitment therapy. The psychological flexibility level, anxiety and depression level, and self-management ability were compared between the two groups before intervention and six weeks after intervention. The incidence of adverse cardiovascular events at six months after intervention was recorded in both groups. Results After intervention, the scores of the acceptance and action questionnaire, the total score of the hospital anxiety and depression scale, and the scores of the anxiety subscale and the depression subscale were lower than those before intervention, and the observation group was lower than the control group (P＜0.05). The daily living ability, disease knowledge, compliance behavior, first aid knowledge, emotion management scores, and total score of self-management ability in both groups were higher than those before intervention, and the observation group was higher than the control group (P＜0.05). The incidence of adverse cardiovascular events after six months in the observation group was lower than that in the control group (P＜0.05). Conclusion AIDET communication mode combined with acceptance commitment therapy can improve the psychological flexibility of patients undergoing percutaneous coronary stenting, reduce their anxiety and depression, improve their self-management ability, and reduce the incidence of adverse cardiovascular events, which is worthy of clinical promotion.
		2023 Vol. 20 (1): 98-102 [Abstract] ( 20 ) HTML (1 KB) PDF (690 KB) ( 44 )

	103	Effect of accelerated rehabilitation surgical guidance on postoperative gastrointestinal function and complications in patients undergoing laparoscopic colorectal surgery
		ZANG Hongcheng1 SHAO Gang1 QI Ruihua2 LOU Ying1 YE Xuqin1
		DOI: 10.20047/j.issn1673-7210.2023.01.23
		Objective To investigate the effects of accelerated rehabilitation surgical guidance on postoperative gastrointestinal function and complications of patients undergoing laparoscopic colorectal surgery. Methods A total of 100 patients received laparoscopic colorectal surgery in the First People’s Hospital of Fuyang District Hangzhou from January 2018 to December 2019 were selected and divided into control group (perioperative routine intervention) and study group (perioperative accelerated rehabilitation surgical guidance) by random number table method, with 50 cases in each group. The postoperative recovery of gastrointestinal function and its complications occurrence were compared between the two groups. Results Catheter removal time, postoperative solid food eating time, postoperative hospitalization time, postoperative bowel sound recovery time, postoperative anal exhaust time, and postoperative first defecation time of the study group were all shorter than those of the control group, postoperative pain score was lower than that of control group (P＜0.05). The incidence of complications in the study group was lower than that in the control group (P＜0.05). Conclusion The application of accelerated rehabilitation surgical guidance to the perioperative management of patients undergoing laparoscopic colorectal surgery can effectively promote the postoperative recovery of patients, accelerate the recovery of gastrointestinal function and reduce the occurrence of complications. This model has high clinical application value.
		2023 Vol. 20 (1): 103-106 [Abstract] ( 26 ) HTML (1 KB) PDF (582 KB) ( 124 )

	107	Correlation analysis of serum vascular endothelial growth factor, homocysteine, and macular edema degree of retinal vein occlusion
		HE Jing MA Nan HUO Hong FAN Hongfang HOU Liping ZHANG Jie WANG Shuzhen▲
		DOI: 10.20047/j.issn1673-7210.2023.01.24
		Objective To analyze the correlation between the levels of vascular endothelial growth factor (VEGF), homocysteine (Hcy), and macular edema degree of retinal vein occlusion. Methods Eighty patients with retinal vein occlusion and macular edema admitted to Zhangjiakou First Hospital of Hebei Province (hereinafter referred to as “our hospital”) from April 2021 to January 2022 were included in the study group, another 80 healthy people who underwent physical examination in our hospital during the same period were included in the health group, and another 80 patients with simple retinal vein occlusion admitted to our hospital during the same period were included in the control group. The serum levels of VEGF and Hcy were compared among the three groups, and the correlation between them and the macular edema degree of retinal vein occlusion was analyzed. Results The levels of serum VEGF and Hcy in study group and control group were higher than those in healthy group, and the study group was higher than the control group, and the differences were statistically significant (P＜0.05). In the study group, 46 patients were mild macular edema of retinal vein occlusion, 24 patients were moderate, and 10 patients were severe. The serum levels of VEGF and Hcy in moderate and severe patients were higher than those in mild patients, and those in severe patients were higher than those in moderate group, the differences were statistically significant (P＜0.05). Correlation analysis results showed that there was no correlation between serum VEGF level and macular edema degree in patients with retinal vein occlusion (P＞0.05), but serum Hcy level was positively correlated with edema degree (rs＞0, P＜0.05). Conclusion Serum levels of VEGF and Hcy in patients with retinal vein occlusion and macular edema are higher than those in patients with simple retinal vein occlusion and healthy people. Clearing Hcy level may increase the severity of macular edema with retinal vein occlusion, which requires clinical observation.
		2023 Vol. 20 (1): 107-110 [Abstract] ( 20 ) HTML (1 KB) PDF (501 KB) ( 50 )

	111	Effect of Roxastat Capsules in the treatment of renal anemia in chronic renal failure patients with maintenance hemodialysis
		LIN Baoli JIN Lisi CHEN Zhi
		DOI: 10.20047/j.issn1673-7210.2023.01.25
		Objective To investigate the effect of Roxastat Capsules in the treatment of renal anemia in chronic renal failure patients with maintenance hemodialysis. Methods A total of 301 chronic renal failure patients with maintenance hemodialysis with renal anemia in Wenzhou Central Hospital, Zhejiang Province from October 2020 to June 2021 were selected, among which 235 patients were treated with subcutaneous injection of recombinant human erythropoietin injection as the conventional group and 66 patients were treated with Roxastat Capsules orally as the observation group. After matching by propensity score matching method, 66 patients were included in each group. The treatment time of the two groups was three months. The indexes of anemia, ferrum metabolism, and inflammation were compared between the two groups before and after treatment. The efficacy of the two groups was compared, and the occurrence of adverse reactions between the two groups during treatment was recorded. Results After treatment, hemoglobin (Hb), erythropoietin (EPO), ferrum (Fe), and transferrin (TRF) in two groups were higher than those before treatment, ferritin (FER) and C-reactive protein (CRP) were lower than those before treatment, and Hb, EPO, Fe, TRF, and FER of observation group were higher than those of conventional group, and CRP was lower than that of conventional group (P＜0.05). The clinical efficacy of observation group was better than that of conventional group, and the total incidence of adverse reactions was lower than that of conventional group (P＜0.05). Conclusion Roxastat Capsules in the treatment of renal anemia in chronic renal failure patients with maintenance hemodialysis, can improve anemia, promote ferrum metabolism, reduce inflammation and adverse reactions, the effect is significant.
		2023 Vol. 20 (1): 111-114 [Abstract] ( 22 ) HTML (1 KB) PDF (505 KB) ( 54 )

	115	Effect of Ropivacaine combined with Sufentanil or Fentanyl in labor analgesia
		WU Yu1 XU Yiming2 SUN Yu’e1 YANG Xuli1▲
		DOI: 10.20047/j.issn1673-7210.2023.01.26
		Objective To explore the effect of Ropivacaine combined with Sufentanil or Fentanyl in labor analgesia. Methods Ninety healthy pregnant women who underwent labor analgesia in the Affliated Drum Tower Hospital of Nanjing University Medical School from August 2017 to August 2020 were selected as subjects. They were divided into study group (45 cases, given Ropivacaine combined with Sufentanil for epidural labor anesthesia) and control group (45 cases, given Ropivacaine combined with Fentanyl for epidural labor anesthesia). The pain conditions of 5, 20, 40, and 60 min analgesia were compared between two groups; the labor time of two groups was recorded. Apgar scores 1 and 5 minutes after birth were measured of two groups; the adverse reactions of two groups were observed. Results Comparison of numerical rating scale (NRS) scores at different time points between two groups showed statistically significant differences (P＜0.05); the NRS scores of study group were lower than those of control group at 20, 40, and 60 min analgesia (P＜0.05). The first stage of labor and the second stage of labor in study group were shorter than those in control group (P＜0.05). There was no significant difference in Apgar score 1 and 5 min after birth (P＞0.05). There was no significant difference in the total incidence of adverse reactions between two groups (P＞0.05). Conclusion The analgesic effect of Ropivacaine combined with Sufentanil in perinatal labor is better than that of Ropivacaine combined with Fentanyl and helps shorten the first stages of labor and second stages of labor.
		2023 Vol. 20 (1): 115-118 [Abstract] ( 34 ) HTML (1 KB) PDF (527 KB) ( 29 )

	119	Analysis on the restriction factors of inheritance of characteristic diagnosis and treatment techniques of folk traditional Chinese medicine
		YANG Jian1 LIU Jianfeng2 SHI Xueqin2 ZHANG Fengxia2 LI Chun3
		DOI: 10.20047/j.issn1673-7210.2023.01.27
		As an integral part of traditional Chinese medicine, characteristic diagnosis and treatment techniques of folk traditional Chinese medicine have their own unique advantages. However, the inheritance status of characteristic diagnosis and treatment techniques of folk traditional Chinese medicine is not optimistic, and many excellent techniques are on the verge of being lost. At the individual, social, and national levels, there are different factors that restrict the inheritance of characteristic diagnosis and treatment techniques of folk traditional Chinese medicine. Some characteristic diagnosis and treatment techniques of folk traditional Chinese medicine cannot be effectively protected due to traditional thinking or problem of personal rights and interests, and some technology holders have low intention to inherit. Due to its own characteristics, the characteristic diagnosis and treatment techniques of folk traditional Chinese medicine lack a comprehensive and relevant understanding of the society, which restricts its inheritance in a wider range. The current national law has high requirements on the holders of characteristic diagnosis and treatment techniques of folk traditional Chinese medicine, and the lack of a complete protection system for their technical intellectual property rights also restricts the inheritance of characteristic diagnosis and treatment techniques of folk traditional Chinese medicine.
		2023 Vol. 20 (1): 119-122,136 [Abstract] ( 20 ) HTML (1 KB) PDF (693 KB) ( 40 )

	123	Qiu Mingyi’s experience in treating Sjögren syndrome with three methods
		WANG Bowen PEI Zijuan TAO Chunhui TAN Ping LIU Haojie FAN Xun
		DOI: 10.20047/j.issn1673-7210.2023.01.28
		Sjögren syndrome is a chronic systemic autoimmune disease characterized by progressive exocrine gland damage. The pathogenesis of Sjögren syndrome is not yet clear. Western medicine mainly uses local replacement therapy and immunotherapy to control symptoms, but the curative effect is unstable. It belongs to the category of “dryness syndrome” in traditional Chinese medicine. At present, it is generally believed that the pathogenesis is yin deficiency and fluid insufficiency, and the fluid is not distributed. Treatment focuses on nourishing yin and promoting fluid, clearing away heat and detoxifying. Professor Qiu Mingyi has a unique opinion on the treatment of this disease and its related complications. He believes that the root pathogenesis is insufficient transformation of the source, and the responsibility lies in the lung, kidney, spleen, and stomach. The loss of vital energy is the pathogenesis of the disease, and the internal and external pathogens are the mechanisms for its persistence. In treatment, syndrome differentiation is combined with disease differentiation, and the three methods of open source, reduce expenditure and eliminate evil are used for differentiation and treatment: it can replenish the lung, spleen, and kidney, replenish qi and yin, and store stomach yin to open up the source of yin and fluid in the zang fu organs; the combination of tonifying and astringent, astringent yin and strengthen essence to save the flow of qi and yin; combined with the method of clearing heat, detoxifying, expelling wind and unblocking collaterals, it can dispel the evil of viscera and meridians based on cause and syndrome. Professor Qiu is flexible in treating Sjögren syndrome, giving consideration to both the symptoms and the symptoms, and improving his Yin and Yang and five phases theory clinical thinking, according to the results of clinical dialectics, applying flexible methods to treat disease, and has a good effect.
		2023 Vol. 20 (1): 123-126 [Abstract] ( 24 ) HTML (1 KB) PDF (688 KB) ( 45 )

	127	Analysis of drug use rule of Chinese herbal compound prescription in the treatment of herpes zoster based on national patent
		WANG Zixuan1 DAN Wenchao1 LI Bin2 ZHANG Guangzhong1
		DOI: 10.20047/j.issn1673-7210.2023.01.29
		Objective To analyze the drug use rule of Chinese herbal compound prescription in the treatment of herpes zoster based on data mining, and to provide reference for clinical treatment. Methods Through searching the patent database of the State Intellectual Property Office, the patents of Chinese herbal compound prescription for treating herpes zoster from January 2001 to September 2021 were obtained, and the prescription database was established for drug frequency statistics and analysis of the nature and flavor, channel tropism, and efficacy of Chinese herbal. After modeling, the Apriori association rule analysis and system cluster analysis were implemented, and the core complex network of Chinese herbal co-occurrence was constructed by Python. Results A total of 179 Chinese herbal compound prescription patents were included, involving 507 drug flavors, and the proportion of high-frequency drugs was the highest for heat-clearing drugs. Among four nature of drugs, cold was the most common, followed by warm. The five flavours were bitter, followed by sweet and pungent. Liver channel is the main channel. Common couplet medicines included Plantaginis Semen-Bupleuri Radix, Olibanum-Myrrha, etc., and the three herb drug combinations included Isatidis Radix-Bupleuri Radix-Glycyrrhizae Radix Et Rhizoma, Plantaginis Semen-Gentianae Radix Et Rhizoma-Bupleuri Radix, Coptidis Rhizoma-Forsythiae Fructus-Lonicerae Japonicae Flos, etc. Traditional Chinese medicines with frequency > 30 were divided into six groups by systematic cluster analysis. Conclusion There are rules to follow in the treatment of herpes zoster with national Chinese herbal compound prescription patent, and the purpose is to “clear heat, promote diuresis, remove toxicity substance, regulate qi, promote blood, and relieve pain”, which accords with the theoretical basis of traditional Chinese medicine in treatment of herpes zoster.
		2023 Vol. 20 (1): 127-131,149 [Abstract] ( 22 ) HTML (1 KB) PDF (2144 KB) ( 117 )

	132	Professor Zhang Dongxiao’s experience in treating granulomatous mastitis from the pathogenesis of “liver fire invading stomach”
		XU Zihan1 ZHANG Dongxiao2
		DOI: 10.20047/j.issn1673-7210.2023.01.30
		Granulomatous mastitis is an increasingly common breast disease in the current society. It is mainly manifested as redness, swelling and heat pain of the breast, followed by abscess and sinus formation after ulcers, long-term failure to heal, during which various immune reactions can be accompanied, which can seriously affect the appearance of the breast. The course of disease is long, and the patient suffers great pain. Clinical and related data show that the incidence of granulomatous mastitis is positively correlated with emotion. Professor Zhang Dongxiao believes that the occurrence of this disease is related to liver qi depression and turning to fire, and offense the spleen and stomach. In traditional Chinese medicine, papilla belongs to liver, breast belongs to stomach, and liver belongs to wood. The liver “likes to be unobstructed and hates depression”. It is the most important organ for regulating emotions in human body, and spleen and stomach is the hub of human qi movement, which belongs to soil and is often restrained by liver’s stagnation. Therefore, Professor Zhang Dongxiao put forward that the basic pathogenesis of this disease is liver fire invading stomach, and the important idea of treating this disease is to sooth liver and clear stomach. This article mainly summarizes the experience of Professor Zhang Dongxiao in treating granulomatous mastitis with the method of soothing liver and clearing stomach, which is introduced from the mechanism of liver fire invading stomach, and attached a test case for clinical reference.
		2023 Vol. 20 (1): 132-136 [Abstract] ( 21 ) HTML (1 KB) PDF (767 KB) ( 54 )

	137	Professor Fu Weimin’s experience in the treatment of post-stroke depression based on the theory of “six fu-organs function well when unobstructed” and brain-gut axis
		WANG Xintong LI Li WANG Yongsheng LIANG Sen
		DOI: 10.20047/j.issn1673-7210.2023.01.31
		Post-stroke depression is a special form of depression, which can seriously affect the recovery of neurological function and the ability to return to society. Professor Fu Weimin believes that the pathogenesis is the imbalance of viscera and qi movement, the endogenous phlegm and blood stasis, and the dysfunction of brain and internal organs. Based on the Chinese medicine theory of “six fu-organs function well when unobstructed”, Professor Fu proposes to use the method of dredging the fu organs as the treatment, clinical syndrome differentiation is often accurate according to different stages of the disease. Different “dredging” methods, such as dredging the fu organs and lowering qi, purging the heart and dredging the fu organs, resolving phlegm and ventilating, promoting blood circulation and dredging the fu organs, and reviving the brain and dredging the fu organs are adopted, with remarkable clinical effects.
		2023 Vol. 20 (1): 137-140 [Abstract] ( 23 ) HTML (1 KB) PDF (636 KB) ( 34 )

	141	Professor Zhang Yu in treating chronic kidney disease with ten methods of activating blood circulation to dissipate blood stasis
		XUE Shunxuan1 ZHANG Yu2
		DOI: 10.20047/j.issn1673-7210.2023.01.32
		Professor Zhang Yu believes that chronic kidney disease has a long course and it is easy to produce blood stasis when the disease enters the collaterals. Modern studies have also confirmed that the pathological changes of kidney such as hypercoagulable state of blood in the kidney and the thrombosis and ischemia it causes, as well as mesangial cell proliferation following tissue damage and crescents formation are all related to blood stasis in traditional Chinese medicine. Based on years of clinical experience, Professor Zhang summarizes ten methods of activating blood circulation to dissipate blood stasis, including invigorating qi and activating blood method, dispelling wind and activating blood method, disinhibit water and activating blood method, kidney-tonifying and activating blood method, purgativing and activating blood method, detoxifying and activating blood method, supplementing lung and activating blood method, invigorating spleen and activating blood method, cooling blood and activating blood method, eliminating accumulation and activating blood method, which has achieved good curative effect.
		2023 Vol. 20 (1): 141-144,153 [Abstract] ( 20 ) HTML (1 KB) PDF (828 KB) ( 53 )

	145	Study on the theory of Houshi Heisan treating ischemic stroke from the combined therapy of cooling and warming
		WANG Xing1 YANG Zhihong2 GUO Zhen2 ZHANG Ruimin1 YAN Dongxue1
		DOI: 10.20047/j.issn1673-7210.2023.01.33
		Based on the analysis of the origin, compatibility characteristics, and the connotation of prescriptions and syndromes of Houshi Heisan, it can be seen that this prescription is the result of Zhang Zhongjing’s extensive collection of various prescriptions. Its composition characteristics of “cold, heat, warm, and cool are melted in one furnace, while qingsan supplements and discharges in one side” embody the prescription compatibility theory of “the combined therapy of cooling and warming” in traditional Chinese medicine. The whole recipe has the functions of warming yang, supplementing qi, and nourishing blood, removing wind, clearing heat, and resolving phlegm, and treating both internal and external wind. It mainly treats “gale” with deficiency of qi and blood, poor operation, re feeling external evil, phlegm dampness and stagnant heat, inducing liver wind, and blocking meridians as the main pathogenesis. Houshi Heisan is effective in treating cold, heat, deficiency, and excess, and it covers all aspects of wind, phlegm, qi, blood, stasis, and heat. It is the “first party” in traditional Chinese medicine treatment of stroke. Its prescription and syndrome connotation is consistent with the etiology and pathogenesis of ischemic stroke with qi deficiency and blood stasis type. Therefore, it analyzes and summarizes the relationship between Houshi Heisan and ischemic stroke and its characteristics and theory in the treatment of ischemic stroke， in order to provide new ideas for the application of Houshi Heisan.
		2023 Vol. 20 (1): 145-149 [Abstract] ( 20 ) HTML (1 KB) PDF (768 KB) ( 76 )

	150	Study of term problems and English translation of dietary symptoms in Jin Gui Yao Lue
		WANG Shanshan1 WANG Tianfang2 GOU Feiyue2 YAN Li1 LIN Fenggai1
		DOI: 10.20047/j.issn1673-7210.2023.01.34
		Dietary conditions are usually examined in the diagnosis and treatment of diseases. Dietary symptoms are commonly seen in Jin Gui Yao Lue, but they are rarely studied till now. Through the study of 61 terms of dietary symptoms in the book, it is found such phenomena exist as similar descriptions, ambiguous expressions, undefined connotations and polysemy. After clarifying the connotations of these terms, it selects the English versions of Li Zhaoguo and Nigel Wiseman, and studies the English translation of these terms, finding that there exist such problems as inappropriate expressions, incorrect and overlong translations. With examples this study analyzes the above problems and puts forward a suggestion that the connotations of terms should be clear no matter in clinical work or translation of traditional Chinese medicine, aiming to provide references for the normalization of traditional Chinese medicine terms and the study of traditional Chinese medicine classics translation.
		2023 Vol. 20 (1): 150-153 [Abstract] ( 29 ) HTML (1 KB) PDF (609 KB) ( 35 )

	154	Multi-slice spiral CT imaging features of thin-walled cystic cavity pulmonary adenocarcinoma with different pathological subtypes and degree of differentiation
		LI Yanan YIN Huikang SONG Wenyue GENG Chengjun▲
		DOI: 10.20047/j.issn1673-7210.2023.01.35
		Objective To explore the correlation between multi-slice spiral CT (MSCT) findings and thin-walled cystic cavity pulmonary adenocarcinoma with pathological subtypes and degree of differentiation. Methods The case data of 78 patients with thin-walled cystic cavity pulmonary adenocarcinoma admitted to the 904th Hospital of the Joint Service Support Force of the Chinese People’s Liberation Army from July 2018 to November 2021 were retrospectively analyzed. According to the pathological subtypes, they were divided into papillary type, microemulsion head type, acinar type, and mural type; according to the degree of differentiation, they were divided into low differentiation, medium differentiation, and high differentiation. The MSCT imaging findings of thin-walled cystic cavity pulmonary adenocarcinoma patients with different pathological subtypes and degrees of differentiation were compared. Results There were significant differences in lobulation sign air and bronchogram sign of thin-walled cystic cavity lung adenocarcinoma with different pathological subtypes (P＜0.05). There were significant differences in lobation sign, burr sign, air bronchus sign, and the thickness of cystic cavity of thin-walled cystic cavity pulmonary adenocarcinoma with different degree of differentiation (P＜0.05). Conclusion The MSCT imaging findings of thin-walled cystic cavity pulmonary adenocarcinoma with different pathological subtypes and differentiation degrees have certain characteristics.
		2023 Vol. 20 (1): 154-157 [Abstract] ( 20 ) HTML (1 KB) PDF (1026 KB) ( 39 )

	158	Exploration and research on project management reform of medical research institutions under the new situation
		YANG Taolian1 DU Jun2 BAI Huijun1
		DOI: 10.20047/j.issn1673-7210.2023.01.36
		Research management plays a vital role in the implementation of research projects, and directly affects the sustainable development of medical innovation research. This paper analyzes the main problems existing in the project management of medical scientific research institutions in resource allocation, project evaluation and process management, and finds that the main reasons are the disunity between the concept and responsibility of scientific research management and the lack of effective stimulation of the enthusiasm of scientific research personnel. By referring to the effective experience and practice of scientific research management at home and abroad, the management countermeasures were put forward from the establishment of fund support mechanism, the implementation of scientific research organization mechanism, the implementation of refined project management mode and the capacity building of scientific research management personnel, so as to provide reference for promoting the high-quality development of medical research management system reform.
		2023 Vol. 20 (1): 158-161 [Abstract] ( 21 ) HTML (1 KB) PDF (630 KB) ( 212 )

	162	Influence of information management on continuous quality improvement of hemodialysis
		LI Hongbin1 WEI Yu2 LIANG Jun1 ZHAO Yuxue1 YAN Runze1
		DOI: 10.20047/j.issn1673-7210.2023.01.37
		Objective To explore the influence of information management on continuous quality improvement of hemodialysis. Methods A total of 160 patients with maintenance hemodialysis (MHD) who had regular dialysis in the Blood Purification Center of Beijing East District First People’s Hospital of Beijing from March 2020 to February 2021 were selected as the research objects. The transformation of the work efficiency of medical staff in hemodialysis room, the changes of dialysis related management indicators and the incidence of adverse events in MHD patients before and after the implementation of information management for six months were observed. Results After the trial, the average time of preparation and prescription for each patient was shorter than that before the trial, and the difference was highly statistically significant (P＜0.01). The time of data collection, data analysis and evaluation after treatment were shorter than those before the trial, and the differences were highly statistically significant (P＜0.01). After the trial, the conforming rates of HGB, Ca, P, and iPTH were higher than those before the trial, and the differences were statistically significant (P＜0.05 or P＜0.01). There was no significant difference in the number of dialysis units before and after the trial (P＞0.05). The frequency of hypotension and the occurrence rate of hypotension after the trial were lower than those before the experiment, and the differences were highly statistically significant (P＜0.01). The incidence of heart failure after the trial was lower than that before the trial, and the difference was statistically significant (P＜0.05). Conclusion Information management can not only improve the work efficiency of medical staff, but also significantly improve the quality control index of hemodialysis in MHD patients and reduce the incidence of adverse events in MHD patients, so as to promote the continuous quality improvement of blood purification.
		2023 Vol. 20 (1): 162-165 [Abstract] ( 20 ) HTML (1 KB) PDF (545 KB) ( 128 )

	166	Effects of pain intervention based on nursing team strategy on pain management, sleep quality, and quality of life of postoperative patients with gastric cancer
		LI Qin WANG Jiayou ZHOU Juan CHEN Shan CHEN Hong▲
		DOI: 10.20047/j.issn1673-7210.2023.01.38
		Objective To explore the effects of pain intervention based on nursing team strategy on pain management, sleep quality, and quality of life of postoperative patients with gastric cancer. Methods A total of 100 postoperative patients with gastric cancer in the Second Affiliated Hospital of Anhui Medical University from September 2019 to October 2021 were selected as the research objects, according to the random number table method, the patients were divided into control group and observation group, with 50 cases in each group. The control group was given routine nursing, and the observation group was given pain intervention under the nursing team strategy. The MOS health questionnaire, pain numerical grading method and Pittsburgh sleep quality index score were compared between the two groups before and after nursing. Results After intervention, the life quality scores of both groups were higher than before intervention, and those of the observation group were higher than those of the control group, the differences were statistically significant (P＜0.05). The overall analysis showed that there were statistically significant differences in the comparison between groups, time point comparison and interaction of pain evaluation between the two groups (P＜0.05), further pairwise comparison, intra-group comparison: pain ovaluata comparison between the two groups at each time point, the differences were statistically significant (P＜0.05); inter-group comparison: pain ovaluata comparison between the observation group at each time point, the differences were statistically significant (P＜0.05). Sleep quality scores of both groups were lower than before intervention, and observation group were lower than those of control group, the differences were statistically significant (P＜0.05). Conclusion For postoperative patients with gastric cancer, pain intervention based on nursing team strategy can improve the sleep quality of patients, improve the pain situation, improve the quality of life, conducive to the rapid recovery of patients, and is worthy of reference and adoption by all clinical departments.
		2023 Vol. 20 (1): 166-169 [Abstract] ( 25 ) HTML (1 KB) PDF (556 KB) ( 41 )

	170	Effect of multidimensional combined prerehabilitation on rapid rehabilitation after total lumbar disc laminectomy
		GAO Min DA Jun LEI Fei WU Wencong LIU Xiaoyan▲ LIU Xiaolan
		DOI: 10.20047/j.issn1673-7210.2023.01.39
		Objective To observe the effect of multidimensional combined prerehabilitation on rapid rehabilitation after total lumbar disc laminectomy. Methods A total of 86 patients who were admitted to the Department of Orthopedics Spinal Surgery in Affiliated Hospital of Southwest Medical University were selected as the study subjects from February 2020 to February 2022, the patients were divided into control group and study group, with 43 cases in each group. The control group was given rapid rehabilitation care, and the study group was given multidimensional combined rapid rehabilitation training, Oswestry disability index (ODI) and Melzack’s simple pain scale (MPQ) were used to assess lumbar function and pain severity at admission (pre-intervention), and three months after surgery (post-intervention). Results After intervention, ODI scores of both groups were higher than before intervention, and the study group was higher than the control group, the differences were statistically significant (P＜0.05). MPQ scores in both groups were lower than before intervention, and the study group was lower than the control group, the differences were statistically significant (P＜0.05). Conclusion After total laminectomy for lumbar disc herniation patients, on the basis of rapid pre-rehabilitation training, superimposed multidimensional rehabilitation nursing can effectively control the degree of postoperative pain and dysfunction. The nursing mode is worthy of extensive clinical promotion and in-depth research.
		2023 Vol. 20 (1): 170-173 [Abstract] ( 24 ) HTML (1 KB) PDF (551 KB) ( 36 )

	174	Effect of seamless nursing and exercise rehabilitation nursing on cardiac function index and self-management ability in patients with heart failure
		QIAO Jiao XUE Shumin YIN Jiao ZHANG Qian WANG Juan▲
		DOI: 10.20047/j.issn1673-7210.2023.01.40
		Objective To study the effects of seamless nursing and exercise rehabilitation nursing on cardiac function index and self-management ability in patients with heart failure. Methods A total of 96 patients with heart failure who were treated in Tangdu Hospital of Air Force Medical University from January to December 2021 were selected as research objects. According to different nursing methods, they were divided into seamless group (seamless nursing, 34 cases), exercise group (exercise rehabilitation nursing, 32 cases) and control group (routine nursing, 30 cases). The cardiac function and self-management ability of the three groups were compared before and after intervention. Results After intervention, the self-care skills, health knowledge level, self-care responsibility, and self-concept of the three groups were higher than those before intervention, while those of the seamless group were higher than those of the exercise group and the control group, and those of the exercise group were higher than those of the control group, and the differences were statistically significant (P＜0.05). After intervention, the end systolic diameter of left ventricle, end diastolic diameter of left ventricle, and brain natriuretic peptide of all groups were lower than those before intervention, while those of the seamless group were lower than those of exercise group and control group, and those of exercise group were lower than those of control group, and the differences were statistically significant (P＜0.05); the left ventricular ejection fraction in each group were higher than that before intervention, and that of the seamless group was higher than that of the exercise group and the control group, while that of the exercise group was higher than that of the control group, and the differences were statistically significant (P＜0.05). Conclusion Seamless nursing can restore heart function in patients with heart failure and increase their self-management ability.
		2023 Vol. 20 (1): 174-177 [Abstract] ( 27 ) HTML (1 KB) PDF (653 KB) ( 38 )

	178	Effect of mind map-guided multi-dimensional staged nursing intervention mode on hemodialysis patients with chronic renal failure
		SHEN Yan SHEN Wei
		DOI: 10.20047/j.issn1673-7210.2023.01.41
		Objective To study the effect of multi-dimensional staged nursing intervention mode guided by mind map- guided multi-dimensional staged nursing intervention mode on hemodialysis patients with chronic renal failure. Methods A total of 80 patients with chronic renal failure hemodialysis in hemodialysis room of Bozhou People’s Hospital in Anhui Province from January 2019 to December 2021 were selected for this study. They were divided into control group (routine nursing) and observation group (routine nursing + mind-mapping guided multidimensional stage nursing) by random number table method, with 40 patients in each group. Complications, short form 36 questionnaire (SF-36) before and after care, mental state before and after care (self-rating anxiety scale [SAS], self-rating depression scale [SDS]) before and after care and patients’ satisfaction with nursing were compared between the two groups. Results The total incidence of complications in observation group was lower than that in control group, and the difference was statistically significant (P＜0.05). After nursing, the scores of physiological function, body pain, physiological function, vitality, overall health, emotional function, social function, and mental health of the two groups were higher than before nursing, while those of the observation group were higher than those of the control group, and the differences were statistically significant (P＜0.05). After nursing, the SAS and SDS scores of the two groups were lower than before nursing, while those of the observation group were lower than the control group, and the differences were statistically significant (P＜0.05). The nursing satisfaction of observation group was higher than that of control group, and the difference was statistically significant (P＜0.05). Conclusion The application of mind map guided multi-dimensional stage nursing in hemodialysis patients with chronic renal failure has a good effect, which can not only reduce related complications, but also improve the quality of life and enhance satisfaction. It is worth popularizing and applying.
		2023 Vol. 20 (1): 178-181,185 [Abstract] ( 23 ) HTML (1 KB) PDF (699 KB) ( 120 )

	182	Influence of comprehensive nursing model based on evidence-based theory on complications related to invasive mechanical ventilation in premature infants
		HAN Lijuan JI Yanjie YANG Shaohua
		DOI: 10.20047/j.issn1673-7210.2023.01.42
		Objective To investigate the influence of comprehensive nursing model based on evidence-based theory on complications related to invasive mechanical ventilation in premature infants. Methods A total of 80 premature infants who received invasive mechanical ventilation in Fuyang People’s Hospital, Anhui Province from January 2019 to October 2021 were selected, 35 cases in the control group received conventional nursing, and 45 cases in the study group received comprehensive nursing based on evidence-based theory, invasive mechanical ventilation indexes, blood gas indexes within 24 h after removal of the machine and the incidence of invasive mechanical ventilation-related complications were compared between the two groups; at discharge, the growth and development of the two groups were compared. Results Invasive mechanical ventilation time, total ventilation time, and offline time in the study group were shorter than those in the control group, and the differences were statistically significant (P＜0.05); the arterial carbon dioxide content in the study group was lower than that in the control group within 24 h after withdrawal, and the arterial oxygen partial pressure and arterial oxygen saturation were higher than that in the control group, the differences were statistically significant (P＜0.05); the complication rate of invasive mechanical ventilation in the study group was lower than that in the control group, and the difference was statistically significant (P＜0.05). At the time of discharge, the body length was larger than the control group, weight was heavier than the control group and head circumference was larger than the study group, and the differences were statistically significant (P＜0.05). Conclusion The comprehensive nursing model based on evidence-based theory can shorten the invasive mechanical ventilation time of premature infants, improve the oxygenation ability of premature infants, reduce the risk of complications, and benefit the growth and development of premature infants.
		2023 Vol. 20 (1): 182-185 [Abstract] ( 22 ) HTML (1 KB) PDF (544 KB) ( 27 )

	186	Construction and application of risk control system for laparoscopic total hysterectomy
		JI Chunli GU Qing▲
		DOI: 10.20047/j.issn1673-7210.2023.01.43
		Objective To explore the construction and application of risk control system for laparoscopic total hysterectomy. Methods A total of 110 patients treated in Nantong Maternal and Child Health Hospital of Jiangsu Province from March 2020 to March 2022 and planned to undergo laparoscopic total hysterectomy were prospectively selected and divided into observation group and control group according to the random number table method, with 55 cases in each group. The control group received routine postoperative management, and the risk control system for laparoscopic total hysterectomy was constructed and applied to the observation group in addition. The rehabilitation indexes (first anal exhaust time, length of hospital stay, and quality of recovery-40 scale [QoR-40] score at seven days after intervention) were compared between the two groups. The scores of Hamilton anxiety scale (HAMA) before intervention (T1), one day before operation (T2), three days after operation (T3), and seven days after operation (T4) were compared between the two groups. The incidence of adverse reactions and nursing satisfaction were recorded and compared between the two groups. Results The first anal exhaust time and length of hospital stay in the observation group were shorter than those in the control group, and the QoR-40 score at seven days after intervention was higher than that in the control group, and the differences were statistically significant (P ＜ 0.05). The HAMA scores of T2, T3, and T4 in the two groups were lower than those of T1, T3, and T4 were lower than those of T2, T4 was lower than that of T3, and the HAMA scores of T2, T3, and T4 in the observation group were lower than those of the control group at the same time point, and the differences were statistically significant (P ＜ 0.05). The total incidence of complications in the observation group was lower than that in the control group, and the total satisfaction rate of nursing was higher than that in the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion The risk control system of laparoscopic total hysterectomy can improve the rehabilitation efficiency of patients, improve anxiety, reduce the incidence of surgical complications, and improve nursing satisfaction.
		2023 Vol. 20 (1): 186-189 [Abstract] ( 20 ) HTML (1 KB) PDF (559 KB) ( 20 )

	190	Effect of phased rehabilitation intervention on postoperative pain and functional recovery in patients undergoing total knee arthroplasty
		CAI Chuanfeng RUAN Renzhi YU Xinyan▲
		DOI: 10.20047/j.issn1673-7210.2023.01.44
		Objective To investigate the measures and effects of phased rehabilitation intervention in postoperative nursing of patients with knee osteoarthritis (KOA). Methods A total of 100 patients with KOA treated in Hefei First People’s Hospital from May 2019 to March 2022 were divided into two groups. The control group (50 cases) received routine rehabilitation intervention after surgery, while the observation group (50 cases) received phased rehabilitation intervention after surgery. The degree of pain, recovery of joint function and ability of daily living were observed 21 days after the operation. Results After intervention, the visual analogue scale score of the two groups was lower than that before intervention, while that of the observation group was lower than that of the control group, and the differences were statistically significant (P＜0.05). After intervention, the hospital for special surgery score, active and passive range of motion in the two groups were higher than those before intervention, while those of the observation group were higher than those of the control group, and the differences were statistically significant (P＜0.05). Conclusion Phased rehabilitation intervention in postoperative nursing of KOA patients undergoing total knee arthroplasty can effectively help patients better relieve postoperative pain and promote better improvement of postoperative joint function.
		2023 Vol. 20 (1): 190-193 [Abstract] ( 22 ) HTML (1 KB) PDF (562 KB) ( 113 )

	194	Nursing effect of painless concept cognitive behavioral model in patients after percutaneous nephrolithotomy
		QIU Huihui XU Ning▲
		DOI: 10.20047/j.issn1673-7210.2023.01.45
		Objective To explore the nursing effect of painless concept cognitive behavioral model intervention in patients after percutaneous nephrolithotomy. Methods A total of 106 patients who received percutaneous nephrolithotomy in Nanjing First Hospital from January to December 2021 were selected as the study objects, and they were divided into control group (53 cases) and observation group (53 cases) according to random number table method. The control group was treated with routine nursing, while the observation group was treated with painless concept cognitive behavioral mode intervention. Both groups were continuously treated until the patients were discharged from hospital. The pain degree [visual analogue scale (VAS) score] and self-efficacy [general self-efficacy scale (GSES) score] before intervention were compared between the two groups, and the complications of the two groups were statistically analyzed. Results At discharge, VAS scores of the two groups were lower than those before intervention, while that of the observation group was lower than that of the control group, and the differences were statistically significant (P＜0.05). At discharge, GSES scores of the two groups were higher than before intervention, while that of the observation group was higher than that of the control group, and the differences were statistically significant (P＜0.05). The total incidence of complications in observation group was lower than that in control group, and the difference was statistically significant (P＜0.05). Conclusion The painless concept cognitive behavioral model can reduce pain, improve self-efficacy and reduce complications in patients after percutaneous nephrolithotomy.
		2023 Vol. 20 (1): 194-封三 [Abstract] ( 24 ) HTML (1 KB) PDF (535 KB) ( 39 )

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