胰腺癌患者血清Kiss-1水平变化及临床意义

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Abstract Objective To investigate the changes of serum kisspeptin-1 (Kiss-1) level in patients with pancreatic cancer, and to analyze its relationship with the prognosis, clinicopathological parameters of patients with pancreatic cancer. Methods A total of 132 patients with pancreatic cancer admitted to Ningbo Hospital of Traditional Chinese Medicine, Zhejiang Province from January 2015 to December 2017 were selected as the pancreatic cancer group, 57 patients with benign pancreatic disease were selected as the benign lesion group and 53 healthy subjects were selected as the control group. Serum levels of Kiss-1, carcinoembryonic antigen (CEA) and carbohydrate antigen 199 (CA199) in the three groups were detected to analyze the correlation between Kiss-1 and CEA and CA199, as well as the relationship between Kiss-1 level and clinical characteristics and prognosis of pancreatic cancer patients. The pancreatic cancer group was divided into low Kiss-1 group (Kiss-1 ＜ 42.13 pg/ml, 76 cases) and high Kiss-1 group (Kiss-1 ≥ 42.13 pg/ml, 56 cases) according to Kiss-1 level. Receiver operating characteristic (ROC) curve was used to analyze the prognostic value of Kiss-1 in pancreatic cancer. Results Serum Kiss-1 level in pancreatic cancer group was lower than that in benign disease group and control group, while CEA and CA199 levels were higher than those in benign disease group and control group, with statistical significance (P ＜ 0.05). There were no significant differences in the levels of serum Kiss-1, CEA and CA199 between the benign lesion group and the control group (P ＞ 0.05). Serum Kiss-1 levels were negatively correlated with CEA and CA199 levels in pancreatic cancer group (r = -0.687, -0.703, P ＜ 0.001). The serum Kiss-1 level of pancreatic cancer patients with TNM stage Ⅲ-Ⅳ, or liver metastasis was lower than that of pancreatic cancer patients with TNM stage Ⅰ-Ⅱ, or no liver metastasis, with statistical significance (P ＜ 0.05). The 3-year survival rate of low Kiss-1 level group was lower than that of high Kiss-1 level group (P ＜ 0.05). Multivariate Cox regression analysis showed that high TNM stage, liver metastasis and low Kiss-1 level were independent risk factors for prognosis of pancreatic cancer patients (OR ＞ 1, P ＜ 0.05). The ROC curve showed that the cutoff value of Kiss-1 for predicting the prognosis of pancreatic cancer was 35.16 pg/ml, the area under the curve was 0.867 (95%CI: 0.790-0.944, P ＜ 0.001), the sensitivity was 72.73%, and the specificity was 66.67%. Conclusion Serum Kiss-1 level is decreased in patients with pancreatic cancer, which is correlated with TNM stage of pancreatic cancer and liver metastasis, and can be used to evaluate the prognosis of patients with pancreatic cancer.

Key words： Pancreatic cancer Kisspeptin-1 Carcinoembryonic antigen Carbohydrate antigen 199 Prognosis

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	TU Xiaolong1 ZHAO Ying2 SHI Guojun1 WANG Yongsheng1 ZHANG Tingsu1 HU Mengyi1

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TU Xiaolong1 ZHAO Ying2 SHI Guojun1 WANG Yongsheng1 ZHANG Tingsu1 HU Mengyi1. Changes of serum Kiss-1 level in patients with pancreatic cancer and its clinical significance[J]. 中国医药导报, 2021, 18(23): 92-95,111.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I23/92

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