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| Research progress of exosomes from different sources in osteoporosis |
| CHEN Chao1 WANG Chunqing2 |
1.Clinical Medicine School, Guizhou Medical University, Guizhou Province, Guiyang 550000, China;
2.Department of Emergency Orthopedics, Affiliated Hospital of Guizhou Medical University, Guizhou Province, Guiyang 550000, China |
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Abstract Osteoporosis is the common disease caused by abnormal bone metabolism, and its main mechanism is reduced osteogenesis and enhanced osteoclast absorption. In recent years, a large number of studies have found that exosomes from different sources play an important role in osteoblast formation and proliferation, osteoclast differentiation and absorption, remodeling of bone microstructure and bone mineralization, tumor staging and metastasis, and bone microenvironment, especially in the field of osteoporosis, through their own or synergistic actions. Exosomes from different sources affect bone metabolism of target cells through osteogenic or osteoclastic metabolic pathways through miRNA in exosomes, and participate in the treatment of anti-osteoporosis and microinterpretation of diseases. Therefore, this article reviews the research progress of exosomes from different sources in osteoporosis, aiming to provide a new research direction for clinical treatment of osteoporosis.
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