不同受精方式治疗非男性因素不孕高龄女性患者的效果

Abstract
Figure/Table
References (25)
Related Citation (0)

Download: PDF (410 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To evaluate the effect of different fertilization methods in advanced maternal age patients with non-male factor infertility. Methods A total of 606 cases of advanced maternal age patients with non-male factor infertility in Reproductive Medicine Center, Shanghai First Maternity and Infant Hospital, Tongji University, from January 2017 to December 2019 were enrolled. They were devided into in vitro fertilization (IVF) group (421 cases) and intracytoplasmic sperm injection (ICSI) group (185 cases) according to the fertilization method. Clinical outcomes and offspring birth were compared between two groups. Results There were significant differences in fertilization rate and blastocyst formation rate between two groups (P < 0.05). There were no significant differences in cleavage rate, D3 available embryo rate, D3 high-quality embryo rate, clinical pregnancy rate, and implantation rate between two groups (P > 0.05). There were no significant differences in gestational age, birth weight, birth rate, low body weight birth rate, and premature birth rate between two groups (P > 0.05). Conclusion In advanced maternal age patients with non-male infertility, conventional IVF treatment resulted in higher rates of fertilization and blastocyst formation than ICSI, and ICSI treatment of non-male infertility do not improve the implantation rate and birth rate.

Key words： Non-male factor infertility Advanced maternal age Intracytoplasmic sperm injection

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	LIU Ya’nan WANG Yu KONG Pengcheng PAN Jiaping TENG Xiaoming

Cite this article:

LIU Ya’nan WANG Yu KONG Pengcheng PAN Jiaping TENG Xiaoming. Effect of different fertilization methods in advanced maternal age patients with non-male factor infertility[J]. 中国医药导报, 2021, 18(23): 80-83.

URL:

https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I23/80

[1] Khot UP，Lang AW，Murali K，et al. Systematic review of the efficacy and safety of colorectal stents [J]. Br J Surg，2002，89（9）：1096-1102.
[2] Zegers-Hochschild F，Adamson GD，Dyer S，et al. The International Glossary on Infertility and Fertility Care，2017 [J]. Fertil Steril，2017，108（3）：393-406.
[3] Dyer S，Chambers GM，De Mouzon J，et al. International Committee for Monitoring Assisted Reproductive Technologies world report：Assisted Reproductive Technology 2008，2009 and 2010 [J]. Hum Reprod，2016，31（7）：1588-1609.
[4] Boulet SL，Mehta A，Kissin DM，et al. Trends in use of and reproductive outcomes associated with intracytoplasmic sperm injection [J]. JAMA，2015，313（3）：255-263.
[5] Devroey P，Van Steirteghem A. A review of ten years experience of ICSI [J]. Hum Reprod Update，2004，10（1）：19-28.
[6] 史艳彬，邵小光.ICSI使用率增长的思考[J].生殖医学杂志，2019，28（6）：697-701.
[7] 朱家红，刘卫卫，王江，等.ICSI对高龄非男性因素不孕患者生育结局的影响[J].生殖医学杂志，2020（4）：458-462.
[8] Kim JY，Kim JH，Jee BC，et al. Can intracytoplasmic sperm injection prevent total fertilization failure and enhance embryo quality in patients with non-male factor infertility? [J]. Eur J Obstet Gynecol Reprod Biol，2014，178：188-191.
[9] Kastrop PM，Weima SM，Van Kooij RJ，et al. Comparison between intracytoplasmic sperm injection and in-vitro fertilization（IVF）with high insemination concentration after total fertilization failure in a previous IVF attempt [J]. Hum Reprod，1999，14（1）：65-69.
[10] Lee SH，Lee JH，Park YS，et al. Comparison of clinical outcomes between in vitro fertilization（IVF）and intracytoplasmic sperm injection（ICSI）in IVF-ICSI split insemination cycles [J]. Clin Exp Reprod Med，2017，44（2）：96-104.
[11] Cooper TG，Noonan E，Von Eckardstein S，et al. World Health Organization reference values for human semen characteristics [J]. Hum Reprod Update，2010，16（3）：231-245.
[12] 谢广妹，杨杰，许思娟，等.不同卵巢刺激方案对高龄不孕患者卵泡液氧化应激及ART结局的影响[J].生殖医学杂志，2020，29（5）：603-608.
[13] 方伟芬，孙燕萍，牛向丽，等.体外受精后不同时期观察受精对胚胎质量的影响[J].中国计划生育和妇产科，2010，2（1）：5-7.
[14] Korkmaz C，Tekin YB，Sakinci M，et al. Effects of maternal ageing on ICSI outcomes and embryo development in relation to oocytes morphological characteristics of birefringent structures [J]. Zygote，2015，23（4）：550-555.
[15] 黄莹，覃爱平.两种授精方式在高龄低获卵患者体外受精-胚胎移植中的应用效果比较[J].广西医学，2020，42（15）：1981-1984，1994.
[16] Kim HH，Bundorf MK，Behr B，et al. Use and outcomes of intracytoplasmic sperm injection for non-male factor infertility [J]. Fertil Steril，2007，88（3）：622-628.
[17] Ou YC，Lan KC，Huang FJ，et al. Comparison of in vitro fertilization versus intracytoplasmic sperm injection in extremely low oocyte retrieval cycles [J]. Fertil Steril，2010，93（1）：96-100.
[18] Eftekhar M，Mohammadian F，Yousefnejad F，et al. Comparison of conventional IVF versus ICSI in non-male factor，normoresponder patients [J]. Iran J Reprod Med，2012，10（2）：131-136.
[19] Bhattacharya S，Hamilton MP，Shaaban M，et al. Conventional in-vitro fertilisation versus intracytoplasmic sperm injection for the treatment of non-male-factor infertility：a randomised controlled trial [J]. Lancet，2001，357（9274）：2075-2079.
[20] Gennarelli G，Carosso A，Canosa S，et al. ICSI Versus Conventional IVF in Women Aged 40 Years or More and Unexplained Infertility：A Retrospective Evaluation of 685 Cycles with Propensity Score Model [J]. J Clin Med，2019，8（10）：1694.
[21] Mcpherson NO，Vincent AD，Pacella-Ince L，et al. Comparison of in vitro fertilisation/intracytoplasmic sperm injection on live birth rates in couples with non-male factor infertility and advanced maternal age [J]. J Assist Reprod Genet，2021，38（3）：669-678.
[22] 徐文杰，黄官友，周从容，等.不同受精方式对高龄不育患者胚胎质量及临床结局的影响[J].生殖医学杂志，2016，25（7）：600-604.
[23] Ola B，Afnan M，Sharif K，et al. Should ICSI be the treatment of choice for all cases of in-vitro conception? Considerations of fertilization and embryo development，cost effectiveness and safety [J]. Hum Reprod，2001，16（12）：2485-2490.
[24] ESHRE Capri Workshop Group. Intracytoplasmic sperm injection （ICSI） in 2006：evidence and evolution [J]. Hum Reprod Update，2007，13（6）：515-526.
[25] Esteves SC，Roque M，Bedoschi G，et al. Intracytoplasmic sperm injection for male infertility and consequences for offspring [J]. Nat Rev Urol，2018，15（9）：535-562.