|
|
|
| Relationship between recurrent respiratory tract infection and serum 25-hydroxyvitamin D level, vitro allergens, and total IgE in infants |
| LIU Suqin1 LI Yan1▲ WANG Lei2 WEI Mengyue1 |
1.Department of Pediatrics, Yangzhou Women and Children Care Service Hospital Affiliated to Yangzhou University Medical College, Jiangsu Province, Yangzhou 225002, China;
2.Department of Child Healthcare, Yangzhou Women and Children Care Service Hospital Affiliated to Yangzhou University Medical College, Jiangsu Province, Yangzhou 225002, China |
|
|
|
Abstract Objective To explore the relationship between 25-(OH)D level, vitro allergens, and total immunoglobulin E (IgE) in recurrent respiratory tract infections(RRTI) in infants. Methods From December 2018 to June 2019, 100 infants with RRTI who admitted to Yangzhou Women and Children Care Service Hospital Affiliated to Yangzhou University Medical College (hereinafter referred to as “our hospital”) were selected as observation group, another 100 infants with the first respiratory tract infection aged from 3 to 18 months in our hospital, who were followed up to two years old and still had only one history of respiratory tract infection as first infection group; 100 infants and toddlers who underwent physical examination in Department of Child Healthcare as healthy group. The first infection group and healthy group were included in control group. The 25-(OH)D levels were compared among all groups; vitro allergen indexes and total IgE were compared between observation group and control group; the risk factors of RRTI in infants were analyzed by logistic regression. Results The level of serum 25-(OH) D in observation group was lower than that in control group (P＜0.01). The level of serum 25-(OH) D in observation group was lower than that in healthy group and first infection group (P＜0.01). The positive rates of house dust, egg white, milk, and oak birch maple walnut sycamore poplar in observation group were higher than those in control group (P＜0.05 or P＜0.01). There was no significant difference in total IgE between two groups (P＞0.05). 25-(OH)D was a protective factor for RRTI (OR＜1, P＜0.05). Conclusion The serum 25-(OH)D level in RRTI children is low, and 25-(OH)D may play a protective role in the occurrence of RRTI. The positive rate of allergens in RRTI children is high, but the vitro allergen positive can not be used to predict whether the children are prone to RRTI.
|
|
|
|
|
|
[1] 马慧娟.小儿反复呼吸道感染的相关因素分析[J].中华医院感染学杂志，2012，22（5）：951-952.
[2] Del-Rio-Navarro BE，Espinosa Rosales F，Flenady V，et al. Immunostimulants for preventing respiratory tract infection in children [J]. Cochrane Database Syst Rev，2006（4）：CD004974.
[3] Wang H，Du Y，Wu Z，et al. Serum Vitamin D Insufficiency in Hospitalized Full-Term Neonates at a Tertiary Hospital in Eastern China [J]. Front Pediatr，2022，10：878992.
[4] 王翠翠，赵辉.大连地区健康体检人群血清25-（OH）-D3水平与空腹血糖受损的相关性研究[J].大连医科大学学报，2022，44（2）：109-114，119.
[5] 黄文霞，李海涛，黄玉冰，等.心力衰竭患者25-羟基维生素D3缺乏与血管内皮功能异常及动脉粥样硬化程度的相关性分析[J].川北医学院学报，2022，37（5）：593- 596，629.
[6] 李波，朱庆峰，耿若琳，等.血清25-羟维生素D水平与慢性HBV感染的相关性研究[J].中国现代医药杂志，2022， 24（1）：10-14.
[7] 蒋鑫芳，连熙娜，王虹，等.多囊卵巢综合征患者血清25-（OH）D3水平与胰岛素抵抗及肥胖的相关性分析[J].医学理论与实践，2021，34（7）：1187-1189.
[8] 谢文秀，张春燕，于晓红.老年非酒精性脂肪肝患者25（OH）D3水平与胰岛素抵抗、氧化应激的相关性[J].武警医学，2021，32（6）：513-517.
[9] 洪燕遂.多囊卵巢综合征患者血清25-（OH）D3水平与性激素、糖代谢水平的关系分析[J].医学检验与临床，2022，33（4）：52-54.
[10] 张夏霞，李沙，许陕陕，等.1，25-二羟基维生素D3在蛋氨酸胆碱缺乏饮食诱导的大鼠肝脏脂质代谢中的作用[J].中华肝脏病杂志，2021，29（2）：163-168.
[11] 汪宝贯.临床患者过敏原感染谱特征及应用价值探讨[J].检验医学与临床，2021，18（14）：2107-2110.
[12] Weatherhead JE，Porter P，Coffey A，et al. Ascaris Larval Infection and Lung Invasion Directly Induce Severe Allergic Airway Disease in Mice [J]. Infect Immun，2018，86（12）：e00533-18.
[13] Doherty TA，Broide DH. Airway innate lymphoid cells in the induction and regulation of allergy [J]. Allergol Int，2019，68（1）：9-16.
[14] López-Rodríguez JC，Benedé S，Barderas R，et al. Airway Epithelium Plays a Leading Role in the Complex Framework Underlying Respiratory Allergy [J]. J Investig Allergol Clin Immunol，2017，27（6）：346-355.
[15] 中华医学会儿科学分会呼吸学组，《中华儿科杂志》编辑委员会.反复呼吸道感染的临床概念和处理原则[J].中华儿科杂志，2008，46（2）：108-110.
[16] 樊莎莎，徐柯.4683例荨麻疹患者的过敏原检测结果分析[J].中国卫生检验杂志，2021，31（23）：2921-2924， 2930.
[17] 荣爽，徐凯，李婷婷，等.维生素与免疫功能[J].营养学报，2020，42（6）：613-617.
[18] Lin Z，Li W. The Roles of Vitamin D and Its Analogs in Inflammatory Diseases [J]. Curr Top Med Chem，2016，16（11）：1242-1261.
[19] Taha R，Abureesh S，Alghamdi S，et al. The Relationship Between Vitamin D and Infections Including COVID-19：Any Hopes？[J]. Int J Gen Med，2021，14：3849-3870.
[20] 范雪莲，曾梓建，蔡志梁，等.广州地区0~7岁儿童血清25羟维生素D水平检测结果分析[J].临床检验杂志，2021， 39（1）：69-72.
[21] 郭靖，刘亚楠，郝明明，等.哮喘患儿合并肺炎支原体感染免疫状态及Th1/Th2平衡的变化[J].中华医院感染学杂志，2020，30（9）：1412-1416.
[22] 朱庆龄，陈俊伟，林卫华，等.泉州地区0~12岁儿童25羟维生素D水平分析[J].中华实用儿科临床杂志，2018， 33（11）：842-845.
[23] 郑双双，詹建英，朱冰泉，等.中国儿童维生素D营养状况流行病学研究发展[J].中国儿科杂志，2019，57（3）：232-234.
[24] Syed MN，Kutac C，Miller JM，et al. Risk Factors of Pneumonia in Primary Antibody Deficiency Patients Receiving Immunoglobulin Therapy：Data from the US Immunodeficiency Network（USIDNET）[J]. J Clin Immunol，2022. DOI：10.1007/s10875-022-01317-2. Epub ahead of print.
[25] Rahimi RA，Cho JL，Jakubzick CV，et al. Advancing Lung Immunology Research：An Official American Thoracic Society Workshop Report [J]. Am J Respir Cell Mol Biol，2022，67（1）：e1-e18.
[26] 叶钦松，孙建新，朱利华.5岁以下小儿反复下呼吸道感染发病因素分析[J].现代实用医学，2018，30（6）：803-805. |
|
|
|
