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| Effect of Salvia Miltiorrhiza Injection in the treatment of type Ⅱ respiratory failure and its influence on respiratory function and hemodynamics |
| LIU Jing1 LI Lei2 FENG Fei2 WANG Meng2 HAO Likun2 GAO Chao2 YANG Huimin2 |
1.Department of Traditional Chinese Medicine, the First Central Hospital of Baoding City, Hebei Province, Baoding 071000, China;
2.Department of Critical Care Medicine, the First Traditional Chinese Medicine Hospital of Baoding City, Hebei Province, Baoding 071000, China |
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Abstract Objective To explore the effect of Salvia Miltiorrhiza Injection in the treatment of type Ⅱ respiratory failure and its influence on respiratory function and hemodynamics. Methods From June 2015 to February 2018, 80 patients with type Ⅱ respiratory failure admitted to the First Central Hospital of Baoding City in Hebei Province were selected as subjects. All patients were divided into control group (conventional treatment, 40 cases) and observation group (conventional treatment combined with Salvia Miltiorrhiza Injection, 40 cases) by random number table method. The treatment effects, respiratory function indexes [forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), FEV1/FVC, PaO2, PaCO2] and hemodynamic parameters [heart rate (HR), mean arterial pressure (MAP), central venous pressure (CVP), stroke volume (SV), cardiac output (CO), thoracic fluid content (TFC), systemic vascular resistance (SVR), pulmonary vessel resistance (PVR)] were observed. Results There was significant difference in the total effective rate between the two groups (P < 0.05). After treatment, the indexes of FVC, FEV1, FEV1/FVC, PaO2 and PaCO2 in two groups were improved compared with those before treatment, and the improvement in observation group was more obvious than that in control group, the differences were statistically significant (P < 0.05). After treatment, the indexes of HR, MAP, CVP, SV, TFC and PVR in two groups were improved compared with those before treatment, and the improvement in observation group was more obvious than that in control group, the differences were statistically significant (P < 0.05). Conclusion Salvia Miltiorrhiza Injection can effectively improve the respiratory function and hemodynamics of patients with type Ⅱ respiratory failure and improve the clinical treatment effect.
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