妊娠中晚期妇女血压变化及焦虑抑郁与心率变异性的关系

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Abstract Objective To investigate the difference of heart rate variability between patients with pregnancy-induced hypertension (PIH) complicated with anxiety and depression and normal women in the middle and late pregnancy, and to understand the changes of cardiovascular autonomic nervous function in patients with pregnancy-induced hypertension complicated with anxiety and depression. Methods From September 2017 to April 2018, the mid-late pregnancy women who underwent dynamic electrocardiogram examination in Beijing Obstetrics and Gynecology Hospital Affiliated to Capital Medical University were divided into three groups. 30 normal pregnant women without complications were the normal group and 30 PIH patients were the control group. 22 PIH patients with anxiety and depression were screened by Beck Anxiety Scale as the observation group, and their heart rate changes were analyzed. Anisotropic correlation parameters. Results Total standard deviation of normal sinus RR interval (SDNN), the mean standard deviation of sinus RR interval every 5 minutes (SDNNin), the root mean square of normal continuous sinus RR interval (rMSSD), the percentage difference of adjacent RR interval > 50 ms (PNN50), triangular index, high frequency spectral power (HF), low frequency power (LF) and very low frequency power (VLF) in control group and observation group were lower than those in normal group, and the difference were statistically significant (P < 0.05). SDNN, SDNNin, rMSSD, PNN50, triangular index, HF, LF and VLF in observation group were lower than those in control group, the differences were statistically significant (P < 0.05). The mean systolic blood pressure (r = -0.649, -0.795, -0.825), mean diastolic blood pressure (r = 0.504, -0.443, -0.640) and anxiety and depression scores (r = -0.527, -0.421, -0.625) were negatively correlated with gestational hypertension (P < 0.01). Conclusion Heart rate variability can be used as a non-invasive reference index for evaluating the changes of cardiac autonomic nervous function in patients with PIH complicated with anxiety and depression.

Key words： Pregnancy induced hypertension Heart rate variability Autonomic nervous function Anxiety and depression

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	XU Ya′nan GAO Hong HU Zhifang YANG Yan

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XU Ya′nan GAO Hong HU Zhifang YANG Yan. Correlation of heart rate variability in hypertensive patients with anxiety and depression during pregnancy[J]. 中国医药导报, 2019, 16(21): 100-103.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I21/100

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