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2022 Vol. 19, No. 35 Published: 2022-12-15

	4	In vivo protection study of β-ecdysterone against MPTP-induced Parkinson’s disease
		QU Lili ZHANG Yingbo DONG Haiying LIU Deshui CHEN Peipei ZHANG Xiaojie
		DOI: 10.20047/j.issn1673-7210.2022.35.01
		Objective To investigate the in vivo neuroprotective effect of β-ecdysterone on MPTP (MPTP)-induced Parkinson’s disease (PD) mice through activation of the PI3K/Akt pathway. Methods Forty-two mice were divided into normal group (group A), model group (group B), sregiline group (group C), β-ecdysterone high group (group D), medium group (group E), and low dose (group F) group by random number table method, with seven mice in each group. Behavioral changes were observed, TH, PI3K, and P-PI3K, Akt and P-Akt, BAX, and BCL-2 protein expression in the brain were detected by Western blot, and BAX and BCL-2 mRNA expression in the brain of mice were detected by RT-qPCR. Results Mice in group B took longer to climb the pole than those in group A, while mice in groups C, D, and E took shorter time to climb the pole than those in group B, and the differences were statistically significant (P＜0.05). The suspension scores of mice in group B were higher than those in group A, while the suspension scores of mice in groups C, D, and E were lower than those in group B, and the differences were statistically significant (P＜0.05). The P-PI3K/PI3K and P-PAkt/Akt ratios in group B were lower than those in group A, while the P-PI3K/PI3K and P-PAkt/Akt ratios in groups C, D, and E were higher than those in group B, and the differences were statistically significant (P＜0.05). The expression of apoptosis-inhibiting protein BCL-2 in group B was lower than that in group A, while the expression of pro-apoptosis protein BAX was higher than that in group A, and the differences were highly statistically significant (P＜0.01); the expression of BCL-2 protein in groups C, D, and E were higher than that in group B, while the expression of BAX protein were lower than that in group B, and the differences were statistically significant (P＜0.05). The expression of BCL-2 mRNA in group B was lower than that in group A, while the expression of BCL-2 mRNA in groups C, D, and E were higher than that in group B, and the differences were statistically significant (P＜0.05). The expression of BAX mRNA in group B was higher than that in group A, while the expression of BAX mRNA in groups C, D, and E were lower than that in group B, and the differences were statistically significant (P＜0.05). Conclusion β-Ecdysterone protects dopaminergic neurons in MPTP-induced PD mice with dose-dependent activation of the PI3K/Akt pathway, which subsequently attenuates apoptosis.
		2022 Vol. 19 (35): 4-7,16 [Abstract] ( 30 ) HTML (1 KB) PDF (1768 KB) ( 135 )

	8	Effects of massage on endoplasmic reticulum stress and inflammation in skeletal muscle blunt contusion in rats
		LIN Jianping1 WANG Hao2 LIU Haichao3 LI Ming1 WANG Shizhong1 CHEN Shaoqing3
		DOI: 10.20047/j.issn1673-7210.2022.35.02
		[Abstract] Objective To explore the effect of massage on endoplasmic reticulum stress and inflammation in skeletal muscle contusion. Methods Twenty-four 6-week-old male SPF SD rats were divided into control group, model group, massage non-acupoint group, and acupoint massage group according to the random number table method, with six rats in each group. Except the blank group, the other groups were established the models of blunt trauma of gastrocnemius. One day after modeling, massage intervention was started. The massage acupoint group was selected as yīnlíngquán, the massage non-acupoint group was selected as non-meridian and non-acupoint, and the blank group and the model group did not receive any intervention. HE staining was used to observe the morphological changes of muscle tissue. The contents of tumor necrosis factor-α (TNF-α) and Ca2+-ATPase (SERCA) were determined by enzyme-linked immunosorbent assay. The expressions of glucose-regulating protein 78 (GRP78) and calcium-reticulin (CRT) were detected by Western blot. Results Compared with blank group, the arrangement of muscle fibers in model group was more disordered, with obvious fracture, dissolution and scar tissue. Compared with blank group, the content of TNF-α in model group was increased (P＜0.01). Compared with model group, TNF-α content in massage acupoint group and massage non-acupoint group was decreased (P＜0.05); compared with massage non-point group, the TNF-α content of massage acupoint group was lower than that of massage non-point group (P＜0.05). Compared with blank group, SERCA content in model group was decreased (P＜0.05). Compared with model group, SERCA content in massage acupoint group and massage non-acupoint group was increased (P＜0.05). Compared with blank group, the protein expressions of GRP78 and CRT in model group were increased (P＜0.05). Compared with model group, the protein expressions of GRP78 and cRT in massage acupoint group and massage non-acupoint group were decreased (P＜0.05); compared with the massage non-acupoint group, the protein expressions of GRP78 and CRT in the massage acupoint group were lower (P＜0.05). Conclusion Massage can improve skeletal muscle blunt contusion and relieve endoplasmic reticulum stress. The mechanism may be related to up-regulation of SERCA and inhibition of endoplasmic reticulum stress proteins and inflammatory factors.
		2022 Vol. 19 (35): 8-11,22 [Abstract] ( 12 ) HTML (1 KB) PDF (1192 KB) ( 28 )

	12	Visualization analysis of research hotspots and trends of post-stroke insomnia in the field of traditional Chinese medicine based on CiteSpace
		LAN Baixin MO Xueni MA Wei LIU Jiao LIU Na JIN Xiaoyu
		DOI: 10.20047/j.issn1673-7210.2022.35.03
		Objective To explore the research hotspots and trends of post-stroke insomnia in the field of traditional Chinese medicine (TCM) based on CiteSpace. Methods By retrieving the relevant literatures on TCM treatment of post-stroke insomnia published from CNKI from the establishment of the database to March 2022 was searched, the scientific knowledge maps of authors, research institutions, keywords concurrence, clusterig, and emergent analysis in this field were drawn by using CiteSpace software. Results A total of 988 literatures were selected, and the in terms of the number of literatures published, the research attention of TCM in this field showed an overall trend of increasing. The basic status quo of research institutions was dominated by core TCM universities, with less cooperation. The hotspots and trends of the research were focused on acupuncture, patients, quality of life, serotonin, and other indicators of observation and treatment. Conclusion The knowledge graph intuitively shows the research hotspots and trends of post-stroke insomnia in TCM, and provides a certain reference value for grasping the current and future research directions.
		2022 Vol. 19 (35): 12-16 [Abstract] ( 12 ) HTML (1 KB) PDF (1465 KB) ( 181 )

	17	Nomogram model and decision curve analysis of depression risk in diabetic retinopathy patients
		JING Silu SHEN Han WANG Xiaofeng
		DOI: 10.20047/j.issn1673-7210.2022.35.04
		Objective To analyze the factors influencing the depression risk in diabetic retinopathy (DR) patients and construct and evaluate a Nomogram model. Methods A total of 329 patients with DR admitted to the First Affiliated Hospital of Nanjing Medical University from October 2018 to October 2021 were selected and divided into depressed group (132 cases) and non-depressed group (197 cases) according to the detection of depressive mood. The clinical data of the two groups were compared, and the influencing factors of depression in DR patients were analyzed by logistic regression model. The Nomogram model was further constructed and the performance of the model was verified by internal data. The clinical net benefit of the model was evaluated by decision curve. Results The incidence of depression in DR patients in this study was 40.1%. The proportion of smokers, the proportion of regular exercise, the proportion of good sleep quality, the proportion of people who do not use mobile phones, and the platelet count in the depressed group were all lower than those in the non-depressed group, the proportion of alcohol drinkers, proportion of hypertension, cholesterol, high-density lipoprotein, platelet distribution width, platelet-large cell ratio, and mean platelet volume were higher than those in the non-depression group, and the differences were statistically significant (P＜0.05). Exercise, sleep quality, mobile phone use, cholesterol, mean platelet volume, and glycosylated hemoglobin level were all influencing factors for depression in DR patients (P＜0.05). Internal verification results showed that C-index was 0.880 (95%CI: 0.843-0.917), and there was no significant difference between the predicted value and the observed value (P＞0.05). The results of decision curve analysis showed that the Nomogram model provided additional clinical benefits when the threshold was greater than 0.04. Conclusion The Nomogram model constructed in this study has good performance, which can predict the risk of depression in patients with DR with certain accuracy, and can provide strategies for medical staff to manage patients.
		2022 Vol. 19 (35): 17-22 [Abstract] ( 10 ) HTML (1 KB) PDF (1084 KB) ( 57 )

	23	Analysis of excavation of the prescription rule of Guide to Clinical Practice with Medical Records · Distention and Fullness based on Ancient and Modern Medical Cases Cloud Platform
		CHEN Yulian1 LIANG Jiayi2 HE Riming3 LU Jiandong3 YANG Shudong3
		DOI: 10.20047/j.issn1673-7210.2022.35.05
		Objective To analyze the rules of prescription medication in Guide to Clinical Practice with Medical Records · Distention and Fullness, and to summarize the diagnosis and treatment ideas of Ye Tianshi in treating distention and fullness syndrome. Methods The medical records and prescriptions of Guide to Clinical Practice with Medical Records · Distention and Fullness were input into the Ancient and Modern Medical Cases Cloud Platform, and the drug frequency, drug attribute, drug compatibility rule, and others of medical records were explored by means of frequency statistics, association rule analysis, cluster analysis, community analysis. Results A total of 30 prescriptions and 61 traditional Chinese medicines were included. The high-frequency drugs were Pinelliae Rhizoma, Armeniacae Semen Amarum, Poria, etc. The four nature of drugs were mainly warm drugs, and the five flavors were mainly pungent and bitter, mainly returning to the lung and spleen channels. Drug efficacy to eliminate dampness and phlegm as the method; drug association analysis suggested that the commonly used couplet medicines of traditional Chinese medicine was Pinelliae Rhizoma - Poria, and three drug formulations were obtained by cluster analysis. “Traditional Chinese medicine syndrome-Traditional Chinese medicine” community analysis found that the dampness- blocking qi syndrome was related to Citri Exocarpium Rubrum-Alpiniae Officinarum Rhizoma-Pogostemonis Herba- Linderae Radix; the stomach-cold syndrome was related to Euodiae Fructus-Toosendan Fructus; the chest with impaired transportation due to qingyang syndrome was related to Atractylodis Macrocephalae Rhizoma - Poria - Cinnamomi Ramulus - Glycyrrhizae Radix Et Rhizoma, etc. Conclusion Ye Tianshi uses the method of Kuxin Tongjiang in the treatment of distention and fullness syndrome, and combines with the methods of releasing heat, eliminating dampness and eliminating stagnation according to the symptoms. He also adds and subtracts drugs according to the different concurrent symptoms, which is getting good compatibility.
		2022 Vol. 19 (35): 23-27 [Abstract] ( 15 ) HTML (1 KB) PDF (1376 KB) ( 247 )

	28	Effect of local injection of hepatocyte growth factor transfected bone marrow mesenchymal stem cells on tendon-bone healing after anterior cruciate ligament reconstruction in rabbits
		YANG Deyong1 Kaishaer Baihetiyaer1 JIANG Junyao2 SHU Li1▲
		DOI: 10.20047/j.issn1673-7210.2022.35.06
		Objective To explore the effect of hepatocyte growth factor (HGF) transfected bone marrow mesenchymal stem cell (MSC) on tendon-bone healing after anterior cruciate ligament (ACL) reconstruction in rabbits. Methods Forty-five male New Zealand rabbits (3.0-3.5 kg) aged three to five months were divided into groups A, B, and C by random number table method, with 15 rabbits in each group. All three groups underwent double hindlimb ACL reconstruction, group A did not inject any substance after ACL operation; in group B, MSCs fibrin glue was injected into the tibial canal after operation; in group C, HGF gene modified MSCs fibrin glue was injected into the tibial canal after operation. Six weeks after operation, HE staining was used to observe the tendon-bone healing; the maximum tensile load and the maximum stretching distance of the graft tendon exiting from the tibial canal were tested; the expression of fibroblast growth factor 2 (FGF2) mRNA and SMAD4 mRNA in bone canal and HGF mRNA in joint fluid were detected by RT-PCR. Results Six weeks after operation, the tendon-bone interface of group A was loosely connected and collagen fibers were disordered; in group B, the tendon-bone interface was closely connected and the gap was small, but the arrangement of collagen fibers was not orderly; in group C, the tendon-bone interface was closely connected and the collagen fibers were neatly arranged. The maximum tensile load of group B was higher than that of group A, and that of group C was higher than that of group B (P＜0.05); there was no significant difference in the maximum stretching distance between groups A, B and groups B, C (P＞0.05). The FGF2 mRNA and SMAD4 mRNA in bone canal in group B were higher than those in group A, and those in group C were higher than those in group B (P＜0.05); HGF mRNA of joint fluid in group C was higher than that in group B (P＜0.05). Conclusion Local injection of HGF transfected bone marrow MSCs can enhance tendon-bone healing after ACL reconstruction in rabbits.
		2022 Vol. 19 (35): 28-31 [Abstract] ( 11 ) HTML (1 KB) PDF (871 KB) ( 51 )

	32	Advances in the relationship between different biomarkers and traditional Chinese medicine syndrome types of heart failure
		GUO Yanan1 WANG Xiaoyan2▲ GAO Jialiang3 HE Hongtao1 WANG Sizhou1 WANG Yanwei1 GENG Bin1 ZHAO Tianzi1
		DOI: 10.20047/j.issn1673-7210.2022.35.07
		Heart failure is a complex clinical syndrome of end-stage cardiovascular disease. The classical and traditional biomarkers in clinical application include brain natriuretic peptide, N-terminal proBNP, cardiac troponin and traditional biomarkers of inflammation. Inflammation plays a key role in the occurrence and progression of heart failure, therefore, several novel biomarkers have been developed in recent years for diagnosis, prognosis, and treatment evaluation. The metabonomics and other “omics” biomarkers could reflect the metabonomic patterns of different traditional Chinese medicine syndrome types of heart failure, and supply a basis for the objective syndrome differentiation and treatment. This paper summarise the research progress of traditional biomarkers, new inflammatory biomarkers and metabolic biomarkers in the diagnosis and prognosis of heart failure. The relationship between different biomarkers and traditional Chinese medicine syndromes of heart failure was summarized. In order to lay a foundation for screening more biomarkers that can be used in the process of traditional Chinese medicine syndrome differentiation and treatment, so as to further improve the objective standard identification level of traditional Chinese medicine syndromes of heart failure.
		2022 Vol. 19 (35): 32-35,44 [Abstract] ( 11 ) HTML (1 KB) PDF (687 KB) ( 159 )

	36	Research progress on the influencing factors of bone destruction in rheumatoid arthritis
		LIU Ruihua CHENG Zengyu XU Haodong ZHOU Xinyao TANG Xiaopo
		DOI: 10.20047/j.issn1673-7210.2022.35.08
		Rheumatoid arthritis (RA) is a common chronic disabling autoimmune disease. Bone destruction is the final outcome of RA joint involvement, and early identification of its influencing factors is the primary strategy for effective intervention. At present, many studies and investigations at home and abroad have paid attention to the influencing factors of bone destruction, but few systematic analysis has been carried out. By searching relevant literature on bone destruction of RA in recent years, and analyzing the related influencing factors, this paper found that general factors, such as female, young age of onset, long course of disease, and low body mass index, imaging abnormalities, such as bone marrow edema and decreased bone mineral density, and abnormal laboratory tests, such as increased levels of RA-related antibodies, cytokines, acute serum reactants, osteoclast hyperplasia, decreased osteoprotegerin, and vitamin D deficiency, are closely related to bone destruction, and can accelerate the process of bone destruction. This finding can provide direction for early clinical intervention, and provide a reference for follow-up research and the establishment of predictive models.
		2022 Vol. 19 (35): 36-39,65 [Abstract] ( 10 ) HTML (1 KB) PDF (671 KB) ( 170 )

	40	Research progress of Keap1-Nrf2 signaling pathway in oxidative stress damage protection
		LIANG Xinmei WANG Yunping LI Dan▲ WANG Wenjing MU Xinyan HAN Qingchen LI Bo ZHANG Lishuang
		DOI: 10.20047/j.issn1673-7210.2022.35.09
		Kelch-like epichlohydrin associated protein 1 (Keap1) -nuclear transcription factor E2-related factor 2 (Nrf2) signaling pathway is one of the most important mechanisms of cell defense against oxidative stress damage, and the downstream phase Ⅱ metabolic enzymes and antioxidant proteins/enzymes regulated by the pathway play an important role in cell defense protection. Keap1-Nrf2 signaling pathway plays an important role in a variety of diseases, and clinical research and development of targeted drugs has begun, which is expected to design and produce specific biomedicines based on this pathway. This paper reviews the basic structure of Keap1-Nrf2 signaling pathway, oxidative stress, regulatory mechanism, and its relationaship with various diseases.
		2022 Vol. 19 (35): 40-44 [Abstract] ( 14 ) HTML (1 KB) PDF (636 KB) ( 187 )

	45	Research progress in the regulation mechanism of myasthenia gravis-related cytokines by traditional Chinese medicine
		WU Xinxin1 SHEN Tong1 ZHOU Yabo1 ZHANG Yu1 YANG Junhong2
		DOI: 10.20047/j.issn1673-7210.2022.35.10
		Myasthenia gravis (MG) is an acquired autoimmune neurological disorder disease. Network imbalance of MG-related cytokines such as interleukin (IL), interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), and transforming growth factor-β (TGF-β) is an important mechanism of MG pathogenesis. In recent years, numerous evidences have shown that traditional Chinese medicine therapy can multi-target the intervention of MG abnormal cytokines. It can inhibit the pro-inflammatory cytokines represented by IL-17, IFN-γ, and TNF-α, and promote the anti-inflammatory cytokines IL-10 and TGF-β. Based on basic research literature, this paper analyzes and summarizes the studies on the regulation of MG-related cytokines by traditional Chinese medicine therapy, in order to provide theoretical basis and positive reference for experiments and clinical.
		2022 Vol. 19 (35): 45-48 [Abstract] ( 12 ) HTML (1 KB) PDF (541 KB) ( 47 )

	49	Advances in the study of vitamin D and liver tissue damage associated with hepatitis B virus infection
		LI Na1 MA Zhen2▲
		DOI: 10.20047/j.issn1673-7210.2022.35.11
		Viral hepatitis B is a serious health hazard for all human beings, and hepatitis B-related liver fibrosis, cirrhosis, and hepatocellular carcinoma are also the focus and difficulty of clinical treatment. In recent years, an increasing number of studies have demonstrated the close relationship between vitamin D deficiency and liver tissue damage due to viral hepatitis B. Vitamin D may slow down the process of liver injury by regulating hepatic stellate cells, immune cells; activating multiple pathways; and maintaining normal mitochondrial structure, function and oxidative capacity. Vitamin D receptor expression is closely related to the staging of liver injury. Vitamin D supplementation during antiviral therapy may reduce liver injury and improve prognosis in patients with hepatitis B.
		2022 Vol. 19 (35): 49-52 [Abstract] ( 13 ) HTML (1 KB) PDF (489 KB) ( 144 )

	53	Analysis of risk factors and construction of predictive models for combined diabetes in maintenance hemodialysis patients
		XIA Fuhai1 WANG Xuefen1 WANG Guoqing2
		DOI: 10.20047/j.issn1673-7210.2022.35.12
		Objective To investigate the risk factors and to construct a predictive model for comorbid diabetes in maintenance hemodialysis patients. Methods From June to September 2021, a total of 227 maintenance hemodialysis patients in the hemodialysis units of the Remin Hospital of Wuhan University and the Central South Hospital of Wuhan University were investigated, and they were divided into 91 cases in the maintenance hemodialysis with diabetes group and 136 cases in the maintenance hemodialysis without diabetes group according to whether they had comorbid diabetes. Risk factors were analyzed using logistic regression equations, and prediction models were developed based on the results. Results The differences in marital status, mobility, sleep quality, Kt/V, prealbumin, body mass index (BMI), pulse pressure difference, vitamin B12, and age were statistically significant when comparing the two groups (P＜0.05). The logistic regression results showed that mobility, BMI, sleep quality, Kt/V, prealbumin, and pulse pressure difference were influential factors for combined diabetes in patients with maintenance hemodialysis (P＜0.05). Conclusion Mobility, BMI, sleep quality, Kt/V, prealbumin, and pulse pressure difference are influential factors in maintenance hemodialysis patients with comorbid diabetes mellitus, and predictive models can help identify patients with comorbid diabetes mellitus on maintenance hemodialysis early.
		2022 Vol. 19 (35): 53-57 [Abstract] ( 11 ) HTML (1 KB) PDF (682 KB) ( 28 )

	58	Qualitative study of nurses’ experiences with case management of postoperative breast cancer patients
		WEI Ling1 WANG Xiumei1 TANG Hong1 XING Jun2 LU Bin3
		DOI: 10.20047/j.issn1673-7210.2022.35.13
		Objective To understand nurses’ perceptions and nursing experiences in case management of postoperative breast cancer patients. Methods From January to March 2022, a combination of convenience and purposive sampling was used to select 12 breast surgery nurses from 2 tertiary care hospitals in Taiyuan, Shanxi. Semi-structured interviews were conducted using the phenomenological research method in qualitative research. The data were organized and analyzed using the Colaizzi 7-step analysis method to refine the themes. Results A total of four themes were distilled: nurses’ general awareness of the importance of case management; the diversity of forms of case management used; the problems nurses had in implementing case management; and the factors that influence nurses’ implementation of case management. Conclusion Effective measures can be taken to continuously improve the implementation of case management by developing targeted nurse training programs, clarifying case manager admission qualifications, emphasizing patient participation in postoperative lymphedema in breast cancer, and improving the support and assurance system related to case management.
		2022 Vol. 19 (35): 58-61 [Abstract] ( 12 ) HTML (1 KB) PDF (646 KB) ( 85 )

	62	Analysis of factors affecting patients with obstructive sleep apnea hypoventilation syndrome
		MA Liyang REN Pan LIU Jing WANG Lu▲
		DOI: 10.20047/j.issn1673-7210.2022.35.14
		Objective To investigate the factors affecting patients with obstructive sleep apnea hypoventilation syndrome (OSAHS). Methods Ninety patients with OSAHS admitted to the Second Affiliated Hospital of Air Force Military Medical University from December 2019 to September 2021 were selected as the observation group, and 100 cases of health checkups at the Second Affiliated Hospital of Air Force Military Medical University during the same period were selected as the control group. The clinical data of the two groups were compared, and logistic regression was used to analyze the relevant factors affecting the occurrence of OSAHS. Results The differences in body mass index (BMI), history of diabetes mellitus, sleep apnea hypoventilation index, maximum hypoventilation time, maximum apnea time, minimum oxygen saturation, and sleep position were statistically significant when compared between the two groups (P＜0.05). Multifactorial unconditional logistic regression analysis showed that BMI≥24 kg/m2, history of diabetes mellitus, and sleep position supine position were influential factors in the occurrence of OSAHS (OR＞1, P＜0.05). Conclusion BMI≥24 kg/m2, history of diabetes, and sleep position in supine position are risk factors for OSAHS and should be strengthened to further reduce the incidence of OSAHS.
		2022 Vol. 19 (35): 62-65 [Abstract] ( 13 ) HTML (1 KB) PDF (559 KB) ( 40 )

	66	Predictive value of RDW combined with Hcy in the recurrence of atrial fibrillation after radiofrequency ablation
		XU Jingping MA Xiaofeng WANG Hong XU Ping
		DOI: 10.20047/j.issn1673-7210.2022.35.15
		Objective To investigate the predictive value of red blood cell distribution width (RDW) combined with homocysteine (Hcy) in the recurrence of atrial fibrillation (hereinafter referred to as atrial fibrillation) after percutaneous radiofrequency catheter ablation (RFCA). Methods From January 2016 to February 2018, 103 patients with atrial fibrillation who underwent RFCA in Qinghai Provincial Hospital of Cardiovascular and Cerebrovascular Diseases were selected. The basic data, blood routine index, biochemical index, and cardiac color Doppler ultrasound were recorded. According to whether RFCA recurrence after three months, the patients were divided into non-recurrence group and recurrence group. The risk factors of postoperative recurrence of atrial fibrillation were analyzed, and receiver operating characteristic (ROC) curve was used to predict the recurrence of atrial fibrillation. Results The mean follow-up time was (17.6±5.7) months, and 13 patients had a recurrence. Left atrial diameter, RDW, total bilirubin, direct bilirubin, uric acid, Hcy, neutrophils, and neutrophil-to-lymphocyte ratio in recurrence group were higher than those in non-recurrence group, and the differences were statistically significant (P＜0.05). RDW and Hcy were independent risk factors for postoperative recurrence of atrial fibrillation (OR＞1, P＜0.05). ROC curve analysis showed that RDW combined with Hcy predicted postoperative recurrence of atrial fibrillation with an area under the curve of 0.797, sensitivity of 69.2%, and specificity of 87.4%. Conclusion RDW and Hcy are independent risk factors for postoperative recurrence of atrial fibrillation. RDW combined with Hcy has high predictive value in the evaluation of postoperative recurrence of atrial fibrillation.
		2022 Vol. 19 (35): 66-69 [Abstract] ( 14 ) HTML (1 KB) PDF (724 KB) ( 200 )

	70	Value of the combine of CT score and serological indexs in predicting early clinical outcome of craniocerebral injury
		YUE Shengkui1 LIU Haobo2 PAN Donghong2 FANG Wei1 XIA Tian1
		DOI: 10.20047/j.issn1673-7210.2022.35.16
		Objective To study the value of CT score and serological indexs in predicting early clinical outcome of craniocerebral injury. Methods Clinical data of 118 patients with craniocerebral injury admitted to Wuxi Ninth People’s Hospital of Jiangsu Province and Yangquan Coal Industry (Group) General Hospital of Shanxi Province from January 2019 to December 2021 were retrospectively analyzed, and they were divided into good prognosis group (76 cases) and poor prognosis group (42 cases) according to the Glasgow outcome scale-extended score at three months after operation. The clinical data, preoperative CT scores, and serum levels of interleukin (IL)-1β, IL-6, and S100 calcium-binding protein B (S100B) were compared between the two groups, and the influencing factors of early clinical outcome in patients with craniocerebral injury and their predictive value for outcome were further analyzed. Results The proportion of Glasgow coma scale (GCS) score of 3-8 points, CT score, and serum levels of IL-1β, IL-6, and S100B in the poor prognosis group were higher than those in the good prognosis group, the differences were statistically significant (P＜0.05). The results of multivariate analysis showed that GCS score of 3-8 points, CT score, and serum levels of IL-1β, IL-6, and S100B were the influential factors for early poor outcome of patients with craniocerebral injury (P＜0.05). The results of the receiver operator characteristic curve showed that CT score and serum levels of IL-1β, IL-6, and S100B alone and in combination all had the value in predicting the early poor outcome of patients with craniocerebral injury (area under the curve＞0.5, P＜0.05). Conclusion CT score combines with IL-1β, IL-6, and S100B has high value in predicting early outcome of patients with craniocerebral injury
		2022 Vol. 19 (35): 70-73 [Abstract] ( 11 ) HTML (1 KB) PDF (702 KB) ( 32 )

	74	Clinical effect of Zhixiong Capsules in treating convalescent period of cerebral infarction with syndrome of static blood blocking collaterals
		YI Lihua ZHENG Lisha WANG Jia LIU Di
		DOI: 10.20047/j.issn1673-7210.2022.35.17
		Objective To explore the clinical effect of Zhixiong Capsules in treating convalescent period of cerebral infarction with syndrone of static blood blocking collaterals. Methods A total of 86 patients with convalescent period of cerebral infarction admitted to Fuxin Mine General Hospital of Liaoning Health Industry Group from January 2019 to January 2022 were selected and divided into control group and combination group by random number table method, with 43 cases in each group. On the basis of conventional treatment, the control group was given Butylphthalide Capsules, and the combination group was given Zhixiong Capsules combined with Butylphthalide Capsules. After 14 days of treatment, the clinical efficacy of two groups was compared, and the simplified Fugl-Meyer scale (FMA) score, modified Barthel index (MBI), National Institutes of Health stroke scale (NIHSS) score, plasma viscosity, whole blood high shear viscosity, whole blood low shear viscosity, and serum vascular endothelial growth factor (VEGF), neuron-specific enolase (NSE), cell matrix-derived factor-1 (SDF-1) levels before and after treatment were compared between the two groups. The occurrence of adverse reactions during treatment was recorded in both groups. Results The overall curative effect of the combination group was better than that of the control group (P＜0.05). After treatment, NIHSS score, plasma viscosity, whole blood high shear viscosity, whole blood low shear viscosity, and serum NSE level were all lower than those before the treatment, while FMA score, MBI, and serum VEGF and SDF-1 levels were all higher than those before the treatment, NIHSS score, plasma viscosity, whole blood high shear viscosity, whole blood low shear viscosity, and serum NSE level in combination group were lower than those in control group, while FMA score, MBI, and serum VEGF and SDF-1 levels were higher than those in control group, the differences were statistically significant (P＜0.05). During the treatment period, no serious adverse reactions occurred in both groups. Conclusion In the convalescent period of cerebral infarction, the treatment effect of Zhixiong Capsules combined with Butylphthalide Capsules is significant, which is conducive to improving the hemodynamics and quality of life of patients, and is worthy of clinical promotion.
		2022 Vol. 19 (35): 74-77 [Abstract] ( 11 ) HTML (1 KB) PDF (601 KB) ( 38 )

	78	Meta-analysis of the effectiveness and safety of nebulized inhaled magnesium sulfate combined with salbutamol in the treatment of asthma in children
		ZHANG Xinyue LI Jiangya LIN Haochang ZHANG Qian LIANG Liju WENG Zhiying
		DOI: 10.20047/j.issn1673-7210.2022.35.18
		Objective To provide evidence-based medical evidence for the clinical treatment of children with this disease through a meta-analysis of the efficacy and safety of nebulized inhaled magnesium sulfate in combination with salbutamol in the treatment of childhood asthma. Methods The randomized controlled trials (RCTs) of nebulized magnesium sulfate combined with salbutamol (trial group) and nebulized salbutamol (control group) for the treatment of asthma in children were collected by searching PubMed, Cochrane Library, Embase, China Knowledge Network, Wanfang database, VIP Chinese journal database, and Chinese biomedical literature database from the establishment of the database to July 2021. The RCTs were screened according to the established inclusion and exclusion criteria, data were extracted and the quality of included studies was evaluated according to the Cochrane risk of bias assessment scale, and meta-analysis was performed using RevMan 5.3 software. Results A total of 14 RCTs with a total of 1 198 patients were included in this study. The results of meta-analysis showed that the total clinical efficiency (RR = 1.15, 95%CI: [1.09, 1.20], P ＜ 0.000 01), forced expiratory volume in first second (MD = 0.10, 95%CI: [-0.02, 0.18], P = 0.02), and peak expiratory flow (MD = 0.38, 95%CI: [0.26, 0.49], P ＜ 0.000 01) in the trial group were higher than those in the control group, and the differences were statistically significant. There was no significant difference in the incidence of adverse reactions between the two groups(P ＞ 0.05). Conclusion Nebulized inhalation of magnesium sulfate combined with salbutamol can effectively improve the clinical efficacy and lung function indexes of children with asthma, and its safety is comparable to that of salbutamol alone.
		2022 Vol. 19 (35): 78-83 [Abstract] ( 17 ) HTML (1 KB) PDF (2449 KB) ( 55 )

	84	The correlation between serum CA125, hs-CRP, and NLR and pelvic endometriosis stage and their predictive value in diagnosis
		QIAN Yan JIN Maosheng YE Guoliu
		DOI: 10.20047/j.issn1673-7210.2022.35.19
		Objective To analyzed the correlation between serum carbohydrate antigen 125 (CA125), high sensitivity C-reactive protein (hs-CRP), and neutrophil/lymphocyte ratio (NLR) and pelvic endometriosis (EMT) and their predictive value in diagnosis. Methods A total of 114 patients diagnosed and treated in the First Affiliated Hospital of Bengbu Medical College (hereinafter referred to as “our hospital”) from August 2018 to August 2020 and confirmed as EMT by postoperative pathology were selected as EMT group, 92 patients with simple ovarian cyst confirmed by postoperative pathology were selected as control group. General, clinical， and surgical information of two groups were collected. The correlation of serum CA125, hs-CRP， and NLR with EMT stage and their predictive value in diagnosis were analyzed. Results Serum CA125, hs-CRP, and NLR in EMT group were higher than those in control group (P＜0.05). Serum CA125, hs-CRP, and NLR in stage Ⅲ EMT patients were higher than those in stage Ⅰ+Ⅱ, and the serum CA125, hs-CRP, and NLR in stage Ⅳ EMT patients were higher than those in stage Ⅰ+Ⅱ and Ⅲ (P＜0.05). Serum CA125, hs-CRP, and NLR levels were positively correlated with the clinical stage of EMT (r＞0, P＜0.05). The area under the curve of the combined detection of CA125, hs-CRP, and NLR in diagnosis of EMT was higher than that of CA125, hs-CRP, and NLR alone. Conclusion The combined detection of CA125, hs-CRP, and NLR can be provided a partial reference value for the diagnosis of EMT.
		2022 Vol. 19 (35): 84-87 [Abstract] ( 9 ) HTML (1 KB) PDF (586 KB) ( 136 )

	88	Relationship between recurrent respiratory tract infection and serum 25-hydroxyvitamin D level, vitro allergens, and total IgE in infants
		LIU Suqin1 LI Yan1▲ WANG Lei2 WEI Mengyue1
		DOI: 10.20047/j.issn1673-7210.2022.35.20
		Objective To explore the relationship between 25-(OH)D level, vitro allergens, and total immunoglobulin E (IgE) in recurrent respiratory tract infections(RRTI) in infants. Methods From December 2018 to June 2019, 100 infants with RRTI who admitted to Yangzhou Women and Children Care Service Hospital Affiliated to Yangzhou University Medical College (hereinafter referred to as “our hospital”) were selected as observation group, another 100 infants with the first respiratory tract infection aged from 3 to 18 months in our hospital, who were followed up to two years old and still had only one history of respiratory tract infection as first infection group; 100 infants and toddlers who underwent physical examination in Department of Child Healthcare as healthy group. The first infection group and healthy group were included in control group. The 25-(OH)D levels were compared among all groups; vitro allergen indexes and total IgE were compared between observation group and control group; the risk factors of RRTI in infants were analyzed by logistic regression. Results The level of serum 25-(OH) D in observation group was lower than that in control group (P＜0.01). The level of serum 25-(OH) D in observation group was lower than that in healthy group and first infection group (P＜0.01). The positive rates of house dust, egg white, milk, and oak birch maple walnut sycamore poplar in observation group were higher than those in control group (P＜0.05 or P＜0.01). There was no significant difference in total IgE between two groups (P＞0.05). 25-(OH)D was a protective factor for RRTI (OR＜1, P＜0.05). Conclusion The serum 25-(OH)D level in RRTI children is low, and 25-(OH)D may play a protective role in the occurrence of RRTI. The positive rate of allergens in RRTI children is high, but the vitro allergen positive can not be used to predict whether the children are prone to RRTI.
		2022 Vol. 19 (35): 88-91 [Abstract] ( 16 ) HTML (1 KB) PDF (597 KB) ( 47 )

	92	Effect comparison of laparoscopic-assisted surgery and open laparotomy in the treatment of magnetic foreign body in children’s digestive tract
		CHEN Long WANG Dayong ZHANG Weiping LIU Tingting SHEN Qiulong WANG Li XIE Fangnan LI Xianling
		DOI: 10.20047/j.issn1673-7210.2022.35.21
		Objective To compare the effect of laparoscopic-assisted surgery and open laparotomy in the treatment magnetic foreign body in children’s digestive tract. Methods From December 2015 to January 2022, 84 patients with magnetic foreign bodies in digestive tract undergoing surgical treatment admitted Beijing Children’s Hospital, Capital Medical University were selected, and they were divided into open laparotomy group (42 cases), laparoscopic group (30 cases) according to the surgical method, and the remaining twelve child patients who were converted from laparoscopy to laparotomy were not included in the group. The number of magnetic foreign bodies, distribution of the magnetic foreign bodies, complications caused by magnetic foreign bodies, operation time, intraoperative blood loss, postoperative feeding time, postoperative hospitalization time, and postoperative complications were compared between two groups. Results There was statistical significance in the number of magnetic foreign bodies in empty ileum between two groups (P＜0.05). There were no significant differences in the incidence of preoperative intestinal obstruction, the incidence of digestive tract perforation caused by magnetic foreign bodies, the number of digestive tract perforation, and the incidence of internal hernia between two groups (P＞0.05). The operation time between two groups was statistically significant (P＜0.05); there were no significant differences in intraoperative blood loss, postoperative feeding time, and postoperative hospitalization time between two groups (P＞0.05). There was no significant difference in the total incidence of postoperative complications between two groups (P＞0.05). The hospitalization expenses of two groups were compared, and the difference was statistically significant (P＜0.05). Conclusion Laparoscopic-assisted surgery has the same efficacy as open laparotomy in the treatment of magnetic foreign bodies in children’s digestive tract. The surgeon should choose the appropriate surgical methods according to the specific conditions.
		2022 Vol. 19 (35): 92-95 [Abstract] ( 26 ) HTML (1 KB) PDF (476 KB) ( 28 )

	96	Expression and significance of novel tumour-testis antigens CT10, SSX1 induced by low dose of 5-aza-2’-deoxycytidine in hepatocellular carcinoma cell HepG2
		ZHANG He ZHAO Huixia ZENG Zhiyan LI Qingyan YUN Chao GUAN Na LI Quiwen XIAO Wenhua
		DOI: 10.20047/j.issn1673-7210.2022.35.22
		Objective To explore expression and significance of novel tumour-testis antigens CT10, SSX1 induced by low dose of 5-aza-2’-deoxycytidine(5-aza-CdR) in hepatocellular carcinoma cell HepG2. Methods The six mRNA expression of MAGE1, MAGE3, CT10, CTp11, NE-ESO-1, and SSX1 in HepG2, SMMC-7721, BEL-7402, MHCC97L and MHCC97M3 liver cancer cell lines were detected by RT-PCR. HepG2 cells that do not express CT10 and SSX1 were selected as the study object as nCTAs, and HepG2 cells were treated with 0, 0.5, 1.0, and 1.5 μmol/L 5-aza-CdR. The control group did not contain 5-aza-CdR, from low to high concentration, they were experiment 1, 2, and 3 groups respectively, the mRNA and protein expressions of CT10 and SSX1 were detected by RT-PCR and Western blot, respectively. Results Different nCTAs expression was found in five hepatocellular cells, the expression was heterogeneous, among them MAGE1, MAGE3, CTp11, and NY-ESO-1 expression in HepG2; MAGE1, MAGE3, CT10, CTp11, and SSX1 expression in both MHCC97L and MHCC97M3; MAGE1, MAGE3, and CTp11 expression in BEL-7402; however, SMMC-7721 only expresses MAGE1 and MAGE3. Experimental 1, 2, and 3 groups could induce the expression of CTA-CT10 and SSX1, among them, 0.5 μmol/L small dose of experiment group 1 could also induce the expression of nCTAs, the relative expression of nCTAs induced in experiment 3 group was significantly higher than that in experiment 1 and 2 group, and the differences were statistically significant (P＜0.05). Conclusion Different hepatocellular carcinoma cells expressed different CTAs, and a small dose of 5-aza-CdR could induce the expression of nCTAs in hepatocellular carcinoma cell lines.
		2022 Vol. 19 (35): 96-100 [Abstract] ( 27 ) HTML (1 KB) PDF (1305 KB) ( 40 )

	101	Relationship between the expression levels of serum lncRNA-MALAT-1 and miR-143 and the clinical features and prognosis of acute myeloid leukemia
		HE Xu HU Yinshan XU Sunqiu YANG Kun MA Chunrong
		DOI: 10.20047/j.issn1673-7210.2022.35.23
		Objective To investigate the relationship between the expression levels of serum long-stranded non-coding RNA (lncRNA)-lung adenocarcinoma metastasis-associated transcript 1 (MALAT-1) and microRNA-143 (miR-143) and the clinical features and prognosis of acute myeloid leukemia. Methods Eighty-seven patients with acute myelogenous leukemia(AML） admitted to the Department of Hematology of Nanchong Central Hospital (hereinafter referred to as “our hospital”) from January 2017 to April 2019 were selected as the AML group, and 32 healthy patients who underwent physical examination in our hospital during the same period were selected as the control group. The expressions of serum lncRNA-MALAT-1 and miR-143 were detected by qPCR. The correlation between the two expressions and the clinical features of AML was analyzed. According to the mean expression values of serum lncRNA-MALAT-1 and miR-143, patients were divided into high and low expression groups. Kaplan-Meier method was used to draw the survival curve of AML patients. Results Serum lncRNA-MALAT-1 expression in the AML group was higher than that in the control group, and miR-143 expression was lower than that in the control group (P＜0.01). Pearson’s correlation coefficient showed that serum lncRNA-MALAT-1 was negatively correlated with miR-143 expression in the AML group (r = -0.709, P＜0.01). Comparison of serum lncRNA-MALAT-1 and miR-143 expression in AML patients with different white blood cell counts, bone marrow primitive cell ratios, and prognostic risk stratification showed statistically significant differences (P＜0.05). Comparison of survival curves between the high expression group and the low expression group of lncRNA- MALAT-1 showed a statistically significant difference (P＜0.05); Comparison of survival curves between the high expression group and the low expression group of miRNA showed a statistically significant difference overall survival rate was higher in the miR-143 high expression group than in the miR-143 low expression group (P＜0.05). Conclusion High expression of serum lncRNA-MALAT-1 and low expression of miR-143 in AML patients is associated with leukocyte count, bone marrow primitive cell ratio, prognostic risk stratification and prognosis.
		2022 Vol. 19 (35): 101-105 [Abstract] ( 24 ) HTML (1 KB) PDF (775 KB) ( 39 )

	106	Clinical effect of Pabolizumab on cutaneous malignant melanoma
		YAO Yuchi1 WU Min2▲
		DOI: 10.20047/j.issn1673-7210.2022.35.24
		Objective To explore the clinical effect of Pabolizumab in the treatment of cutaneous malignant melanoma. Methods A total of 64 patients with cutaneous malignant melanoma admitted to the Huai’an First Affiliated Hospital of Nanjing Medical University from March 2019 to January 2021 were selected as the research objects, and they were divided into study group and control group by random number table method, with 32 cases in each group. The control group was treated with surgery combined with chemotherapy, and the study group was treated with Pabolizumab on the basis of the control group. After four months of treatment, the clinical efficacy, quality of life, and adverse reactions of the two groups were evaluated, and the 1-year was recorded by follow-up. Results The disease control rate of the study group was higher than that of the control group, and the difference was statistically significant (P＜0.05); there was no significant difference in clinical remission rate between the two groups (P＞0.05). After treatment, the scores of social function, psychological function, and physical function of the two groups were higher than those before treatment, and the study group was higher than the control group (P＜0.05). The total incidence of adverse reactions in the study group was higher than that in the control group (P＜0.05). The survival curve of the study group was higher than that of the control group (P＜0.05). Conclusion Pabolizumab can significantly improve the disease control rate in the treatment of cutaneous malignant melanoma. There may be adverse reactions such as abnormal thyroid function， but the patients can tolerate it.
		2022 Vol. 19 (35): 106-109,134 [Abstract] ( 25 ) HTML (1 KB) PDF (784 KB) ( 260 )

	110	Mesh meta-analysis of multiple regimens for the treatment of ulcerative colitis with syndrome of intermingled heat and cold
		LIU Shenfan1 GONG Yucheng2 KOU Mengjia2 WANG Zhibin2
		DOI: 10.20047/j.issn1673-7210.2022.35.25
		Objective To compare the efficacy of multiple regimens for ulcerative colitis (UC) with syndrome of intermingled heat and cold by mesh meta-analysis. Methods Randomized controlled trials (RCT) on intervention in the treatment of UC with syndrome of intermingled heat and cold were collected by searching CNKI, Wanfang Data, VIP, PubMed, Embase, and Web of Science. The clinical total effective rate of the included literatures was analyzed by Stata 15.0 and gemtc software package of R 3.6.1. Results A total of 33 RCTs were included, involving 2 263 patients. It includes eight schemes (scheme A [oral Chinese medicine], scheme B [oral Chinese medicine + Chinese medicine enema], scheme C [oral Chinese medicine + western medicine], scheme D [oral Chinese medicine + western medicine + Chinese medicine enema], scheme a [oral western medicine + western medicine enema], scheme b [oral western medicine + western medicine enema], scheme d [oral western medicine + Chinese medicine enema], and scheme e [Chinese medicine enema]). The results of mesh meta-analysis comparing the clinical total effective rate of eight schemes showed that scheme B was higher than scheme a [OR＝9.12, 95%CI: 2.38-42.82], scheme b [OR＝2.64, 95%CI: 1.11-6.61], scheme d [OR＝2.85, 95%CI: 1.20-7.03], and scheme e [OR＝10.32, 95%CI: 1.68-81.73], scheme A [OR＝2.46, 95%CI: 1.30-4.18], scheme C [OR＝4.80, 95%CI: 3.22-7.31], scheme D [OR＝3.71, 95%CI: 1.21-13.18] were higher than those of scheme a, and scheme C was higher than scheme A [OR＝0.52, 95%CI: 0.24-0.98], the differences were statistically significant (P＜0.05). The ranking probability of each scheme in descending order is as follows: scheme B＞scheme C＞scheme D＞scheme d＞scheme A＞scheme b＞scheme a＞scheme e. Conclusion The efficacy of Chinese medicine and the integration of traditional and western medicine in the treatment of UC with syndrome of intermingled heat and cold is better than that of western medicine, and oral Chinese medicine combined with Chinese medicine enema may be the best clinical treatment of UC with syndrome of intermingled heat and cold.
		2022 Vol. 19 (35): 110-114 [Abstract] ( 25 ) HTML (1 KB) PDF (1416 KB) ( 36 )

	116	Application effect of thoracoscopy without tube in the resection of pulmonary bullae
		WEI Shenhai1 TIAN Yulin2 WU Bingqun1 HU Pengcheng1 TIAN Jintao1 SONG Xiaoping1 PAN Shouqiang1
		DOI: 10.20047/j.issn1673-7210.2022.35.26
		Objective To evaluate the advantages and safety of thoracoscopy without tube in the resection of pulmonary bullae. Methods Fifty-one patients in the First Hospital of Tsinghua University from July 2017 to April 2021 planned to undergo the resection of pulmonary bullae due to pneumothorax were selected as the research objects and divided into the thoracoscopy without tube group and thoracoscopy with tracheal intubation group according to their wishes. In the thoracoscopy without tube group, 20 patients underwent the resection of pulmonary bullae by thoracoscopy without tube. In the thoracoscopy with tracheal intubation group, 31 patients underwent the resection of pulmonary bullae by thoracoscopy with tracheal intubation. The duration of anesthesia, operation time, minimum pulse oxygen saturation during the operation, blood loss during the operation, postoperative retention time in the operating room, retention time of drainage tube, postoperative addition of painkillers, postoperative hospital stay, occurrence of cough or pharyngeal discomfort within one month after the operation, and recurrence of pneumothorax within six months after the operation were recorded and compared between the two groups. Results The duration of anesthesia and postoperative retention time in the operating room in the thoracoscopy without tube group were shorter than those in the thoracoscopy with tracheal intubation group, the minimum pulse oxygen saturation during the operation and the occurrence of cough or pharyngeal discomfort within one month after the operation were lower than those in the thoracoscopy with tracheal intubation group, the differences were statistically significant (P＜0.05). There were no significant differences in the retention time of drainage tube, postoperative addition of painkiller, postoperative hospital stay, and recurrence of pneumothorax within six months after the operation between the two groups (P＞0.05). Conclusion Thoracoscopy without tube in the resection of pulmonary bullae can shorten the time of anesthesia and reduce postoperative complications such as cough and pharyngeal discomfort, which is safe and reliable and worthy of further promotion.
		2022 Vol. 19 (35): 116-119 [Abstract] ( 21 ) HTML (1 KB) PDF (489 KB) ( 36 )

	120	Study on point selection rule of acupuncture treatment for pruritus based on data mining
		XU Jing1 ZHAO Baixiao2 DUAN Xingwu3 ZHU Zebing1 LI Danyang1 LIU Yajie1
		DOI: 10.20047/j.issn1673-7210.2022.35.27
		Objective To explore the point selection rules, association rules and mechanism of action of acupuncture in the treatment of pruritus through data mining. Methods The clinical research literatures on the treatment of pruritus by acupuncture from China National Knowledge Infrastructure, Chinese Biology Medicine, Wanfang Data, VIP, and PubMed database were retrieved from the inception to December 2021 and the data was established. The main point association rules and cluster analysis were analyzed by using software to calculate the frequency and channel tropism of points. Results A total of 90 literatures were collected, involving 102 points, and the total frequency of points was 615, including 77 specific points and 485 specific points. The top five points used most frequently were xuèhǎi, qūchí, zúsānlǐ, sānyīnjiāo and hégǔ. The most selected points were the large intestine channel and the spleen channel. In addition to the ashi point, the 101 points were mainly distributed on the limbs, followed by the waist and back. In all the specific points, the he-sea point was used the most frequently. In the analysis of association rules, five strong links were obtained, which were: xuèhǎi-qūchí, xuèhǎi-zúsānlǐ, qūchí -zúsānlǐ, xuèhǎi-sānyīnjiāo, and zúsānlǐ-sānyīnjiāo. The 25 most frequent points were selected for cluster analysis, and seven effective clusters were obtained, which were: fēngshì-bǎich?仵ngwō, géshù -fēngmén-wěizhōng, fēngchí-fēngfǔ-dàzhuī-bǎihuì, gānshù-píshù-fèishù-shènshù, yánglíngquán, wàiguān-zhōngwǎn, and zúsānlǐ-sānyīnjiāo-xuèhǎi-qūchí-hégǔ-shénmén-guānyuán-tàichōng-yīnlíngquán. Conclusion The most frequent point selection is xuèhǎi, and the specific point is mainly he-sea point, and the points of the large intestine channel and the spleen channel are more taken. The core of the point compatibility is xuèhǎi, qūchí, and sānyīnjiāo. The selection of points for the treatment of pruritus reflected the thought of syndrome differentiation and treatment in traditional Chinese medicine, emphasizing the interplay between channel circulation and channel qi, and the use of specific points.
		2022 Vol. 19 (35): 120-124 [Abstract] ( 12 ) HTML (1 KB) PDF (1364 KB) ( 212 )

	125	Study on the rule of medication in the treatment of hypertension with anxious neurosis based on the implicit structure model
		LIN Ping1 CUI Weifeng2 QING Hui2 LI Ling3 LEI Siyuan1
		DOI: 10.20047/j.issn1673-7210.2022.35.28
		Objective To explore the rule of medication based on syndrome differentiation in treating hypertension with anxious neurosis based on the implicit structure model, and to provide evidence for clinical syndrome differentiation and medication. Methods A total of 180 patients with hypertension with anxious neurosis who were outpatients or inpatients in the Department of Hypertension, the Affiliated Hospital of Henan Academy of Traditional Chinese Medicine and Henan Provincial People’s Hospital from January 2018 to August 2020 were collected through a unified clinical information collection table. The implicit structure model of Lantern 5.0 was constructed with symptoms and Chinese medicine as the factors, and implicit interpretation was carried out, and SAS 10.0 was used to mine the association rules of drug-drug and drug-symptom. Results Six common witness types of hypertension with anxious neurosis were summarized, which were syndrome of hyperactivity of yang due to yin deficiency, syndrome of stagnation of liver qi and spleen deficiency, syndrome of phlegm-turbidity accumulated in interior, syndrome of deficiency of both heart and spleen, syndrome of kidney yin insufficiency, syndrome of qi stagnation and blood stasis. Commonly used drugs were Poria, Gastrodiae Rhizoma, Citri Reticulatae Pericarpium, Glycyrrhizae Radix Et Rhizoma Praeparata Cum Melle, Pinelliae Rhizoma, Angelicae Sinensis Radix, Atractylodis Macrocephalae Rhizoma, Bupleuri Radix, Chuanxiong Rhizoma, Scutellariae Radix, Ziziphi Spinosae Semen Tostum, Paeoniae Radix Alba, Uncariae Ramulus Cum Uncis, Gardeniae Fructus, Codonopsis Radix, etc. Commonly used formulations were Tianma Gouteng Drink, Suanzaoren Decoction, Erchen Decoction, Chaiqin Decoction, Qiju Dihuang Decoction,Chaihu Shugan Powder, etc. Conclusion The patients with hypertension with anxious neurosis are mostly phlegm and turbidities. The treatment is based on syndrome differentiation, such as dispersing liver and regulating qi, nourishing liver and kidney, promoting blood circulation for removing blood stasis, nourishing heart for tranquillization and so on. The roots are treated following the principles of invigorating the spleen and eliminating phlegm, and symptoms following the principles of regulating qi, invigorating blood, nourishing yin, and soothing the nerves.
		2022 Vol. 19 (35): 125-129,139 [Abstract] ( 12 ) HTML (1 KB) PDF (1671 KB) ( 46 )

	130	Acupoint selection rules of acupuncture in the treatment of perimenopausal insomnia based on data mining
		LIU Yanran1 QIANG Xia1 HE Nan1 GUO Xinrong1 WANG Weigang2
		DOI: 10.20047/j.issn1673-7210.2022.35.29
		Objective To analyze the acupoint selection rules of acupuncture in the treatment of perimenopausal insomnia based on data mining. Methods The relevant literatures of China National Knowledge Infrastructure, Wanfang Data Knowledge Service Platform and China Biology Medicine from November 2011 to November 2021 on acupuncture in the treatment of perimenopausal insomnia were searched by computer. SPSS Modeler 18.0 Apriori algorithm was used to analyze the association rules of acupoints and draw a complex network diagram. SPSS Statistics 25.0 was adopted to cluster acupoints and draw a tree diagram. Results Finally, a total of 51 articles were included, with 51 point prescriptions, and 74 acupoints were involved. The most frequent points were sānyīnjiāo, shénmén, and xīnshù. The top three channels were taiyang bladder channel of foot, governor channel, conception channel. There were 37 points involved in special acupoints, and the top three points were back-shu point, yuan-primary point and shu-stream point. Association rules were analyzed on the top 20 acupoints with the highest frequency, and 18 strong association rules were obtained. There were mainly five groups of acupoint compatibility. Conclusion The treatment of perimenopausal insomnia should pay attention to the regulation of the functions of the viscera, regulate thoroughfare channel, conception channel and governor channel according to the physiological characteristics of perimenopausal women, and regulate the mind according to the pathological state of insomnia.
		2022 Vol. 19 (35): 130-134 [Abstract] ( 14 ) HTML (1 KB) PDF (1467 KB) ( 35 )

	135	Visualization analysis of softening hardness and dispersing mass in traditional Chinese medicine based on CiteSpace
		LI Siting WANG Zhiguo
		DOI: 10.20047/j.issn1673-7210.2022.35.30
		Objective To analyze the research status, hotspot and development trend of softening hardness and dispersing mass of traditional Chinese medicine by using visualization software CiteSpace. Methods The relevant literature on softening hardness and dispersing mass from the inception of the China National Knowledge Infrastructure database to March 2022 was searched by computer. CiteSpace software was used for visual analysis of authors, research institutions and keywords. Results A visual analysis was conducted on 1 689 articles from 1998 to 2022. The core authors were represented by Zhang Junping, Ye Xiaohan and Gao Tianshu. Major research institutions included Tianjin University of Traditional Chinese Medicine, the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, etc. High frequency keywords involved five categories of research types and methods, disease treatment, commonly used drugs, combined therapy and mechanism research. Research on diseases had shifted from endometriosis, hysteromyoma, breast hyperplasia to atherosclerosis, coronary heart disease, pulmonary nodules, etc. The transformation of empirical results had been emphasized, and research methods had expanded data mining, cluster analysis, and other methods on the basis of clinical research and clinical experience. Conclusion Data mining, clustering analysis, and other research and analysis methods are the current research focus. The clinical research of softening hardness and dispersing mass in the treatment of micro-accumulation diseases and achievement transformation of empirical prescriptions are the research trend in the future.
		2022 Vol. 19 (35): 135-139 [Abstract] ( 15 ) HTML (1 KB) PDF (1750 KB) ( 23 )

	140	Clinical effect of treating lumbar disc herniation of qi stagnation and blood stasis by Lingshu Kaihe acupuncture
		HAO Shuai1 YUAN Yundong1 WANG Yanjun2 QI Liqing3
		DOI: 10.20047/j.issn1673-7210.2022.35.31
		[Abstract] Objective To investigate use the clinical effect of Lingshu Kaihe acupuncture on lumbar disc herniation of qi stagnation and blood stasis. Methods A total of 80 patients with lumbar disc herniation of qistagnation and bloodstasis type admitted to the Third Department of Orthology, Hebei Hospital of Traditional Chinese Medicine from August 2020 to October 2021 were selected and they there divided into the treatment group (treated with Lingshu Kaihe acupuncture) and the control group (treated with ordinary acupuncture) by random number table method, with 40 cases in each group. Both groups were treated continuously for two weeks. The visual analogue scale (VAS), the Japanese Orthopaedic Association Evaluation Therapy (JOA) score, and the levels of interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) were compared between the two groups before and after treatment, and the improvement of lumbar and lower limb pain symptoms was evaluated. Results After treatment, VAS scores of the two groups were lower than that those before treatment, JOA scores were higher than that those before treatment, and VAS score of the treatment group was lower than that of the control group, and JOA score was higher than that of the control group (P＜0.05). After treatment, the levels of L-1β and TNF-α of the two groups were lower than those before treatment, and the treatment group was lower than the control group (P＜0.05). Conclusion Lingshu Kaihe acupuncture is effective in the treatment of qi stagnation and blood stasis type lumbar disc herniation, which can significantly reduce inflammatory indicators, relieve pain and improve the quality of life.
		2022 Vol. 19 (35): 140-143 [Abstract] ( 15 ) HTML (1 KB) PDF (627 KB) ( 28 )

	144	Exploreing the rules of the prescription medication for the treatment of urinary diseases in the Selected Clinical Cases of Zhao Shaoqin based on data mining
		YANG Peng1 LIU Tonghua2 WU Lili2 QIN Lingling2 ZHANG Chengfei2 PENG Chuan2 ZHANG Qiu’e2
		DOI: 10.20047/j.issn1673-7210.2022.35.32
		Objective To analyze the ideas of formulae for the treatment of urological diseases in Selected Clinical Cases of Zhao Shaoqin, and to explore the rules and characteristics of Zhao Shaoqin’s clinical treatment of urological system. Methods The database was established with the medical cases involving urinary system diseases in Selected Clinical Cases of Zhao Shaoqin, Excel, SPSS and IBM SPSS Modeler statistical software were used to conduct disease distribution statistics, drug frequency statistics, sex and taste normalization statistics, efficacy classification statistics, drug pairs, angle drugs, prescription rules and cluster factor extraction of new formula analysis. Results Uremia was the most frequently discussed medical case in the database. The two herbs with the highest frequency were garden burnet root and divaricate saposhnikovia root; drug multiple cold; the most bitter taste; more return to the liver meridian; the most frequently used drugs were hemostatic agents and antipyretic agents. The core drug pairs and angle drug were obtained by association analysis, such as divaricate saposhnikovia root, danshen root-garden burnet root, madder-divaricate saposhnikovia root, garden burnet root. Three core drug combinations were sorted out by cluster analysis. Factor analysis showed that there were six groups of principal components. Conclusion Zhao Shaoqin’s treatment of urological diseases emphasized the use of ying-blood component drugs, taking into account the wei-qi component, and the use of cold and bitter drugs, mostly using liver meridian drugs.
		2022 Vol. 19 (35): 144-147,156 [Abstract] ( 12 ) HTML (1 KB) PDF (1146 KB) ( 37 )

	148	Effects of acupuncture and moxibustion combined with five elements music therapy on anxiety and depression, sleep quality, and quality of life in patients with early-onset ovarian insufficiency with spleen-kidney yang deficiency type
		SHI Jufang SUN Hongyan▲ SUN Li LIU Chunli LIANG Zhichao YANG Hui
		DOI: 10.20047/j.issn1673-7210.2022.35.33
		Objective To explore the effects of acupuncture and moxibustion combined with five elements music therapy on anxiety and depression, sleep quality, and quality of life in patients with early-onset ovarian insufficiency of spleen-kidney yang deficiency type. Methods A total of 83 patients with early-onset ovarian insufficiency of spleen-kidney yang deficiency type in Shijiazhuang Municipal Hospital of Traditional Chinese Medicine from September 2020 to September 2021 were selected. They were divided into observation group (41 cases) and control group (42 cases). The patients in the control group were treated with acupuncture and moxibustion, and the observation group was treated with five element music therapy on the basis of control group, the treatment lasted for three months. Symptom scores, Pittsburgh sleep quality index scale (PSQI), quality of life scale-100 (QOL-100) were compared between two groups before treatment, one and three months after treatment; the scores of self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were compared between two groups before treatment and three months after treatment. Results After one and three months of treatment, symptom scores and PSQI scores of two groups were lower than those before treatment; after three months of treatment, symptom scores and PSQI scores in both groups were lower than those after one month of treatment (P＜0.05). After one and three months of treatment, symptom scores and PSQI scores in observation group were lower than those in control group (P＜0.05). After three months of treatment, the SAS and SDS scores of two groups were lower than those before treatment, and observation group was lower than control group (P＜0.05). After one and three months of treatment, QOL-100 scores in both groups were higher than those before treatment; after three months of treatment, the QOL-100 scores in both groups were higher than those after one month of treatment, the QOL-100 scores of observation group was higher than those of control group (P＜0.05). Conclusion Acupuncture and moxibustion combined with five elements music therapy can effectively alleviate the symptoms of patients with early-onset ovarian insufficiency of spleen-kidney yang deficiency type, reduce their anxiety and depression, and improve their sleep quality and quality of life, which is worthy of clinical promotion.
		2022 Vol. 19 (35): 148-151 [Abstract] ( 12 ) HTML (1 KB) PDF (522 KB) ( 45 )

	152	Clinical experience on channel palpation method combined with qi transformation-and-transportation of six channels by Professor Wang Juyi in treating primary headache
		SUN Jie1 MENG Xiaonan2
		DOI: 10.20047/j.issn1673-7210.2022.35.34
		Primary headache is one kind of headache disease, of which the etiology and pathogenesis are complex. Professor Wang Juyi, a famous doctor in the capital and a master of meridian medicine, believes that the idea of acupuncture and moxibustion in treating primary headache should not be limited to the differentiation of viscera, qi and blood, or the selection of points at local pain points, should be based on syndrome differentiation of meridians. Professor Wang Juyi advocates the application of channel palpation, not only includes local pain, but also focuses on the location along the distal part of the corresponding meridians to identify the diseased meridians and the deficiency and excess. With the help of the qi transformation-and-transportation of six channels, distinguish the “disease complex” or “complication disease” of multiple meridians, and show the characteristics of the same name and transmission of external and internal meridians. All meridians can be selected simultaneously during treatment. Reduce local acupoint selection, attach importance to the selection of specific acupoints of the same name meridian of hands and feet, and seek the same breath to improve clinical efficacy. This article introduces channel palpation method combined with qi transformation-and-transportation of six channels in treating primary headache, hoping to provide new ideas for its clinical treatment.
		2022 Vol. 19 (35): 152-156 [Abstract] ( 13 ) HTML (1 KB) PDF (679 KB) ( 238 )

	157	Effect of cross-media health education on self-care ability and adaptability of patients with enterostomy
		YANG Yang WANG Wenshuang XIAN Hongtao SHAO Yinfang WANG Xinran▲
		DOI: 10.20047/j.issn1673-7210.2022.35.35
		Objective To explore the effect of cross-media health education on self-care ability and adaptability of patients with enterostomy. Methods A total of 66 patients with enterostomy admitted to Xuanwu Hospital, Capital Medical University from August 2018 to May 2020 were selected as the research objects. According to the random number table method, the patients were divided into control group and intervention group, control group 35 cases, intervention group 31 cases. The patients in the control group were given routine health education, and the intervention group was given cross-media health education on the basis of the control group. The self-care ability and the level of postoperative psychosocial adaptation were compared one day before discharge, one month after discharge, and three months after discharge. Results The overall analysis found that the differences between the two groups, time points and interaction were statistically significant (P＜0.05); further analysis and intra-group comparison: there were statistically significant differences in the scores of self-care ability of the two groups at each time point (P＜0.05), comparison between groups: one and three months after discharge, the self-care ability of the intervention group was higher than that of the control group, the differences were statistically significant (P＜0.05); further analysis and intra-group comparison: the stoma adaptability scores of each time point in the intervention group were compared, and the differences were statistically significant (P＜0.05). Comparison between groups: one day before and three months after discharge, the stoma adaptability score of the intervention group was higher than that of the control group, and the differences were statistically significant (P＜0.05) Conclusion The cross-media health education can effectively improve the self-care ability of patients with enterostomy, promote early adaptation to the stoma, and improve postoperative quality of life.
		2022 Vol. 19 (35): 157-160,168 [Abstract] ( 11 ) HTML (1 KB) PDF (707 KB) ( 100 )

	161	Application of the joint Status-Background-Assessment-Suggestion communication mode of the pediatric early warning system in the determination of the condition of critically ill children kept in hospital
		WANG Qing CHANG Chunrong WANG Weifang ZHENG Shaomin▲
		DOI: 10.20047/j.issn1673-7210.2022.35.36
		Objective To investigate the application of the combined status-background-assessment-recommendation (SBAR) communication model of the pediatric early warning system (PEWS) in the determination of the condition of critically ill children who were kept on hold. Methods The clinical data of 200 children in the emergency detention area of Hebei Children’s Hospital from July 2019 to June 2020 were retrospectively analyzed, and the children were divided into control group and study group according to the mode of care, with 100 cases in each group. In the control group, routine consultation and treatment were performed, while in the study group, routine consultation and treatment+PEWS+SBAR were performed, and the length of stay, unplanned PICU admission rate, disability rate, morbidity and mortality rate, and satisfaction of the child’s family were counted and compared. Results There was no statistically significant difference in the PEWS scores between the two groups (P＞0.05). The retention time in the study group was shorter than that in the control group, and the difference was statistically significant (P＜0.05). The rate of unplanned PICU admission in the study group was lower than that in the control group, and the difference was statistically significant (P＜0.05). There was no statistically significant difference between the two groups in terms of disability and morbidity and mortality rates (P＞0.05). The overall satisfaction rate of family members in the study group was higher than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion The use of PEWS+SBAR communication model in critically ill children in the emergency holding room can effectively shorten the stay of children, reduce the unplanned PICU admission rate, and improve family satisfaction.
		2022 Vol. 19 (35): 161-164 [Abstract] ( 9 ) HTML (1 KB) PDF (570 KB) ( 176 )

	165	Effects of improved nutritional pathway management on nutritional indexes and grade of kobuta water swallow test in patients with dysphagia after ischemic stroke
		JIANG Zhu CHEN Weiyan CHEN Jia SHEN Yun▲
		DOI: 10.20047/j.issn1673-7210.2022.35.37
		Objective To observe the effects of improved nutritional pathway management on nutritional indexes and grade of kobuta water swallow test in patients with dysphagia after ischemic stroke. Methods A total of 198 stroke patients with dysphagia admitted to the Department of Neurology of Wuxi People’s Hospital, Jiangsu Province from January 2019 to April 2021 were selected, they were divided into control group and observation group, by random number table method, with 99 cases in each group. The control group received conventional nutrition management, and the observation group received improved nutrition path management, hemoglobin (Hb), prealbumin (PA), albumin (Alb), and swallowing function of the two groups were compared. Results After nursing, the levels of Hb and Alb in control group were higher than before nursing, the levels of Hb, PA and Alb in observation group were higher than before nursing, and the observation group was higher than control group (P＜0.05); the kobuta water swallow test grading of the two groups was better than before nursing, and the observation group was better than the control group (P＜0.05). Conclusion Improved nutritional pathway management can improve the nutritional status and swallowing function of stroke dysphagia, which has a certain nursing reference value.
		2022 Vol. 19 (35): 165-168 [Abstract] ( 11 ) HTML (1 KB) PDF (557 KB) ( 93 )

	169	Effect of nutrient intake method based on food viscosity adjustment on immune and nutritional function of patients with radiotherapy after laryngeal cancer surgery
		ZHUANG Yu1 WANG Juan1 BIAN Lijuan2▲
		DOI: 10.20047/j.issn1673-7210.2022.35.38
		Objective To analyze the influence of nutrient intake method based on food viscosity adjustment on the immunity and nutritional function in patients with radiotherapy after laryngeal cancer surgery. Methods A total of 296 patients with radiotherapy after laryngeal cancer surgery admitted to the Department of Oncology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School from November 2017 to October 2021 were selected and divided into study group (148 cases) and control group (148 cases) by random number table method. The study group received nutrition intake method based on food viscosity adjustment, while the control group received routine dietary health guidance. The nutritional status and immune function indexes of the two groups were compared after two months. Results After intervention, albumin, prealbumin, and transferrin in two groups were higher than those before intervention, and the study group was higher than the control group, the differences were statistically significant (P＜0.05). The levels of CD3+, CD4+, CD4+/CD8+ in both groups were higher than those before intervention, and the study group was higher than the control group, the differences were statistically significant (P＜0.05). Conclusion The implementation of nutrition intake dietary health guidance based on food viscosity adjustment for patients with radiotherapy after laryngeal cancer surgery can effectively restore and stabilize the nutritional state, enhance immune function, and contribute to promoting the outcome of the disease, which has clinical research and promotion value.
		2022 Vol. 19 (35): 169-171,180 [Abstract] ( 9 ) HTML (1 KB) PDF (604 KB) ( 55 )

	172	Effect of collaborative nursing on self-management ability and health behavior in elderly patients with coronary heart disease after PCI under TTM
		DUAN Wenjie1 LI Xiaoqiong2 JIANG Yanyan2 XIAO Bilian2 LIU Na3▲
		DOI: 10.20047/j.issn1673-7210.2022.35.39
		Objective To investigate the effect of collaborative nursing under cross transtheoretical model (TTM) in elderly patients with coronary heart disease after percutaneous coronary intervention (PCI). Methods A total of 100 elderly patients with coronary heart disease who received PCI in the Third Clinical Medical College of China Three Gorges University from January 2019 to December 2021 were selected. According to the random number table method, the patients were divided into the reference group and the research group, with 50 cases in each group. The reference group was given routine nursing and the study group was given collaborative nursing under TTM. After three months, self-management ability, health behavior, postoperative bleeding, and the occurrence of negative events were compared between the two groups. Results After three months of follow-up, the scores of health promotion lifestyle profile Ⅱ and self-care ability scale in both groups were higher than before intervention, and the research group was higher than the reference group, the differences were statistically significant (P＜0.05). The incidence of internal bleeding events and negative events in the research group was lower than that in the reference group, the differences were statistically significant (P＜0.05). Conclusion Collaborative nursing under TTM can improve the self-management ability of elderly patients with coronary heart disease after PCI, improve their health behaviors, and help reduce the occurrence of postoperative bleeding and negative events.
		2022 Vol. 19 (35): 172-175 [Abstract] ( 12 ) HTML (1 KB) PDF (564 KB) ( 41 )

	176	Effect of extended nursing based on information short distance communication on children with leukemia and their families
		YANG Ting WANG Yanqing TONG Chanjuan
		DOI: 10.20047/j.issn1673-7210.2022.35.40
		Objective To explore the effect of extended nursing based on information short distance communication on children with leukemia and their families. Methods A total of 120 children with leukemia and 120 family members who were diagnosed and treated in Children’s Hospital Affiliated to Zhejiang University School of Medicine from December 2019 to December 2021 were selected. They were divided into routine group and intervention group by random number table method, with 60 children and 60 family members in each group. The routine group received routine nursing intervention, and the intervention group received extended nursing based on information short-distance communication on the basis of the routine group. The knowledge cognition, hope level and psychological resilience of children were compared after three weeks of intervention. Results After intervention, the scores of leukemia knowledge cognition of family members in the two groups were higher than those before intervention, and the intervention group was higher than the routine group, and the differences were statistically significant (P ＜ 0.05); the resilience scale scores of the two groups were higher than those before intervention, and the intervention group was higher than the conventional group, and the differences were statistically significant (P ＜ 0.05); the Herth hope scale scores of family members in the two groups were higher than those before intervention, and the scores of the intervention group were higher than those of the conventional group, and the differences were statistically significant (P ＜ 0.05). Conclusion To give leukemia children based on information short distance communication extended care, can help the family to improve disease knowledge cognition, enhance the hope level of the family and children with mental flexibility.
		2022 Vol. 19 (35): 176-180 [Abstract] ( 11 ) HTML (1 KB) PDF (683 KB) ( 144 )

	181	Nursing effect of acceptance and commitment therapy in postoperative patients with glioma
		WANG Li ZHANG Lingxia▲
		DOI: 10.20047/j.issn1673-7210.2022.35.41
		Objective To observe the intervention effect of acceptance and commitment therapy in postoperative patients with glioma. Methods A total of 100 patients with glioma who received craniotomy in the Nanjing First Hospital, Jiangsu Province from January 2017 to January 2021 were selected, and they were divided into observation group and control group, with 50 cases in each group by random number table method. The control group received routine surgical intervention after operation, and the observation group received acceptance and commitment therapy intervention, both groups intervened until patients were discharged. The negative emotions (self-rating anxiety scale [SAS], self-rating depression scale [SDS]), psychological flexibility acceptance, and action questionnaire ([AAQ-Ⅱ] and post-traumatic growth level post-traumatic growth questionnaire [PTGI]) of patients in both groups before intervention and at discharge were assessed, and compared the evaluation results between the two groups. Results The SAS and SDS scores of both groups at discharge were decreased than those before intervention, and the scores of the observation group were significantly lower than those of the control group, the differences were statistically significant (P＜0.05). The AAQ-Ⅱ score of the two groups was lower than before intervention, and the PTGI score was higher than before intervention, and the observation group was lower than the control group, and the PTGI score was higher, the differences were statistically significant (P＜0.05). Conclusion Acceptance and commitment therapy for intervention in patients after glioma surgery can significantly reduce negative emotion, improve psychological flexibility and is beneficial to improve the level of post-traumatic growth.
		2022 Vol. 19 (35): 181-184 [Abstract] ( 9 ) HTML (1 KB) PDF (598 KB) ( 158 )

	185	Application effect of specialized pain intervention in patients with perianal abscess surgery
		LIU Liping1 XU Xiangjun1 KONG Zhenzhi2 QI Ru1 GAO Lin1
		DOI: 10.20047/j.issn1673-7210.2022.35.42
		Objective To explore the application effect of specialized pain intervention in patients with perianal abscess surgery. Methods A total of 100 patients with perianal abscess who received one-time radical surgery in Affiliated Hospital of Jining Medical College from August 2021 to February 2022 were selected. They were divided into control group and observation group, with 50 cases in each group by random number table method. The control group received routine nursing, and the observation group received specialized pain intervention on the basis of routine nursing. The degree of postoperative pain, complications, wound healing, and recovery time of the two groups were observed. Results The comparison of visual analog scale (VAS) scores at each postoperative time point between the two groups, the differences was statistically significant (P＜0.05), and the VAS scores at each postoperative time point in the observation group were lower than those in the control group, the differences was statistically significant (P＜0.05); the total incidence of postoperative urinary retention, constipation, anal pain， and other complications in the observation group was lower than that in the control group, the differences were statistically significant (P＜0.05); the wound healing scores of the two groups at each postoperative time point, the differences was statistically significant (P＜0.05), and the wound healing scores of the observation group were lower than those of the control group at each postoperative time point, the differences were statistically significant (P＜0.05). The mean time of wound healing and hospitalization in the observation group was shorter than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion Specialized pain intervention strategy applied in the surgical treatment of perianal abscess patients can help patients better relieve the degree of postoperative pain, reduce postoperative complications, promote postoperative wound healing faster, and effectively shorten the postoperative rehabilitation time of patients.
		2022 Vol. 19 (35): 185-188 [Abstract] ( 10 ) HTML (1 KB) PDF (590 KB) ( 87 )

	189	Application and thinking of simulator teaching in clinical medical skills training
		ZHANG Jing1 RUI Na1 RAN Hong2 ZHANG Pingyang2▲
		DOI: 10.20047/j.issn1673-7210.2022.35.43
		Clinical medicine is a highly practical discipline. For a long time, clinical skills training of medical students has been carried out on patients by participating in the diagnosis and treatment process. However, as the scope of clinical practice of medical students is restricted by Law of the People’s Republic of China on Medical Practitioners, coupled with the influence of multiple factors such as the increasing awareness of patients’ rights protection and the tense relationship between doctors and patients in recent years, traditional teaching methods are often difficult to implement. If students stick to the learning approach mainly based on observation, the effect of clinical skills training is not very satisfactory. Simulator teaching has been promoted with the continuous development of electronic computer technology in medical education. In recent years, multi-functional system simulation or virtual training system simulators have been promoted, which are mainly used in ultrasound medicine, anesthesia, surgery, obstetrics, ophthalmology, etc. The application results show that the effect and advantages of simulator teaching to improve clinical skills training are affirmative, which can be promoted in application of multi-level trainees and multi-professions. However, it must be pointed out that simulator teaching is only a learning method, which has to be carried out on basis of the high-quality theoretical knowledge education. Standard teaching scheme and high quality plan execution are the core links of simulator teaching quality assurance, and the selection of specific teaching methods should be flexible.
		2022 Vol. 19 (35): 189-192 [Abstract] ( 10 ) HTML (1 KB) PDF (596 KB) ( 97 )

	193	Research on the application of traditional Chinese medicine knowledge in medical insurance reform
		ZHAO Zhupei LIU Qian ZHU Tingyu SHI Xueqin ZHANG Fengxia AN Hong LI Yu LIU Jianfeng
		DOI: 10.20047/j.issn1673-7210.2022.35.44
		The “healthy China” strategy elevates safeguarding people’s health to a national strategic level, and medical security is the overall requirement and strong support for the implementation of the strategy. The state attaches great importance to and promotes the development of traditional Chinese medicine. With its extensive cultural and technical content, traditional Chinese medicine should give full play to its unique advantages in preventing and treating diseases, improve people’s health and contribute to the building of a healthy China. Traditional Chinese medicine knowledge is an important part of traditional Chinese medicine. Collecting, sorting out, studying and promoting it and applying it in medical insurance reform can promote it. This paper explains the application of traditional Chinese medicine knowledge in medical insurance reform from the aspects of improving the use efficiency of medical insurance funds, strengthening the role of medical treatment and rehabilitation, enhancing the service level of primary medical institutions to promote hierarchical diagnosis and treatment, strengthening the ability of telemedicine service, promoting the rational application of new artificial intelligence technology, and promoting the development of commercial insurance.
		2022 Vol. 19 (35): 193-196 [Abstract] ( 13 ) HTML (1 KB) PDF (597 KB) ( 260 )

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