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| Advances in the study of vitamin D and liver tissue damage associated with hepatitis B virus infection |
| LI Na1 MA Zhen2▲ |
1.Graduate School, Inner Mongolia Medical University, Inner Mongolia Autonomous Region, Hohhot 010050, China;
2.Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia Autonomous Region, Hohhot 010050, China |
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Abstract Viral hepatitis B is a serious health hazard for all human beings, and hepatitis B-related liver fibrosis, cirrhosis, and hepatocellular carcinoma are also the focus and difficulty of clinical treatment. In recent years, an increasing number of studies have demonstrated the close relationship between vitamin D deficiency and liver tissue damage due to viral hepatitis B. Vitamin D may slow down the process of liver injury by regulating hepatic stellate cells, immune cells; activating multiple pathways; and maintaining normal mitochondrial structure, function and oxidative capacity. Vitamin D receptor expression is closely related to the staging of liver injury. Vitamin D supplementation during antiviral therapy may reduce liver injury and improve prognosis in patients with hepatitis B.
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