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| Effects of Flubiprofen Axetil on postoperative analgesia and cognitive function in cirrhotic patients |
| LIU Ying1 WANG Lu2 ZHANG Xuedi3 YAN Jiawei3 YANG Jingru1 WANG Liwei1 |
1.Graduate School, Xuzhou Medical University, Jiangsu Province, Xuzhou 221004, China;
2.the First Department of Anesthesiology, Xuzhou Central Hospital, Jiangsu Province, Xuzhou 221009, China;
3.Department of Clinical Laboratory, Xuzhou Infectious Diseases Hospital, Jiangsu Province, Xuzhou 221004, China |
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Abstract Objective To study the effects of Flubiprofen Axetil on postoperative analgesia and cognitive function in cirrhosis patients. Methods A total of 60 cirrhosis patients who underwent surgical treatment in Xuzhou Central Hospital of Jiangsu Province from July 2020 to December 2021 were selected. According to the random number table method, they were divided into observation group and control group, with 30 cases in each group. Before the surgery, the observation group was given 20 mg Flurbiprofen Axetil, followed by intravenous controlled analgesia pump (Flurbiprofen Axetil 2.00 mg/kg+Desoxine 0.50 mg/kg+ Paronosetron 0.15 mg, plus normal saline to 100 ml); control group was given an intravenous analgesic pump (Desoxine 0.50 mg/kg+ Paronosetron 0.15 mg, plus normal saline to 100 ml). The scores of mini-mental state examination (MMSE) were compared between two groups at 24 h preoperative (T1), 24 h postoperative (T3), and 48 h postoperative (T4); visual analog scale (VAS) scores at 12 h postoperative (T2), T3, and T4 were compared between two groups; the levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were compared between two groups before surgery (Ta), after surgery (Tb) and T3, and the occurrence of adverse reactions within 48 h after surgery were recorded between two groups. Results There were no significant differences in the scores of MMSE at T1, T3, and T4 between two groups (P＞0.05). The scores of VAS at T2, T3, and T4 of observation group were lower than those of control group, and the differences were statistically significant (P＜0.05). There were no significant differences in the levels of IL-6 and TNF-α at Ta, Tb, and T3 between two groups (P＞0.05). There was no significant difference in the incidence of POCD between two groups within 48 h after surgery (P＞0.05). There was no significant difference in the total incidence of adverse reactions between two groups within 48 h after surgery (P＞0.05). Conclusion Flubiprofen Axetil and its combination of Desosxin are satisfactory for postoperative analgesia and can reduce postoperative pain in cirrhosis patients. No effect of Flulofenen Axetil on cognitive function and inflammation level in cirrhosis patients are observed.
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