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Advances in the relationship between different biomarkers and traditional Chinese medicine syndrome types of heart failure |
GUO Yanan1 WANG Xiaoyan2▲ GAO Jialiang3 HE Hongtao1 WANG Sizhou1 WANG Yanwei1 GENG Bin1 ZHAO Tianzi1 |
1.Department of Cardiology, Hebei Province Hospital of Traditional Chinese Medicine, Hebei Province, Shijiazhuang 050011, China;
2.Department of Cardiology, Wangjing Hospital, China Academy of Chinese Medical Sciences,Beijing 100102, China;
3.Department of Cardiology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China |
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Abstract Heart failure is a complex clinical syndrome of end-stage cardiovascular disease. The classical and traditional biomarkers in clinical application include brain natriuretic peptide, N-terminal proBNP, cardiac troponin and traditional biomarkers of inflammation. Inflammation plays a key role in the occurrence and progression of heart failure, therefore, several novel biomarkers have been developed in recent years for diagnosis, prognosis, and treatment evaluation. The metabonomics and other “omics” biomarkers could reflect the metabonomic patterns of different traditional Chinese medicine syndrome types of heart failure, and supply a basis for the objective syndrome differentiation and treatment. This paper summarise the research progress of traditional biomarkers, new inflammatory biomarkers and metabolic biomarkers in the diagnosis and prognosis of heart failure. The relationship between different biomarkers and traditional Chinese medicine syndromes of heart failure was summarized. In order to lay a foundation for screening more biomarkers that can be used in the process of traditional Chinese medicine syndrome differentiation and treatment, so as to further improve the objective standard identification level of traditional Chinese medicine syndromes of heart failure.
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