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2019 Vol. 16, No. 21 Published: 2019-07-25

	7	Effect of acute stress on AMPA receptors trafficking and fear memory in mice
		CHEN Yuanhao1 ZHOU Mengsheng1 YIN Xiaoyu1 HE Yi1 WANG Wei2 HAO Jingru1 HAN Yuan1 GAO Can1
		Objective To investigate the effect of acute restraint stress on AMPA receptors trafficking and fear memory in mice and its mechanism. Methods Sixty-four male C57BL/6 mice were divided into control group, Propranolol group, restraint stress group, combined group (restraint stress + Propranolol), according to random number table method, with 16 mice in each group. In the propranolol group and combined group, 10 mg/kg Propranolol solution was administered intragastrically, at the same time, the control group and the restraintstress group were intragastrically administered with an equal volume of normal saline, and the administration volume were 20 mL/kg. After 30 minutes of administration, the restraint stress group and combined group were restrained with 50 mL EP tube for 30 minutes. The fear memory of mice was evaluated by fear conditioning test. The expression of GluA1 in hippocampus, the level of serine phosphorylation at the 831th (pS-831) and the 845th (pS-845) of GluA1, the expression of calcium/calmodulin dependent protein kinase Ⅱ (CaMKⅡ) and its phosphorylation (p-CaMKⅡ) level, and the expression of GluA1 in the hippocampus cell membrane were measured by Western blot. Results Compared with the control group, the context-dependent and tone-dependent freezing time in the restraint stress group increased (P < 0.05), the expression of pS-831, pS-845 and p-CaMKⅡ in hippocampus increasd (P < 0.05), and the expression of GluA1 in cell membrane increased (P < 0.05), while the expression of GluA1 and CaMKⅡ in total protein had no significant difference (P > 0.05). Compared with the restraint stress group, the context-dependent and tone-dependent freezing time in the combined group decreased (P < 0.05), the expression of pS831, pS845 and p-CaMKⅡ in hippocampus decreased (P < 0.05), and the expression of GluA1 in cell membrane decreased (P < 0.05), while the expression of GluA1 and CaMK Ⅱ in total protein had no significant difference (P > 0.05). Conclusion Acute restraint stress can promote the formation of fear memory in mice, which may be related to the regulation of GluA1 subunit phosphorylation and the increased trafficking of AMPA receptors. Moreover, β-adrenergic receptors (β-ARs) may be one of the important targets for restraint stress-induced fear memory.
		2019 Vol. 16 (21): 7-11 [Abstract] ( 192 ) HTML (1 KB) PDF (879 KB) ( 268 )

	12	Effect of cinobufacini combined with Cisplatin on cell viability, apoptosis and cell cycle distribution of MDA-MB-231 cells
		XIAO Cong* ZHANG Yimin* SUN Shengrong
		Objective To study the effects of cinobufacini combined with Cisplatin on cell viability, apoptosis and cell cycle distribution of breast cancer MDA-MB-231 cells. Methods Breast cancer MDA-MB-231 cells were cultured in vitro. CCK-8 assay was used to detect the effect of cinobufacini combined with Cisplatin on cell viability. Scratch test was performed to detect the effect of cinobufacini combined with Cisplatin on cell migration. Flow cytometry was used to analyze the effects of cinobufacini combined with Cisplatin on the apoptosis rate and cell cycle distribution of breast cancer cells. Results CCK-8 results showed that compared with the control group, the cell viability in the cinobufacini group, the Cisplatin group and the cinobufacini+Cisplatin group was decreased, the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01). The scratch results showed that the migration ability of the cinobufacini+Cisplatin group was significantly decreased compared with the control group, the difference was highly statistically significant (P ＜ 0.01). Flow cytometry showed that compared with the control group, the proportion of G1 phase in the cinobufacini+Cisplatin group increased significantly and the apoptosis was more obvious, the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01). Conclusion Cinobufacini combined with Cisplatin shows a synergic effect in inhibiting MDA-MB-231 cells, which may be related to the induction of cell cycle arrest at G1 phase, inhibition of cell migration and promotion of cell apoptosis.
		2019 Vol. 16 (21): 12-16 [Abstract] ( 287 ) HTML (1 KB) PDF (1008 KB) ( 110 )

	17	Effects of Hypericum perforatum extract on mice behavior
		FU Songnian1 Abudoukeremu·Abudoureheman2 LUO Fuxiang3 Zulikaer·Maimaiti3 MA Li3 LI Zhijian3
		Objective To investigate the effects of Hypericum perforatum extract (ESJWT) on of behavior in mice. Methods Thirty Kunming mice were randomly divided into three groups according to the random number table method, with 10 mice in each group. The control group was given the same amount of purified water, and the ESJWT low and high dose groups were given the same amount of samples for 14 days. The drop of the rotating rod in mice was determined. 50 Kunming mice were randomly divided into control group and ESJWT low-dose and high-dose groups with 8 mice in each group. The control group was given the same amount of purified water, and the ESJWT low-dose and high-dose groups were given the same amount of samples for 14 days. The voluntary activity of mice for 5 minutes was measured and recorded. Results There was no significant difference in the latency of rod rotation test among the three groups (P > 0.05). Total activity distance of ESJWT mice in low and high dose groups was significantly shorter than that in control group, the difference was highly statistically significant (P < 0.01). All around activity distance of mice in low and high dose ESJWT group was shorter than that in control group, the number of all around activity entry in ESJWT high-dose group was less than that in control group, the difference was statistically significant (P < 0.05). The duration of central activity in ESJWT high dose group was shorter than that in ESJWT low-dose group and control group, the number of central activity entry in ESJWT high-dose group was less than that in control group, the latency of central activity in ESJWT low and high dose group was shorter than that in control group, the difference was statistically significant (P < 0.05 or P < 0.01). Conclusion ESJWT can reduce the spontaneous activity of mice, and has no significant effect on the rod test of Kunming mice.
		2019 Vol. 16 (21): 17-20 [Abstract] ( 199 ) HTML (1 KB) PDF (542 KB) ( 68 )

	21	Macrotranscriptome analysis of subgingival plaque in patients with chronic periodontitis
		XIAO Weizhuo1* ZHANG Long2* WANG Xiaodong3 ZHANG Baorong1,3
		Objective To analyze the transcriptome of subgingival plaque in chronic periodontitis and explore the changes of subgingival plaque community in chronic periodontitis. Methods From January 2017 to January 2018, 7 cases of subgingival plaque patients diagnosed as chronic periodontitis in the Department of Stomatology of Aviation General Hospital and meeting the inclusion conditions were selected. Relevant RNA was extracted and trace RNA was used to build a database. High-throughput second-generation sequencing technology was used to analyze the macrotranscriptome and the gene expression of related bacteria was observed. Results In the subgingival plaque of chronic periodontitis, the gene sequence of Venn treponema was highly expressed. Among the homologous protein families closely related to periodontitis, the most expressed gene sequences were related to bacterial translation. Among the active carbohydrate enzyme-related genes, the most expressed ones were the sequences of carbohydrate related domain genes and glycoside hydrolytic enzyme genes. Conclusion Macrotranscriptome sequencing analysis is conducted to understand the gene expression of different bacteria in subgingival plaque of chronic periodontitis patients and the gene expression of related bacteria physiological metabolism, so as to propose new research methods and opinions on the pathogenicity of dental plaque, and deepen the understanding of the pathogenicity of plaque.
		2019 Vol. 16 (21): 21-23,42 [Abstract] ( 212 ) HTML (1 KB) PDF (1188 KB) ( 225 )

	24	Research progress in quality of life and sychology in patients with allergic rhinitis
		HE Chan1 FENG Yan2 WANG Binquan2
		Allergic rhinitis is a common disease in otolaryngology head and neck surgery and the most common chronic disease affecting human health. Practice has proved that, due to the long course of disease, symptoms repeated attacks, seriously affected the quality of life and mental health of patients. Therefore, in order to improve the quality of life and psychological state of patients, the correct and targeted evaluation tools should be used first to evaluate the quality of life and psychology of patients, and explore various factors affecting the quality of life and psychology of patients. In this paper, based on extensive literature review at home and abroad, the quality of life and psychological assessment tools for patients with allergic rhinitis, quality of life status, quality of life influencing factors and other aspects of the research status of review, and put forward targeted recommendations for the future clinical treatment and nursing work to provide guidance and reference.
		2019 Vol. 16 (21): 24-27,50 [Abstract] ( 699 ) HTML (1 KB) PDF (777 KB) ( 139 )

	28	Pathogenesis and non-surgical treatment of adolescent idiopathic scoliosis
		GUAN Huanhuan1 LI Xiaohe2▲ GAO Shang1 WANG Jianzhong1 WANG Haiyan1
		This paper introduces the pathogenesis and non-surgical treatment of adolescent idiopathic scoliosis (AIS), which is widely accepted at present. It concludes that the causes of AIS are polygenic genetic factors, nervous system regulation and biomechanical abnormalities, hormone secretion abnormalities, etc. Non-surgical treatment includes exercise therapy, brace therapy, electrotherapy and massage therapy, etc. The cause of AIS has not been determined yet, but a lot of experiments have been carried out for various factors, and a lot of results have been obtained. However, the conclusions of each experimental are different, and it still needs to be further explored. In addition, the majority of AIS patients who take non-surgical treatment, can achieve good therapeutic effect through scientific and reasonable standardized treatment.
		2019 Vol. 16 (21): 28-31 [Abstract] ( 196 ) HTML (1 KB) PDF (738 KB) ( 272 )

	32	TCM diet therapy for low FODMAP diet and digestive diseases
		HAN Boyu1,2 JIN Hong3 PAN Yuyan1 LUO Mengxue1 FANG Shuangshuang1 WEI Wei1
		FODMAP diet means diet includes lysates of oligosaccharides, disaccharides, monosaccharides and polyols. Rapid fermentability and poor absorption, increased production of intestinal gas and intestinal expansion are the same characters among them. Many studies have found that low FODMAP diet could improve abdominal pain and distention, as well as other gastrointestinal symptoms significantly. This paper mainly discusses the relationship between low FODMAP diet and TCM diet therapy, and the important role of physique in the digestive symptoms caused by FODMAP diet. It is suggested that through the prevention and conditioning of TCM diet, individuals can gradually get rid of the taboo of low FODMAP diet, which is of positive significance for improving the quality of life.
		2019 Vol. 16 (21): 32-34 [Abstract] ( 288 ) HTML (1 KB) PDF (691 KB) ( 37 )

	35	Research progress on the role of macrophage autophagy in inflammatory diseases
		CHENG Mengqun YIN Jianbin ZHANG Xuan
		Macrophages are one of the important innate immune cells in the body, which are involved in immune defense and regulation of inflammation. Autophagy can regulate the phagocytosis and antigen presenting function of macrophages. It can also regulate the role of macrophages in the occurrence, development and regression of inflammation by regulating the polarization direction of macrophages. Macrophage autophagy is involved in the occurrence, development and regression of many inflammatory diseases, such as sepsis, acute lung injury, inflammatory liver injury, atherosclerosis, rheumatoid arthritis and so on. This article reviews the research progress of macrophage autophagy in inflammatory diseases, and analyzes the possibility of macrophage autophagy as a potential target for treatment of inflammatory diseases.
		2019 Vol. 16 (21): 35-38 [Abstract] ( 397 ) HTML (1 KB) PDF (700 KB) ( 285 )

	39	New progress in treatment of vascular dementia with traditional Chinese medicine
		SHAO Yalan1* ZHENG Luxi2* YANG Shulong1
		Vascular dementia (VD) is a syndrome of learning and memory dysfunction caused by ischemic or hemorrhagic stroke. At present, the influencing factors and pathogenesis of the disease have not been completely clarified, resulting in the lack of a reliable and effective treatment of VD at home and abroad. In recent years, a lot of researches have been done on the treatment of VD in traditional Chinese medicine, including the use of traditional Chinese medicine decoction, Chinese patent medicine, acupuncture treatment, and acupuncture and medicine to improve the cognitive function of patients with VD. It has the characteristics of high safety and small side effects.
		2019 Vol. 16 (21): 39-42 [Abstract] ( 185 ) HTML (1 KB) PDF (743 KB) ( 68 )

	43	Application Progress of circulating tumor DNA in the treatment of breast cancer
		HAO Shuai TIAN Wuguo GAO Bo HE Yujun LUO Donglin
		Breast cancer is one of the most common malignant tumors in women and the leading cause of death from cancer. Tumor cell DNA is continuously released into the blood during the development of tumor. These circulating tumor DNA (ctDNA) carry the information of tumor-related gene mutation, making it a potential cancer biomarker. As a kind of liquid biopsy, ctDNA detection is simple and easy, and can dynamically monitor tumor progression and treatment response with minimally invasive methods. It has been widely studied in the field of breast cancer, and has potential clinical application value in the aspects of disease efficacy monitoring, drug resistance identification, recurrence prediction and prognosis judgment.
		2019 Vol. 16 (21): 43-46 [Abstract] ( 247 ) HTML (1 KB) PDF (704 KB) ( 243 )

	47	Research progress on inappropriate medication use in the elderly
		ZHAO Liyan1 ZHAO Zhongpeng2 CHENG Yanqin1 LI Mingchun1
		Older people are more likely to have adverse drug events (ADE) due to their decreased physiological function and often have multiple underlying diseases. ADE may manifest as one or more syndromes of the elderly, including falls, convulsions, dizziness, incontinence, sleep disorders, etc., seriously affecting the life and behavioral abilities of the elderly, while giving harder for diagnosis and treatment. Identification and early intervention of inappropriate medication use in the elderly are important for reducing the risk of medication, avoiding and reducing ADE. In recent years, the research focuses on the potential inappropriate medication (PIM) use standards for the elderly, multiple drug use and medcation reconciliation, and PIM prevention, this article reviews these three aspects.
		2019 Vol. 16 (21): 47-50 [Abstract] ( 180 ) HTML (1 KB) PDF (706 KB) ( 96 )

	51	Advances in neuroendoscopic surgery for hypertensive intracerebral hemorrhage
		SHI Shuang1 ZHANG Biao1 YANG Gang2 ZHANG Zhengbao1 YANG Biao1 NIU Wenyong1 DENG Wei1 QIN Chuan1
		Hypertensive intracerebral hemorrhage is the most common subtype of stroke with high mortality and disability. Its prognosis is closely related to the age, location, volume, speed of bleeding, timing of operation, mode of operation and whether or not to take anticoagulants orally. On the premise of strictly grasping the indications and timing of operation, compared with local anesthesia minimally invasive puncture plus urokinase lysis (including stereotactic, CT-guided hard and soft channel puncture) and craniotomy microhematoma removal surgery, neuroendoscopic hematoma removal surgery not only reduces further trauma to brain tissue, but also can More thorough removal of intracerebral hematoma and hemostasis, with more minimally invasive, better efficacy advantages. At present, the assistant means of neuroendoscopy in the surgical treatment of hypertensive intracerebral hemorrhage include CT guidance, stereotactic guidance, B-ultrasound assistance, neuronavigation assistance and mobile phone software assistance. The use of various assistant means makes the neuroendoscopy more accurate in locating the hematoma, reduces the trauma to brain tissue and improves the prognosis of patients. This paper summarizes the assistant methods and their respective operative methods and characteristics of neuroendoscopy in the treatment of hypertensive intracerebral hemorrhage.
		2019 Vol. 16 (21): 51-54 [Abstract] ( 178 ) HTML (1 KB) PDF (699 KB) ( 33 )

	55	Research progress on the application of standardized patients in the teaching of internal medicine nursing
		ZOU Xiangni1 WANG Dongmei2 WANG Shurong2 GUO Rui3 ZHANG Min4
		The standardized patient has three functions: model patient, evaluator and instructor. It has been widely used in China and is of great significance in nursing teaching and assessment. It can not only stimulate students′ interest in learning, but also exercise their clinical thinking ability, improve their clinical operation skills, form a good professional attitude and standardized behavior, and enable nursing students to have good communication with patients from the perspective of patients. In contrast, it cannot completely replace the clinical reality. Therefore, this paper aims to analyze the application of standardized patient and its significance and role, as well as the advantages and disadvantages of standardized patient, so as to provide references for the application and development of standardized patient in nursing teaching in the future.
		2019 Vol. 16 (21): 55-58 [Abstract] ( 228 ) HTML (1 KB) PDF (695 KB) ( 118 )

	59	Prevalence rate of mild cognitive impairment among the elderly in a suburban area of Shanghai City and analysis on its influencing factors
		HUANG Wuquan1,2 LU Yuan3 YU Dehua3
		Objective To understand the prevalence rate of mild cognitive impairment (MCI) among the elderly in a suburban area of Shanghai City, and to explore the risk factors of MCI in the elderly, so as to provide scientific basis for the prevention and treatment of MCI in the elderly. Methods Using cluster sampling method, 705 elderly people over 65 years old in Jiading Town Street of Jiading District in Shanghai were selected from July to December 2018 for general health status questionnaire survey and Montreal cognitive assessment-basic (MoCA-B) test. Results Seven hundred and three valid questionnaires were obtained. The MoCA-B score of the elderly in community was 24(21,26) points. The prevalence rate was 19.1%. Univariate analysis showed that compared with the MCI group, the age of the non-MCI group was lower (P ＜ 0.05); the prevalence rate of MCI among the elderly in community with different educational levels, number of children born, living conditions, economic satisfaction degrees, activity status and whether they had diabetes mellitus, coronary heart disease and stroke had significant differences (P ＜ 0.05), and there was no significant difference in the prevalence rate of MCI between hypertensive patients and non-hypertensive patients (P ＞ 0.05). Multivariate unconditional Logistic regression analysis showed that advanced age (OR = 1.047, 95%CI: 1.010-1.084), three or more children born (OR = 1.876, 95%CI: 1.004-3.503), and diabetes mellitus (OR = 2.003, 95%CI: 1.338-2.997) were risk factors for MCI; living with children (OR = 0.305, 95%CI: 0.095-0.980) and above moderate exercise (OR = 0.260, 95%CI: 0.089-0.761) were protective factors for MCI. Conclusion With the increase of age, the average score of MoCA-B scale of the elderly decreases significantly. MCI intervention should be carried out as soon as possible for the elderly, who are not active and doesn′t live with their children, in order to prevent and delay the occurrence of Alzheimer′s disease.
		2019 Vol. 16 (21): 59-63,68 [Abstract] ( 226 ) HTML (1 KB) PDF (749 KB) ( 141 )

	64	Effect of Modified Bixie Fenqing Decoction in the treatment of chronic nonbacterial prostatitis
		SHEN Longjiang ZUO Meiling CHEN Tao HUANG He PENG Hongliang QIAN Xiaohui
		Objective To analyze the effect of Modified Bixie Fenqing Decoction in the treatment of chronic nonbacterial prostatitis. Methods Clinical data of 80 patients with chronic nonbacterial prostatitis admitted to Department of Urology of the Fourth Hospital of Changsha City from January 2017 to March 2018 was retrospectively analyzed. According to different treatment methods, they were divided into the control group and the observation group, with 40 cases in each group. The control group was treated by Cernilton Tablets, and the observation group was treated by Modified Bixie Fenqing Decoction. The scores of National Institutes of Health chronic prostatitis symptom index (NIH-CPSI), sex hormones [testosterone (T), estradiol (E2), prolactin (PRL)] in the prostatic fluid, tumor necrosis factor alpha (TNF-α), macrophage inflammatory protein-1 alpha (MIP-1α), cyclooxygenase-2 (COX-2), prostaglandin (PGE2) and the level of urodynamics of the two groups were compared before and after treatment. Results Before treatment, there were no statistically significant differences in NIH-CPSI score and urodynamics (maximum urine flow rate and average urine flow rate) between the two groups (P ＞ 0.05). After treatment, the NIH-CPSI score of the two groups was decreased compared with that before treatment, and the urodynamics was increased compared with that before treatment. Moreover, the NIH-CPSI score of the observation group was lower than that of the control group, and the urodynamics was higher than that of the control group, the differences were statistically significant (P ＜ 0.05). Before treatment, there were no statistically significant differences in levels of sex hormone, TNF-α, MIP-1α, COX-2, PGE2 between the two groups (P ＞ 0.05). After treatment, the levels of T in prostatic fluid of the two groups were increased, while the levels of E2, TNF-α, MIP-1α, COX-2, PGE2 were decreased compared with those before treatment. The level of T of the observation group was higher than that of the control group, and the levels of E2, TNF-α, MIP-1α, COX-2 and PGE2 were lower than those of the control group, the differences were statistically signficant (P ＜ 0.05). How ever, there was no statistically significant difference of PRL levels between the two groups (P ＞ 0.05). Conclusion Modified Bixie Fenqing Decoction has good effect for the treatment of chronic nonbacterial prostatitis, which can effectively improve urine flow rate, and it is worthy of clinical popularization and application.
		2019 Vol. 16 (21): 64-68 [Abstract] ( 188 ) HTML (1 KB) PDF (489 KB) ( 266 )

	69	Clinical effect of Modified Zishen Tongguan Pills in the treatment of chronic urinary tract infection with syndrome of kidney deficiency and dampness heat
		XIA Jinbin
		Objective To observe the clinical effect of Modified Zishen Tongguan Pills in the treatment of chronic urinary tract infection with syndrome of kidney deficiency and dampness heat. Methods From February 2016 to February 2018, 60 patients with chronic urinary tract infection admitted to Shunyi Hospital of Beijing Chinese Medicine Hospital were selected and divided into the control group and the treatment group by random number table method, with 30 cases in each group. The control group was treated with sensitive antibiotics, on basis of which, the treatment group was treated with the Modified Zishen Tongguan Pills (Cortex Cinnamomi 6 g, Rhizoma Anemarrhenae 6 g, Cortex Phellodendri 6 g, Herba Plantaginis 15 g). The count of white blood cells (high magnification), count of bacterial colonies in urine routine, clinical efficacy and traditional Chinese medicine symptom effects were observed and compared between the two groups. Results After treatment, the count of white blood cells and count of bacterial colonies in the urine routine of the two groups were lower than those before treatment (P ＜ 0.05), which of the treatment group were significantly lower than those of the control group (P ＜ 0.05). The result of clinical efficacy showed that the total effective rate of the treatment group was significantly higher than that of the control group (P ＜ 0.05). The result of traditional Chinese medicine symptom effect showed that the total effective rate of traditional Chinese medicine symptom in the treatment group was higher than that in the control group, the difference was statistically significant (P ＜ 0.05). Conclusion Modified Zishen Tongguan Pills have good clinical effects in treating chronic urinary tract infection.
		2019 Vol. 16 (21): 69-72,76 [Abstract] ( 189 ) HTML (1 KB) PDF (827 KB) ( 105 )

	73	Clinical effect of proximal fibula osteotomy combined with injection of chitosan into the articular cavity in the treatment of early and middle medial compartment osteoarthritis of knee joint
		HE Junyuan TANG Jianbang▲ ZHENG Weihong GAO Dawei WU Yufeng
		Objective To study the clinical effect of proximal fibula osteotomy combined with injection of chitosan into the articular cavity in the treatment of early and middle medial compartment osteoarthritis of knee joint. Methods The clinical data of 83 patients with early and middle medial compartment knee osteoarthritis admitted to Zhongshan Hospital of Traditional Chinese Medicine in Guangdong Province from January 2016 to December 2017 were retrospectively analyzed. According to the different treatment, the patients were divided into observation group and control group. In the observation group, 42 cases were treated with proximal fibula osteotomy combined with intra-articular chitin injection, while in the control group, 41 cases were treated with proximal fibula osteotomy alone. The changes of preoperative general data, surgical clinical data, visual analogue score (VAS), WOMAC score and American knee association score (AKS) were analyzed and compared. Results There were no statistical significances in the comparison of pain to operation time, operation time, intraoperative blood loss and hospitalization time between the two groups (P ＞ 0.05). Comparison of preoperative VAS, WOMAC and AKS scores between the two groups showed no statistically significant difference (P ＞ 0.05). VAS score and WOMAC score decreased gradually at 1, 3 and 6 months after surgery in the observation group, while AKS knee and knee function score increased gradually, with statistically significant difference from that before surgery (P ＜ 0.05); VAS scores and WOMAC scores at 1, 3 and 6 months after surgery in the observation group were lower than those in the control group, while AKS knee and knee function scores were higher than those in the control group, with statistical ly significant differences (all P ＜ 0.05). Conclusion Proximal fibular osteotomy combined with injection of chitosan into the articular cavity for the treatment of early and middle medial compartment knee osteoarthritis can significantly relieve knee pain, improve knee joint function, and delay the process of knee osteoarthritis.
		2019 Vol. 16 (21): 73-76 [Abstract] ( 153 ) HTML (1 KB) PDF (487 KB) ( 97 )

	77	The preventive effect of Celebrex on the acute phase of post-menopausal osteoporosis induced by zoledronic acid
		XIAO Heng ZHAO Chenyang XIE Shiwei LI Quan
		Objective To analyze the clinical effect of Celebrex Prophylaxis Zoledronic Acid on acute phase response (APR) of postmenopausal osteoporosis (PMO). Methods From January 2016 to November 2018, 100 cases of postmenopausal osteoporosis (PMO) patients admitted to Panzhihua Central Hospital of Sichuan Province were selected. According to the random number table method, the patients were divided into control group and observation group, with 50 cases in each group. All patients were treated with Zoledronic Acid. In order to prevent APR caused by Zoledronic Acid, Acetaminophen was used as an intervention in the control group and Celebrex was used as an intervention in the observation group. The incidence rate of APR was observed in the two groups, and the pain degree of adverse reactions to musculoskeletal pain in the two groups were evaluated by visual analogue score (VAS), and the quality of life before and after intervention in the two groups were evaluated by the 16-item Chinese osteoporosis quality of life scale (COQOL-16). Results After the intervention, the incidence of influenza-like symptoms, incidence of fever, and incidence of musculoskeletal pain in the observation group were lower than those in the control group (P ＜ 0.05). On the 1st to 3rd day after intervention, the VAS scores of the musculoskeletal pain in the observation group were lower than those in the control group (P ＜ 0.05). On the 4th and 5th day statistically after intervention, there was no significant difference in VAS scores of musculoskeletal pain patients between the two groups of musculoskeletal pain patients (P ＞ 0.05). On the 3rd day, the COQOL-16 scores of the observation group were not significantly different from those before treatment (P ＞ 0.05), but lower than the control group, the difference was significant (P ＜ 0.05). Conclusion Celebrex can prevent APR caused by Zoledronic Acid in treating PMO, reduce the degree of musculoskeletal pain and fever, and not reduce the quality of life of patients.
		2019 Vol. 16 (21): 77-80 [Abstract] ( 238 ) HTML (1 KB) PDF (520 KB) ( 94 )

	81	Factors influencing the ability of daily living of elderly patients with lower extremity fractures after discharge
		WU Xiaoxiu FANG Xucheng
		Objective To explore the daily living ability and its influencing factors of elderly patients with lower limb fracture after discharge from hospital. Methods A total of 223 elderly patients with lower extremity fractures were selected from the First People′s Hospital of Anqing City in Anhui Province from August 2016 to December 2017. The age, sex, education, marital status, fracture side, fracture location, fracture type, injury cause, complications, timing of operation, anesthesia, American society of anesthesiologists ASA classification, complications after fracture, time of loading after operation, and anti-osteoporosis treatment were recorded, and the correlation between the above data and the daily life function recovery scale (FRS) was analyzed. Results The FRS score of 223 patients was 22-98 points, and average (68.54±6.38) points after 3 months. Multivariate Logistic regression equation showed that the fracture site (hip fracture) (OR = 1.872, 95% CI: 1.208-4.054), age ≥75 years (OR = 2.613, 95%CI: 1.792-6.945) and the number of complications after fracture (OR = 4.105, 95%CI: 2.425-10.413) were the factors affecting patients′ daily living ability (P ＜ 0.05). Conclusion Many factors can affect the daily living ability of the elderly patients with lower limb fracture after operation. Clinicians should make accurate judgments according to the patients′ situation, and carry out targeted treatment to improve the daily living ability of the patients.
		2019 Vol. 16 (21): 81-84 [Abstract] ( 627 ) HTML (1 KB) PDF (494 KB) ( 80 )

	85	Effect of total pelvic floor suspension of polypropylene mesh combined with Buzhong Yiqi Decoction in the repair of patients with pelvic organ prolapse
		YANG Ting1 LI Bin2 WANG Jie1▲
		Objective To investigate the effect of total pelvic floor suspension of polypropylene mesh tablets combined with Buzhong Yiqi Decoction in the repair of pelvic organ prolapse. Methods From January 2017 to April 2018, 90 gynecological inpatients in Baoji Maternal and Child Health Hospital were collected and divided into two groups of combined group (polypropylene mesh total pelvic floor suspension combined with Buzhong Yiqi Decoction, 45 patients) and control group (polypropylene mesh total pelvic floor suspension, 45 patients) according to the random number table method. Polypropylene mesh was used for total pelvic floor suspension in both groups, and Buzhong Yiqi Decoction was taken after surgery 3 days in combined group, while Buzhong Yiqi Decoction was not taken orally after surgery in control group. After 6 courses of treatment, the efficacy and complications of two groups were observed and compared. Results The efficacy of combined group was better than that of control group, and the difference was statistically significant (P < 0.05). After treatment, the quantitative scores of qi deficiency symptoms in two groups were lower than those before treatment, and combined group was significantly lower than that in control group, the difference was statistically significant (P < 0.05 or P < 0.01). The incidence of vaginal secretion increase, pruritus, leucorrhea 3 degree or more, vaginal pain, discomfort after sexual life recovery in combined group was significantly lower than that in control group, with a highly significant difference (P < 0.01). Conclusion Total pelvic floor suspension of polypropylene mesh combined with Buzhong Yiqi Decoction for the treatment of pelvic organ prolapse has a significant effect on patients with pelvic organ prolapse. It can significantly reduce the grading and quantitative score of symptoms of qi deficiency syndrome, reduce the incidence of complications, and can be widely used in clinical practice.
		2019 Vol. 16 (21): 85-87,92 [Abstract] ( 181 ) HTML (1 KB) PDF (645 KB) ( 73 )

	88	The correlation between Notch1 signaling pathway and vasculogenic mimicry in cervical cancer
		FANG Hong1 ZHOU Zhongming1 LI Yunjun1 LU Lin2
		Objective To explore the correlation between Notch1 signaling pathway and vasculogenic mimicry (VM) in cervical cancer. Methods Paraffin sections were collected from 68 cervical cancer patients who underwent surgical treatment in Hubei Provincial Hospital of Traditional Chinese Medicine between January 2012 and December 2015 as cervical cancer group. Paraffin sections of normal cervix were also collected from 27 patients who were surgically treated for uterine leiomyoma as control group. CD31 immunohistochemistry and periodic acid-Schiff (PAS) reaction were performed to detect VM formation. IHC was performed to detect Jagged1, Notch1 and Hes1 expression. The correlations of VM with Jagged1, Notch1 and Hes1 were analyzed. The correlations of VM, Jagged1, Notch1 and Hes1 with patients′ clinic-pathological features and postoperative prognosis were analyzed. Results The positive expression rates of Jagged1, Notch1 and Hes1 in cervical cancer group were significantly higher than those in control group (P < 0.05). VM was only in cervical cancer tissues, with the positive expression rate of 39.7%. Jagged1 was associated with lymph node metastasis of cervical cancer (P < 0.05). Notch1 was associated with tumor size and tissue differentiation (P < 0.01). Hes1 was not associated with any clinic-pathological parameters of patients (P > 0.05). VM was associated with tumor size and lymph node metastasis (P < 0.01). VM was positively correlated with Jagged1 and Notch1 expression (r = 0.283, 0.304, all P < 0.05). VM was an independent risk factor for postoperative prognosis of cervical cancer patients (HR = 2.21, 95%CI: 1.85-2.64, P < 0.05). Conclusion VM formation in cervical cancer predicts patients′ poor postoperative prognosis. The up-regulated Jagged1/Notch1 signaling pathway in cervical cancer might be involved in promoting VM formation. In the future, targeted Notch1 pathway treatment might be expected to prevent VM formation in cervical cancer and improve patients′ prognosis.
		2019 Vol. 16 (21): 88-92 [Abstract] ( 183 ) HTML (1 KB) PDF (696 KB) ( 87 )

	93	Expression of polar protein Par3 in cervical squamous cell carcinoma and its clinical significance
		GUO Chunfeng ZHAO Junda MA Junqi
		Objective To explore the polarity protein Par3 (Par3 protein) in chronic cervicitis, cervical intraepithelial neoplasia Ⅱ-Ⅲ (CINⅡ-Ⅲ), cervical squamous cell carcinoma (CSCC) and the expression differences in metastasis lymph node tissue and its clinical significance. Methods From January 2016 to December 2017, Xinjiang Medical University First Affiliated Hospital of CINⅡ-Ⅲ CSCC, as well as the line of hysterectomy for benign disease patients with cervical tissue samples archived paraffin embedding tissue, a total of 93 cases were seleeted from Department of Gynaecology. Among them 14 cases of chronic cervicitis, 36 cases of CINⅡ-Ⅲ, and 43 cases of cervical squamous cell carcinoma. Another 7 cases of cervical squamous cell carcinoma lymph node metastasis tissue samples. The expression of polar protein Par3 in the above tissues was detected by immunohistochemical staining. Results The positive expression rate of Par3 protein in chronic cervicitis, CINⅡ-Ⅲ, CSCC and metastasis lymph node tissues were 100.0% (14/14), 97.2% (35/36), 62.8% (27/43), 0 respectively, the differences between each group had statistical significance (P ＜ 0.05). The Par3 protein expression was 100% (7/7) in the high differentiation group of CSCC, while the expression was down-regulated to 55.6% (20/36) in the low and medium differentiation group, with statistically significant difference (P ＜ 0.05). They were grouped according to whether lymph node metastasis had occurred (7 cases in lymph node metastasis group 36 cases in the group without lymph node metastasis. The positive expression rate of Par3 protein in cervical tissues of the lymph node metastasis group was 28.6% (2/7), while that of the non-metastasis group was 58.3% (21/36), with statistically significant difference (P ＜ 0.05). The low expression of Par3 protein was correlated with histological differentiation and lymph node metastasis, and the difference was statistically significant (P ＜ 0.05). Conclusion Polarity protein Par3 in chronic cervicitis, CINⅡ-Ⅲ CSCC and are differentially expressed, the expression of CSCC is down-regulated, and its abnormal low expression is related to the occurrence and development of CSCC, which can be used as an early warning indicator to judge the development of cervical intraepithelial neoplasia into CSCC, as well as an indicator to judge the malignancy degree and prognosis of CSCC.
		2019 Vol. 16 (21): 93-96 [Abstract] ( 177 ) HTML (1 KB) PDF (640 KB) ( 70 )

	97	Effect of Xiaojin Capsules combined with Triptorelin on postoperative recurrence of endometriosis
		TONG Yujing HONG Yu▲ WANG Kun CHEN Yanlei XU Lizhuo WANG Yaoping ZHAI Qi
		Objective To investigate the effect of Xiaojin Capsules combined with Triptorelin on postoperative recurrence of endometriosis. Methods From March 2016 to July 2017, 94 patients with endometriosis admitted to the Department of Obstetrics and Gynecology, Tangshan People′s Hospital in Hebei Province were selected as subjects. According to the random number table method, they were divided into control group and combined group, with 47 cases in each group. All patients were treated with laparoscopic resection. The control group was given Triptorelin. The combined group was treated with Xiaojin Capsules on the basis of the control group. Visual analog scale (VAS) was used to assess the degree of dysmenorrhea in two groups of patients. Menopausal symptoms were assessed in two groups using the Kapperman rating scale. The levels of vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9) and matrix metalloproteinase inhibitor-1 (TIMP-1) were measured before and after treatment in both groups. After 1 year of follow-up, the recurrence of the two groups was recorded. Results The total effective rate of combined group was higher than that of control group, and the difference was statistically significant (P < 0.05). After treatment, VAS decreased, uterine volume decreased and Kupperman score increased in both groups (P < 0.05). After treatment, the VAS and Kupperman scores of combined group were lower than those of control group, and the uterine volume was smaller than that of control group, the differences were statistically significant, the levels of VEGF, MMP-9 and TIMP-1 in both groups were lower than those before treatment (P < 0.05). After treatment, the levels of VEGF, MMP-9 and TIMP-1 in combined group were lower than those in control group, the differences were statistically significant(P < 0.05). Following up for 1 year, the recurrence rate of combined group was lower than that of control group, the differences were statistically significant (P < 0.05). Conclusion Xiaojin Capsules combined with Triprin can reduce the recurrence of endometriosis after operation.
		2019 Vol. 16 (21): 97-99,103 [Abstract] ( 228 ) HTML (1 KB) PDF (609 KB) ( 128 )

	100	Correlation of heart rate variability in hypertensive patients with anxiety and depression during pregnancy
		XU Ya′nan GAO Hong HU Zhifang YANG Yan
		Objective To investigate the difference of heart rate variability between patients with pregnancy-induced hypertension (PIH) complicated with anxiety and depression and normal women in the middle and late pregnancy, and to understand the changes of cardiovascular autonomic nervous function in patients with pregnancy-induced hypertension complicated with anxiety and depression. Methods From September 2017 to April 2018, the mid-late pregnancy women who underwent dynamic electrocardiogram examination in Beijing Obstetrics and Gynecology Hospital Affiliated to Capital Medical University were divided into three groups. 30 normal pregnant women without complications were the normal group and 30 PIH patients were the control group. 22 PIH patients with anxiety and depression were screened by Beck Anxiety Scale as the observation group, and their heart rate changes were analyzed. Anisotropic correlation parameters. Results Total standard deviation of normal sinus RR interval (SDNN), the mean standard deviation of sinus RR interval every 5 minutes (SDNNin), the root mean square of normal continuous sinus RR interval (rMSSD), the percentage difference of adjacent RR interval > 50 ms (PNN50), triangular index, high frequency spectral power (HF), low frequency power (LF) and very low frequency power (VLF) in control group and observation group were lower than those in normal group, and the difference were statistically significant (P < 0.05). SDNN, SDNNin, rMSSD, PNN50, triangular index, HF, LF and VLF in observation group were lower than those in control group, the differences were statistically significant (P < 0.05). The mean systolic blood pressure (r = -0.649, -0.795, -0.825), mean diastolic blood pressure (r = 0.504, -0.443, -0.640) and anxiety and depression scores (r = -0.527, -0.421, -0.625) were negatively correlated with gestational hypertension (P < 0.01). Conclusion Heart rate variability can be used as a non-invasive reference index for evaluating the changes of cardiac autonomic nervous function in patients with PIH complicated with anxiety and depression.
		2019 Vol. 16 (21): 100-103 [Abstract] ( 178 ) HTML (1 KB) PDF (596 KB) ( 95 )

	104	Clinical value of prenatal serological screening in the prevention and control of birth defects in the middle stage of pregnancy
		TONG Fei HUANG Weitong WANG Zongjie
		Objective To explore the clinical value of prenatal serological screening in the prevention and control of birth defects in women during the middle stage of pregnancy. Methods A total of 19 508 pregnant women who underwent serological prenatal screening in Nanning Maternity and Child Healthcare Hospital from January 2016 to February 2018 were selected as the study objects, the alpha-fetoprotein (AFP), serum chorionic gonadotropin beta (β-HCG) and unconjugated estriol (uE3) were tested by Beckmann-Kurt UniCel DXI 800 automatic chemiluminescence analyzer, and the risk of 21-trisomy syndrome, nerve tube defect (NTD) and 18- trisomy syndrome were analyzed by Tengcheng software combined with gestational weeks (according to the B-ultrasound and last menstrual period), age and weight, the high-risk pregnant women for prenatal diagnosis were screened and followed up. Results Among 19 508 pregnant women, 1651 cases were found to be at high risk of 21-trisomy syndrome, NTD and 18-trisomy syndrome, with a positive rate of 8.46%. Among 1651 high-risk pregnant women who were prenatal diagnosed and followed up, 787 cases were analyzed for prenatal diagnosis, and 726 cases with 21-trisomy syndrome were diagnosed by chromosome karyotype examination, 11 of them were confirmed, the positive coincidence rate was 1.52%; 61 cases with 18-trisomy syndrome were diagnosed by chromosome karyotype analysis, the positive coincidence rate was 4.92%. 433 cases had high risk of neural tube defect, 7 cases were diagnosed by B ultrasonic, and the positive coincidence rate was 1.62%. Among the high-risk pregnant women who did not receive prenatal diagnosis, 12 cases of spontaneous abortion and 16 cases of death from other causes, and the rest were normal infants. The follow-up results of 17 860 screened as low-risk pregnant women at 3 months after birth were all normal infants. There were significant differences in the diagnosis of three diseases, spontaneous abortion and other causes of death between high-risk and low-risk pregnant women (P < 0.01). In the mid-pregnancy serological prenatal screening of 19 508 women, 1618 cases were false positive, the total accuracy rate was 91.71%. Conclusion Serological prenatal screening in the second trisomy of pregnancy can timely detect and hand the adverse pregnancy caused by diseases such as 21-trisomy syndrome, NTD and 18-trisomy syndrome, so as to reduce the birth of children with birth defects, improve the quality of the birth population, and achieve the purpose of eugenics.
		2019 Vol. 16 (21): 104-107 [Abstract] ( 218 ) HTML (1 KB) PDF (634 KB) ( 38 )

	108	Clinical effect comparison on removable partial denture with RPI clasp and three-arm clasp in repairing distal-extension free end deletion
		MI Tingting1,2 LIU Yumei3 LI Wen4 HOU Xipeng2 GUAN Yu2 JIE Huifei5▲
		Objective To compare the effect of removable partial denture with RPI clasp and three-arm clasp in repairing distal-extension free end deletion. Methods From May 2015 to May 2016, 82 patients (160 dentures) wearing distal-extension free end cast bracket removable partial denture in Beijing Rytime Stomatological Hospital were retrospectively analyzed. They were divided into RPI clasp group (41 cases, 81 dentures) and three-arm clasp group (41 cases, 79 dentures) according to the different retainers of clasp. RPI clasp group was repaired with RPI clasp retainer casting bracket removable partial denture, and three-arm clasp group was repaired with three-arm clasp retainer casting bracket removable partial denture. Self-made questionnaires were used to compare the oral examination and subjective evaluation of the two groups. Results The effect of abutment loosening, clasp retention and overall restoration after removable partial dentures in the RPI clasp group were better than those in the three-arm clasp group with statistical significances (P < 0.05), but there was no significant difference in abutment occlusion between the two groups (P > 0.05). Subjective evaluation in the RPI clasp group was better than that in the three-arm clasp group, and the difference was statistically significant (P < 0.01). Conclusion RPI clasp repair with distal-extension free end deletion can improve the loose state of the abutment teeth and the overall recovery is good, which is worthy of clinical application. At the same time, oral hygiene should be strengthened, the overall design of prostheses should be strengthened, and regular reviews should be conducted.
		2019 Vol. 16 (21): 108-111,129 [Abstract] ( 226 ) HTML (1 KB) PDF (969 KB) ( 127 )

	112	Effect of glass fiber post zirconia all-ceramic crown on restoration of anterior teeth defect and its influence on patients′masticatory ability
		LI Dingxin WANG Yuwei ZHAO Fei QI Baoming GAO Zhiqiang
		Objective To investigate the effect of glass fiber post zirconia all-ceramic crown on the repair of anterior teeth defects and its effect on chewing ability. Methods A total of 102 patients (128 teeth) with anterior teeth defect admitted to Department of Stomatology,Tangshan Union Medical College Hospital in Hebei Province from January to October 2017 were selected. They were divided into observation group 47 cases (60 teeth) and control group 55 cases (68 teeth) by random number table method. The observation group was restored with glass fiber post zirconia all-ceramic crown, while the control group was restored with metal post cobalt-chromium ceramic crown. The success rate, restoration effect, periodontal, gingival crevicular fluid, masticatory efficiency and patient satisfaction of two groups were observed. Results There was no statistically significant difference in the repair success rate between the observation group and the control group (P ＞ 0.05). The number of eligible patients on restoration integrity, color matching, marginal fitness, marginal staining and gingival condition of the observation group were more than those of the control group, and the differences were statistically significant (P < 0.05). After restoration, the gingival bleeding index, periodontal pocket depth, and attachment loss levels were significantly higher than those before restoration (P < 0.05), and the observation group was significantly higher than the control group (P < 0.05). There were no significant differences in the levels of gingival crevicular fluid (GCF) and alkaline phosphatase (ALP) between the two groups before restoration (P > 0.05). There were no significant differences in the levels of GCF and ALP before and after repair in the observation group (P > 0.05); there were significant differences in the levels of GCF and ALP before and after restoration in the control group (P < 0.05). After restoration, the levels of GCF and ALP in the observation group were lower than those in the control group (P < 0.05). One month after restoration, there was no difference in masticatory efficiency between the two groups (P < 0.05). The masticatory efficiency of the affected side in the observation group recovered significantly, and there was no significant difference between the two groups (P > 0.05), and it was significantly higher than that of the control group (P < 0.05). The satisfaction rate of the observation group was higher than that of the control group (P < 0.05). Conclusion Glass fiber post zirconia all-ceramic crown can significantly improve the restoration effect of anterior teeth defect, has little effect on periodontal tissue and masticatory ability, and has high satisfaction with patients.
		2019 Vol. 16 (21): 112-115 [Abstract] ( 146 ) HTML (1 KB) PDF (504 KB) ( 68 )

	116	Study on the quality standard of Tibetan medicine Corydalis impartiens
		CHEN Weisi1 WANG Jing1,2 YANG Zhonghui3 XIANG Qianben3 SUO Guojia3 CAO Peng2 HUANG Yiping1,2 PENGMAO Cairang3
		Objective To establish a quality standard for Tibetan medicine Corydalis impartiens. Methods Ten batches of Corydalis impatiens samples were determined by thin-layer chromatography with protoopioids as reference substance; the moisture content, ash content and extract were determined. The content of protopine in Corydalis impatiens was determined by high performance liquid chromatography with X-Bridge C18 column (250.0 mm×4.6 mm, 5 μm) and acetonitrile-triethylamine acetic acid solution (20∶80) as the mobile phase, meanwhile high performance liquid chromatography fingerprint was established and the similarity was calculated. Results The thin-layer chromatographyresults of 10 batches of Corydalis impartiens had one accurate characteristic spot. The original opioid has a good linear relationship in the mass concentration range of 11.71-585.80 μg/mL, the average recovery rate was 99.84% and the RSD was 2.75%. By high performance liquid chromatography fingerprint analysis, 14 common characteristic peaks were identified, and the similarity was above 0.9. Conclusion The method is simple, repeatable, which can be used for the quality control of Corydalis impatiens.
		2019 Vol. 16 (21): 116-119 [Abstract] ( 235 ) HTML (1 KB) PDF (836 KB) ( 120 )

	120	Quality control research of Xinhui Citri Reticulatae Pericarpium
		ZHANG Huai CHEN Mingquan NONG Genlin HE Fenglei QIN Ren′an
		Objective To establish the quality control method of Xinhui Citri Reticulatae Pericarpium. Methods The chromatographic conditions of high performance liquid chromatography (HPLC) were Atlantis T3-C18 column (4.6 mm × 250.0 mm, 5 μm), and mobile phase was acetonitrile-0.5% acetic acid water system, gradient elution was at a flow rate of 1.0 mL/min. The detection wavelength was set at 283 nm and 330 nm. The contents of hesperidin, nobiletin and tangeretin in 46 batches of Xinhui Citri Reticulatae Pericarpium with different origins, different harvesting time and different aging time were detected. The ratio range was calculated. Pearson correlation analysis was performed on the aged years and the contents of the three compounds. Results The hesperidin content was not less than 2.56%, the nobiletin content was not less than 0.27%, and the tangeretin content was not less than 0.18%, and the ratio range of the three flavonoids was 100∶(7.58-22.09)∶(4.89-14.55). There was no correlation between the aging of aging and hesperidin or nobiletin. The age of aging was negatively correlated with hesperidin (r = -0.345, P ＜ 0.05); there was a positive correlation among hesperidin, nobiletin and tangeretin (r = 0.544, 0.581, 0.873, all P ＜ 0.01). Conclusion The limited standards and ratio ranges of these three compounds could control the quality of Xinhui Citri Reticulatae Pericarpium effectively.
		2019 Vol. 16 (21): 120-124 [Abstract] ( 163 ) HTML (1 KB) PDF (549 KB) ( 132 )

	125	Dynamic analysis of air pollutants caused by moxibustion in traditional Chinese medicine
		LUO Ling1 LI Ming2
		Objective To understand the effects of indoor air pollutants on human health during the treatment of moxibustion in traditional Chinese medicine clinic. Methods From April to May 2018, the concentration changes of carbon menoxide (CO), supended particles (PM10, PM2.5), formaldehyde (HCHO) and volatile organic compound (TVOC) during the combustion of old and new moxibustion in the simulated clinic were monitored and analyzed quantitatively. Results There were statistically significant differences in water content and ash content between Aged Artemisia argyi and New Artmisia argyi (P ＜ 0.05). Many combustion emissions of gas pollutants under the New Artmisia argyi, but suspended micro chips emissions was higher than the New Artmisia argyi. Based on the four-parameter Sigmoid equation, the highest concentration of CO in combustion emission of Aged Artemisia argyi was only 41.1% of that of New Artmisia argyi, 21.4% of TVOC and 55.8% of HCHO. Aged Artemisia argyi combustion produced PM10 and PM2.5 were higher than New Artmisia argyi, among which, Aged Artemisia argyi PM10 peak was about 1.70 times of New Artmisia argyi PM10, Chenai PM2.5 peak was about 1.85 times of New Artmisia argyi PM2.5. Conclusion The gas pollutants produced in the process of moxibustion are lower than the national safety standards, but the burning of Aged Artemisia argyi and New Artmisia argyi both caused the instantaneous total suspended particulate in the clinic to significantly exceed the standard, resulting in a potential health impact on the human body.
		2019 Vol. 16 (21): 125-128 [Abstract] ( 196 ) HTML (1 KB) PDF (1179 KB) ( 143 )

	130	Professor Situyi "cure for the root" in the treatment of endometriosis commonly used medicine on the corner
		LIU Jiaqian1 ZHENG Weilin1 LUO Meicheng1 LIANG Xuefang2
		Endometriosis is a common and difficult disease in women of childbearing age, which seriously affects the quality of life of patients. Professor Situyi engaged in diagnosis and treatment of endometriosis for nearly 50 years, in the "cure", on the basis of therapeutic principles, think that the main pathogenesis of endometriosis, kidney and blood stasis, to tonify the kidney and regulate blood circulation to remove blood stasis as the basic treatment, And clever use of drugs, according to the menstrual cycle stages of treatment, along with the diagnosis and treatment of endometriosis, clinical good effect.
		2019 Vol. 16 (21): 130-133 [Abstract] ( 241 ) HTML (1 KB) PDF (767 KB) ( 79 )

	134	Exploring the source of chief physician Geng Lianqi′s academic thought
		ZHANG Jingsha GENG Lianqi
		The academic thoughts of chief physician Geng Lianqi, a famous traditional Chinese medicine doctor in Binhai New Area of Tianjin, are mainly as follows: "Yang-qi is the first, Yin blood is the foundation; according to the situation, the evil of Yin is eliminated; five sides are balanced, six parts are unobstructed; Yin and Yang are constipated, Qi and Blood are harmonious". This paper takes explaining the academic thought as the core, discusses from the Yin-Yang theory, the Five Elements theory and the theory of correspondence between heaven and man, reinterprets the academic thought of chief physician Geng Lianqi, who originated from the classical medical books, into the classical works of traditional Chinese medicine, and puts forward the importance of differentiating Yang-qi first in treating diseases, and regards supporting Yang-qi as the first choice for treating diseases, and combining the viscera syndrome differentiation and meridian syndrome differentiation organically, and the treatment methods are finally unified into the unification of Qi and Blood, Yin and Yang, the outside and the inside, and finally reach the state of neutralization.
		2019 Vol. 16 (21): 134-137 [Abstract] ( 230 ) HTML (1 KB) PDF (723 KB) ( 116 )

	138	Clinical study of Bushen Huayu Prescription combined with Western medicine in the treatment of cerebral small vessel disease
		LIANG Fang1 HUO Qingping1 CHEN Xu2 ZHAO Yuwu3
		Objective To observe the curative effect of Bushen Huayu Prescription combined with Western medicine for intervenion of cerebral small vessel disease (CSVD). Methods Total 252 subjects with CSVD were collected, the patients were from Shanghai Sixth People′s Hospital and Shanghai Eighth People′s Hospital, the time limit was from March 2015 to December 2017. All patients were divided into Bushen Huayu intervention group and placebo control group, with 126 cases in each group. The course was 24 weeks, the indices were detected at 0, 12, 24 weeks after intervention: 24 h ambulatory blood pressure; serum total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), fasting blood glucose (FBG), 2-hour post-meal blood glucose (2hPBG), glycosylated hemoglobin (HbA1c), the changes of all indices above between two groups were compared before and after intervention, at the same time, and the changes of memory and executive screening scale (MES) of the two groups were compared at 0, 24 weeks after intervention. Results Before intervention, there were no statistically significant differences of the mean systolic blood pressure in 24 hours, mean diastolic blood pressure in 24 hours, TC, TG, LDL-C, HDL-C, FBG, 2hPBG and HbA1c between the two groups (P ＞ 0.05); after intervention, the systolic blood pressure in 24 hours, mean diastolic blood pressure in 24 hours, TC, TG, LDL-C, FBG in the two groups were significantly lower than those before intervention, HDL-C were significantly higher than those before intervention, the level of HbA1c in the Bushen Huayu intervention group was lower than that before intervention, with statistically significant differences (P ＜ 0.05 or P ＜ 0.01); there was no statistically signifcant difference of 2hPBG in the two groups after intervention compared with those before intervention (P ＞ 0.05); there were no statistically significant differences of the indices above between the two groups after intervention (P ＞ 0.05). After intervention, the scores of MES in the two groups were all higher than those before intervention, and the score of MES in Bushen Huayu intervention group was higher than that in placebo control group, the differences were highly statistically signifcant (P ＜ 0.01). The statistical results of full analysis set were consistent with per protocol set. Conclusion Bushen Huayu Prescription combined with basci Western medicine for intervenion of CSVD can decrease blood pressure, blood lipid, HbA1c, and increase MES scores, which is helpful to delay or block the evolution process of CSVD patients from mild cognitive impairment to severe cognitive impairment, and to dementia finally.
		2019 Vol. 16 (21): 138-142 [Abstract] ( 190 ) HTML (1 KB) PDF (795 KB) ( 142 )

	143	Meta-analysis of correlation between TCM syndromes and left ventricular ejection fraction in chronic heart failure
		LI Xingxing1* WU Yang2* FAN Zongjing2 CUI Jie2 LIU Qinyao2 LI Zhengyu1 LI Mingxuan1 LI Yan2
		Objective To systematically evaluate the correlation between TCM syndromes and left ventricular ejection fraction in chronic heart failure. Methods The electronic databases such as CNKI, VIP, Wanfang and PubMed were retrieved by computer, and the references included in the literature were retrieved. Literature data on correlation between TCM syndromes of chronic heart failure and left ventricular ejection fraction were selected. The retrieval time was from the establishment of database to August 2018. Two graduate students independently searched and screened the literature according to the inclusion and exclusion criteria. The quality of the included literature was evaluated according to Newcastle-Ottawa Scale score. Finally, RevMan 5.3 software was used for Meta-analysis. Results A total of 9 articles with 971 patients were enrolled. The baselines included in the literature were comparable. Chronic heart failure with syndrome of water overflowing due to yang deficiency was compared with syndrome of qi deficiency of heart and lung [MD = -11.47, 95%CI (-15.52, -7.42), P < 0.000 01], syndrome of deficiency both qi and yin [MD = -8.75, 95%CI (-10.72, -6.78), P < 0.000 01], syndrome of blood stasis due to qi deficiency [MD =-7.33, 95%CI (-8.07, -6.59), P < 0.000 01] respectively, the difference was statistically significant. The sensitivity analysis was consistent, the funnel plot showed partial publication bias. Conclusion The low left ventricular ejection fraction can be used as one of the reference indicators for the objective diagnosis of chronic heart failure.
		2019 Vol. 16 (21): 143-146,150 [Abstract] ( 181 ) HTML (1 KB) PDF (1160 KB) ( 69 )

	147	Effect of Salvia Miltiorrhiza Injection in the treatment of type Ⅱ respiratory failure and its influence on respiratory function and hemodynamics
		LIU Jing1 LI Lei2 FENG Fei2 WANG Meng2 HAO Likun2 GAO Chao2 YANG Huimin2
		Objective To explore the effect of Salvia Miltiorrhiza Injection in the treatment of type Ⅱ respiratory failure and its influence on respiratory function and hemodynamics. Methods From June 2015 to February 2018, 80 patients with type Ⅱ respiratory failure admitted to the First Central Hospital of Baoding City in Hebei Province were selected as subjects. All patients were divided into control group (conventional treatment, 40 cases) and observation group (conventional treatment combined with Salvia Miltiorrhiza Injection, 40 cases) by random number table method. The treatment effects, respiratory function indexes [forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), FEV1/FVC, PaO2, PaCO2] and hemodynamic parameters [heart rate (HR), mean arterial pressure (MAP), central venous pressure (CVP), stroke volume (SV), cardiac output (CO), thoracic fluid content (TFC), systemic vascular resistance (SVR), pulmonary vessel resistance (PVR)] were observed. Results There was significant difference in the total effective rate between the two groups (P < 0.05). After treatment, the indexes of FVC, FEV1, FEV1/FVC, PaO2 and PaCO2 in two groups were improved compared with those before treatment, and the improvement in observation group was more obvious than that in control group, the differences were statistically significant (P < 0.05). After treatment, the indexes of HR, MAP, CVP, SV, TFC and PVR in two groups were improved compared with those before treatment, and the improvement in observation group was more obvious than that in control group, the differences were statistically significant (P < 0.05). Conclusion Salvia Miltiorrhiza Injection can effectively improve the respiratory function and hemodynamics of patients with type Ⅱ respiratory failure and improve the clinical treatment effect.
		2019 Vol. 16 (21): 147-150 [Abstract] ( 200 ) HTML (1 KB) PDF (783 KB) ( 99 )

	151	Differentiation and analysis of the compatibility application of "Lishui Sanwei" of Lepidium seed, Semen pharbitidis, and Stedhania tetrandra in Qian′s Tingli Pills
		YIN Yue1 WU Wenjie2 WANG Qingyu2 ZHU Zehua2 FAN Shiqi2 LIU Chang2
		With the help of Chinese Medical Code Software System and the Ancient Literature Database and China National Knowledge Infrastructure （CNKI）, Wanfang Data Knowledge Service Platform, the " Draba nemorosa, Pharbitis nil (Linn.) Choisy, Stephania tetrandra S. Moore" as the key words, this article looked up and sorted out 72 prescriptions in which the three Chinese herbs were combined as described in the medical books of the different eras. Among them, the books recording the Tingli Pills had the largest number, with the total number 15. Through sorting out the development of prescriptions, the preliminary conclusions were drawn from the composition of the prescriptions and the changes in the doses. Qian′s Pills were transferred from the Peaceful Holy Benevolent Prescriptions and transformed in the General Medical Collection of Royal Benevolence, with high credibility. Through the different effects of drug efficacy, gender taste characteristics, channel tropism, dosage forms and decoction methods, the compatibility of Chinese herbal medicines in Qian′s Pills with scorpion venom, venom and Chinese medicinal herbs were analyzed, and research progress of modern pharmacology was applied to further digging up of the clinical application value in classical prescriptions of ancient Chinese medicine, and provide theoretical reference and basis for the research of substances of Chinese medicine taste and efficacy carried out by modern scientific and technological means.
		2019 Vol. 16 (21): 151-154,162 [Abstract] ( 224 ) HTML (1 KB) PDF (1052 KB) ( 187 )

	155	Clinical study of acupuncture combined with self-designed prescription for clearing heat and regulating collaterals in treating wind-heat type peripheral facial paralysis
		LIU Haiyong1 MENG Hongmei2 LI Yanjie2 LIU Yong2 GAO Zhian2 LI Rui2 XUE Zhihui2 LI Chunxia1
		Objective To explore the clinical application effect of acupuncture combined with self-designed prescription for clearing heat and regulating collaterals in treating wind-heat type peripheral facial paralysis. Methods From April 2017 to December 2018, 120 patients with wind-heat peripheral facial paralysis in Sanhe City Hospital of Hebei Province were selected. They were divided into observation group and control group by random number table method, with 60 cases in each group. The observation group was treated with acupuncture combined with self-designed prescription for clearing heat and regulating collaterals, while the control group was treated with conventional Western medicine. Both groups were treated with 1 course of treatment for 10 days, with 2 courses of treatment. Facial nerve function evaluation system, facial nerve simple clinical scoring method and facial nerve muscle strength test were used to evaluate the efficacy. Adverse events occurred during treatment were recorded and analyzed statistically. Results After treatment, the scores of facial nerve function in the two groups were lower than before treatment (P ＜ 0.01), and the observation group was lower than that in the control group (P ＜ 0.01). After treatment, the index of muscle strength level in the two groups was increased compared with that before treatment (P ＜ 0.01), the observation group was higher than that of the control group (P ＜ 0.05). After treatment, the simple scoring index of the two groups was increased compared with that before treatment (P ＜ 0.01), the observation group was higher than that of control group (P ＜ 0.05). The effective rate of the observation group was significantly higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Acupuncture combined with self-designed heat-clearing and collateral-activating prescription has a significant effect in treating wind-heat type peripheral facial paralysis, which can effectively improve patients′ facial functions and improve their quality of life, and has a good safety, which can be popularized in clinical practice.
		2019 Vol. 16 (21): 155-158 [Abstract] ( 234 ) HTML (1 KB) PDF (772 KB) ( 152 )

	159	Clinical effect of small needle knife combined with Mulligan dynamic joint loosening in the treatment of periarthritis adhesion
		LI Junhe1 SUN Yunting2 WANG Yanwu2
		Objective To observe the clinical effect of small needle knife combined with Mulligan dynamic joint loosening in the treatment of periarthritis adhesion. Methods From May 2017 to May 2018, 62 cases of acupuncture and moxibustion clinic of Hangzhou Hospital of Traditional Chinese Medicine, Zhejiang Province were selected as the subjects of study. They were divided into two groups of 31 cases according to the random number table method. The treatment group was given to a small needle knife and Mulligan dynamic joint loosening. Treatment including small needle knife once a week, Mulligan dynamic joint loosening 3 times a week. The control group was treated with a small needle knife once a week. The visual simulation scale (VAS) and shoulder joint activity (ROM) were used before and after 4 weeks of treatment to assess the degree of pain and joint activity of the shoulder joint. Results After treatment, VAS of two groups were lower than before treatment, and the treatment group was lower than control group, the difference was statistically significant (P < 0.05). After treatment, the shoulder lift, abduction, internal and external rotation and extension angle of two groups were improved compared with those before treatment, and the improvement of the treatment group was more obvious than that of control group, with statistical significance (P < 0.05). After treatment, the distance of back touching test between two groups was shorter than that before treatment, and the treatment group was shorter than control group, the difference was statistically significant (P < 0.05). Conclusion The clinical effect of small needle knife combined with Mulligan dynamic joint mobilization in the treatment of scapulohumeral periarthritis adhesions is reliable and worthy of recommendation.
		2019 Vol. 16 (21): 159-162 [Abstract] ( 197 ) HTML (1 KB) PDF (495 KB) ( 117 )

	163	Clinical effect of small needle knife combined with Modified Shuanghe Decoction in the treatment of knee osteoarthritis with syndrome of blockade of phlegm and blood stasis
		TONG Ying1* SHAO Zhonglin2* ZHANG Weiping2 YANG Junzhao2 HU Rongxue2 TAN Jiahui2
		Objective To observe the clinical efficacy of small needle knife combined with Modified Shuanghe Decoction in the treatment of knee osteoarthritis with syndrome of blockade of phlegm and blood stasis. Methods From January 2018 to January 2019, 60 cases of knee osteoarthritis patients with syndrome of blockade of phlegm and blood stasis admitted to Outpatient Department of Rheumatology of the First Affiliated Hospital of Heilongjiang University of Chinese Medicine were selected and randomly divided into needle knife group and Chinese medicine group and needle knife combined with Chinese medicine group by random number table method, with 20 cases in each group. The needle knife group was treated with needle knife release. The Chinese medicine group was treated with Modified Shuanghe Decoction orally. The needle knife combined with Chinese medicine group was treated with Modified Shuanghe Decoction combined with needle knife release. All three groups took 2 months as a course. The knee joint visual analogue scale (VAS) and Lysholm scale before and after treatment and therapeutic effect of Chinese medicine after treatment were observed among the three groups. Results There were no significant differences of VAS score and Lysholm score among the three groups before treatment (P ＞ 0.05). After treatment, the Lysholm score of the needle knife combined with Chinese medicine group was higher than that of the needle knife group and the Chinese medicine group, and the VAS score was lower than that of the needle knife group and the Chinese medicine group, the differences were all statistically significant (P ＜ 0.05). The total effective rate of the needle knife combined with Chinese medicine group was higher than that of the needle knife group and the Chinese medicine group, the differences were statistically significant (P ＜ 0.05), while there was no significant difference of the total effective rate between the needle knife group and the Chinese medicine group (P ＞ 0.05). Conclusion Small needle knife combined with Modified Shuanghe Decoction in the treatment of knee osteoarthritis with syndrome of blockade of phlegm and blood stasis can effectively relieve knee pain, improve knee function, control disease development, and enhance patients′ quality of life, which is worthy of clinical promotion.
		2019 Vol. 16 (21): 163-166,188 [Abstract] ( 220 ) HTML (1 KB) PDF (863 KB) ( 83 )

	167	One case with threatened rupture of distal aortic dissection after TEVAR treated by TEVAR one more and literature analysis
		HE Yiwei1,2 XIONG Pan3 ZHANG Yongheng1 LIU Jianping1 TANG Xiaojiao1
		Standford type B aortic dissection is dangerous and has a high mortality rate. Once this disease is diagnosed, immediate surgery is needed. Thoracic endovascular aortic repair (TEVAR) is the first treatment for Standford type B aortic dissection, but distal stent rupture has become a complication of TEVAR, which is very important to deal with. The author analyzes the clinical data of one patient with rupture of distal aortic dissection after TEVAR treated by TEVAR one more on May 24, 2018 in Suining Central Hospital of Sichuan Province. It was found that the distal stent ruptured into thoracic cavity after TEVAR, then the patients were treated by TEVAR again and assisted by shock correction, hypoproteinemia correction, thoracic drainage and thoracentesis as the main comprehensive treatment, the postoperative recovery is good, with no serious complications. It is suggested that TEVAR is an effective treatment for Standford B aortic dissection.
		2019 Vol. 16 (21): 167-171 [Abstract] ( 209 ) HTML (1 KB) PDF (730 KB) ( 144 )

	172	Antibiotic resistance analysis of ESBLs-producing Escherichia coli and Klebsiella pneumoniae in urinary tract infections in elderly patients
		ZHANG Wenjing WANG Jiahe
		Objective To investigate the drug resistance of extended spectrum β-lactamases (ESBLs) producing Escherichia coli and Klebsiella pneumoniae in urinary tract infections in elderly patients so as to provide guidance for clinical rational use of antibiotics. Methods From January 2015 to December 2017, in Shengjing Hospital of Chinese Medical University, identification of bacteria and antibiotic susceptibility tests were performed on the strains isolated from the clean midstream urine specimens of elderly patients. ESBLs was detected by disk diffusion confirmatory test in the 1063 strains of Escherichia coli and 202 strains of Klebsiella pneumoniae. Results The detection rate of ESBLs-producing Escherichia coli and ESBLs-producing Klebsiella pneumoniae in three years was 42.24% and 38.61% respectively, and ESBLs-producing strains were more resistant to most drugs than non-ESBLs producing strains. The drug resistance rates of ESBL-producing Klebsiella pneumoniae to Amikacin, Nitrofurantoin, Piperacillin-tazobactam, Cefperazone-sulbactam (14.10%, 44.68%, 24.36%, 54.17% respectively) were higher than ESBL-producing Escherichia coli (4.23%, 6.70%, 2.46%, 15.00% respectively), and the differences were statistically significant (P < 0.05). Conlusion The drug resistance of ESBLs-producing Escherichia coli and ESBLs-producing Klebsiella pneumoniae is more severe. So the antimicrobial agents should be chosen reasonably according to the results of the drug susceptibility.
		2019 Vol. 16 (21): 172-176 [Abstract] ( 169 ) HTML (1 KB) PDF (622 KB) ( 121 )

	177	Application effect of 3D-STI in the evaluation of left ventricular function in patients with type 2 diabetes
		XU Le1 WEN Dehui1▲ ZHENG Yingjuan1 SHI Baolin2 LIU Weiliang1 GU Jun3
		Objective To investigate the application effect of three-dimensional speckle tracking technology (3D-STI) in the evaluation of left ventricular function in patients with type 2 diabetes mellitus. Methods From January 2017 to April 2018, 81 patients with type 2 diabetes mellitus from the First Affiliated Hospital of Hebei North University ("our hospital" for short) were selected. According to whether the intima-media thickness (IMT) of the common carotid artery was thickened, it was divided into TM1 group (IMT≤1.0 mm) (n = 38) and TM2 group (1.0 mm<IMT<1.2 mm) (n = 43), and healthy subjects with matched age and gender in the same period in our hospital were selected as the control group (n = 40). Left ventricular global longitudinal strain (GLS), circumferential strain (GCS), area strain (GAS), radial strain (GRS), left ventricular ejection fraction (LVEF), carotid IMT and related clinical indicators were compared in each group, and the correlation between strain values and IMT and glycated hemoglobin (HbA1c) was analyzed. Results Compared with the control group, GLS in TM1 group decreased, and the difference was statisticlly significant (P < 0.05). Compared with the control group and the TMI group, GLS, GCS, GAS and GRS in TM2 group decreased significantly (P < 0.01 or P < 0.05), IMT and HbA1c were negatively correlated with left ventricular strain in all directions (r < 0, P < 0.05). Conclusion Subclinical left ventricular dysfunction in early stage of type 2 diabetes mellitus can be detected by 3D-STI. If carotid IMT thickening occurs, left ventricular systolic function will be further impaired and left ventricular ejection fraction will be reduced. 3D-STI is a sensitive method to detect these slight abnormalities.
		2019 Vol. 16 (21): 177-180 [Abstract] ( 154 ) HTML (1 KB) PDF (569 KB) ( 76 )

	181	Predictive value of fragmented QRS wave for recurrence after catheter ablation in patients with hypertrophic cardiomyopathy and atrial fibrillation
		LI Banghe1 WAN Haiwei2 DONG Peng1 LI Wei1 YAN Ping1
		Objective To investigate the predictive value of fragmented QRS wave for recurrence in patients with hypertrophic cardiomyopathy and atrial fibrillation after catheter ablation. Methods A total of 95 patients with hypertrophic cardiomyopathy and atrial fibrillation who underwent catheter ablation at the Aviation General Hospital from February 2016 to February 2018 were enrolled. All patients were divided into recurrent group (45 cases) and non-recurrence group (50 cases) according to whether there was recurrence after operation. The general data, levels of cardiac function related index, operation time, fluoroscopy time, fragmentation QRS wave and corrected QT interval (QTc) were compared between the two groups, and multivariate Logisitic regression analysis was performed. Results There were no significant differences in the age, gender, paroxysmal atrial fibrillation and atrial fibrillation between the two groups (all P > 0.05). The left atrial diameter of the recurrent group was greater than that of the non-recurrent group, and the difference was highly statistically significant (P < 0.05). The proportion of patients with fragmentation QRS wave and the QTc level in the recurrent group were higher than those in the non-recurrent group, the differences were highly statistically significant (all P < 0.01). Multivariate Logisitic regression analysis found that both fragmentation QRS wave and QTc were risk factors for recurrence after catheter ablation in patients with hypertrophic cardiomyopathy and atrial fibrillation (all P < 0.01). Conclusion Fragmentation of QRS and QTc have high predictive value for recurrence after catheter ablation in patients with hypertrophic cardiomyopathy and atrial fibrillation. It is worthy of clinical application.
		2019 Vol. 16 (21): 181-184 [Abstract] ( 211 ) HTML (1 KB) PDF (613 KB) ( 139 )

	185	Effect of Xiaozhiling Injection combined with PPH on prolapse hemorrhoids with constipation
		YU Li GE Ning ZHAO Qian LI Jingru
		Objective To explore the effect of different solid doff methods in the treatment of prolapse hemorrhoids with constipation. Methods A total of 108 cases of prolapsed hemorrhoids with constipation in Anorectal Ward of Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine from March 2017 to March 2018 were selected as the research objects. According to the random number table method, the patients were divided into the control group and the observation group, 54 cases in each group. The patients in the control group were treated with procedure for prolapse and hemorrhoids (PPH), while the patients in the observation group were treated with Xiaozhiling Injection on the basis of the control group. The defecation times, hospitalization time and the incidence of complications were compared between the two groups. Patients of two groups were followed up for 6 months and the therapeutic effect was observed. Results The total effective rate of the observation group was lower than that of the control group, and the difference was statistically significant (P ＜ 0.05). The defecation times of the observation group were more than those of the control group, and the hospitalization time of the observation group was shorter than that of the control group, the differences were statistically significant (P ＜ 0.05). The total incidence of complications in the observation group was lower than that in the control group, the difference was statistically significant (P ＜ 0.05). Conclusion Xiaozhiling Injection combined with PPH can effectively treat prolapsed hemorrhoids with constipation and improve the treatment efficiency, which is worthy of popularization and application.
		2019 Vol. 16 (21): 185-188 [Abstract] ( 249 ) HTML (1 KB) PDF (599 KB) ( 126 )

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