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2021 Vol. 18, No. 23
Published: 2021-08-15
 
 
4 Changes of early islet function in pigs with severe heat stroke
QIAO Zeyuan1 NI Jun2 ZHANG Jing2 XIE Guoqi2
Objective To observe the changes of early islet function in pigs with severe heat stroke. Methods Twelve healthy CV level male Bama miniature pigs were divided into control group (six pigs) and model group (six pigs) according to random number table method. The control group was placed at room temperature, and the model group was placed in the climate chamber with constant temperature and humidity. The severe heat stroke model of pigs was established under the conditions of 44-47 ℃ and relative humidity of (65±5) %. The core temperature of the model group > 42℃ was regarded as the success of modeling, that was the experiment ended. General conditions and core temperature of the two groups were monitored. Blood samples were collected from the two groups for examination after the end of the experiment to compare the changes in blood glucose and insulin levels. hematoxylin-exosin staining was used to observe the tissue morphology of the islets, liver and kidney of the two groups, and immunohistochemical staining was used to observe the expression level of insulin in the islets of the two groups. Results After the model group entered the constant temperature and humidity climate cabin, the core temperature of the model group showed an increasing trend, while the core temperature of the control group did not change. At the core temperature ＞ 42℃, the model group showed depression of spirit, unstable gait, conjunctival congestion, and weakened or disappeared corneal reflex, while the control group showed no abnormal symptoms. There was no significant difference in blood glucose and insulin levels in the control group before and after the experiment (P ＞ 0.05). After the experiment, the blood glucose level of the model group was higher than before, and the blood insulin level of the model group was lower than before, and the blood glucose level of the model group was higher than that of the control group, and the blood insulin level of the control group was lower than that of the control group, the difference was statistically significant (P ＜ 0.05). After the experiment, there were no significant changes in islet, liver and kidney tissue in the control group. The islet margin of model group was not clear, the shape was irregular, the cell edema, a few granulocytes infiltration, and the blood stasis of the capillary. The renal tubules and collecting ducts were dilated, thrombosis was observed in the vessels, epithelial granules were degenerative, and a few inflammatory cells were infiltrated. The structure of hepatic lobules was disordered, the hepatic sinuses were slightly stasis and dilated, the hepatic cells were slightly edema and granular degeneration, and lymphocyte infiltration was observed. Immunohistochemical staining results showed that in the control group, a large number of positive expressions of brown insulin was observed. The cells were closely arranged and uniform with complete morphology. In the model group, the islets were less stained and irregular in shape. The average optical density of insulin in islets in model group was lower than that in control group, and the difference was statistically significant (P < 0.05). Conclusion Islet tissue damage, decreased insulin expression and elevated blood glucose occurred in early stage after severe heat stroke in pigs, which may be related to the impaired islet function.
2021 Vol. 18 (23): 4-7,32 [Abstract] ( 86 ) HTML (1 KB)  PDF (881 KB)  ( 13 )
8 Discussion on the mechanism of action of blister beetle in the treatment of liver cancer based on network pharmacology and molecular docking
LIN Xiaotong1 HUANG Zhongming1 PENG Huiting1 CHEN Hongyu1 WANG Wenping2 WANG Sisi2 CAO Yang2
Objective To explore the molecular mechanism of blister beetle in the treatment of liver cancer based on network pharmacological analysis and molecular docking. Methods Combined with literature review and traditional Chinese medicine systems pharmacology database and analysis platform, the active constituents of blister beetle were screened, and the target of action was predicted by SwissTargetPrediction. GeneCards and OMIM databases were used to retrieve the disease targets of liver cancer. The Venn diagram of common targets of drug-disease intersection was drawn by R software. Cytosacpe software was used to make the network diagram of blister beetle-active ingredient-target for liver cancer. Proteinprotein interaction (PPI) network diagrams of key target proteins were constructed by String database. Key targets were enriched in KEGG pathway and GO biological process by R software. Molecular docking of key targets with active ingredients was carried out. Results There were six active components of blister beetle, 145 targets in total. There were 1442 targets for liver cancer. The Venn diagram showed that there were 44 common targets of drug-disease intersection. PPI network suggested that the key targets were IL-6, MAPK1/3, ESR1, and PTGS2. GO enrichment analysis showed that key targets involved in the biological processes of regulating cell proliferation, hormone secretion and regulation in vivo, and protein transport. KEGG pathway enrichment analysis showed that the main signaling pathways involved in cell proliferation, apoptosis, angiogenesis, tumor-related inflammation and other aspects. Molecular docking results indicated that 3-phenyl-4-azafluorene showed the best binding activity. Conclusion The mechanism of action of blister beetle in the treatment of liver cancer reflects the characteristics of multi-component, multi-target and multi-channel action of traditional Chinese medicine.
2021 Vol. 18 (23): 8-12 [Abstract] ( 67 ) HTML (1 KB)  PDF (1288 KB)  ( 102 )
13 Visualization analysis of brown adipose tissue literature based on Cite-Space
LU Chenxia1 XIAO Mingzhong2,3 LI Xiaodong1,2,3
Objective To discuss the research progress, hot spots and development trends of brown adipose tissue (BAT). Methods Based on the database of “Web of Science core collection”, the published literatures on BAT related studies from 2014 to 2020 were retrieved by using the related entries of subject = “Brown Adipose Tissue”. Bibliometrics analysis method and CiteSpace 5.7.R1 software were used to conduct visual analysis on the publication year, major countries / regions, institutions, journals and keywords. Results In this study, a total of 3089 literatures related to BAT were included; the country with the highest number of publications is the United States (1194). A total of 132 academic institutions participated in the research, with the Chinese Academy of Sciences and Harvard Medical School in the United States publishing the most papers. BAT studies have been published in 718 open academic journals, the number of publications was topped by Scientific Reports (127 papers). The authors’ contribution was more prominent was PATRICK CN RENSEN etc., obesity, gene expression, thermogenesis and adipose tissue were the main focus of BAT research. Conclusion Research on BAT is increasing year by year, mainly distributed in Europe, the United States and Asia, and the research content focuses on the field of metabolic and endocrine diseases.
2021 Vol. 18 (23): 13-17 [Abstract] ( 60 ) HTML (1 KB)  PDF (912 KB)  ( 125 )
18 Effect of cyanidin-3-O-glucoside on JNK/FOXO1 of human primary osteoblasts
CHEN Lin1 HU Bosen1 ZHOU Bo1 CHEN Yong2
Objective To observe the effect of cyanidin-3-O-glucoside (C3G) on the proliferation of human primary osteoblasts and its effect on c-Jun N-terminal kinase/forkhead box O1 (JNK/FOXO1). Methods The cancellous bone tissues were collected from 60-90 years old patients with osteoporosis and femoral neck or intertrochanteric fracture who underwent artificial femoral head replacement or total hip replacement in Central Hospital Affiliated to Shenyang Medical College from June 2017 to June 2018, and osteoblasts were isolated and cultured in vitro. MTT assay was used to detect the proliferation activity of human primary osteoblasts in control group (α-MEM medium containing 0 μmol/L C3G), C3G group (α-MEM medium containing 100 μmol/L C3G). Real-time fluorescence quantitative PCR was used to detect mRNA expression of FOXO1, activiating transcripition factor-4 (ATF4), and osteoprotegerin (OPG) in control group and C3G group. Cells were treated with JNK pathway inhibitor (SP600125), and FOXO1 mRNA expression in SP600125-control group and SP600125-C3G group were detected by real-time fluorescence quantitative PCR. Results The proliferation rate of human primary osteoblasts in C3G group was higher than that in control group, and the difference was statistically significant (P < 0.05). The mRNA expression of FOXO1, ATF4, and OPG in C3G group were decreased than those in control group, and the differences were statistically significant (P < 0.05). There were no significant differences in the mRNA expression of FOXO1 between SP600125-control group and SP600125-C3G group (P > 0.05). Conclusion C3G may affect FOXO1 gene level through JNK pathway to promote human primary osteoblasts proliferation.
2021 Vol. 18 (23): 18-21 [Abstract] ( 108 ) HTML (1 KB)  PDF (828 KB)  ( 143 )
22 Explore the potential molecular mechanism of Shuilu Erxiandan in the treatment of diabetic nephropathy based on network pharmacology and molecular docking
LI Yameng1 HOU Yawei1 XU Yukun2 LI Rui2
Objective To explore the potential molecular mechanism of Shuilu Erxiandan in the treatment of diabetic nephropathy (DN) based on network pharmacology and molecular docking. Methods The active ingredients were obtained from traditional Chinese medicine systems pharmacology detabase and TCMID databases. Meanwhile, the literatures from January 2015 to September 2020 were collected from CNKI and Wanfang to obtain the component targets. The network diagram of “drug-active ingredient-target” was constructed by Cytoscape 3.7.2. DN targets were found based on GeneCards, TTD, OMIM and DRUGBANK; “drug-disease” target Venn plot was drawn by R packet; Cytoscape 3.7.2 combined with STRING was used for protein protein interaction analysis. GO and KEGG pathways were analyzed using Metascape combined with bioinformatics platform. Molecular docking was mainly conducted by Autodockvina combined with PyMol. Results A total of seven active components, including quercetin, kaemferol’ and lutein, were obtained from Siliu Erxiandan. A total of 1261 DN targets were obtained, and 70 intersection targets were obtained. GO and KEGG analysis showed that intersection targets were mainly involved in the regulation of lipopolysaccharide reaction, activation of oxygen metabolism, angiogenesis and other biological functions.They were enriched in AGE-RAGE, HIF-1, ErbB and other pathways. Molecular docking of quercetin with MAPK1, CCND1 and lutein with AKT1 and VEGFA showed good docking activity. Conclusion Shuulu Erxiandan mainly regulates the expression of AKT1, MAPK1, VEGFA and other related targets through quercetin and lutein, and then interferes with multiple pathways such as AGE-RAGE, HIF-1 and ERbB, and regulates multiple biological functions such as lipopolysaccharide reaction, activation of oxygen metabolism and angiogenesis, so as to play a role in the treatment of DN.
2021 Vol. 18 (23): 22-28，46 [Abstract] ( 116 ) HTML (1 KB)  PDF (3922 KB)  ( 65 )
29 Relationship among psychological resilience, life satisfaction and life attitude of medical students
WANG Chuanming1 YU Qinming2 JI Shunxin1
Objective To explore the relationship and the mechanism among psychological resilience, life satisfaction and life attitude of medical students, and to provide a basis for formulating intervention measures to improve life attitude of medical students. Methods Using pure random sampling, a total of 2069 medical students from five medical schools in Northeast China were selected from April to October 2020. The connor-Davidson resilience scale, satisfaction with life scale and life attitude scale were used to conduct an anonymous questionnaire survey. Based on the analysis of the current characteristics of psychological resilience, life satisfaction and life attitude of medical students, correlation and regression analysis of the three variables were carried out, and the mediating effect of life satisfaction was tested. Results Pearson correlation analysis showed that psychological resilience, life satisfaction, and life attitude were all positively correlated (r = 0.33-0.88, P ＜ 0.01). The results of multiple linear regression showed that both psychological resilience and life satisfaction can positively predict life attitude (P ＜ 0.01), and both can explain 33% of the variation in life attitude. Life satisfaction of medical students was the mediating effect between psychological resilience and life attitude (χ2/df=3.916, NFI=0.947, CFI=0.895, IFI=0.927, TLI=0.933, RMSEA=0.079). Conclusion The psychological resilience, life satisfaction and life attitude of medical students are in a good state of development; psychological resilience and life satisfaction can positively predict life attitude; life satisfaction has a partial mediating effect on the relationship between psychological resilience and life attitude.
2021 Vol. 18 (23): 29-32 [Abstract] ( 41 ) HTML (1 KB)  PDF (680 KB)  ( 93 )
33 Progress of pathophysiological mechanism and treatment of constipation in patients with Parkinson disease
MA Xue1,2,3,4 WANG Qiang2,3,4 WANG Yuan2,3,4 YUAN Wei2,3,4 LIU Zhibin2,3,4
Constipation is one of the most common precursor non-motor symptoms of Parkinson disease, and the severity of constipation is associated with the risk of Parkinson disease in the future. Constipation not only causes clinical symptoms of Parkinson disease, but also affects the pathophysiological changes of movement fluctuations in patients with advanced Parkinson disease through its negative effects on the absorption of Levodopa. The high socio-economic burden of constipation and other constipation-related intestinal complications in patients with Parkinson disease call for an accurate and effective treatment strategy, which requires an in-depth understanding of the complex pathophysiological factors that affect constipation in patients with Parkinson disease. Therefore, it is very important to study the mechanism of constipation in Parkinson disease. This article will focus on the pathophysiological mechanism and treatment status of constipation in Parkinson disease.
2021 Vol. 18 (23): 33-37 [Abstract] ( 116 ) HTML (1 KB)  PDF (557 KB)  ( 161 )
38 Research progress on influencing factors and prevention of adverse reactions of Zoledronic Acid in the treatment of osteoporosis
WU Hongliang1* ZHENG Sihang1* JING Shengjie2 XING Ruida3 GONG Helong1 TIAN Ye1
Osteoporosis is one of the global health problems, which seriously affects the health and quality of life of patients. Bisphosphonates are currently the first-line drugs recommended by the international community for the treatment of osteoporosis. As the third-generation bisphosphonates, Zoledronic Acid is widely used in clinical practice because of its strong anti-bone resorption effect and effective relief of osteoporosis symptoms. However, with the deepening of research, more and more medical workers have pointed out in their reports that there are many kinds of adverse reactions when using Zoledronic Acid, and the incidence of acute phase reaction, osteonecrosis of the jaw, ocular complications, kidney injury, hypocalcemia and other adverse reactions is higher or the symptoms are more serious in clinical practice. In this paper, the mechanism, adverse reactions and their influencing factors, prevention and control of adverse reactions of Zoledronic Acid in the treatment of osteoporosis are reviewed to provide a reference for clinical use of Zoledronic Acid.
2021 Vol. 18 (23): 38-42 [Abstract] ( 103 ) HTML (1 KB)  PDF (529 KB)  ( 52 )
43 Research progress of precise hepatectomy for hepatocellular carcinoma
WANG Kejing1 HUANG Zuhong2 SHI Qinglan3 BAI Wenjie2 LI Quan1 XIAO Wei1
As one of the common malignant tumors, liver cancer has a high incidence and fatality rate. Surgical resection of liver cancer patients has been widely carried out clinically, and a variety of surgical technical problems have also been overcome. At present, the development of humanities medicine and the research and innovation of science and technology have promoted the development of liver surgery from simply pursuing the number of resections and overcoming the difficulty of surgery to more and more focusing on the patient-centric precision medical model. Under this background, the concept of precision liver resection has gradually been accepted by liver surgeons. This article reviews the development and application of precision liver resection for hepatocellular carcinoma, in order to provide reference for clinical practice.
2021 Vol. 18 (23): 43-46 [Abstract] ( 86 ) HTML (1 KB)  PDF (516 KB)  ( 74 )
47 Mediating effect of perceived stress on family communication and family resilience of stroke inpatients
ZHANG Man1,2 LIU Annuo1▲ REN Haiyan2 JIANG Yan2 FANG Yueyan2 TANG Qiqiang2
Objective To analyze the mediating effect of perceived stress on family communication and family resilience of stroke patients. Methods Using the convenience sampling method, a total of 179 stroke patients who were hospitalized in the neurology department of a grade A tertiary hospital in Anhui Province from February to May 2020 were selected as the research objects. The general information questionnaire, family resilience rating scale, family communication scale, perceived stress scale were used to investigate it, the mediation model was constructed and tested. Results There were statistically significant differences in the total scores of family resilience of inpatients with different occupations, family per capita monthly income, and first-onset stroke inpatients (P ＜ 0.05). Family communication score was positively correlated with perceived pressure score (r = 0.615, P < 0.01), and negatively correlated with family resilience score (r = -0.547, P < 0.01); perceived stress was negatively correlated with family resilience (r = -0.489, P < 0.01). The mediating effect test results showed that perceived stress plays a partial mediating role between family communication and family resilience, and the mediating effect was -0.212, accounting for 34.30% of the total effect (-0.618). Conclusion Family communication can not only directly predict the family resilience level of stroke patients, but also indirectly affect family resilience through the perception of pressure. Clinical nurses can take interventional measures for the patient’s family communication and perceived stress status to enhance the patient’s family resilience.
2021 Vol. 18 (23): 47-50,54 [Abstract] ( 106 ) HTML (1 KB)  PDF (745 KB)  ( 188 )
51 Analysis of the current situation and coping styles of the psychological pressure of graduate students in medical colleges and universities
LIU Liming CHENG Wei TAN Xi XU Xunhang YU Jingfei YU Hongda LU Yun LANG Shuang
Objective To exploring the psychological pressure status and coping methods of graduate students in medical colleges and universities, and to provid scientific basis for the maintenance of their physical and mental health. Methods Using the convenient sampling method, using the existing postgraduate psychological stressor scale, stress response characteristic questionnaire and coping style questionnaire, an online questionnaire survey were conducted among 124 graduate students at Beijing University of Chinese Medicine. The survey time was November 2020. The current situation and influencing factors of the psychological stressors, stress response characteristics and coping styles of postgraduate students with different characteristics were analyzed. Results There were statistically significant differences in the psychological stress scores of different grades, the frequency of contact with tutors and teachers (P ＜ 0.05). The results of multiple linear regression showed that the frequency of contact with the tutor and teachers were related factors that affected the psychological stress score of graduate students (P ＜ 0.05). Conclusion The alleviation of the psychological pressure of graduate students in medical schools can start from the employment and academic aspects. At the same time, they can help and guide the mental health of graduate students in a targeted manner. In addition, graduate students themselves should strengthen communication with their supervisors.
2021 Vol. 18 (23): 51-54 [Abstract] ( 85 ) HTML (1 KB)  PDF (612 KB)  ( 173 )
55 Correlation analysis between occupational burnout and social support of young medical staff in grade A tertiary hospitals in Beijing
CHEN Qu1 CHAI Qiuxiang2 MENG Kai3
Objective To analyze the correlation between occupational burnout and social support of young medical staff in grade A tertiary hospitals in Beijing, and to propose targeted intervention measures to relieve burnout of young medical staff. Methods From August to October 2016, a multi-stage stratified sampling method was used to randomly select 674 young medical staff aged <35 years old from five grade A tertiary hospitals in Beijing as the survey subjects. The questionnaire consists of general information questionnaire, occupational burnout scale and social support rating scale. A total of 674 questionnaires were issued, and 663 valid questionnaires were retrieved. The effective response rate was 98.4%. Results There was a statistically significant difference in the burnout scores of young medical staff of different genders and department (P < 0.05). There were statistically significant differences in the social support scores of in-service young medical staff of different ages, titles, marital status, departments, and employment methods (P ＜ 0.05). Emotional exhaustion, dehumanization and social support were negatively correlated with social support of various dimensions (r ＜ 0, P ＜ 0.01), and personal accomplishment was positively correlated with social support of various dimensions (r ＞ 0, P ＜ 0.01). Gender, department, objective support and utilization of support were related factors that affect emotional exhaustion; objective support and utilization of support could affect dehumanization; objective support, utilization of support, subjective support, and marital status were independent influencing factors of personal accomplishment (P ＜ 0.05). Conclusion Increasing the social support can be of help to alleviate the occupational burnout.
2021 Vol. 18 (23): 55-59 [Abstract] ( 149 ) HTML (1 KB)  PDF (611 KB)  ( 206 )
60 Influencing factors analysis of β2-microglobulin concentration after long-term interferon α1b administration in children with CHB
CHAI Yantao1* WANG Fuchuan2* HOU Jun1 JIA Fan3 LIU Jia4 JIANG Qiyu1 ZHANG Min2▲ BI Jingfeng1▲
Objective To explore the related factors of serum β2-microglobulin concentration after long-term administration of interferon in children with chronic hepatitis B (CHB). Methods Serum samples of 108 children with CHB who were treated at the Fifth Medical Center of People’s Liberation Army General Hospital from December 2017 to September 2019 were collected after long-term interferon α1b application. Multiple linear regression analysis method was used, with serum β2-microglobulin concentration as the dependent variable, taking gender, age, body mass index (BMI), course of treatment, administration time (the interval between sampling time and the last medication before sampling), administration dose, virus genotyping and other information as independent variables, the related influencing factors of serum β2-microglobulin concentration were analyzed. Results There was no correlation between β2-microglobulin and age, course of treatment, time of administration and BMI (P ＞ 0.05). There were no statistically significant differences in different genders, viral hepatitis type B genotypes, and doses of β2-microglobulin (P ＞ 0.05). Dosage, age, time of administration, and course of treatment are related factors that affect the concentration of serum β2-microglobulin (P ＜ 0.05), among them, the serum β2-microglobulin concentration increases with the increase of the dose, and decreases with the increase of age, administration time and treatment course. Conclusion The concentration of serum β2-microglobulin is not only related to the dose, but the time, duration of treatment and age also have certain effects on the concentration of serum β2-microglobulin.
2021 Vol. 18 (23): 60-63,79 [Abstract] ( 118 ) HTML (1 KB)  PDF (982 KB)  ( 71 )
64 Influence of psychological capital on health promotion behaviors of patients with coronary heart disease in Urumqi
HUANG Ying1 DUAN Yongmei2 WANG Huicai3 GAO Ying4
Objective To understand the current situation of health promotion behavior of patients with coronary heart disease, and to analyze the impact of psychological capital on health promotion behavior, and to provide basis for relevant research. Methods Using convenience sampling, a total of 360 patients with coronary heart disease who were hospitalized in the Heart Center of the First Affiliated Hospital of Xinjiang Medical University from January to March 2021 were surveyed by general information questionnaire, positive psychological capital questionnaire, and health promotion lifestyle scale Ⅱ. Results The actual total score of psychological capital was (121.8±17.2) points, and the actual total score of health promotion behavior was (126.0±21.8) points. There were statistically significant differences in the health promotion behavior and psychological capital scores of patients with coronary heart disease of different ages, past mental illness history, and educational level (P ＜ 0.05). The level of psychological capital dimensions were positively correlated with health promotion behaviors dimensions (r ＞ 0, P ＜ 0.05). The results of multiple linear regression showed that self-efficacy (a), resilience (b), hope (c) and optimism (d) were related factors that affect the health promotion behavior of patients with coronary heart disease (P < 0.05). The regression equation was as follows: Y = 0.55a-0.62b+0.98c+0.65d+71.08. Conclusion Psychological capital has a positive effect on the health promotion behavior of patients, and improving the level of psychological capital of patients with coronary heart disease is conducive to changing their health promotion behavior.
2021 Vol. 18 (23): 64-67 [Abstract] ( 55 ) HTML (1 KB)  PDF (610 KB)  ( 178 )
68 Expression levels of serum pentraxin 3 and fibroblast growth factor 2 in patients with chronic heart failure and their correlation with myocardial remodeling and cardiac function
YU Hongbo1 LIU Yaqun2 YIN Dong3
Objective To detect the expression levels of serum pentagerin 3 (PTX3) and fibroblast growth factor 2 (FGF2) in patients with chronic heart failure (CHF), and to analyze the relationship between them and myocardial remodeling and cardiac function. Methods A total of 89 CHF patients in Qinhuangdao Jungong Hospital (hereinafter referred to as “our hospital”) from April 2018 to May 2019 were selected as the research subjects, and they were taken as the experimental group, and 90 healthy subjects in our hospital during the same period were taken as the control group. According to cardiac function status, CHF patients were divided into gradeⅠ(14 cases), grade Ⅱ(18 cases), grade Ⅲ (31 cases), and grade Ⅳ (26 cases). Serum PTX3 and FGF2 levels of the included subjects were detected. The relationship between cardiac function grade and serum PTX3 and FGF2 levels was analyzed. The relationship between the serum levels of PTX3, FGF2 and cardiac function and myocardial remodeling in CHF patients was analyzed. Results Serum levels of the serum level of PTX3 and FGF2 in experimental group were higher than those in the control group (P ＜ 0.05). In patients with CHF, compared with grade Ⅰ, serum levels of PTX3 and FGF2 were increased in patients with grades Ⅱ, Ⅲ, Ⅳ (P ＜ 0.05). Compared with grade Ⅱ, the serum levels of PTX3 and FGF2 were increased in patients with grade Ⅳ(P ＜ 0.05). Compared with grade Ⅲ, the serum levels of PTX3 and FGF2 were increased in patients with grade Ⅳ (P ＜ 0.05). Compared with gradeⅠ, the left ventricular end diastolic dimension (LVEDD) and left atrium diameter (LAD) in patients with grades Ⅱ, Ⅲ, Ⅳ, left ventricular mass index (LVMI) in patients with grade Ⅳ were increased, left ventricular cardiac output (LVCO) in patients with grades Ⅲ, Ⅳ, left ventricular ejection fraction (LVEF) and left ventricular reconstruction index (LVRI) in patients with grade Ⅳ were decreased (P ＜ 0.05). Compared with grade Ⅱ, the LVEDD and LAD in patients with grade Ⅳ were increased, the LVCO in patients with gradesⅢ, Ⅳ, the LVEF in patients with grade Ⅳ were decreased (P ＜ 0.05). Compared with grade Ⅲ, the LVEDD and LAD in patients with grade Ⅳ were increased, the LVCO and LVEF were decreased (P ＜ 0.05). Serum level of PTX3 in CHF patients was positively correlated with LVEDD and LVMI, and negatively correlated with LVEF and LVCO (P ＜ 0.05); the level of FGF2 was positively correlated with LVEDD, LAD and LVMI, and negatively correlated with LVEF and LVERI (P ＜ 0.05). Conclusion The elevated serum levels of PTX3 and FGF2 in CHF patients are closely related to cardiac function and myocardial remodeling indexes, and affect the severity of the disease.
2021 Vol. 18 (23): 68-71,99 [Abstract] ( 103 ) HTML (1 KB)  PDF (802 KB)  ( 173 )
72 Influencing factors of myocardial ischemia in patients with non-obstructive coronary artery disease
DING Nan ZHANG Peisheng LIANG Xue ZHANG Pu WANG Weiping
Objective To investigate the related factors of myocardial ischemia in patients with non-obstructive coronary artery disease (NOCAD). Methods A total of 113 NOCAD patients who received coronary angiography or coronary computed tomography angiography with coronary artery stenosis < 50% in the Fifth Affiliated Hospital of Zhengzhou University from August 2018 to June 2020 were selected. Based on myocardial contrast echocardiography, they were divided into two groups: ischemia group (59 cases) and non-ischemia group (54 cases). Age, dyslipidemia, diabetes mellitus, hypertension, obesity, left ventricular hypertrophy, number of diseased coronary arteries, interventricular septal thickness, left ventricular mass index, and other indicators were included. Multivariate logistic regression analysis was used to explore the influencing factors of myocardial ischemia. Results More than 50% of the enrolled patients had myocardial ischemia. There were statistically significant differences in obesity, left ventricular hypertrophy, interventricular septal thickness and left ventricular mass index between two groups (P ＜ 0.05). But there were no statistically significant differences in the age, sex, body mass index, diabetes mellitus, hypertension, dyslipidemia, smoking, blood glucose, total cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, left ventricular end diastolic dimension, left ventricular end systolic dimension, left ventricular posterior wall thickness, number of diseased coronary arteries (P ＞ 0.05). Multivariate logistic regression analysis showed that age, obesity, hypertension, dyslipidemia, number of diseased coronary arteries, diabetes mellitus, left ventricular mass index, and interventricular septal thickness were not associated with myocardial ischemia (P ＞ 0.05). Left ventricular hypertrophy was an independent risk factor for myocardial ischemia (OR ＞ 1，P ＜ 0.05). Conclusion Left ventricular hypertrophy is an independent risk factor for myocardial ischemia in NOCAD patients.
2021 Vol. 18 (23): 72-75 [Abstract] ( 50 ) HTML (1 KB)  PDF (419 KB)  ( 102 )
76 Efficacy of scalp acupuncture combined with neuromuscular elctrical stimulation and swallowing training in the treatment of pharyngeal dysphagia during the recovery phase of stroke
HUANG Jinxiu ZHOU Wenji SUN Mingying OU Xiaofeng WANG Fei PANG Jinxi
Objective To expore the efficacy of scalp acupuncture combined with neuromuscular elctrical stimulation（NMES） and swallowing training in the treatment of pharyngeal dysphagia during the recovery phase of stroke. Methods From August 2017 to June 2019, fourty-two patients who were diagnosed as pharyngeal dysphagia after stroke in the Department of Rehabilitation, Department of Acupuncture, and Department of Encephalopathy Hangzhou Traditional Chinese Medicine Hospital were selected, the patients were divided into treatment group and control group by random number table, with 21 patients in each group. The control group was treated with NMES and swallowing rehabilitation training, while the treatment group was additively treated with scalp acupuncture. The Kobata drinking water test, VDS score and Rosenbek osmotic/aspiration scale (PAS) grade were evaluated before and after 3 weeks of treatment. Results After three weeks of treatment, the grading of kobata drinking water test and PAS in depressions in the two groups were improved compared with before treatment, and the grading of drinking water test and PAS in the treatment group were significantly improved compared with the control group, the difference was statistically significant (P ＜ 0.05). VDS scores of the two groups were lower than before treatment, and the treatment group was lower than the control group, the differences were statistically significant (P ＜ 0.05). Conclusion Scalp acupuncture combined with NMES and rehabilitation training significantly improved the swallowing function of patients with pharyngeal dysphagia in the convalescent stage of stroke, which is worthy of clinical promotion.
2021 Vol. 18 (23): 76-79 [Abstract] ( 149 ) HTML (1 KB)  PDF (413 KB)  ( 79 )
80 Effect of different fertilization methods in advanced maternal age patients with non-male factor infertility
LIU Ya’nan WANG Yu KONG Pengcheng PAN Jiaping TENG Xiaoming
Objective To evaluate the effect of different fertilization methods in advanced maternal age patients with non-male factor infertility. Methods A total of 606 cases of advanced maternal age patients with non-male factor infertility in Reproductive Medicine Center, Shanghai First Maternity and Infant Hospital, Tongji University, from January 2017 to December 2019 were enrolled. They were devided into in vitro fertilization (IVF) group (421 cases) and intracytoplasmic sperm injection (ICSI) group (185 cases) according to the fertilization method. Clinical outcomes and offspring birth were compared between two groups. Results There were significant differences in fertilization rate and blastocyst formation rate between two groups (P < 0.05). There were no significant differences in cleavage rate, D3 available embryo rate, D3 high-quality embryo rate, clinical pregnancy rate, and implantation rate between two groups (P > 0.05). There were no significant differences in gestational age, birth weight, birth rate, low body weight birth rate, and premature birth rate between two groups (P > 0.05). Conclusion In advanced maternal age patients with non-male infertility, conventional IVF treatment resulted in higher rates of fertilization and blastocyst formation than ICSI, and ICSI treatment of non-male infertility do not improve the implantation rate and birth rate.
2021 Vol. 18 (23): 80-83 [Abstract] ( 50 ) HTML (1 KB)  PDF (410 KB)  ( 75 )
84 Clinical analysis of neonatal sepsis deaths
YAN Huiheng1 LI Hui2 HE Qianmin1 WANG Yanli1 CHEN Yunbin1
Objective To analyze the clinical characteristics of neonatal deaths with early-onset sepsis (EOS) and late-onset sepsis (LOS). Methods Data of neonatal sepsis cases hospitalized in Department of Neonatology, Guangdong Women and Children Hospital from January 2016 to December 2020 were retrospectively analyzed. According to the time of onset, they were divided into EOS group (38 cases) and LOS group (46 cases). Basic data (gender, gestational age, birth weight, perinatal related factors) and clinical characteristics (sepsis related test results, the incidence of complications) were compared between two groups. Results There were no significant differences in gender, gestational age, preterm, birth weight, extremely low birth weight infant, small for gestational age, cesarean section between two groups (P  >0.05). The time from onset to death in EOS group was shorter than that in LOS group, and the difference was statistically significant (P < 0.05). There were no significant differences in the incidence of premature rupture of membranes ≥18 h, Ⅲ degree contamination of amniotic fluid, fetal distress, maternal age > 35 years old, maternal chorionic amniotis, and maternal infection in late pregnancy between two groups (P > 0.05). The detection rate of Klebsiella pneumoniae in EOS group was lower than that in LOS group; white blood cell count (WBC) <5×109/L and the incidence of WBC increase in EOS group were lower than those in LOS group, and the differences were statistically significant (P < 0.05). There were no significant differences in the incidence of platelet count (PLT) <100×109/L, PLT≤30×109/L, C-reactive protein ≥100 mg/L, procalcitonin ≥30 ng/ml and detection rate of group B streptococcus, Escherichia coli between two groups (P > 0.05). The incidence of neonatal necrotizing enterocolitis in EOS group was lower than that in LOS group, and the incidence of perinatal asphyxia was higher than that in LOS group, and the differences were statistically significant (P < 0.05). There were no significant differences in the incidence of bacterial meningitis, infectious pneumonia, neonatal hyperglycemia, neonatal hypoglycemia, and neonatal pulmonary hemorrhage between two groups (P > 0.05). Conclusion EOS and LOS in neonatal period have different risk factors, pathogens and complications, which should be paid more attention in clinical work.
2021 Vol. 18 (23): 84-87,103 [Abstract] ( 69 ) HTML (1 KB)  PDF (765 KB)  ( 71 )
88 Effect of Bevacizumab combined with Cisplatin in the treatment of gastric cancer with ascites
TANG Xiaolong1 CHEN Xufeng1 ZHENG Yang1 YANG Shenglan1 CHEN Liang2
Objective To observe the efficacy of Bevacizumab combined with Cisplatin in the treatment of gastric cancer with ascites. Methods A total of 102 patients with gastric cancer and ascites admitted to the No.904 Hospital of PLA Joint Service Support Force from June 2017 to June 2020 were selected. The patients were divided into control group and study group by random number method, with 51 cases in each group. The control group was given Cisplatin intraperitoneal administration, and the research group was combined with Bevacizumab on the basis of the control group, with 21 days as a treatment cycle, a total of two cycles of treatment. The efficacy of the two groups was compared. The levels of tumor markers (carbohydrate antigen [CA] 125, carcinoembryonic antigen [CEA], CA199), and mRNA expression of matrix metalloproteinase (MMP)-2, Gil1, and MMP-9 in ascites were compared between the two groups. The incidence of adverse reactions in the two groups was recorded. Results The objective remission rate and disease control rate in the study group were higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). After two cycles of treatment, the levels of CEA, CA125, and CA199 in ascites in both groups were lower than before treatment, and those in the study group were lower than those in the control group, with statistical significance (P ＜ 0.05). After two cycles of treatment, the mRNA expressions of MMP-2, Gil1, and MMP-9 in ascites in both groups were lower than before treatment, and those in the study group were lower than those in the control group, with statistical significance (P ＜ 0.05). There was no significant difference in the total incidence of adverse reaction between the two groups (P ＞ 0.05). Conclusion Intraperitoneal administration of Bevacizumab combined with Cisplatin in the treatment of ascites in gastric cancer can effectively alleviate the progression of ascites with reliable efficacy.
2021 Vol. 18 (23): 88-91,107 [Abstract] ( 114 ) HTML (1 KB)  PDF (590 KB)  ( 126 )
92 Changes of serum Kiss-1 level in patients with pancreatic cancer and its clinical significance
TU Xiaolong1 ZHAO Ying2 SHI Guojun1 WANG Yongsheng1 ZHANG Tingsu1 HU Mengyi1
Objective To investigate the changes of serum kisspeptin-1 (Kiss-1) level in patients with pancreatic cancer, and to analyze its relationship with the prognosis, clinicopathological parameters of patients with pancreatic cancer. Methods A total of 132 patients with pancreatic cancer admitted to Ningbo Hospital of Traditional Chinese Medicine, Zhejiang Province from January 2015 to December 2017 were selected as the pancreatic cancer group, 57 patients with benign pancreatic disease were selected as the benign lesion group and 53 healthy subjects were selected as the control group. Serum levels of Kiss-1, carcinoembryonic antigen (CEA) and carbohydrate antigen 199 (CA199) in the three groups were detected to analyze the correlation between Kiss-1 and CEA and CA199, as well as the relationship between Kiss-1 level and clinical characteristics and prognosis of pancreatic cancer patients. The pancreatic cancer group was divided into low Kiss-1 group (Kiss-1 ＜ 42.13 pg/ml, 76 cases) and high Kiss-1 group (Kiss-1 ≥ 42.13 pg/ml, 56 cases) according to Kiss-1 level. Receiver operating characteristic (ROC) curve was used to analyze the prognostic value of Kiss-1 in pancreatic cancer. Results Serum Kiss-1 level in pancreatic cancer group was lower than that in benign disease group and control group, while CEA and CA199 levels were higher than those in benign disease group and control group, with statistical significance (P ＜ 0.05). There were no significant differences in the levels of serum Kiss-1, CEA and CA199 between the benign lesion group and the control group (P ＞ 0.05). Serum Kiss-1 levels were negatively correlated with CEA and CA199 levels in pancreatic cancer group (r = -0.687, -0.703, P ＜ 0.001). The serum Kiss-1 level of pancreatic cancer patients with TNM stage Ⅲ-Ⅳ, or liver metastasis was lower than that of pancreatic cancer patients with TNM stage Ⅰ-Ⅱ, or no liver metastasis, with statistical significance (P ＜ 0.05). The 3-year survival rate of low Kiss-1 level group was lower than that of high Kiss-1 level group (P ＜ 0.05). Multivariate Cox regression analysis showed that high TNM stage, liver metastasis and low Kiss-1 level were independent risk factors for prognosis of pancreatic cancer patients (OR ＞ 1, P ＜ 0.05). The ROC curve showed that the cutoff value of Kiss-1 for predicting the prognosis of pancreatic cancer was 35.16 pg/ml, the area under the curve was 0.867 (95%CI: 0.790-0.944, P ＜ 0.001), the sensitivity was 72.73%, and the specificity was 66.67%. Conclusion Serum Kiss-1 level is decreased in patients with pancreatic cancer, which is correlated with TNM stage of pancreatic cancer and liver metastasis, and can be used to evaluate the prognosis of patients with pancreatic cancer.
2021 Vol. 18 (23): 92-95,111 [Abstract] ( 59 ) HTML (1 KB)  PDF (674 KB)  ( 75 )
96 Analysis of surgical value and survival in patients over 90 years of age with colorectal cancer
ZENG Weigen PANG Guoyi ZHAO Qi XIE Dehong QU Hao HAN Jiagang ZHAO Baocheng WANG Zhenjun▲
Objective To analyze the surgical value and prognosis of patients with colorectal cancer aged over 90 years. Methods The clinical data of 94 patients over 90 years old with colorectal cancer admitted to Beijing Chao-yang Hospital, Capital Medical University from May 2003 to October 2019 were retrospectively analyzed, and they were divided into surgery group (72 cases) and non-surgery group (22 cases) according to whether they had undergone surgery or not. The clinical characteristics of the two groups were compared, and the influencing factors for the prognosis of patients were analyzed. Results The age, Eastern Cooperative Oncology Group (ECOG) physical status score, Charlson comorbidity index, and tumor stage in the non-surgery group were higher than those in the surgery group, and the differences were statistically significant (P ＜ 0.05). The difference of survival curve between the two groups was statistically significant (P ＜ 0.05). Univariate analysis showed that ECOG score ≥four points (HR = 2.024, 95%CI: 1.056-3.879, P = 0.034), the tumor stage at stage Ⅲ-Ⅳ (HR = 3.952, 95%CI: 2.201-7.097, P ＜ 0.001), Charlson comorbidity index ≥ ten (HR = 3.607, 95%CI: 2.079-6.258, P ＜ 0.001), no surgical treatment (HR = 4.465, 95%CI: 2.382-8.371, P ＜ 0.001) were correlated with prognosis. Multivariate analysis showed that the tumor stages at stage Ⅲ-Ⅳ (HR = 3.389, 95%CI: 1.830-6.279, P ＜ 0.001), Charlson comorbidity index ≥ten (HR = 2.570, 95%CI: 1.396-4.732, P = 0.002), and the absence of surgical treatment (HR = 2.190, 95%CI: 1.071-4.476, P = 0.032) were independent risk factors for poor prognosis. Conclusion Age ≥90 years old should not be a contraindication to surgery in patients with colorectal cancer, which can significantly prolong life.
2021 Vol. 18 (23): 96-99 [Abstract] ( 117 ) HTML (1 KB)  PDF (603 KB)  ( 87 )
100 Clicinal analysis of Cetuximab in the treatment of elderly k-RAS wild-type metastatic colorectal cancer
TAN Qin1 REN Shun’an2 ZHOU Rengui1▲
Objective To explore the efficacy of Cetuximab in the treatment of elderly k-RAS wild-type metastatic colorectal cancer (mCRC), and to provide a method for the treatment of this disease. Methods A total of 68 elderly patients with k-RAS wild-type mCRC admitted to NO. 904 Hospital of the Joint Logistics Support Force of the Liberation Army from October 2015 to October 2019 were selected as the research subjects. According to random number table method, they were divided into study group and control group, with 34 cases in each group. The control group received conventional chemotherapy, and the research group received Cetuximab in addition to the control group. The therapeutic effect was evaluated after 12 weeks of continuous treatment. The recent anti-tumor effect and the changes of tumor markers before and after treatment were compared between the two groups, and the safety of the two groups was statistically analyzed. Results The clinical control rate in the study group was higher than that in the control group, and the difference was statistically significant (P ＜ 0.05). Before treatment, there were no significant differences in serum carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 199 between the two groups (P ＞ 0.05). After treatment, CEA and CA199 in both groups were lower than those before treatment, and those in the study group were lower than those in the control group, with statistical significance (all P ＜ 0.05). There was no statistical significance in the incidence of acne-like rash, myelosuppression, liver function injury and digestive tract reaction between the two groups (P ＞ 0.05). Conclusion Cetuximab treatment for elderly patients with k-RAS wild-type mCRC can significantly enhance the anti-tumor efficacy, reduce the level of tumor markers and the patient are well tolerated.
2021 Vol. 18 (23): 100-103 [Abstract] ( 96 ) HTML (1 KB)  PDF (567 KB)  ( 65 )
104 Changes and clinical significance of PCT, CRP and coagulation function in patients with incision infection after modified radical mastectomy for breast cancer
CHEN Dapeng
Objective To analyze the changes and clinical significance of procalcitonin (PCT), C-reactive protein (CRP), coagulation function indexes in patients with incision infection after modified radical mastectomy for breast cancer. Methods Clinical data of 125 breast cancer patients admitted to Bozhou People’s Hospital from June 2017 to October 2020 were retrospectively analyzed. Patients in both groups received modified radical mastectomy for breast cancer, and they were divided into infected group (65 cases) and uninfected group (60 cases) according to whether incision infection occurred after surgery. The changes of PCT, CRP, interleukin (IL) -5, activated partial thromboplastin time (APTT), prothrombin time (PT), and fibrinogen (FIB) in the operation time, hospitalization time, before and after operation were compared between the two groups. Results The operation time and hospitalization time of the infected group were longer than those of the uninfected group, and the differences were statistically significant (P ＜ 0.05). There were no significant differences in the levels of serum inflammatory between the two groups before operation (P ＞ 0.05). The levels of PCT, CPR, and IL-5 after operation in both groups were increased compared with those before operation, and those in the infected group were higher than those in the uninfected group (all P ＜ 0.05). There was no significant difference in the level of coagulation function between the two groups before operation (P ＞ 0.05). The levels of APTT and PT after operation in both groups were increased compared with those before operation, while FIB was decreased. The levels of APTT and PT in the infected group were lower than those in the uninfected group, while the level of FIB was higher than that in the uninfected group, with statistical significance (all P ＜ 0.05). Conclusion The levels of  serum PCT, CPR and coagulation function can be used as effective indicators to predict incision infection after modified radical mastectomy for breast cancer.
2021 Vol. 18 (23): 104-107 [Abstract] ( 145 ) HTML (1 KB)  PDF (565 KB)  ( 107 )
108 Efficacy and safety of ultrasound-guided vacuum assisted breast biopsy in the treatment of benign breast tumors
ZHANG Ruhui LIU Shangjun WANG Pei
Objective To research the efficacy and safety of ultrasound-guided vacuum assisted breast biopsy (VABB) in the treatment of benign breast tumors. Methods A total of 118 patients with benign breast tumors who underwent surgical treatment in the Maanshan Shiqiye Hospital, Anhui Province from January 2019 to January 2021 were selected as the research subjects, they were divided into observation group (67 cases) and control group (51 cases) according to different surgical methods. Patients in the observation group were treated with ultrasound-guided VABB, and patients in the control group were treated with open surgery. Operation-related indexes, postoperative complications, breast deformity, residual mass and recurrence were compared between the two groups. Results The operation time, wound healing time and hospitalization time of observation group were shorter than those of control group (P ＜ 0.05). The amount of intraoperative blood loss was less than that of control group (P ＜ 0.05). 24 h postoperative pain score was lower than that of control group (P ＜ 0.05). The length of purpura marks was shorter than that of control group (P ＜ 0.05). The total incidence of postoperative complications in the observation group was significantly lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). The rate of breast deformity in the observation group was significantly lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). No residual mass and in situ recurrence were observed in the observation group. Conclusion Compared with open surgery, ultrasound-guided VABB in the treatment of benign breast tumor has shorter operation time, less surgical trauma, faster postoperative recovery, fewer postoperative complications, and less impact on the appearance of the breast, which is worthy of active promotion in clinical practice.
2021 Vol. 18 (23): 108-111 [Abstract] ( 63 ) HTML (1 KB)  PDF (565 KB)  ( 90 )
112 Effect of low frequency repeated transcranial magnetic stimulation combined with group psychotherapy in the treatment of adolescence patients with migraine
LIU Ming WU Yanmin REN Jie
Objective To explore the effect of low frequency repeated transcranial magnetic stimulation combined with group psychotherapy in the treatment of adolescence patients with migraine. Methods A total of 60 adolescent migraine patients with Toronto alexithymia scale (TAS-20) score ≥52 points admitted to Shijiazhuang People’s Hospital from October 2017 to February 2019 were selected as the study subjects. According to random number table method, they were divided into control group (30 cases) and combined group (30 cases). Both groups received four weeks of low frequency repeated transcranial magnetic stimulation, while the combined group received group psychotherapy at the same time. The changes of repeatable battery for the assessment of neuropsychological status (RBANS), visual analogue scale (VAS), Hamilton anxiety scale (HAMA), Hamilton depression scale (HAMD), and TAS-20 scores were compared between the two groups before and after treatment. Results After treatment, the RBANS scores in both groups were higher than those before treatment, and the combined group was higher than that in control group, the differences were statistically significant (P ＜ 0.05). After treatment, the scores of VAS, HAMA, HAMD, and TAS-20 in both groups were lower than those before treatment, and the combined group was lower than the control group, with statistical significance (P ＜ 0.05). Conclusion Low frequency repeated transcranial magnetic stimulation combined with group psychotherapy can effectively improve the cognitive function, anxiety, depression, and alexithymia levels of adolescent migraine patients, and further improve migraine symptoms.
2021 Vol. 18 (23): 112-115 [Abstract] ( 79 ) HTML (1 KB)  PDF (435 KB)  ( 49 )
116 Analysis of influencing factors of osteoporosis in patients with type 2 diabetes mellitus
ZHAO Jianyong
Objective To analyze the influencing factors of osteoporosis in patients with type 2 diabetes mellitus (T2DM). Methods The clinical data of 100 patients with T2DM admitted to Department of Endocrinology, Chaohu Hospital Affiliated to Anhui Medical University from July 2017 to July 2020 were retrospectively analyzed. The patients were divided into T2DM group (45 cases) and T2DM with osteoporosis group (55 cases) according to whether the patients were associated with osteoporosis. The gender, age, T2DM duration, body mass index (BMI), diastolic blood pressure, systolic blood pressure, fasting blood glucose, 2 h postprandial blood glucose, glycosylated hemoglobin (HbA1c), 25-hydroxyvitamin D3 (25[OH]D3), parathyroid hormone (PTH), and bone mineral density (BMD) were compared between the two groups. Multivariate logistic regression was used to analyze the influencing factors of osteoporosis in T2DM. Results The T2DM duration, HbA1c, and PTH in T2DM with osteoporosis group were significantly higher than those in T2DM group, while BMI, 25(OH)D3, and BMD were significantly lower than those in T2DM group, the differences were statistically significant (P ＜ 0.05). Multivariate logistic regression analysis showed that T2DM duration, HbA1c, and PTH level were independent risk factors for T2DM with osteoporosis (OR ＞ 1, P ＜ 0.05). The increase of BMI, 25(OH)D3, and BMD were the protective factors for T2DM with osteoporosis (OR ＜ 1, P ＜ 0.05). Conclusion Serum 25(OH)D3 level is significantly decreased and PTH level is significantly increased in T2DM patients with osteoporosis, both of which are important risk factors leading to osteoporosis in T2DM patients.
2021 Vol. 18 (23): 116-118,147 [Abstract] ( 182 ) HTML (1 KB)  PDF (909 KB)  ( 63 )
119 Exploring the rule of traditional Chinese medicine in improving endometrial receptivity based on data mining method
YU Qin ZHAO Yilin ZHOU Juan YAN Hua
Objective To explore the rule of traditional Chinese medicine in improving endometrial receptivity through data mining method. Methods The literatures on the improvement of endometrial receptivity by traditional Chinese medicine published on CNKI, Wanfang database and VIP from January 2010 to June 2020 were collected, and the statistics of traditional Chinese medicine, drug flavor, drug properties, frequency of channel tropism, association rule analysis and cluster analysis were performed by Excel and SPSS statistical software. Results A total of 110 prescriptions were included, involving 142 kinds of traditional Chinese medicine. The most frequent drug was dodder seed. The drug flavor is mainly sweet, bitter, and pungent. In terms of drug properties, warm and flat drugs were mostly used, which mainly belong to the liver, spleen and kidney channels. A total of 21 core drug combinations and four cluster formulae were obtained. Conclusion The improvement of endometrial receptivity is mainly tonifying and replenishing liver and kidney and regulating qi and blood. The liver and kidney should be paid attention to while the spleen and stomach should be taken into account.
2021 Vol. 18 (23): 119-122 [Abstract] ( 108 ) HTML (1 KB)  PDF (1098 KB)  ( 23 )
123 Discussion on the treatment of diabetes upper consumption from lung with “substantial yang and functional yin”
SHI Min LIU Fulin XIA Xuting ZHANG Ting LIAO Chenmin
According to the description of the physiological characteristics and functions of the lung based on the basic theory of traditional Chinese medicine, this article sorts out the theoretical origin of the lung with “substantial yang and functional yin”, and discusses the physiological and pathological characteristics of the lung in conjunction with the connotation and interrelationship of “lung substance”and “lung function”, and discusses the pathogenesis of diabetes upper consumption. It is believed that the lung substance is the highest among the viscera, which is connected with the weather, and connects all vessels, regulates the water passages, governs purification and descending. Its substance is yang, and its function is yin. The incidence of diabetes upper consumption is closely related to the function of lung qi governing diffusion, purification and descending and the abnormal distribution of body fluid. Therefore, based on the theoretical basis of “substantial yang and functional yin”, the treatment of diabetes upper consumption should be based on the relationship between substance and function of the lung, and dialectically combine prescription medicine with the combination of benefiting qi and diffusion, promoting production of fluid and purification and descending
2021 Vol. 18 (23): 123-126 [Abstract] ( 46 ) HTML (1 KB)  PDF (755 KB)  ( 42 )
127 Origin and development of hand diagnosis
SHI Xueqin GAO Ya AN Hong ZHAO Zhupei ZHU Tingyu LIU Meihan QIN Peijie▲ LIU Jianfeng▲
Hand diagnosis of diseases has a long history in Chinese medical history. As far as the Qin and Han dynasties, there were relatively mature treatises, which laid the foundation of hand diagnosis medicine; in Tang and Song dynasties, hand diagnosis medicine entered the development stage, especially its application in pediatrics; in the Yuan, Ming and Qing dynasties, hand diagnosis medicine entered the stage of improvement, and there were hand diagnosis charts attached. In modern times, combined with modern scientific experimental research methods, in basic research and clinical research, hand diagnosis medicine has entered a stage of prosperity and development. Throughout the history of hand diagnosis medicine, the basic theories are constantly enriched, the scope of clinical application is constantly expanded, and the idea of “know the inside from the outside” is constantly interpreted in depth.
2021 Vol. 18 (23): 127-130 [Abstract] ( 85 ) HTML (1 KB)  PDF (708 KB)  ( 116 )
131 Analysis of Liu Lanying’s medication rule in the treatment of depression based on Apriori algorithm and complex network
YANG Jiangwei1 LIANG Wenjie2 LIN Chen3 LIU Lanying1
Objective To explore the medication rule and characteristics of Liu Lanying in the treatment of depression. Methods The data of depression patients treated by Liu Lanying in Tongde Hospital of Zhejiang Province from January 2018 to January 2019 were selected. Frequency analysis, Apriori algorithm and complex network of Gephi software were used to mine the characteristics of core drugs and compatibility. Results Female patient was 75.34%, long course patient was 71.23%, in 73 patients. Reinforcing drugs were 1124 times (51.13%), qi-invigorating drugs were 634 times (26.48%). The top three were Astragali Radix, Pseudostellariae Radix and Acanthopanacis Senticosi Radix et Rhizoma Seu Caulis. The most meridian tropism of drugs were spleen stomach meridian (spleen was 16 times, stomach was nine times). The top three drug compatibility support were Astragali Radix-Pseudostellariae Radix, Glycyrrhizae Radix et Rhizoma-Astragali Radix, Glycyrrhizae Radix et Rhizoma-Pseudostellariae Radix. Core drugs were Astragali Radix, Glycyrrhizae Radix et Rhizoma, Paeoniae Radix Alba, Margaritifera Concha, Pseudostellariae Radix, Polygalae Radix, Acanthopanacis Senticosi Radix et Rhizoma Seu Caulis, Atractylodis Macrocephalae Rhizoma, Cynanchi Paniculati Radix et Rhizoma and Bone Fossil of Big Mammals. Conclusion Liu Lanying’s treatment for depression is based on invigorating spleen and replenishing qi, which is different from dispersing liver, regulating qi, and relieving qi stagnation, which may be related to the gender and course of depression.
2021 Vol. 18 (23): 131-134 [Abstract] ( 102 ) HTML (1 KB)  PDF (719 KB)  ( 119 )
135 Clinical effect of eight methods of intelligent turtle time-based thunder fire moxibustion in treating irritable bowel syndrome with diarrhea and spleen and kidney yang deficiency
LI Haiyan SHI Si SUN Hong SHAO Xiaoping▲
Objective To observe clinical effect of eight methods of intelligent turtle time-based thunder fire moxibustion in treating irritable bowel syndrome with diarrhea and spleen and kidney yang deficiency. Methods One hundred patients with irritable bowel syndrome with diarrhea and spleen and kidney yang deficiency treated in Outpatient Department of Nantong Hospital of Traditional Chinese Medicine in Jiangsu Province from July 2019 to July 2020 were selected and divided into two groups according to random number table method, with 50 cases in each group. Experimental group was treated with eight methods of intelligent turtle time-based thunder fire moxibustion, control group was treated with eight methods of intelligent turtle on time thunder fire moxibustion. All patients were treated for 28 days. Total effective rate of traditional Chinese medicine syndrome, traditional Chinese medicine syndrome score, irritable bowel syndrome symptom severity scale (IBS-SSS) score and irritable bowel syndrome quality of life (IBS-QOL) score before and after treatment in two groups were observed. Results There was no significant difference in total effective rate of traditional Chinese medicine syndrome between two groups (P > 0.05). Overall analysis showed that the time, inter group and interaction of traditional Chinese medicine syndrome score and IBS-SSS score were statistically significant (P < 0.05). Within group comparison: traditional Chinese medicine syndrome score and IBS-SSS score of two groups at 14 and 28 days after treatment were lower than those before treatment, and traditional Chinese medicine syndrome score and IBS-SSS score of two groups at 28 days after treatment were lower than those at 14 days after treatment, the differences were statistically significant (P < 0.05). Comparison between groups: traditional Chinese medicine syndrome score and IBS-SSS score of experimental group at 14 and 28 days after treatment were lower than those of control group, the differences were statistically significant (P < 0.05). Overall analysis showed that the time, inter group and interaction of IBS-QOL score were statistically significant (P < 0.05). Within group comparison: IBS-QOL score of two groups at 14 and 28 days after treatment were higher than those before treatment, and IBS-QOL score of two groups at 28 days after treatment were higher than those at 14 days after treatment, the differences were statistically significant (P < 0.05). Comparison between groups: IBS-QOL score of experimental group at 14 and 28 days after treatment were higher than those of control group, the differences were statistically significant (P < 0.05). Conclusion The curative effect of two groups is comparable, but the treatment with eight methods of intelligent turtle time-based thunder fire moxibustion has better clinical effects in alleviating the severity of clinical symptoms and improving idiosyncratic quality of life in patients with diarrhea due to spleen and kidney yang deficiency.
2021 Vol. 18 (23): 135-139 [Abstract] ( 73 ) HTML (1 KB)  PDF (770 KB)  ( 147 )
140 Effect of modified Banxia Xiexin Decoction in the treatment of chronic gastritis with Helicobacter pylori infection
WU Liguo1 MA Minkai1 QIN Wei2 CHEN Na1 ZHANG Lixia1
Objective To observe clinical effect of modified Banxia Xiexin Decoction in the treatment of chronic gastritis with Helicobacter pylori (Hp) infection. Methods Seventy-six patients of chronic gastritis with Hp infection in the Fourth Central Hospital of Baoding City in Hebei Province from July to December 2019 were selected and divided into two groups, each group of 38 cases. Control group was given routine Western medicine treatment, while observation group was treated with modified Banxia Xiexin Decoction on the basis of control group. The treatment course of both groups was two weeks. Traditional Chinese medicine syndrome score, Hp eradication rate, serum motilin and gastrin levels of two groups were observed before and after treatment, and clinical effects of two groups were statistically analyzed. Results After treatment, the scores of abdominal distension or abdominal pain, body sleepiness, sticky or loose stool, mental sleepiness, bad breath and poor appetite in two groups were lower than those before treatment, and observation group was lower than control group, the differences were statistically significant (P < 0.05). There was no significant difference in Hp eradication rate between two groups (P > 0.05). After treatment, the serum motilin level of two groups was higher than that before treatment, and the gastrin level of two groups was lower than that before treatment, and the serum motilin level of observation group was higher than that of control group, and the gastrin level of observation group was lower than that of control group, the differences were statistically significant (P < 0.05). Clinical effect of observation group was better than that of control group, and the difference was statistically significant (P < 0.05). Conclusion Modified Banxia Xiexin Decoction can effectively improve clinical symptoms of patients, regulate the content of serum motilin and gastrin, and its clinical efficacy is better than that of Western medicine alone.
2021 Vol. 18 (23): 140-143 [Abstract] ( 127 ) HTML (1 KB)  PDF (730 KB)  ( 161 )
144 Clinical study on self-designed Shugan Hewei Yuyang Decoction in the treatment of gastric ulcer with liver and stomach disharmony type
WANG Liyuan1 ZHU Weining2 SHI Ling3
Objective To study clinical effect of self-designed Shugan Hewei Yuyang Decoction in the treatment of gastric ulcer with liver and stomach disharmony type. Methods One hundred and twenty patients with liver and stomach disharmony type gastric ulcer admitted to Department of Spleen and Gastric Diseases in Weihai Hospital of Traditional Chinese Medicine from February to June 2020 were selected and divided into control group and treatment group according to random number table method, with 60 cases in each group. Control group was treated with Pantoprazole, and treatment group was treated with Shugan Hewei Yuyang Decoction on the basis of control group. The course of treatment was four weeks. Clinical efficacy and traditional Chinese medicine syndrome score before and after treatment were compared between two groups. Results Clinical total effective rate of treatment group was higher than that of control group (P < 0.05). After treatment, the scores of abdominal pain, abdominal distension, belching and pantothenic acid, shantaixi in two groups were lower than those before treatment, and those in treatment group were lower than those in control group, the differences were statistically significant (P < 0.05). Conclusion Shugan Hewei Yuyang Decoction is an effective method in the treatment of gastric ulcer, which can effectively eliminate or improve the clinical symptoms and promote the healing of peptic ulcer. It is worthy of further study and promotion.
2021 Vol. 18 (23): 144-147 [Abstract] ( 55 ) HTML (1 KB)  PDF (756 KB)  ( 71 )
148 Application of fenxiao zouxie method in remission of bronchial asthma in children
SI Xiuying1 YANG Yang1 GUO Zheng1 LIANG Yuan1 PAN Guangxia1 WANG Youpeng2
Bronchial asthma has become a common disease in children. The incidence rate is increasing year by year. It is very important to treat and actively prevent children’s bronchial asthma. Especially in the treatment of remission stage, it is an important part of the disease. On the basis of summarizing the experience of predecessors, Professor Wang Youpeng creatively applied the method of fenxiao zouxie to this disease. He respectes the idea of “treating serious diseases with combined prescriptions” and “fu tan” of bronchial asthma in clinical practice. On the basis of Wendan Decoction, the representative of this method, Xiebai Powder, Conglong Decoction, Sanzi Yangqin Decoction and Xuanbei Ganju Decoction are used for treatment according to different syndrome types, in clinical practice, the curative effect is remarkable.
2021 Vol. 18 (23): 148-151 [Abstract] ( 145 ) HTML (1 KB)  PDF (720 KB)  ( 80 )
152 Current situation of marketing authorisation holders pharmacovigilance working in Hebei Province
GUO Shasha1 LIU Hongxing1 WANG Bing2 WEI Li3 WANG Fang2
Objective To study the current situation of pharmacovigilance work in marketing authorization holders in Hebei Province and to provide reference for the development and supervision of pharmacovigilance work of marketing authorization holders. Methods The data of the 2019 annual pharmacovigilance report submitted by the marketing authorization holders in the jurisdiction collected by Center for Drug Monitoring and Evaluation of Hebei from January to March 2020 were extracted by Excel software. The pharmacovigilance system, individual adverse drug reactions, risk assessment and control, and post-marketing safety studies of the holders were analyzed retrospectively. Results Among the marketing authorization holders, 94.25% have specialized agencies and 85.06% have full-time personnel; 28.74% have a sound pharmacovigilance management system; 98.85% of self-contained collection routes established, but the number of adverse reaction reports reported self-collection was 0.58% of the total; holders who found product risk accounted for 10.34%. Conclusion Marketing authorization holders should strengthen the study and training of relevant laws and regulations, raise the awareness of law and subject responsibility, improve the pharmacovigilance management system, set up specialized agencies and provide full-time staff according to law, improve the ability of independent collection of reports and risk management, and effectively carry out pharmacovigilance work. It is suggested that the national medical products administration should further promote the construction of the system of laws and regulations on drug alert, refine the supporting technical guidelines, and provide technical guidance for marketing authorization holders.
2021 Vol. 18 (23): 152-155,164 [Abstract] ( 58 ) HTML (1 KB)  PDF (800 KB)  ( 103 )
156 Effect of FMEA-based nursing model on negative emotion and daily activity ability in patients with cerebral infarction
ZHANG Lijuan1 ZHOU Yixia1,2 LI Yi3 LI Wei4 XU Xu5 XU Jianwei6,7
Objective To explore the effect of nursing model based on failure mode and influence analysis （FMEA） on negative emotion and daily activity ability of patients with cerebral infarction. Methods In a prospective study, a total of 105 patients with cerebral infarction treated in a Grade 3A hospital in Guiyang from November 2019 to August 2020 were divided into two groups control group 53 cases and experimental group 52 cases by random number table methed. All patients received routine nursing, and the experimental group increased the nursing mode based on FMEA. During the intervention, the death and loss of follow-up of the patients in the two groups were observed; after the intervention, the scores of self-rating anxiety scale（SAS），self-rating depression scale（SDS） and Barthel index scale were compared between the two groups. Results During the intervention period, there were death and loss of follow-up in both the control group and the test group, and there was no significant difference in the number of death and loss of follow-up between the two groups（P ＞ 0.05）; after intervention, the scores of SAS and SDS decreased and the Barthel index increased in both groups. The scores of SAS and SDS in the test group were lower than those in the control group，while the Barthel index was higher than that in the control group, the differences were statistically significant （P ＜ 0.05）. Conclusion The nursing model based on FMEA can effectively reduce the anxiety and depression of patients with cerebral infarction and improve the ability of daily activities.
2021 Vol. 18 (23): 156-159,180 [Abstract] ( 55 ) HTML (1 KB)  PDF (702 KB)  ( 81 )
160 Effect of early intensive cardiac rehabilitation training on the rehabilitation and quality of life in patients with acute non-ST-segment elevation myocardial infarction after PCI
SUN Yongmei1 GU Honglian1 ZHANG Mei2 LIN Ying1 GE Mingjie1
Objective To investigate the effect of early intensive cardiac rehabilitation training on the rehabilitation effect and quality of life of patients with acute non-ST-elevation myocardial infarction after percutaneous coronary intervention （PCI). Methods A total of 80 patients with acute non-ST-segment elevation myocardial infarction after PCI admitted to Huaibei People’s Hospital from May 2017 to August 2018 were selected. According to random number table method, they were divided into intervention group and control group, with 40 cases in each group. The control group was given early routine rehabilitation training with standard exercise, and the intervention group was given early intensive cardiac rehabilitation training. Follow-up for 6 months, the heart function, endpoint events and quality of life were compared between two groups. Results After 6 months of follow-up, the left ventricular ejection fraction （LVEF) of the two groups was higher than before the intervention, the wall motion index （WMSI) was lower than before the intervention (P ＜ 0.05), the LVEF of the intervention group was higher than that of the control group, and the WMSI was lower in the control group  (P ＜ 0.05); the incidence of end-point events in the intervention group was lower than that in the control group  (P ＜ 0.05); the scores of the two groups of patients on the multidimensional assessment scale （MIDAS) were lower than before the intervention  (P ＜ 0.05); the body of the intervention group, the total score of activity, emotional response, dependence, diet, and MIDAS was lower than that of the control group  (P ＜ 0.05). Conclusion Early intensive rehabilitation training can help protect the cardiac function of patients with acute non-ST-segment elevation myocardial infarction after PCI, reduce the occurrence of malignant endpoint events, and improve the quality of life of patients.
2021 Vol. 18 (23): 160-164 [Abstract] ( 101 ) HTML (1 KB)  PDF (651 KB)  ( 74 )
165 Influence of comfort nursing theory from the perspective of quality nursing on chemotherapy patients with malignant tumor in indwelling infusion port
LI Ying LI Na TIAN Li▲

Objective To explore the influence of comfort nursing theory on chemotherapy patients with malignant tumor in the perspective of high quality nursing. Methods A total of 120 patients with malignant tumor treated in Beijing Friendship Hospital, Capital Medical University from January 2019 to December 2019 were selected. According to random number table method, they were divided into control group and experimental group, with 60 cases in each group. The control group received routine nursing at the infusion port, on the basis of the control group the experimental group was given nursing intervention in the perspective of high quality nursing comfort nursing theory. After 6 months of follow-up, quality of life, level of hope and psychological status of both groups were evaluated. Results Fifty cases were actually included in the control group and 40 cases were included in the experimental group when invalid questionnaires and patients died of illness were excluded. After 6 months of follow-up, self-rating anxiety scale (SAS) and self-rating depression scale (SDS) scores in both groups were lower than before intervention (P ＜ 0.05). SAS and SDS scores in experimental group were significantly lower than those in control group (P ＜ 0.05); the scores of positive action and intimate relationship in control group were significantly higher than those before intervention (P ＜ 0.05); the total scores of positive action, intimate relationship and hope in the experimental group were higher than those before intervention (P ＜ 0.05); the scores of positive action, intimate relationship and hope level in experimental group were significantly higher than those in control group (P ＜ 0.05); the quality of life scores in both groups were higher than before intervention (P ＜ 0.05); the scores of physiological function, physiological function, social function and body pain in the experimental group were significantly higher than those in the control group (P ＜ 0.05). Conclusion From the perspective of high quality nursing, the application of comfort nursing theory can reduce the anxiety and depression of patients with malignant tumor in the indwelling infusion port, enhance the level of hope, and improve the quality of life.
2021 Vol. 18 (23): 165-168 [Abstract] ( 72 ) HTML (1 KB)  PDF (674 KB)  ( 87 )
169 Application effect of Parkinson disease nursing care studio on Parkinson disease patients under multidisciplinary collaboration
SHEN Qi ZHANG Xiuwen▲
Objective To investigate the application effect of Parkinson disease nursing care studio on Parkinson disease patients under multidisciplinary collaboration. Methods A total of 96 patients admitted to Parkinson disease nursing care studio in the First Affiliated Hospital of PLA Air Force Military Medical University from January 2018 to December 2019 were selected, and they were divided into research group and control group by using random number table method, with 48 cases in each group. Patients in the control group were performed routine nursing, and those in the research group were performed multi-disciplinary treatment. After 6 months of intervention, the self-care level, the caregivers’ nursing level, the quality of life and the difference in motor function between the two groups were compared. Results After 6 months of intervention, the score of exercise of self-care a-gency (ESCA) in the research group was significantly higher than that before intervention in the same group and the control group after intervention (P ＜ 0.05); the difference in ESCA score between before and after intervention in the control group was not statistically significant (P ＞ 0.05). The family caregiver task inventory (FCTI) scores of the caregivers in the two groups were significantly lower than those before intervention (P ＜ 0.05); the FCTI score of the research group was significantly lower than that of the control group (P ＜ 0.05). The unified Parkinson disease rating scale (UPDRS) score of the two groups was significantly lower than that before the intervention (P ＜ 0.05); the UPDRS score of the research group was significantly lower than that of the control group (P ＜ 0.05). The Parkinson’s disease quality of life questionnaire (PDQL) score of the two groups was significantly higher than that before the intervention (P ＜ 0.05); the PDQL score of the research group was significantly higher than that of the control group (P < 0.05). Conclusion The Parkinson disease nursing care studio under multidisciplinary collaboration can help to improve the self-care level and the nursing level of caregivers of Parkinson disease patients, enhance the motor function of the patients, and improve their quality of life, which is worth popularizing.
2021 Vol. 18 (23): 169-172 [Abstract] ( 118 ) HTML (1 KB)  PDF (674 KB)  ( 129 )
173 Effect of diversified cognitive behavioral therapy on health-related behaviors and quality of life in patients with chronic rhinosinusitis surgery
GUAN Shuiping1 TAO Rong2 MAO Zhijuan3 GU Xiaochun2▲
Objective To investigate the effect of diversified cognitive behavioral therapy on the health-related behaviors and quality of life of patients with chronic rhinosinusitis surgery. Methods A total of 118 patients with chronic rhinosinusitis undergoing surgery in Nantong Hospital of Traditional Chinese Medicine from March 2017 to October 2018 were selected. According to the random number table method, they were divided into experimental group and control group, with 59 cases in each group. The control group implemented routine nursing interventions, and the treatment group jointly implemented diversified cognitive behavioral therapy. The health-related behaviors, quality of life and nursing satisfaction of the two groups were compared after 6-month follow-up. Results The treatment group actually completed 58 cases and the control group actually completed 54 cases. Follow-up for 6 months, the health-related behavior scores of the two groups were higher than those before the intervention in the same group (P ＜ 0.05), the scores of the treatment group following medical drugs, reasonable diet，moderate exercise, smoking cessation, and alcohol cessation were higher than those of the control group (P ＜ 0.05). The quality of life scores of the two groups were lower than before the intervention in the same group (P ＜ 0.05), the scores of nasal symptoms, sinusitis-related symptoms, sleep disorders, and affective disorders in the treatment group were lower than those in the control group (P ＜ 0.05). Conclusion Diversified cognitive behavioral therapy can help promote the development of health-related behaviors in patients with chronic rhinosinusitis surgery and improve the quality of life.
2021 Vol. 18 (23): 173-176,192 [Abstract] ( 158 ) HTML (1 KB)  PDF (907 KB)  ( 91 )
177 Effect of health education of knowledge, belief and practice on the compliance behavior and prognosis of patients with isolated superior mesenteric artery dissection
SHI Jing JIANG Haiying▲
Objective To explore the effect of health education of knowledge, belief and practice on the compliance behavior and prognosis of patients with isolated superior mesenteric artery dissection (ISMAD). Methods From January 2015 to March 2020, 126 patients with ISMAD admitted to the First Affiliated Hospital of Nanjing Medical University were selected as research objects. According to the random number table method, they were divided into observation group (63 cases) and control group (63 cases). The patients in control group received regular health education, and the patients in observation group received health education of knowledge, belief and practice. The pain degree(visual analogue scale [VAS] was used), compliance behavior (self-made questionnaire on compliance behavior of ISMAD patients was used) of two groups before and after intervention were compared, and the incidence of complications was recorded. Results After six months of follow-up, observation group completed follow-up of 60 cases, and control group completed follow-up of 56 cases. After six months of follow-up, VAS scores of two groups were lower than thos of the same group before intervention, and observation group was lower than control group (P < 0.05); the scores of standardized diet, smoking cessation and alcohol restriction, blood pressure monitoring, medication management, regular follow-up scores, and total scores of two groups were higher than those of the same group before intervention, and observation group was higher than control group (P < 0.05). The total incidence of complications in observation group was lower than that in control group (P < 0.05). Conclusion Health education on knowledge, belief and practice can help promote the development of compliance behavior for patients with superior mesenteric artery dissection, relieve their pain and reduce the occurrence of complications.
2021 Vol. 18 (23): 177-180 [Abstract] ( 101 ) HTML (1 KB)  PDF (638 KB)  ( 108 )
181 Effect of nursing measures based on FMEA model on psychological status and sleep quality of maintenance hemodialysis patients
LIU Qingyan1 SUN Mengjie1 TAO Mingfen2
Objective To explore the effect of nursing measures based on failure mode and effect analysis (FMEA) model on psychological status and sleep quality of maintenance hemodialysis patients. Methods From March 2018 to October 2020, 92 patients with maintenance hemodialysis in Xuancheng People’s Hospital of Anhui Province were selected as study objects. They were divided into observation group and control group according to the random number table method, with 46 cases in each group. Control group was given routine nursing intervention, and observation group was given nursing intervention based on FMEA model. The scores of self-rating depression scale (SDS), self-rating anxiety scale (SAS), Pittsburgh sleep quality index (PSQI) and short form 36-item short form health survey (SF-36), satisfaction, and the incidence of complications were compared between two groups. Results After three months of intervention, the score of SDS, SAS and PSQI in two groups were lower than those before intervention, and observation group was lower than control group, and the differences were statistically significant (P ＜ 0.05). After three months of intervention, SF-36 score in two groups were higher than those before intervention, and observation group was higher than control group, and the differences were statistically significant (P ＜ 0.05). The catheter infection rate and fistula occlusion rate of observation group were lower than those of control group, and the satisfaction of patients was higher than that of control group, and the differences were statistically significant (P ＜ 0.05). Conclusion The nursing measures based on FMEA model can effectively improve the psychological status, sleep quality and life quality of patients with maintenance hemodialysis, which is worth popularizing.
2021 Vol. 18 (23): 181-184 [Abstract] ( 179 ) HTML (1 KB)  PDF (638 KB)  ( 109 )
185 Correlation analysis of self-management level and family management mode in children with acute attack of asthma
WANG Simin LIANG Juan▲
Objective To observe the self-management level in children with acute attack of asthma and to analyze its correlation with family management mode. Methods From January 2018 to December 2019, 100 children with acute attack of asthma admitted to the Department of Pediatric, the First Affiliated Hospital of the Chinese People’s Liberation Army Air Force Military Medical University were prospectively enrolled. They were inhaled with Salbutamol and treated with inhaled glucocorticoids for long-term treatment after symptom control. The self-management level (assessed by the family self-management scale for children with bronchial asthma) and family management mode (assessed by the family management measurement [FAMM]) of all children were evaluated before treatment, three days after treatment, and one week after treatment, respectively, and the correlation between them was analyzed. Results Before treatment, three days after treatment, and one week after treatment, There were high statistical significance in each dimension and total score of the family self-management scale for children with bronchial asthma (P < 0.01); and pairwise comparison showed that the differences in each dimension and total score of the family self-management scale for children with bronchial asthma at each time point were statistically significant (P < 0.05). Before treatment, three days after treatment, and one week after treatment, there were high significant differences in each dimension and total score of FAMM (P < 0.01); and pairwise comparison showed that each dimension and total score of FAMM at each time point were statistically significant (P < 0.05). The family self-management scale for children with bronchial asthma (daily life management, disease medical management, and emotional cognitive management) and total score were positively correlated with children’s daily life, disease management ability, and parental mutual support in FAMM; and was negatively correlated with energy consumption, difficulty in disease management, and fear of disease effects in FAMM (P < 0.05). Conclusion The self-management level of children with acute attack of asthma is closely related to family management mode, clinical intervention can be carried out accordingly to improve the self-management level or family management mode.
2021 Vol. 18 (23): 185-188 [Abstract] ( 118 ) HTML (1 KB)  PDF (674 KB)  ( 60 )
189 Tuberculosis induced by Sintilimab in patients with non-small cell lung cancer: a case report
LIU Di1,2 GONG Jun2 LIAO Zhengkai2 ZHOU Yunfeng2
Programmed death receptor-1/ programmed death-ligand-1 antibody has been widely used in the treatment of malignancies, it has been gradually reported as an immune-related adverse event. The case was a 67-year-old male patient with stage Ⅳ non-small cell lung cancer who was treated with second-line chemotherapy combined with Sintilimab after first-line treatment progression. Subsequently, the patient developed cough, wheezing and night sweats, further examination showed that mycobacterium tuberculosis was cultured, and he was diagnosed with tuberculous pleurisy. Tuberculosis induced by Sintilimab in patients with advanced non-small cell lung cancer after chemoradiotherapy has not been reported. In order to raise clinicians’ awareness of the potential risk of Sintilimab-induced tuberculosis, this paper is hereby reported.
2021 Vol. 18 (23): 189-192 [Abstract] ( 171 ) HTML (1 KB)  PDF (679 KB)  ( 92 )
193 Research on the problems and countermeasures of the assessment system under the background of “traditional Chinese medicine law”
LUO Xian Ranna·Ahati YANG Zi ZHANG Xinyu HE Nan WANG Wei FAN Linjie LI Dan LI Ruifeng
The assessment system for professionals with expertise in traditional Chinese medicine is a major measure to promote the inheritance and innovative development of Chinese medicine under the background of the “traditional Chinese medicine law”. At present, the assessment system is still in the trial and exploration stage, and it faces many problems and challenges in actual progess. This article fully understands the current situation of the assessment system, and comprehensively sorts out and analyzes the material review link and the problems existing in the assessment link of the assessment system through methods such as literature search, material collection and expert interviews. This article finds that the main problems in the current assessment system are mainly these: some substantive conditions are required to be reduced, leading to increased risk factors, some assessment dimensions lack assessment standards, and the list of disease names and technical names for candidates to fill in is not complete and derived. The industrial chain of training institutions that has been released has increased the difficulty of review and supervision. In the end, this article puts forward the following suggestions in response to the problem: relevant departments should further improve the operability evaluation indicators, strictly abide by the “strict evaluation” evaluation standards, improve the list of disease names and technical names, increase regulatory enforcement and qualification review, and improve local Chinese medicine management system, etc. These suggestions provide a reference for comprehensively and smoothly advancing the work of the assessment system and improving relevant policies and regulations.
2021 Vol. 18 (23): 193-196 [Abstract] ( 77 ) HTML (1 KB)  PDF (401 KB)  ( 93 )
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