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| Effects of Hypericum perforatum extract on mice behavior |
| FU Songnian1 Abudoukeremu·Abudoureheman2 LUO Fuxiang3 Zulikaer·Maimaiti3 MA Li3 LI Zhijian3 |
1.Psychological Medical Center, the First Affiliated Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi 830011, China;
2.School of Pharmacy, Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi 830011, China;
3.Department of Toxicology, Uygur Medical Research Institute, Xinjiang Uygur Autonomous Region, Urumqi 830049, China |
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Abstract Objective To investigate the effects of Hypericum perforatum extract (ESJWT) on of behavior in mice. Methods Thirty Kunming mice were randomly divided into three groups according to the random number table method, with 10 mice in each group. The control group was given the same amount of purified water, and the ESJWT low and high dose groups were given the same amount of samples for 14 days. The drop of the rotating rod in mice was determined. 50 Kunming mice were randomly divided into control group and ESJWT low-dose and high-dose groups with 8 mice in each group. The control group was given the same amount of purified water, and the ESJWT low-dose and high-dose groups were given the same amount of samples for 14 days. The voluntary activity of mice for 5 minutes was measured and recorded. Results There was no significant difference in the latency of rod rotation test among the three groups (P > 0.05). Total activity distance of ESJWT mice in low and high dose groups was significantly shorter than that in control group, the difference was highly statistically significant (P < 0.01). All around activity distance of mice in low and high dose ESJWT group was shorter than that in control group, the number of all around activity entry in ESJWT high-dose group was less than that in control group, the difference was statistically significant (P < 0.05). The duration of central activity in ESJWT high dose group was shorter than that in ESJWT low-dose group and control group, the number of central activity entry in ESJWT high-dose group was less than that in control group, the latency of central activity in ESJWT low and high dose group was shorter than that in control group, the difference was statistically significant (P < 0.05 or P < 0.01). Conclusion ESJWT can reduce the spontaneous activity of mice, and has no significant effect on the rod test of Kunming mice.
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