|
|
New progress in treatment of vascular dementia with traditional Chinese medicine |
SHAO Yalan1* ZHENG Luxi2* YANG Shulong1 |
1.Department of Physiology, School of Basic Medical Sciences, Nanchang University, Jiangxi Province, Nanchang 330006, China;
2.Medical College, Nanchang University, Jiangxi Province, Nanchang 330006, China |
|
|
Abstract Vascular dementia (VD) is a syndrome of learning and memory dysfunction caused by ischemic or hemorrhagic stroke. At present, the influencing factors and pathogenesis of the disease have not been completely clarified, resulting in the lack of a reliable and effective treatment of VD at home and abroad. In recent years, a lot of researches have been done on the treatment of VD in traditional Chinese medicine, including the use of traditional Chinese medicine decoction, Chinese patent medicine, acupuncture treatment, and acupuncture and medicine to improve the cognitive function of patients with VD. It has the characteristics of high safety and small side effects.
|
|
|
|
|
[1] Singh M,Prakas A. Possible role of endothelin receptor against hyperhomoocysteinemia and beta-amyloid induced AD type of vascular dementia in rats [J]. Brain Res Bull,2017,133:31-41.
[2] Jiang S,Yan C,Qiao Z,et al. Mismatch negativity as a potential neurobiological marker of early-stage Alzheimer disease and vascular dementia [J]. Neurosci Lett,2017, 647:26-31.
[3] Moonga I,Niccolini F,Wilson H,et al. Hypertension is associated with worse cognitive functon and hippocampal hypometabolism in Alzheimer disease [J]. Eur J Neurol,2017,24(9):1173-1182.
[4] Bornstein NM,Brainin M,Guekht A,et al. Diabetes and the brain:issues and unmet needs [J]. Neurol Sci,2014,35(7):995-1001.
[5] Toda N,Okamura T. Hyperhomocysteinemia impairs regional blood flow:involvements of endothelial and neuronal nitric oxide [J]. Pflugers Arch,2016,468(9):1517-1525.
[6] Rodionov RN,Dayoub H,Lynch CM,et al. Overexpression of dimethylarginine dimethylaminohydrolase protects against cerebral vascular effects of hyperhomocysteinemia [J]. Circ Res,2010,106(3):551-558.
[7] Rusanen M,Kivipelto M,Quesenberry CP,et al. Heavy smoking in midlife and long-term risk of Alzheimer disease and vascular dementia [J]. Arch Intern Med,2011,171(4):333-339.
[8] 欧春影,李传玲.血管性痴呆相关危险因素及其机制的研究新进展[J].中华临床医师杂志,2016,10(2):248-251.
[9] Xi Y,Wang M,Zhang W,et al. Neuronal damage,central cholinergic dysfunction and oxidative damage correlate with cognitive deficits in rats with chronic cerebral hypoperfusion [J]. Neurobiol Learn Mem,2014,109:7-19.
[10] Dong C,Bach SV,Hayner KA,et al. Proteasome modulates positive and negative translational regulators in long-term synaptic plasticity [J]. J Neuro Sci,2014,34(9):3171-3282.
[11] Cerveliati C, Romani A, Seripa D,et al. Oxidative balance,homocysteine,and uric acid levels in olders patients with Late Onset Alzheimer disease or vascular dementia [J]. J Neuro Sci,2014,337(1/2):156-161.
[12] 刘晓慧,刘学源.血管性痴呆的分子机制和遗传机制[J].神经病学与神经康复学杂志,2016,12(2):87-93.
[13] 黄玮.血管性痴呆的发病机制研究进展[J].中国医药指南,2012,10(5):62-64.
[14] 胡久略,郅琳,卞华,等.补肾醒脑方对血管性痴呆大鼠胆碱能抗炎通路的影响[J].中医研究,2015,28(12):66-70.
[15] 刘永辉,戚慧敏.补肾安神益智汤治疗血管性痴呆疗效观察[J].中医临床研究,2014,6(4):17-19.
[16] 刘占兵.通窍活血汤加减联合吡拉西坦治疗血管性痴呆73例疗效观察[J].国医论坛,2014,29(6):35-36.
[17] 李轶璠,赵永辰,李德儒,等.加味桃红四物汤联合高压氧治疗血管性痴呆临床研究[J].中华中医药杂志,2016,31(8):3355-3357.
[18] 陈松怡.补肾健脾养血活血方治疗血管性痴呆的临床疗效观察[J].内蒙古中医药,2014,33(35):32-33.
[19] 李向前.健脾活血化痰法治疗血管性痴呆的临床研究[J].中医临床研究,2015,7(24):6-7.
[20] 宫淑华.补肾活血方治疗老年血管性痴呆的临床分析[J].中外医疗,2016,35(8):139-140,148.
[21] 于文涛,高维娟,方朝义,等.补肾活血方对血管性痴呆大鼠海马BDNF mRNA及受体Trk8 mRNA表达的影响[J].中国中西医结合杂志,2017,37(8):985-990.
[22] Zhang Y,Wang LL,Wu Y,et al. Paeoniflorin attenuates hippocampal damage in a rat model of vascular dementia [J]. Exp Ther Med,2016,12(6):3729-3734.
[23] Zhang J,Guo W,Tian B,et al. Puerarin attenuates cognitive dysfunction and oxidative stress in vascular dementia rats unduced by chronic ischemia [J]. Int J Clin Exp Pathol,2015,8(5):4695-4704.
[24] 张晓双,孙建宁,白黎明,等.梓醇对血管性痴呆大鼠学习记忆能力及海马Bax、Bcl-2蛋白表达的影响[J].华西药学杂志,2017,32(1):40-42.
[25] Ye Y,Zhu W,Wang XR,et al. Mechanisms of acupuncture on vascular dementia-A review of animal studies [J]. Neurochem Int,2017,107:204-210.
[26] Zhu Y,Zeng Y,Wang X,et al. Effect of electroacupuncture on the expression of mTOR and elF4E in hippocampus of rats with vascular dementia [J]. Neurol Sci,2013, 34(7):1093-1097.
[27] 戎军.头针配合功能训练对血管性痴呆患者认知障碍的影响[J].上海针灸杂志,2013,32(3):173-174.
[28] 戴晓红,郭玉红,张宏伟,等.头针快速提插捻转法为主治疗血管性痴呆疗效观察[J].上海针灸杂志,2013,32(9):709-710.
[29] 高向明.穴位埋线治疗老年性痴呆临床观察[J].临床医药文献电子杂志,2016,3(37):7339-7340.
[30] 唐中生,李霞,吴春朋,等. 穴位埋线对血管性痴呆大鼠血液流变学和海马CA1区神经元p75NTR表达的影响[J].实用医学杂志,2016,32(16):2628-2631.
[31] Zhong XY,Su XX,Liu J,et al. Clinical Effects of Acupuncture Combined with Nimodipine for Treatment of Vascular Dementia in 30 Cases [J]. J Tradit Chin Med,2009, 29(3):174-176.
[32] 吴咚咚,李岩,张智龙,等.针药结合治疗血管性痴呆的临床疗效观察[J].针灸临床杂志,2017,33(3):16-18. |
|
|
|