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| Study on the rule of medication in the treatment of hypertension with anxious neurosis based on the implicit structure model |
| LIN Ping1 CUI Weifeng2 QING Hui2 LI Ling3 LEI Siyuan1 |
1.The First Clinical Medical College, Henan University of Chinese Medicine, Henan Province, Zhengzhou 450046, China;
2.Henan Academy of Traditional Chinese Medicine, Henan Province, Zhengzhou 450004, China;
3.Department of Hypertension, Henan Provincial People’s Hospital, Henan Province, Zhengzhou 450003, China |
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Abstract Objective To explore the rule of medication based on syndrome differentiation in treating hypertension with anxious neurosis based on the implicit structure model, and to provide evidence for clinical syndrome differentiation and medication. Methods A total of 180 patients with hypertension with anxious neurosis who were outpatients or inpatients in the Department of Hypertension, the Affiliated Hospital of Henan Academy of Traditional Chinese Medicine and Henan Provincial People’s Hospital from January 2018 to August 2020 were collected through a unified clinical information collection table. The implicit structure model of Lantern 5.0 was constructed with symptoms and Chinese medicine as the factors, and implicit interpretation was carried out, and SAS 10.0 was used to mine the association rules of drug-drug and drug-symptom. Results Six common witness types of hypertension with anxious neurosis were summarized, which were syndrome of hyperactivity of yang due to yin deficiency, syndrome of stagnation of liver qi and spleen deficiency, syndrome of phlegm-turbidity accumulated in interior, syndrome of deficiency of both heart and spleen, syndrome of kidney yin insufficiency, syndrome of qi stagnation and blood stasis. Commonly used drugs were Poria, Gastrodiae Rhizoma, Citri Reticulatae Pericarpium, Glycyrrhizae Radix Et Rhizoma Praeparata Cum Melle, Pinelliae Rhizoma, Angelicae Sinensis Radix, Atractylodis Macrocephalae Rhizoma, Bupleuri Radix, Chuanxiong Rhizoma, Scutellariae Radix, Ziziphi Spinosae Semen Tostum, Paeoniae Radix Alba, Uncariae Ramulus Cum Uncis, Gardeniae Fructus, Codonopsis Radix, etc. Commonly used formulations were Tianma Gouteng Drink, Suanzaoren Decoction, Erchen Decoction, Chaiqin Decoction, Qiju Dihuang Decoction,Chaihu Shugan Powder, etc. Conclusion The patients with hypertension with anxious neurosis are mostly phlegm and turbidities. The treatment is based on syndrome differentiation, such as dispersing liver and regulating qi, nourishing liver and kidney, promoting blood circulation for removing blood stasis, nourishing heart for tranquillization and so on. The roots are treated following the principles of invigorating the spleen and eliminating phlegm, and symptoms following the principles of regulating qi, invigorating blood, nourishing yin, and soothing the nerves.
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