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| The correlation between serum CA125, hs-CRP, and NLR and pelvic endometriosis stage and their predictive value in diagnosis |
| QIAN Yan JIN Maosheng YE Guoliu |
| Department of Obstetrics and Gynecology, the First Affiliated Hospital of Bengbu Medical College, Anhui Province, Bengbu 233000, China |
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Abstract Objective To analyzed the correlation between serum carbohydrate antigen 125 (CA125), high sensitivity C-reactive protein (hs-CRP), and neutrophil/lymphocyte ratio (NLR) and pelvic endometriosis (EMT) and their predictive value in diagnosis. Methods A total of 114 patients diagnosed and treated in the First Affiliated Hospital of Bengbu Medical College (hereinafter referred to as “our hospital”) from August 2018 to August 2020 and confirmed as EMT by postoperative pathology were selected as EMT group, 92 patients with simple ovarian cyst confirmed by postoperative pathology were selected as control group. General, clinical， and surgical information of two groups were collected. The correlation of serum CA125, hs-CRP， and NLR with EMT stage and their predictive value in diagnosis were analyzed. Results Serum CA125, hs-CRP, and NLR in EMT group were higher than those in control group (P＜0.05). Serum CA125, hs-CRP, and NLR in stage Ⅲ EMT patients were higher than those in stage Ⅰ+Ⅱ, and the serum CA125, hs-CRP, and NLR in stage Ⅳ EMT patients were higher than those in stage Ⅰ+Ⅱ and Ⅲ (P＜0.05). Serum CA125, hs-CRP, and NLR levels were positively correlated with the clinical stage of EMT (r＞0, P＜0.05). The area under the curve of the combined detection of CA125, hs-CRP, and NLR in diagnosis of EMT was higher than that of CA125, hs-CRP, and NLR alone. Conclusion The combined detection of CA125, hs-CRP, and NLR can be provided a partial reference value for the diagnosis of EMT.
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