|
|
Professor Zhang Yu in treating chronic kidney disease with ten methods of activating blood circulation to dissipate blood stasis |
XUE Shunxuan1 ZHANG Yu2 |
1.School of Clinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, China;
2.Department of Nephrology, Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing 100091, China |
|
|
Abstract Professor Zhang Yu believes that chronic kidney disease has a long course and it is easy to produce blood stasis when the disease enters the collaterals. Modern studies have also confirmed that the pathological changes of kidney such as hypercoagulable state of blood in the kidney and the thrombosis and ischemia it causes, as well as mesangial cell proliferation following tissue damage and crescents formation are all related to blood stasis in traditional Chinese medicine. Based on years of clinical experience, Professor Zhang summarizes ten methods of activating blood circulation to dissipate blood stasis, including invigorating qi and activating blood method, dispelling wind and activating blood method, disinhibit water and activating blood method, kidney-tonifying and activating blood method, purgativing and activating blood method, detoxifying and activating blood method, supplementing lung and activating blood method, invigorating spleen and activating blood method, cooling blood and activating blood method, eliminating accumulation and activating blood method, which has achieved good curative effect.
|
|
|
|
|
[1] 李定祥.五脏血瘀证与血液高凝状态相关性研究[D].长沙:湖南中医药大学,2007.
[2] 姜明刚.红花注射液治疗糖尿病肾病肾功能衰竭的疗效观察[J].中国医药指南,2019,17(8):180-181.
[3] 张依轮,刘娜,王立范,等.水蛭对局灶节段性肾小球硬化大鼠肾组织转化生长因子和Ⅰ型胶原表达的影响[J].中国中医药科技,2021,28(5):726-729.
[4] 杨帆,曹晨,方敬,等.水蛭冻干粉对糖尿病肾病大鼠肾组织损伤的保护作用[J].中草药,2021,52(4):1020-1025.
[5] 刘凯.基于AngⅡ-TLR4/NF-κB通路研究地龙蛋白对自发性高血压大鼠血压及早期肾损害的影响[D].兰州:甘肃中医药大学,2020.
[6] 李曼曼,许钒,付士平,等.基于AngⅡ/TRPC6通路探讨当归芍药散对肾病综合征大鼠足细胞的保护机制[J].中国实验方剂学杂志,2021,27(19):9-18.
[7] 李露,贺小兰.桂枝茯苓丸联合真武汤治疗糖尿病肾病性水肿的临床观察[J].内蒙古中医药,2020,39(1):22- 23.
[8] 于子凯,李刘生,张昱,等.基于真实世界的加味黄芪赤风汤治疗IgA肾病的临床疗效评价[J].世界中医药,2018, 13(11):2819-2822.
[9] 赵明明,李澎,杨斌,等.基于活性氧簇-自噬通路调控的加味黄芪赤风汤对肾小球足细胞的保护机制研究[J].中国中西医结合杂志,2020,40(6):727-732.
[10] 王如梦.加味黄芪赤风汤对IgA肾病患者蛋白尿及尿TGF-β1、MCP-1的影响[D].北京:北京中医药大学,2021.
[11] 张丽敏,常美莹,张昱.应用蝉苏地黄汤治疗IgA肾病蛋白尿的经验探析[J].世界中西医结合杂志,2020,15(6):1042-1045.
[12] 赵明明,杨斌,张昱,等.蝉苏地黄汤对阿霉素大鼠肾脏纤维化及自噬相关蛋白LC3和Beclin-1表达的影响[J].世界中西医结合杂志,2017,12(1):57-61.
[13] 薛必贞.益气活血温阳通下法治疗慢性肾功能衰竭验案一则[J].中国民间疗法,2005,13(12):43-44.
[14] 王巧花.基于Wnt/β-catenin信号通路研究桃核承气汤对慢性肾衰竭大鼠的作用机制[D].福州:福建中医药大学,2021.
[15] 李刘生,赵明明,张昱.张昱基于“虚-风-瘀-毒”复杂病机网络诊治IgA肾病的经验[J].世界中西医结合杂志,2017,12(4):450-455,472.
[16] 金童,邵赛聪,周丽红,等.复方鱼腥草合剂对糖尿病大鼠肾小球足细胞的影响[J].时珍国医国药,2021,32(4):858-860.
[17] 张雨轩.活血解毒化瘀中药抑制UUO大鼠对侧肾脏肾小球系膜细胞焦亡的机制研究[D].石家庄:河北中医学院,2020.
[18] 王春红,战蕾,万丽莉.金水宝片治疗慢性肾小球肾炎疗效及对血管内皮功能 的影响分析[J].药品评价,2020, 17(22):25-27.
[19] 王如梦,赵明明,常美莹,等.基于咽肾相关理论探讨金银花治疗IgA肾病作用机制的网络药理学研究[J].世界中西医结合杂志,2021,16(4):665-672.
[20] 郭杨志,杜娟,姜敏.当归内酯联合消渴丸对糖尿病肾病大鼠肾脏保护及血管内皮生长因子信号通路的调节作用[J].解剖学报,2021,52(3):439-445.
[21] 张文杰,赖星海,陈佳薇.山药多糖治疗肥胖糖尿病肾病大鼠的效果观察及对其肾功能和肠道微生态的影响[J].中国微生态学杂志,2021,33(1):37-42.
[22] 吴胜斌,王应灯.人参皂苷对糖尿病肾病大鼠体内ColⅣ、Nrf2和NQO1表达的影响[J].河北医药,2021,43(15): 2245-2249.
[23] 马少飞.加味小蓟饮子治疗IgA肾病(下焦湿热型)血尿的临床观察[D].昆明:云南中医学院,2018.
[24] 孙国强.八正散加减治疗下焦湿热型IgA肾病的临床研究[J].航空航天医学杂志,2021,32(1):90-91.
[25] 王寒,龚保源,张学团,等.丹参多酚酸盐辅助治疗糖尿病肾病效果及对患者炎性因子水平和血清氧化应激指标的影响[J].中国卫生工程学,2021,20(6):1027-1028, 1031.
[26] 赵延栋,李夏玉,王云卿,等.益气养阴活血祛瘀法治疗慢性肾脏病1~4期慢性肾功能不全临床研究[J].新中医,2020,52(8):97-99. |
|
|
|