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2022 Vol. 19, No. 33 Published: 2022-11-25

	5	Network pharmacologic analysis and experimental verification of Huoxue Jiedu Ⅰ Prescription against atherosclerosis
		TANG Ziwei GU Yimeng WU Yanyan YANG Lin XUE Mei
		DOI: 10.20047/j.issn1673-7210.2022.33.01
		Objective To explore the material basis and mechanism of Huoxue Jiedu Ⅰ Prescription in the treatment of atherosclerosis based on network pharmacology, and to carry out experimental verification. Methods The active ingredients and targets of Huoxue Jiedu Ⅰ Prescription were retrieved through the traditional Chinese medicine systems pharmacology database and analysis platform, and the information of protein targets was standardized by using Uniprot protein database. Target genes related to atherosclerosis were obtained from online Mendelian inheritance in man, GeneCards, and DrugBank databases, and common targets of drugs and diseases were screened. The “ingredient-target” network was constructed and key active components were screened. The STRING platform was used to construct the common target protein-protein interaction network and screen the key target genes. Matascape database was used for enrichment analysis of GO and KEGG pathways, and a multidimensional network diagram of “drug-target-pathway” was constructed. Thirty SPF 8-week-old male ApoE-/- mice, weighing 18-22 g, were fed with high-fat diet for 12 weeks to establish atherosclerosis model. They were divided into model group, statin group, and Huoxue Jiedu Ⅰ Prescription group according to the random number table method, with ten mice in each group. Ten male C57BL/6J mice of the same age and genetic background were selected as normal control group. Statin group was given 3.400 mg/(kg·d) of Atorvastatin, Huoxue Jiedu Ⅰ Prescription group was given 2.171 g/(kg·d) of drug liquid, normal control group and model group was given the same amount of normal saline. All the four groups were given gavage for 12 weeks. At the end of the experiment, colorimetric method was used to detect blood lipid indexes of the four groups, and HE staining and plaque proportion of aorta were quantitatively analyzed. The protein expressions of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), caspase-3, and nuclear factor-κBp65 (NF-κBp65) in aortic tissues of the four groups were detected by Western blot. Results A total of 25 active ingredients of Huoxue Jiedu Ⅰ Prescription were screened, 214 potential targets were identified, and 118 targets were common with atherosclerotic diseases. GO analysis showed 2 173 results, including 165 pathways. The key active ingredients of Huoxue Jiedu Ⅰ Prescription in the treatment of atherosclerosis include quercetin, baicalin, β-sitosterol, ellagic acid, berberine, tetrandrine afrika, berberine, etc. It can regulate TNF, AKT1, IL-6, VEGFA, TP53, IL-1B, JUN, CASP3, PTGS2, PPARG, and other related targets. It may affect the occurrence and development of atherosclerosis through TNF, Toll-like receptor, NF-κB, HIF-1, PI3K-Akt, apoptosis, T-cell receptor, MAPK, Foxo, and other signaling pathways. The results of the experiment showed that serum total cholesterol (TC), triglyceride (TG), and low density lipoprotein cholesterol (LDL-C) in the model group were higher than those in the normal control group, and the level of high density lipoprotein cholesterol in the model group was lower than that in the normal control group, serum TC, TG, and LDL-C in the Huoxue Jiedu Ⅰ Prescription group were lower than those in the model group, and the differences were statistically significant (P ＜ 0.05). The results of HE staining of aortic root showed that there was no atherosclerotic plaque deposition in the aortic root of the normal control group, and different degrees of atherosclerotic plaque deposition could be observed in the aortic root wall of the other three groups. Quantitative analysis of plaque proportion showed that the proportion of plaque area in the Huoxue Jiedu Ⅰ Prescription group was lower than that in the model group, and the difference was statistically significant (P ＜ 0.05). The protein levels of TNF-α, IL-6, caspase-3, and NF-κBp65 in the model group were higher than those in the normal control group, while those in the Huoxue Jiedu Ⅰ Prescription group were lower than those in the model group, and the differences were statistically significant (P ＜ 0.05). Conclusion This study preliminarily reveales the “multi-component, multi-target, multi-pathway” action network of Huoxue Jiedu Ⅰ Prescription in the treatment of atherosclerosis, and experimentally verifies that its mechanism of action is related to the inhibition of related inflammatory pathways and apoptosis, providing a research basis for the clinical application of Huoxue Jiedu Ⅰ Prescription in the treatment of atherosclerosis.
		2022 Vol. 19 (33): 5-12,17 [Abstract] ( 22 ) HTML (1 KB) PDF (3645 KB) ( 101 )

	13	Effect of moxibustion of zúsānlǐ and tàixī on cell apoptosis and expression of related proteins in decidua tissues of pregnant rats with kidney deficiency-corpus luteum inhibition of abortion model
		HU Shan CHEN Pengdian▲ NING Yan▲ MA Fei LIU Yulei QIU Tingting QIN Xiaoling TANG Meng
		DOI: 10.20047/j.issn1673-7210.2022.33.02
		Objective To observe the effect of moxibustion of zúsānlǐ and tàixī on cell apoptosis and expression of related proteins in decidua tissues of pregnant rats with kidney deficiency-corpus luteum inhibition of abortion model. Methods Thirty-two pregnant female SD rats (SPF, 8-10 weeks, 220-250 g) were divided into normal group, model group, Dydrogesterone group, and moxibustion group according to the random number table method, with eight rats in each group. The normal group was given normal saline intragastric administration, and the other groups were given “Hydroxyurea + Mifepristone” to prepare the kidney deficiency-corpus luteum inhibition of abortion model of pregnant SD rats. At the same time, the Dydrogesterone group was given Dydrogesterone Tablets 3.02 mg/kg, 2 ml/day by gavage. In the moxibustion group, bilateral zúsānlǐ and tàixī points were moxibusted for 15 min/(time·point) every day, and the samples were collected after nine days of continuous intervention. The number of embryos in each group was calculated and the diameter of uterus was measured. The cell apoptosis of decidua tissues of each group was detected by TUNEL method, and the apoptosis index (AI) value was calculated. The protein expressions of Bax, Bcl-2, and Caspase-3 in decidua tissues of each group were determined by immunohistochemistry. Results Compared with the normal group, the uterine diameter of the model group was decreased, and the difference was statistically significant (P ＜ 0.05). Compared with the model group, the uterine diameter of the moxibustion group was increased, and the difference was statistically significant (P ＜ 0.05). There were no significant differences in the total number of intrauterine embryos between normal group and model group, model group and moxibustion group (P ＞ 0.05). Compared with the normal group, the average OD value of Bax and Caspase-3 protein in the model group was increased, and the differences were statistically significant (P ＜ 0.05). Compared with the model group, the average OD value of Bax and Caspase-3 protein in the moxibustion group was decreased, and the differences were statistically significant (P ＜ 0.05). Compared with the normal group, the average OD value of Bcl-2 protein in the model group was decreased, and the difference was statistically significant (P ＜ 0.05). Compared with the model group, the average OD value of Bcl-2 protein in the moxibustion group was increased, and the difference was statistically significant (P ＜ 0.05). Compared with the normal group, the cell AI value of the model group was increased, and the difference was statistically significant (P ＜ 0.05). Compared with the model group, the cell AI value of the moxibustion group was decreased, and the difference was statistically significant (P ＜ 0.05). Conclusion Moxibustion at zúsānlǐ and tàixī may regulate cell apoptosis at the maternal-fetal interface by up-regulating the expression of Bcl-2 protein, down-regulating the overexpression of Bax and Caspase-3 protein and reducing the AI in decidua tissues of pregnant rats with kidney deficiency and corpus luteum inhibition of abortion
		2022 Vol. 19 (33): 13-17 [Abstract] ( 23 ) HTML (1 KB) PDF (1266 KB) ( 46 )

	18	Visual analysis of research hotspots and directions of traditional Chinese medicine in the treatment of thoracolumbar compression fractures based on CiteSpace
		LU Huoyan1 GENG Pengzhan1 DAI Ye2 CHENG Xiaoyue3 GUO Ran4 ZHAO Ruoqi5 SHI Mengya5 ZHAO Jian1 WANG Peng1
		DOI: 10.20047/j.issn1673-7210.2022.33.03
		Objective To analyze the research hotspot and directions of traditional Chinese medicine in the treatment of thoracolumbar compression fractures based on CiteSpace software. Methods Literatures related to the treatment of thoracolumbar compression fractures with traditional Chinese medicine from January 2000 to December 2021 were included in CNKI database as the research object, CiteSpace V5.6.R4 software was used to analyze the annual number of publications, the cooperation between authors and institutions, and keywords, and to make corresponding knowledge maps. The results were analyzed and related literature was read for discussion. Results A total of 3 685 related literatures were included, involving 840 authors and 657 institutions. From 2006 to 2019, the number of documents issued had increased steadily; according to the author’ cooperation map, three research teams had been formed. Through the analysis of the cooperation map of research institutions, it was known that Gansu, Hunan and other places have formed a cooperation network, forming a regional nature, and the cooperation among institutions is relatively close. From the keyword knowledge map, we know that there were 237 keywords in total, including five highly central high-frequency keywords (≥0.10), the top five keywords were thoracolumbar compression fracture, thoracolumbar fracture, nursing, percutaneous vertebroplasty, and constipation. Osteoporosis had the highest frequency, with a total of 559 times; it had formed seven clusters of constipation, clinical efficacy, spinal implants, thoracolumbar compression fractures, bone mineral density, quality of life, and Taohong Siwu Decoction. At present, the research hotspots were pillow cushion and manual reduction, Taohong Siwu Decoction and so on. There were many studies on the treatment of its complications constipation. Conclusion There is still much room for development in the research field of traditional Chinese medicine in the treatment of thoracolumbar compression fractures. The degree of cooperation between the research authors and institutions is poor. At present, the research direction of traditional Chinese medicine treatment is mainly pillow cushion and manual reduction.
		2022 Vol. 19 (33): 18-23 [Abstract] ( 20 ) HTML (1 KB) PDF (1831 KB) ( 63 )

	24	Analysis of serum metabolomics of premature infants in different growth patterns
		CHEN Ying1 WANG Yumei2 XU Wenying1 ZHANG Peiying1
		DOI: 10.20047/j.issn1673-7210.2022.33.04
		Objective To analyze the characteristics of serum metabolites and to search for differential metabolites and metabolic pathways of preterm infants in different growth patterns using metabolomics techniques. Methods Serum samples were collected from 55 preterm infants by six months of adjusted age who were hospitalized in Neonatal Intensive Care Unit and were followed by Department of Child Health Care of Huai’an Maternal and Child Health Hospital Affiliated to Yangzhou University from March 2019 to December 2020. They were divided into catch-up growth group (35 cases) and without catch-up growth group (20 cases) according to whether the Z-score difference between corrected age of six months and birth weight was ≥0.67. The serum metabolic profiles were detected by liquid chromatography-tandem mass spectrometry, the metabolites and metabolic pathways with significant differences between two groups were identified, respectively. Results A total of 28 serum differential metabolites were obtained. Among them, there were 27 upregulated substances, mainly amino acids, glycerol phospholipids, and organic heterocyclic compounds, etc.; down-regulated substance 1, belonging to fatty acids. The metabolite difference pathways mainly concentrated in metabolism and synthesis of amino acids. The most significant enrichment pathways were arginine and proline metabolism and glutathione metabolism. Conclusion Premature infants with catch-up growth in the early stage are more prone to lack of various nutrients, especially amino acids, because of their rapid growth. It should pay attention to the reasonable supplement of amino acids for preterm infants. Metabonomics analysis can provide scientific basis for nutritional evaluation and intervention of preterm infants.
		2022 Vol. 19 (33): 24-28 [Abstract] ( 24 ) HTML (1 KB) PDF (1456 KB) ( 42 )

	29	Visual analysis of CiteSpace-based traditional Chinese medicine for the prevention and treatment of ankylosing spondylitis
		GAO Ruiyong1 WANG Yudong1 JIN Zhu1 LIU Gaoqing1 SUN Mingshuai2 WANG Lihe2
		DOI: 10.20047/j.issn1673-7210.2022.33.05
		Objective To visual analysis the research hotspots and trends in traditional Chinese medicine for the prevention and treatment of ankylosing spondylitis by CiteSpace software, and to provide a reference for the further development of the field in the future. Methods The relevant literatures on traditional Chinese medicine for the prevention and treatment of ankylosing spondylitis from January 2000 to December 2020 was retrieved from China National Knowledge Network, the number of publications was statistically analyzed, and the included literatures were exported in RefWorks format and visualized by applying CiteSpaceV5.8.R1 software to produce knowledge graph of information such as authors, research institutions, and keywords. Results A total of 1 620 articles were included, and the annual number of articles published in the literature has generally shown an increasing trend in the last 20 years. A total of 634 authors were included in the atlas, including ten authors with ≥ten publications; 530 institutions were included, with 167 collaborations between institutions; 711 keywords were included, with 12 keywords appearing ≥40 times in the field; 13 large clusters were formed, reflecting current research hotspots; keywords that had emerged in recent years include inflammatory factors, data mining, and meta-analysis. Conclusion CiteSpace knowledge graph visualization was used to analyze the research hotspots and trends of traditional Chinese medicine against ankylosing spondylitis, which is conducive to the unique therapeutic advantages of traditional Chinese medicine and provides reference ideas for future scientific and clinical research in this field.
		2022 Vol. 19 (33): 29-32,48 [Abstract] ( 27 ) HTML (1 KB) PDF (2365 KB) ( 107 )

	33	Simultaneous determination of 7 components in Tenghuang Jiangu Pills by high performance liquid chromatography - quantitative analysis of multi-components by single-marker
		ZHAO Yuwei1 NAN Minlun2 SI Yingqi3 LING Yuqi4 YIN Han4 HE Yufang5
		DOI: 10.20047/j.issn1673-7210.2022.33.06
		Objective To establish a method of high performance liquid chromatography-quantitative analysis of multi-components by single-marker to simultaneously determine the contents of echinacoside, acteoside, naringin, epimedin A, epimedin B, epimedin C, icariin in Tenghuang Jiangu Pills. Methods The analysis of methanol extract of this drug was performed on a 25℃ thermostatic Agilent ZORBAX Extend C18(4.6 mm×250 mm, 5 μm), with the mobile phase comprising of water (containing 0.1% phosphoric acid)-acetonitrile flowing at 1.0 ml/min in a gradient elution manner, and the detection wavelength was set at 280 nm．Using icariin as the internal reference substance, the relative correction factor of the other six components was established and the contents of each component were calculated．In order to validate the accuracy, the seven components in Tenghuang Jiangu Pills were determined and compared by both high performance liquid chromatography-quantitative analysis of multi-components by single-marker and an external standard method. Results The contents of seven components in 11 batches of Tenghuang Jiangu Pills were determined, seven constituents showed good linear relationships within their own ranges（r ≥ 0.999 7）, whose average recoveries were 97.70%-99.25% with the RSD of 0.53%-1.57%. The two methods did not show significant difference in assay results. Conclusion The method can be used for the simultaneous determination of seven components in Tenghuang Jiangu Pills, and the purpose of multi-index quality control was achieved．
		2022 Vol. 19 (33): 33-36 [Abstract] ( 29 ) HTML (1 KB) PDF (732 KB) ( 21 )

	37	Research progress of traditional Chinese medicine regulating Th1/Th2 imbalance and inhibiting IL-23/Th17 axis in the treatment of psoriasis vulgaris
		MENG Jiaoyu1 LI Ling’e2 WANG Yajing1 LIU Qianying3 LYU Ziyue3
		DOI: 10.20047/j.issn1673-7210.2022.33.07
		Psoriasis vulgaris is called “Baibi” in traditional Chinese medicine. Modern medicine believes that the occurrence and development of psoriasis is related to the abnormal activation of T lymphocytes. Studies have shown that the helper T lymphocyte (Th)1/Th2 balance in patients with psoriasis is shifted toward the differentiation dominance of Th1 cells, and that Th17 cells can induce and exacerbate inflammatory responses in psoriatic lesions through the IL-23/Th17 axis. Studies on the treatment of psoriasis vulgaris by traditional Chinese medicine have found that traditional Chinese medicine decoction, Chinese patent medicine, and external treatment of traditional Chinese medicine such as fire acupuncture therapy and traditional Chinese medicine medicated bath can effectively improve the Th1 drift in patients with psoriasis and inhibit the IL-23/Th17 axis, so as to achieve the purpose of the treatment of psoriasis. Therefore, this paper reviews the literature on the clinical efficacy and mechanism of traditional Chinese medicine in the treatment of psoriasis vulgaris, in order to provide more geographical and methodological basis for the clinical application of traditional Chinese medicine in the diagnosis and treatment of psoriasis vulgaris, and to provide some new ideas and directions for the treatment of psoriasis vulgaris in the future.
		2022 Vol. 19 (33): 37-40,58 [Abstract] ( 31 ) HTML (1 KB) PDF (642 KB) ( 74 )

	41	Research progress of HSPB5
		FU Jia LI Shiqi ZHAO Xiaoting ZHENG Xiaodong
		DOI: 10.20047/j.issn1673-7210.2022.33.08
		HSPB5 is a protein with a highly conserved crystal structure, which exists in the form of dynamic oligomers in vivo. HSPB5 expression is regulated by various physiological and pathological factors, such as increased expression under heat stress, and its activity is regulated by various post-translational modifications such as phosphorylation, acetylation, and glycosylation. Under physiological conditions, HSPB5, as a chaperone-like protein can reduce the aggregation of misfolded proteins, and can also interact with various proteins to inhibit apoptosis. Under pathological conditions, HSPB5 can also affect multiple disease processes, such as Alzheimer’s disease, cardiomyopathy, tumor, and hypoxia, etc. This paper briefly reviews the role and the mechanism of HSPB5 in physiological and pathological conditions states. Regulating the expression level and activity of HSPB5 may serve as a new therapeutic strategy for a variety of diseases.
		2022 Vol. 19 (33): 41-44 [Abstract] ( 22 ) HTML (1 KB) PDF (470 KB) ( 168 )

	45	Research progress in animal models of acute and chronic pruritus of skin origin
		QIU Caixiong LI Kangliang HE Shuang HUANG Chunhua WU Guanyi
		DOI: 10.20047/j.issn1673-7210.2022.33.09
		Animal models of pruritus of skin are origin often used in drug antipruritus experiments. Pruritic substances such as histamine, dextran, and compound 48/80 are often used to induce histamine-dependent acute pruritus models. Atopic dermatitis, psoriasis and other skin inflammatory disease models are also chronic pruritus animal models. This article reviews the research progress of animal model of acute and chronic pruritus of skin origin. It was found that animal strain, pruritus substance type and concentration, and administration method could affect the effect of pruritus behavior in animals. The characteristics and duration of pruritus in different models were different.
		2022 Vol. 19 (33): 45-48 [Abstract] ( 25 ) HTML (1 KB) PDF (573 KB) ( 392 )

	49	Correlation between vaginal microbiota and cervical precancerous lesions
		HAN Buwei1 LIU Yang1 HE Hui1 GONG Yi2 LIU Ning1 ZHOU Lina1 HAO Xinying1 LIU Li3
		DOI: 10.20047/j.issn1673-7210.2022.33.10
		The female reproductive tract has a microbiome that lives in symbiosis with the human body, Lactobacillus is usually the dominant bacterium, this genus plays an important role in maintaining the health of the female reproductive tract. Dysregulation of reproductive tract microbiota may promote the development of human papillomavirus (HPV) infection and cervical intraepithelial neoplasias (CIN), and eventually lead to cervical malignancy. As the severity of CIN increases, depletion of dominant Lactobacillus increases, which may negatively affect the rate of disease regression, for example, leading to a pro-inflammatory environment that increases the expression of HPV E6 and E7 oncogenes and proliferation of malignant cells. This paper reviews the correlation between the composition of vaginal microbiota and the occurrence and development of cervical cancer, in order to better understand the influence of the microbiota on cervical cancer, which may contribute to explore new diagnostic or prognostic microbial markers of cervical cancer, and seek new prevention or treatment drug targets.
		2022 Vol. 19 (33): 49-52 [Abstract] ( 19 ) HTML (1 KB) PDF (491 KB) ( 156 )

	53	Research progress on pathogenesis and prognosis of myocardial infarction with non-obstructive coronary arteries
		QU Feng LIN Fei CHEN Zhigang ZHAO Guoan
		DOI: 10.20047/j.issn1673-7210.2022.33.11
		Myocardial infarction with non-obstructive coronary arteries (MINOCA) is a heterogeneous group of diseases with different pathogenesis, accounting for 1%-15% of acute myocardial infarction. The pathogenesis of MINOCA is complex, and there is no unified conclusion yet, and the prognosis of MINOCA with different pathogenesis is also different. Based on the latest research progress of MINOCA at home and abroad, this paper reviews the diagnosis and pathogenesis of MINOCA in depth, expounds its prognosis from multiple aspects, analyzes its predictive factors, and provides evidence-based medical evidence for the early diagnosis and precise treatment of MINOCA.
		2022 Vol. 19 (33): 53-58 [Abstract] ( 18 ) HTML (1 KB) PDF (1283 KB) ( 185 )

	59	Comparison of clinical characteristics and differences in the treatment of cartilage injuries of the knee and ankle joints
		MO Yafeng1 ZHOU Fengzhen2 ZHOU Kun1 TANG Yanghua1
		DOI: 10.20047/j.issn1673-7210.2022.33.12
		The knee and ankle joints are the main weight-bearing joints of the human body and have a high incidence of articular cartilage injury, which is prone to varying degrees of joint pain and functional impairment. The treatment of cartilage injuries in the knee and ankle joints is often not differentiated in clinical practice. This paper summarizes and analyzes the anatomical structure, composition, molecular biology, and biomechanics of the knee and ankle joints, hoping to provide some reference for precise clinical treatment. The relevant literatures were searched, collected, and organized in Chinese and English databases through a combination of subject terms and free words, and significant differences were found in the clinical characteristics of knee and ankle cartilage, leading to differences in disease incidence and related treatment measures.
		2022 Vol. 19 (33): 59-62 [Abstract] ( 25 ) HTML (1 KB) PDF (534 KB) ( 40 )

	63	Research progress of myosin light chain kinase 3 gene in heart disease
		ZENG Jing LIU Xiaoyang BAI Yang WANG Dawei▲
		DOI: 10.20047/j.issn1673-7210.2022.33.13
		Myosin light chain kinase (MYLK) 3 gene is a member of the MYLK family, which is mainly expressed in myocardial tissue. Its protein product, cardiac MYLK, plays an important role in cardiac development, cardiac contraction, and sarcomeric tissue formation. When its expression is reduced or absent, it can affect myocardial formation and development, leads to congenital heart disease, heart hypertrophy, dilated heart disease, and other heart diseases. The discovery of MYLK3 gene makes the clinical further understanding of heart diseases from the gene level, which may provide a new theoretical basis and therapeutic target for the diagnosis and treatment of heart diseases. This article reviews the structure and function of MYLK3 gene and its research progress in heart disease.
		2022 Vol. 19 (33): 63-65,87 [Abstract] ( 24 ) HTML (1 KB) PDF (467 KB) ( 95 )

	66	Risk factor analysis and estoblishment of predictive modeling of postoperative venous thromboembolism in patients with esophageal cancer
		WANG Mingbo1 HUANG Chao1 DONG Keqin1 ZHANG Jianfeng2 LIU Boheng1 TIAN Ziqiang1
		DOI: 10.20047/j.issn1673-7210.2022.33.14
		Objective To investigate the risk factors of postoperative venous thromboembolism (VTE) in patients with esophageal cancer and to construct a statistical model for personalized prediction of the incidence of postoperative VTE in patients. Methods The clinical data of 127 patients who underwent standard radical esophageal cancer surgery in the Department of Thoracic Surgery of the Fourth Hospital of Hebei Medical University from January 2020 to June 2021 were retrospectively analyzed and divided into VTE group (32 patients) and non-VTE group (95 patients). Logistic regression analysis was used to explore the risk factors for postoperative VTE in patients with esophageal cancer and to construct a column line graph predicting the risk of postoperative VTE in patients with esophageal cancer. Results Age, hypertension, diabetes mellitus, body mass index, preoperative D-dimer, duration of surgery, and open left chest were higher in the VTE group than in the non-VTE group, with statistically significant differences (P ＜ 0.05). Multi-factor logistic analysis showed that diabetes was an independent risk factor for the development of VTE (OR ＞ 1, P ＜ 0.05); while the length of surgery and the mode of surgery were independent protective factors for the development of VTE (OR ＜ 1, P ＜ 0.05). Column plots were constructed to predict the risk of postoperative VTE in patients with esophageal cancer, and the calibration curve was more closely aligned with the ideal curve, with an area under the curve of 0.769 for the ROC curve, and the decision curve showed that interventions in patients with a threshold probability of 0 to 73.1% may result in clinical benefit. Conclusion Diabetes mellitus, duration of surgery, and mode of surgery are independent risk factors for postoperative VTE in patients with esophageal cancer, and the column line graph model constructed in this study has a high predictive value for the occurrence of postoperative VTE.
		2022 Vol. 19 (33): 66-70 [Abstract] ( 27 ) HTML (1 KB) PDF (748 KB) ( 34 )

	71	Clinical effect of Shengjiang Decoction combined with Banxia Houpu Decoction in the treatment of subclinical hypothyroidism of Hashimoto thyroiditis with liver depression and spleen deficiency
		ZHANG Chen LI Jing SHANG Juju
		DOI: 10.20047/j.issn1673-7210.2022.33.15
		Objective To investigate the clinical effect of Shengjiang Decoction combined with Banxia Houpu Decoction in the treatment of subclinical hypothyroidism of Hashimoto thyroiditis with liver depression and spleen deficiency. Methods From February to May 2022, 64 patients with subclinical hypothyroidism of Hashimoto thyroiditis with liver stagnation and spleen deficiency who visited Department of Endocrinology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University were selected as research objects. They were divided into treatment group and control group according to the random number table method, with 32 cases in each group. The control group was given Levothyroxine Sodium Tablets, and the treatment group was given Shengjiang Decoction combined with Banxia Houpu Decoction, the duration of treatment was four weeks. The clinical symptoms of the two groups were compared, the clinical symptom score, serum thyroid thyroid-stimulating hormone (TSH), thyroglobulin antibody (TGAb), and thyroid peroxidase antibody (TPOAb) before and after treatment were compared between two groups. Results The clinical efficacy of treatment group was better than that of control group, and the difference was statistically significant (P ＜ 0.05). After treatment, the scores of fatigue, insomnia, abnormal defecation, and emotional irritability or depression in treatment group were lower than those before treatment, and the scores in treatment group were lower than those in control group, and the differences were statistically significant (P ＜ 0.05). After treatment, the levels of TSH in two groups were lower than those before treatment, and the differences were statistically significant (P ＜ 0.05); the levels of TPOAb and TGAb in treatment group were lower than those before treatment, and the levels of TPOAb and TGAb in treatment group were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion The treatment of Shengjiang Decoction combined with Banxia Hopu Decoction can effectively improve the clinical symptoms, TSH, TPOAb, and TGAb of subclinical hypothyroidism of Hashimoto thyroiditis with liver stagnation and spleen deficiency, and improve the thyroid function.
		2022 Vol. 19 (33): 71-74 [Abstract] ( 30 ) HTML (1 KB) PDF (557 KB) ( 42 )

	75	Effect of Dapagliflozin on islet function in type 2 diabetes mellitus with obesity and poor glucose control
		ZHOU Jie WU Xinhua YAN Yan SHI Wen ZHU Ping▲
		DOI: 10.20047/j.issn1673-7210.2022.33.16
		Objective To explore the effect of Dapagliflozin on islet function in type 2 diabetic mellitus (T2DM) patients with obesity and poor glucose control. Methods A total of 73 T2DM patients with obesity and poor glucose control treated in Huai’an Cancer Hospital of Jiangsu Province from June 2019 to March 2021 were selected as the research objects. According to the random number table method, they were divided into experimental group (37 cases) and control group (36 cases). The control group was treated with Risenatide, experimental group was treated with Dapagliflozin combined with Risenatide. The insulin resistance index (HOMA-IR), islet β-cell function index (HOMA-β), fasting blood glucose and 2-h postprandial blood glucose, glycosylated hemoglobin (HbA1c), body mass index (BMI), and body fat rate were compared between two groups before treatment and six months after treatment; the time to blood glucose target between two groups were compared; the adverse reactions during treatment were recorded. Results After treatment, HOMA-IR, fasting blood glucose, 2-h postprandial blood glucose, HbA1c, BMI, and body fat rate in two groups were lower than those before treatment, and those in the experimental group were lower than those in control group (P ＜ 0.05). HOMA-β in two groups was higher than that before treatment, and that in experimental group was higher than that in control group (P ＜ 0.05). There was no significant difference in the incidence of total adverse reactions between two groups (P ＞ 0.05). Conclusion Dapagliflozin in the treatment of T2DM patients with obesity and poor glucose control can effectively improve the islet function, regulate the blood glucose level, improve the degree of obesity and have good safety.
		2022 Vol. 19 (33): 75-78 [Abstract] ( 36 ) HTML (1 KB) PDF (542 KB) ( 61 )

	79	Clinical efficacy of endoscopic posterior lumbar interbody fusion in the treatment of single-level lumbar degenerative diseases
		SHANG Rongan FENG Wanli WANG Junfeng XIA Xiujia CAO Panju ZHANG Jie WANG Xiaoming KANG Jian
		DOI: 10.20047/j.issn1673-7210.2022.33.17
		Objective To investigate the clinical efficacy of endoscopic posterior lumbar interbody fusion for treatment of single-level lumbardegenerative disease. Methods The clinical data of 48 patients of single segment lumbar degenerative diseases treated in Baoji Hospital of Traditional Chinese Medicine from May 2018 to January 2021 were retrospectively analyzed. They were divided into minimally invasive group and open group according to different surgical methods, with 24 cases in each group. The minimally invasive group was treated with endoscopic posterior lumbar interbody fusion, and the open group was treated with traditional posterior lumbar fusion. The perioperative indexes, visual analogue scale (VAS) score of low back pain and Oswestry dysfunction index (ODI) were compared between the two groups. The clinical efficacy was evaluated according to the scoring standard of low back pain surgery in the spine group of Chinese orthopaedic society. Results The incision length of the minimally invasive group was shorter than that of the open group, the operation time was longer than that of the open group, the blood loss was less than that of the open group, and the length of hospital stay was shorter in the open group, and the differences were statistically significant (P ＜ 0.05). Intra-group comparison: there were statistically significant differences between the two groups at each time point (P ＜ 0.05). Comparison between groups: there were no significant differences in VAS score and ODI index between the two groups before operation (P ＞ 0.05), and the VAS score and ODI index of the micro-wound group were lower than those of the open group at one week after operation (P ＜ 0.05). However, there were no significant differences in VAS score and ODI index between the two groups at six months after operation and at the last follow-up (P ＞ 0.05). There was no significant difference in clinical efficacy between the two groups (P ＞ 0.05). Conclusion Endoscopic lumbar decompression and interbody fusion technology for the treatment of single level lumbar degenerative diseases has the advantages of small tissue trauma, less surgical bleeding, short hospital stay, fast postoperative recovery, and less damage to the posterior structure of the lumbar spine. At the same time, it can achieve similar curative effects to traditional open surgery.
		2022 Vol. 19 (33): 79-82 [Abstract] ( 25 ) HTML (1 KB) PDF (567 KB) ( 28 )

	83	Effect of percutaneous minimally invasive percutaneous plate osteosynthesis through lateral extension approach in the treatment of intra-articular calcaneal fractures
		GUO Ping1 XU Feng2▲
		DOI: 10.20047/j.issn1673-7210.2022.33.18
		Objective To explore the therapeutic effect of minimally invasive percutaneous plate osteosynthesis throngh lateral extended approach for patients with intra-articular calcaneal fractures. Methods From June 2017 to June 2021, 82 patients with intra-articular calcaneal fractures from Zhangjiagang Second People’s Hospital in Jiangsu Province were selected and they were divided into experimental group and reference group according to the random number table method, with 41 patients in each group. The experimental group was treated with percutaneous minimally invasive plate internal fixation through the lateral extended approach, and the reference group was treated with traditional lateral L-shaped plate internal fixation. The perioperative indicators (preoperative waiting time, intraoperative bleeding, operation time, hospitalization time) and fracture recovery were compared between the two groups, and the Gissane angle, B?觟hler angle, and foot joint function (marland foot function score [MFS]) were compared before and six months after the operation, and the complications occurred within three months after the operation. Results The hospitalization time of the experimental group was shorter than that of the control group (P ＜ 0.05). There was no significant difference in excellent and good rate between the two groups (P ＞ 0.05). There were no significant differences in Gissane angle and B?觟hler angle between the two groups before operation and six months after operation (P ＞ 0.05). Gissane angle and B?觟hler angle in the two groups at six months after operation were significantly higher than those before operation (P ＜ 0.05). At six months after operation, the MFS scores of the two groups were higher than those before operation, and the function and range of motion in the MFS scores of the experimental group were higher than those of the reference group (P ＜ 0.05). The total incidence of complications in the experimental group was lower than that in the reference group (P ＜ 0.05). Conclusion The application of external extended approach percutaneous minimally invasive plate internal fixation for patients with intra-articular calcaneal fractures can shorten hospital stay, improve foot function, improve mobility, and reduce complications.
		2022 Vol. 19 (33): 83-87 [Abstract] ( 23 ) HTML (1 KB) PDF (601 KB) ( 30 )

	88	Effect of mini open and minimally invasive transforaminal lumbar interbody fusion in the treatment of lumbar degenerative diseases
		XIAO Jun ZHUGE Hengyan XU Kefeng JIN Genyang
		DOI: 10.20047/j.issn1673-7210.2022.33.19
		Objective To compare the effect of mini open and minimally invasive transforaminal lumbar interbody fusion in the treatment of lumbar degenerative diseases. Methods A total of 84 patients with lumbar degenerative diseases admitted to the 904 Hospital of PLA Joint Logistic Support Force from June 2014 to December 2020 were prospectively selected and divided into control group and study group according to the random number table method, with 42 cases in each group. The study group was treated with minimally invasive transforaminal lumbar interbody fusion, while the control group was treated with mini open transforaminal lumbar interbody fusion. The patients were followed up for one year. The operation conditions of the two groups were compared, and the lumbar function and anatomical indexes before and one year after operation were statistically analyzed. The adjacent segment imaging degeneration and facet joint intrusion of the two groups were recorded one year after operation. Results The operation time of study group was longer than that of control group (P ＜ 0.05). There were significant differences in intraoperative blood loss and postoperative drainage volume between the two groups (P ＞ 0.05). At one year after operation, the Japanese Orthopaedic Association (JOA) score, fuse segmental angles, and intervertebral space height of two groups were higher than those before operation, and the Oswestry disability index (ODI) and intervertebral motion of two groups were lower than those before operation (P ＜ 0.05). There were no significant differences in JOA score, ODI, fusion segment angle, intervertebral space height, and intervertebral motion between the two groups before and one year after operation (P ＞ 0.05). The incidence of adjacent segment imaging degeneration in the study group was lower than that in the control group (P ＜ 0.05). There was no significant difference in the degree of facet joint intrusion of left and right side of L4 superstratum between the two groups (P ＞ 0.05). Conclusion The efficacy of mini open transforaminal lumbar interbody fusion is comparable to that of minimally invasive transforaminal lumbar interbody fusion in the treatment of lumbar degenerative diseases, but the operation time of mini open transforaminal lumbar interbody fusion is shorter, and the risk of early adjacent segment imaging degeneration after minimally invasive transforaminal lumbar interbody fusion is lower.
		2022 Vol. 19 (33): 88-91 [Abstract] ( 29 ) HTML (1 KB) PDF (550 KB) ( 34 )

	92	Expression of MMP2, IGF2BP2, and HMGA2 in invasive placental tissue
		YE Fangbing ZHU Baoju▲
		DOI: 10.20047/j.issn1673-7210.2022.33.20
		Objective To investigate the expressions of matrix metalloproteinase 2 (MMP2), insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2), and high mobility group box A2 (HMGA2) in invasive placental tissue. Methods From March to December 2021, 23 pregnant women diagnosed with invasive placenta in the Second Affiliated Hospital of Zhengzhou University were selected as invasive placenta group, and 29 pregnant women with normal pregnancy in the same period were selected as control group. Western blot and real-time PCR were used to detect the expressions of MMP2, IGF2BP2, and HMGA2 in placental tissues of the two groups. Results The protein and mRNA expression levels of MMP2, IGF2BP2, and HMGA2 in invasive placenta group were higher than those in control group, and the differences were statistically significant (P ＜ 0.05). Conclusion The elevated expression of MMP2, IGF2BP2, and HMGA2 in placental tissue may be related to the occurrence of invasive placental tissue.
		2022 Vol. 19 (33): 92-95 [Abstract] ( 18 ) HTML (1 KB) PDF (785 KB) ( 18 )

	96	Clinical effect of Qishen Granules in the treatment of type 2 diabetes mellitus patients with ophthalmoxerosis with deficiency of both qi and yin
		JU Pin1 ZHAO Lei2 LI Yuexin1 ZUO Tao2
		DOI: 10.20047/j.issn1673-7210.2022.33.21
		Objective To observe the clinical effect of Qishen Granules in the treatment of type 2 diabetes mellitus patients with ophthalmoxerosis with deficiency of both qi and yin. Methods From December 2020 to May 2021, 74 type 2 diabetes mellitus patients with ophthalmoxerosis with deficiency of both qi and yin (148 eyes in total) admitted to the Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine were collected and divided into control group and treatment group according to the random number table method, with 37 cases in each group. The control group was given 0.3% Sodium Hyaluronate Eye Drops, and the treatment group was given Qishen Granules orally on this basis. The treatment course was 14 days in both groups. Keratograph 5M ocular surface analyzer was used to measure the relevant indicators before and after treatment, including the non-invasive first tear film break-up time (NIBUTf), non-invasive average tear film break-up time (NIBUTav), lacrimal river height (LTMH), meibomian gland loss score, and ocular surface disease index (OSDI). Results After treatment, the OSDI in the two groups were lower than those before treatment, and the treatment group was lower than the control group, and the differences were statistically significant (P ＜ 0.05). After treatment, NIBUTf and LTMH in the two groups were higher than those before treatment, NIBUTav in the treatment group was higher than that before treatment, and NIBUTf, NIBUTav, and LTMH in the treatment group were higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). After treatment, the meibomian gland loss scores in the treatment group was lower than that before treatment and the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Qishen Granules can effectively improve the main symptoms of type 2 diabetes mellitus patients with ophthalmoxerosis with deficiency of both qi and yin, and the value of clinical promotion.
		2022 Vol. 19 (33): 96-99 [Abstract] ( 23 ) HTML (1 KB) PDF (587 KB) ( 110 )

	100	Influence of Conbercept on diabetic retinopathy patients with macular edema
		YIN Xiaomin1 XUE Han2 ZHAI Liping3
		DOI: 10.20047/j.issn1673-7210.2022.33.22
		Objective To investigate the influence of Conbercept on diabetic retinopathy patients with macular edema. Methods A total of 84 diabetic retinopathy patients (84 eyes in total) with macular edema admitted to Taizhou Hospital of Traditional Chinese Medicine of Jiangsu Province from January 2016 to May 2021 were selected as the research objects. They were divided into control group and study group by random number table method, with 42 cases in each group. The control group was treated with retinal photocoagulation, and the study group was treated with Conbercept on the basis of the control group. The course of treatment in both groups was three months. The macular foveal central macular thickness (CMT), best corrected visual acuity (BCVA), erythroeyte deformation index (EDI), plasma viscosity (PV), and mean defect of visual field (MD) were compared between the two groups before and after treatment. The macular improvement and complications of the two groups were recorded. Results After three months of treatment, the CMT, EDI, PV, and MD of the two groups were lower than those before treatment, and the BCVA was higher than that before treatment, the CMT, EDI, and PV of the study group were lower than those of the control group, and the BCVA was higher than that of the control group (P ＜ 0.05). The macular regression grade of the study group was better than that of the control group (P ＜ 0.05). There was no significant difference in the total incidence of complications between the two groups (P ＞ 0.05). Conclusion Conbercept combines with retinal photocoagulation can improve visual acuity, improve microcirculation, reduce macular edema, and improve visual field loss in diabetic retinopathy patients with macular edema, which is safe and reliable.
		2022 Vol. 19 (33): 100-103 [Abstract] ( 27 ) HTML (1 KB) PDF (515 KB) ( 52 )

	104	Discussion on the relevant factors of metastasis of triple negative breast cancer from the perspective of traditional Chinese medicine syndrome types
		MEI Heting1 LU Wenping2 ZHUO Zhili2 WANG Yanan1 ZHANG Dongni2 WU Xiaoqing2 CUI Yongjia2
		DOI: 10.20047/j.issn1673-7210.2022.33.23
		Objective To explore the relevant factors of metastasis of triple negative breast cancer (TNBC) from the perspective of traditional Chinese medicine syndrome types. Methods A retrospective analysis was performed on the clinical data of 133 patients with complete medical records who were treated for the first time in Guang’anmen Hospital from June 2019 to January 2022. They had received western standardized treatment and had no history of traditional Chinese medicine treatment. Patients were divided into metastatic group (20 cases) and non-metastatic group (113 cases) according to whether metastasis had occurred at the time of visit. Logistic regression analysis was used to explore the related factors of TNBC metastasis. Results There were significant differences in traditional Chinese medicine syndrome type, operation type, T stage and N stage between the two groups (P ＜ 0.05). Multivariate regression showed spleen and stomach weakness (OR = 6.617, 95%CI:1.037-42.202), tumor size (T＞5 cm, OR = 14.512, 95%CI:1.797-117.185) and lymph node metastasis (0＜N≤3, OR = 0.086, 95%CI:0.007-0.990) were independent risk factors for metastasis (P ＜ 0.05). Conclusion The syndrome type-PWXR syndrome、T and N were independent relevant factors leading to metastasis，and treatment should take care of the spleen and stomach in order to secure the organs.
		2022 Vol. 19 (33): 104-107 [Abstract] ( 26 ) HTML (1 KB) PDF (825 KB) ( 104 )

	108	Discussion on protection of traditional Chinese medicine knowledge based on liveness and inheritance
		WANG Shiheng QIN Peijie ZHAO Zhupei SHI Xueqin ZHU Tingyu ZHANG Fengxia LIU Qian LIU Jianfeng
		DOI: 10.20047/j.issn1673-7210.2022.33.24
		Traditional Chinese medicine knowledge is the treasure of the Chinese nation and plays a huge role in preventing and treating diseases and improving health, it must be protected. At present, there are some problems in the protection of traditional Chinese medicine knowledge, especially inheritance and protection. The problems of inheritance are mainly manifested in the aging of inheritors and the shortage of successors. The protection problems are mainly manifested in the emphasis on the protection of material carrier, economic value and cultural value, the neglect of the protection of medical value and folk traditional Chinese medicine, and the use of modern intellectual property rights system to protect traditional Chinese medicine knowledge. The current protection measures of traditional Chinese medicine knowledge do not fully comply with the development rules and characteristics of traditional Chinese medicine knowledge, and have many disadvantages, resulting in a lot of traditional Chinese medicine knowledge can not be better protected and inherited, on the verge of extinction. Traditional Chinese medicine knowledge has the characteristics of inheritance and vitality, which is the basis for the continuous development and innovation of traditional Chinese medicine knowledge from generation to generation. The protection of traditional Chinese medicine knowledge must be carried out around this feature, so as to achieve better protection. Based on the vitality and inheritance characteristics of traditional Chinese medicine knowledge, this study explores how to better protect traditional Chinese medicine knowledge and puts forward opinions and suggestions, aiming to provide certain reference and reference value for the better development of traditional Chinese medicine.
		2022 Vol. 19 (33): 108-111 [Abstract] ( 30 ) HTML (1 KB) PDF (541 KB) ( 34 )

	112	Professor Huang Shijing’s experience in the treatment of encephalopathy by using the Peiyuan Tongzhi Method
		ZHAO Zehua1 ZHU Shiqin1 YANG Rui2 CHEN Mingqi1 SHI Yanan2 HUANG Shijing2
		DOI: 10.20047/j.issn1673-7210.2022.33.25
		Professor Huang Shijing is clinically good at the prevention and treatment of encephalopathy in traditional Chinese medicine. Based on the theory of the pathogenesis of encephalopathy of “deficiency of qi caused stagnation”, he uses Peiyuan Tongzhi Method to treat a variety of neurological diseases, such as depression, leukoencephalopathy, stroke, and so on. He summarizes the three treatment methods of Yiqi Kaiyu, Peiyuan Tongnao, and Guben Jiedu, which are rich in content, outstanding in levels and remarkable in efficacy, and enrichis the connotation of Peiyuan Tongzhi Method. Professor Huang Shijing is good at estimating the “deficiency” and “stagnation” of diseases in clinical practice, understanding the characteristics of syndromes, adding and subtracting drugs with syndromes, and the model of diseases, syndromes, and symptoms combination has a higher and more practical modern clinical reference value, and this paper attaches a case for the reader.
		2022 Vol. 19 (33): 112-115 [Abstract] ( 28 ) HTML (1 KB) PDF (643 KB) ( 189 )

	116	Efficacy of self-made Shengqing Yizhi Decoction in the treatment of mild vascular cognitive impairment after cerebral infarction with qi deficiency and phlegm obstruction syndrome
		LI Fuhai1 WANG Xuehong1 LIU Ling2 ZHANG Xiaoguang1 CAO Haifang1 LI Xiangyang1 ZHAO Hanqing2
		DOI: 10.20047/j.issn1673-7210.2022.33.26
		Objective To investigate the clinical efficacy of self-made Shengqing Yizhi Decoction in treating patients with mild vascular cognitive impairment after cerebral infarction with qi deficiency and phlegm obstruction syndrome. Methods A total of 172 patients with mild vascular cognitive impairment after cerebral infarction of qi deficiency and phlegm-blocked type in the Department of Cerebral Diseases, Yixian Hospital of Traditional Chinese Medicine of Hebei Province from January 2021 to October 2021 were selected as the research objects, and they were divided into control group and treatment group by random number table method, with 86 cases in each group. The control group was given Niergoline, Citicoline and Oxacetam Capsules for oral treatment. In the treatment group, self-made Shengqing Yizhi Decoction was added to based on the control group. The total treatment course of both groups was three months. The changes of traditional Chinese medicine syndromes and cognitive level were compared between the two groups before and after treatment. Results During the experiment, five patients in the control group fell off. After treatment, the total scores of traditional Chinese medicine syndrome in both groups were lower than those before treatment, and the treatment group was lower than the control group, the differences were statistically significant (P ＜ 0.05). After treatment, the mini-mental state examination scores and montreal cognitive assessment scores of the two groups were higher than those before treatment, and the treatment group was higher than the control group, the differences were statistically significant (P ＜ 0.05). Conclusion Shengqing Yizhi Decoction made at home mixed with western medicine is considerably more successful in treating vascular cognitive impairment than oral western medicine alone.
		2022 Vol. 19 (33): 116-119 [Abstract] ( 30 ) HTML (1 KB) PDF (608 KB) ( 51 )

	120	Experience agent of Professor Yin Kejing in the treatment of ankylosing spondylitis with the combination of acupuncture and medicine
		LU Xiaowei1 LI Zhizhi1 BAI Youyou1 WANG Qiang1 YIN Kejing2
		DOI: 10.20047/j.issn1673-7210.2022.33.27
		Ankylosing spondylitis is a chronic progressive inflammatory disease with multi-system damage and extremely high disability rate. Traditional Chinese medicine has obvious advantages in the treatment of this disease. The clinical experience of Professor Yin Keqing in the treatment of ankylosing spondylitis with acupuncture and medicine is now introduced. It believes that ankylosing spondylitis is caused by deficiency of yang, invasion of cold and dampness, stasis of meridians and collaterals, and internal and external pathogens. The treatment is based on warming the kidney and strengthening the spine, and then nourishing the liver and kidney to soften the muscles and bones, and supplementing the middle jiao products. One is to nourish qi and blood, nourish the bones; the other is to relieve the dryness of medicinal properties, and cooperate with methods such as dissipating blood stasis, dehumidification and dredging collaterals. Exorcise evil without harming righteousness. The acupoints selected from the theory of bypassing the channels and collaterals are combined with the governor channel acupoints for the treatment of dredging the collaterals and relieving pain. The combination of acupuncture and medicine is comprehensive.
		2022 Vol. 19 (33): 120-123 [Abstract] ( 27 ) HTML (1 KB) PDF (621 KB) ( 23 )

	124	Experience summary of Professor Chen Zhigang in the treatment of rapid eye movement sleep behavior disorder based on the brain’s marrow-spirit-qi system
		LI Xi1 CHEN Zhigang2 ZHANG Chang3 REN Shan2
		DOI: 10.20047/j.issn1673-7210.2022.33.28
		Rapid eye movement sleep behavior disorder (RBD) is a disease characterized by the loss of muscle atonia and abnormal behaviors occurring during rapid eye movement (REM). It is mainly manifested as muscle atonia during REM and abnormal body movements associated with vivid dreams. Western medicine treatment mainly includes Clonazepam and Melatonin, but its therapeutic effect is limited. The understanding of this disease in traditional Chinese medicine is still unclear. Professor Chen Zhigang, combining clinical experience, believes that the disease is related to kidney, and the core pathogenesis should be explored from the brain’s marrow-spirit-qi system. Brain’s marrow is the basic structure，while brain’s qi is one of the substances to maintain brain functional activities and brain’s spirit is the external manifestation of brain function. Brain’s marrow injury cause brain’s qi deficiency, then mind disorders and nightmare happens. Based on the brain’s marrow-spirit-qi system, this paper discusses the pathogenesis of the disease in traditional Chinese medicine, and provides ideas and reference for the diagnosis and treatment of Chinese medicine.
		2022 Vol. 19 (33): 124-127,133 [Abstract] ( 29 ) HTML (1 KB) PDF (712 KB) ( 44 )

	128	Clinical effect of self-designed Xiaozhang Qingsu Decoction combined with acupuncture in the treatment of habitual constipation of qi movement block type
		ZHANG Jianjun1 LIU Haiyong2▲ WANG Juan3 LIU Yandong4 LIU Yali5 BAI Huifang5 LING Shujuan6 WANG Fenglin7
		DOI: 10.20047/j.issn1673-7210.2022.33.29
		Objective To observe the effect of self-designed Xiaozhang Qingsu Decoction combined with acupuncture in the treatment of habitual constipation of qi movement block type. Methods A total of 120 patients with habitual constipation who visited Sanhe Hospital of Hebei Province from November 2020 to September 2021 were selected as the research objects. They were divided into treatment group, control group 1 and control group 2 by random number table method, with 40 cases in each group. The control group 1 was treated with self-designed Xiaozhang Qingsu Decoction combined with Bisacodyl Enteric-coated Tablets, the control group 2 was treated with acupuncture combined with Bisacodyl Enteric-coated Tablets, and the treatment group was treated with self-designed Xiaozhang Qingsu Decoction combined with acupuncture on the basis of oral Bisacodyl Enteric-coated Tablets. Treatment for one weeks. The levels of vasoactive intestinal peptide (VIP), motilin (MTL), and serum 5-hydroxytryptamine (5-HT) were observed before treatment, one week after treatment and three months after treatment, and the therapeutic effect of traditional Chinese medicine syndrome diagnosis was observed after treatment. Results The overall analysis showed that there were statistically significant differences in VIP levels between the treatment group and the control group 1, between the treatment group and the control group 2, between the groups, time points, and interaction （P ＜ 0.05）. Intra-group comparison: compared with before treatment, the VIP level of treatment group, control group 1 and control group 2 was decreased one week after treatment, and the VIP level of treatment group was decreased three months after treatment, and the differences were statistically significant (P ＜ 0.05). Comparison between groups: the VIP level of the treatment group was significantly lower than that of control group 1 and control group 2 at one week and three months after treatment, and the differences were statistically significant (P ＜ 0.05). The overall analysis showed that there were statistically significant differences in MTL levels between the treatment group and the control group 1, between the treatment group and the control group 2, between the groups, time points, and interaction (P ＜ 0.05). Intra-group comparison: compared with before treatment, MTL levels in treatment group, control group 1 and control group 2 were increased at one week and three months after treatment, and the differences were statistically significant (P ＜ 0.05). Comparison between groups: after three months of treatment, the MTL level of the treatment group was significantly higher than that of control group 1 and control group 2, and the differences were statistically significant (P ＜ 0.05). The overall analysis showed that there were statistically significant differences in 5-HT levels between the treatment group and the control group 1, between the treatment group and the control group 2, between the groups, time points, and interaction (P ＜ 0.05). Intra-group comparison: compared with before treatment, the levels of 5-HT in treatment group, control group 1 and control group 2 were increased one week and three months after treatment, and the differences were statistically significant (P ＜ 0.05). Comparison between groups: the level of 5-HT in the treatment group was significantly higher than those in the control group 1 and 2 at one week and three months after treatment, and the differences were statistically significant (P ＜ 0.05). The cure of treatment group was better than that of control group 1 and control group 2, and the differences were statistically significant (P ＜ 0.05). Conclusion The self-designed Xiaozhang Qingsu Decoction combined with acupuncture has obvious effect on the treatment of habitual constipation of qi movement block type, which provides a new choice for the treatment of habitual constipation of qi movement block type.
		2022 Vol. 19 (33): 128-133 [Abstract] ( 24 ) HTML (1 KB) PDF (732 KB) ( 41 )

	134	Tracing the origin of the thought of “the spirit of great physician” and its philosophical interpretation
		KANG Jian WU Yonggang ZHANG Yajun
		DOI: 10.20047/j.issn1673-7210.2022.33.30
		Sun Simiao’s thought of “the spirit of great physician” on medical ethics, which has rich connotation and long history. Clarifying the origin and explaining the philosophy behind it are important to promote the creative transformation and innovative development of the traditional medical ethics thought of “the spirit of great physician”. Actually，the combination of “great physician” and “sincerity” is a evolution of the ideological history of Chinese traditional medicine from “withcraft and medicine homologous”, then to “separate the witchcraft and medicine”, and finally “intergration the medicine and philosophy”. The interpretation of “great medicine” with “sincerity” is essentially the performance of medicine obtains metaphysical support then to moves towards rationalism. With the thought of “the spirit of great physician”, Sun Simiao made medicine from “the technology of a variety of handicrafts artisan” to a new height of “no matter which kind of skill, when it develops to the extreme, it will conform to the law of nature, which is the Tao”. The spirit of mutual interpretation and integration of medical and philosophy embodied in The Spirit of Great Physician is of great practical significance to the current medical ethics education.
		2022 Vol. 19 (33): 134-137,142 [Abstract] ( 30 ) HTML (1 KB) PDF (814 KB) ( 40 )

	138	Clinical effect of Niuhuang Xifeng Capsules in the treatment of mechanical thrombectomy patients with acute anterior circulation cerebral infarction
		LI Yang1 ZHOU Hong2 ZOU Yuntao2 ZHANG Lunzhong2
		DOI: 10.20047/j.issn1673-7210.2022.33.31
		Objective To explore the clinical effect of Niuhuang Xifeng Capsules in the treatment of mechanical thrombectomy patients with acute anterior circulation cerebral infarction. Methods Eighty-four mechanical thrombectomy patients with acute anterior circulation cerebral infarction treated in Weifang Hospital of Traditional Chinese Medicine in Shandong Province from March to December 2021 were selected and divided into control group and experimental group according to random number table method, 42 cases in each group. The control group was treated with conventional western medicine for 30 days after thrombectomy, the experimental group was given Niuhuang Xifeng Capsules for 30 days after treatment on the basis of the control group. National Institute of Health stroke scale (NIHSS) score, modified Rankin scale (mRS) score, traditional Chinese medicine symptom score and serum S100β protein level were compared between the two groups immediately after operation and 30 days after operation. The levels of white blood cell count (WBC), alanine aminotransferase (ALT), and creatinine (Cr) before treatment and 30 days after treatment were compared between the two groups. The efficacy of the two groups was compared. Results Immediately after operation, there were no significant differences in NIHSS score, mRS score, traditional Chinese medicine symptom score, and serum S100β protein level between the two groups (P ＞ 0.05). Thirty days after operation, NIHSS score, mRS score, traditional Chinese medicine symptom score, and serum S100β protein level of two groups were lower than those immediately after operation, and experimental group was lower than that control group, the differences were statistically significant (P ＜ 0.05). Before treatment and 30 days after treatment, there were no significant differences in WBC, ALT, and Cr levels between and within the two groups (P ＞ 0.05). The effect of experimental group was better than that of control group, the difference was statistically significant (P ＜ 0.05). Conclusion Niuhuang Xifeng Capsules can effectively promote the improvement of neural function defect in mechanical thrombectomy patients with acute anterior circulation cerebral infarction, and there is no obvious adverse reaction.
		2022 Vol. 19 (33): 138-142 [Abstract] ( 23 ) HTML (1 KB) PDF (678 KB) ( 31 )

	143	Effect of predictive nursing combined with catheter tracking nursing on urinary tract infection and pain in elderly patients undergoing laparoscopic urology surgery
		LYU Di1 LIU Guang2 XIAO Jing1
		DOI: 10.20047/j.issn1673-7210.2022.33.32
		Objective To explore the effect of predictive nursing combined with catheter tracking nursing on urinary tract infection and pain in elderly patients undergoing laparoscopic urology surgery. Methods A total of 90 elderly patients who underwent laparoscopic surgery in Department of Urology, Beijing Friendship Hospital, Capital Medical University from October 2019 to October 2021 were selected, according to the random number table method, they were divided into control group and study group, with 45 cases in each group. The control group was given routine nursing, and the study group was given predictive nursing combined with catheter tracking nursing. The incidence of urinary tract infection, nursing satisfaction, the incidence of adverse events of catheter, and the degree of pain before and after intervention were compared between the two groups at 1, 2, and 3 weeks after intervention. Results After 1, 2 and 3 weeks of intervention, the incidence of urinary system infection in the study group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). After intervention, the visual analogue scale scores of the two groups were lower than those before intervention, and the study group was lower than the control group, and the differences were statistically significant (P ＜ 0.05). The total incidence of adverse events in the study group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). The total satisfaction rate of the study group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The implementation of predictive nursing combined with catheter tracking nursing can significantly reduce the occurrence of urinary system infection and catheter adverse events in elderly patients with laparoscopic surgery in urology, reduce postoperative pain, improve nursing satisfaction, and has high clinical promotion value.
		2022 Vol. 19 (33): 143-146 [Abstract] ( 22 ) HTML (1 KB) PDF (574 KB) ( 63 )

	147	Application of holistic nursing intervention based on FTS concept in patients with lower extremity arteriosclerosis obliterans
		JIANG Haiying ZHANG Xiwei BAI Xiaodan SHEN Jing XIE Jing ZOU Junjie SHI Jing▲
		DOI: 10.20047/j.issn1673-7210.2022.33.33
		Objective To explore the application of holistic nursing intervention based on fast track surgery （FTS） concept in patients with lower extremity arteriosclerosis obliterans. Methods A total of 82 patients with lower extremity arteriosclerosis obliterans received from the First Affiliated Hospital of Nanjing Medical University from November 2019 to December 2021 were selected, according to the random number table method, they were divided into control group and experimental group, with 41 cases in each group, the control group received routine rehabilitation nursing intervention, the experimental group implemented holistic nursing intervention based on FTS concept, the changes of compliance behavior before and after intervention and sleep quality 3,7,15 d after intervention of patients in the two groups were observed and compared between the two groups. Results After the intervention, the scores of reasonable diet, exercise, regular medication, and regular review in the two groups were higher than those before the intervention, and the experimental group was higher than the experimental group, and the differences were statistically significant (P ＜ 0.05); overall analysis showed that there were statistically significant differences between groups, time points and interaction (P ＜ 0.05); further pairwise comparison and intra-group comparison: there were statistically significant differences in Pittsburgh sleep quality index (PSQI) between the two groups at each time point (P ＜ 0.05); comparison between groups: PSQI in the experimental group was lower than that in the control group at each time point, and the differences were statistically significant (P ＜ 0.05). Conclusion The holistic nursing intervention based on FTS concept for patients with lower extremity arteriosclerosis obliterans has a considerable effect on strengthening patients’ compliance behavior and sleep quality.
		2022 Vol. 19 (33): 147-150 [Abstract] ( 23 ) HTML (1 KB) PDF (617 KB) ( 176 )

	151	Application of exercise therapy combined rehabilitation care based on HACCP principles in maintenance hemodialysis patients
		XUE Wenjing WU Han LIU Fang CHENG Li
		DOI: 10.20047/j.issn1673-7210.2022.33.34
		Objective To investigate and study the effectiveness and value of the application of exercise therapy combined rehabilitation care based on the principles of hazard analysis and critical control points (HACCP) in maintenance hemodialysis patients. Methods Ninety maintenance hemodialysis patients treated at Bozhou People’s Hospital in Anhui Province from January 2020 to January 2022 were selected as the study subjects, and the patients were included in the observation group and control group by the random number table method, with 45 cases in each group. The observation group used exercise therapy and rehabilitation care based on HACCP principles for intervention during dialysis, while the control group used conventional nursing intervention during dialysis. The residual renal function indicators and quality of life scores were collected before and after the intervention, and the occurrence of dialysis-related complications during the treatment intervention were also collected. Results After the intervention, the creatinine (Cre) level in both groups were lower than those before the intervention, while that in the observation group was lower than that in the control group, and the differences were statistically significant (P ＜ 0.05); the CCr in both groups were higher than before the intervention, while that in the observation group was higher than that in the control group, and the differences were statistically significant (P ＜ 0.05). After the intervention, the physiological condition, psychological condition, management behavior, and restrictive behavior of both groups were higher than those before the intervention, while those of the observation group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). The incidence of dialysis complications during treatment in the observation group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Exercise therapy combined rehabilitation care based on HACCP principles have good intervention effects on maintenance hemodialysis patients, which can effectively improve patients’ residual renal function indexes while enhancing their quality of life, reduce dialysis-related adverse effects, and help patients establish correct disease cognition, and have good application value in nursing practice.
		2022 Vol. 19 (33): 151-154 [Abstract] ( 23 ) HTML (1 KB) PDF (594 KB) ( 46 )

	155	Application effectiveness of comprehensive care strategy for patients with novel Bunyavirus infection
		WANG Haiyun SUN Zhenhua LI Shuang ZHAO Xiaoling▲
		DOI: 10.20047/j.issn1673-7210.2022.33.35
		Objective To investigate the specific measures and effects of comprehensive care during the treatment of patients with novel Bunyavirus infection. Methods One hundred and one patients with novel Bunyavirus infection who were treated in Jiangsu Provincial People’s Hospital from July 2020 to November 2021 were selected and divided into two groups using the random number table method. The control group (50 cases) was given conventional care and the observation group (51 cases) was given all-round care. The improvement of psychological condition, complications, and nursing satisfaction were observed and compared between the two groups. Results After the intervention, the scores of self-assessment anxiety scale and self-assessment depression scale in both groups were lower than before the intervention, while those in the observation group were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05); the scores of psychological resilience scale in both groups were higher than those before the intervention, while that in the observation group was higher than that in the control group, and the differences were statistically significant (P ＜ 0.05). The incidence of complications in the observation group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). After the intervention, the scores of health education, psychological guidance, service attitude, nursing skills, and nursing effect were higher in both groups than before the intervention, while those of the observation group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Holistic care for patients with novel Bunyavirus infection has been shown to improve psychological status, reduce complications, and result in higher satisfaction with care.
		2022 Vol. 19 (33): 155-158,163 [Abstract] ( 24 ) HTML (1 KB) PDF (719 KB) ( 46 )

	159	Application evaluation of knowledge-attitude-practice theoretical model in continuous nursing of patients with gastric cancer undergoing chemotherapy
		QIU Tingting WU Xiancui▲
		DOI: 10.20047/j.issn1673-7210.2022.33.36
		Objective To analyze the effect of knowledge-attitude-practice (KAP) theoretical model in continuous nursing of patients with gastric cancer undergoing chemotherapy. Methods A total of 174 patients with gastric cancer undergoing chemotherapy in Nanjing First Hospital from July to November 2021 were selected. They were divided into two groups by drawing lots method, with 87 cases in each group. The control group implemented routine nursing+routine continuous nursing, and the observation group implemented routine nursing+KAP theoretical mode continuous nursing. The intervention time was three months. The hope level (Herth hope scale [HHI]), cancer-related fatigue (Chinese version of cancer-related fatigue scale [CRF]), and medical compliance of patients in both groups were compared. Results After intervention, the dimensions scores and total score of HHI in both groups were higher than those before intervention, and observation group was higher than control group (P ＜ 0.05); the dimensions scores and total score of CRF in both groups were lower than those before intervention, and observation group was lower than control group (P ＜ 0.05); the medical compliance of observation group was better than that of control group (P ＜ 0.05). Conclusion The continuous nursing of KAP theoretical model is given in patients with gastric cancer undergoing chemotherapy, which can improve their hope level, reduce cancer-related fatigue, and improve medical compliance.
		2022 Vol. 19 (33): 159-163 [Abstract] ( 25 ) HTML (1 KB) PDF (654 KB) ( 48 )

	164	Effects of the Levin conservation model applied to the care of patients with craniocerebral injury
		QIAO Yuanyuan1 ZHOU Li2 ZHAO Mingyu3 LIU Pengyu4 YAN Mingchun1 HU Yue1 JIANG Yanyan3▲
		DOI: 10.20047/j.issn1673-7210.2022.33.37
		[Abstract] Objective To investigate the effects of introducing Levine conservation model intervention in the care of patients with craniocerebral injury. Methods One hundred patients with craniocerebral injury admitted to the Sinopharm Gezhouba Central Hospital from June 2019 to June 2021 were selected and grouped by the random number table method. The conventional group (50 cases) was given conventional care and the intervention group (50 cases) was then given intervention based on the Levin conservation model. After two weeks of the intervention, the patients’ self-management ability, improvement in neurological function, and complications during hospitalization were compared. Results After the intervention, the disease, mood, life, rehabilitation exercise, and social and interpersonal management scores in the intervention group were higher than before the intervention, while those in the intervention group were higher than in the conventional group, with statistically significant differences (P ＜ 0.05). After the intervention, the modified Rankin scale and National Institutes of Health stroke scale scores in both groups were lower than before the intervention, while those in the intervention group were lower in the intervention group than in the conventional group, with statistically significant differences (P ＜ 0.05). The overall complication rate in the intervention group was lower than that in the conventional group, and the difference was statistically significant (P ＜ 0.05). Conclusion Care under the Levin conservation model for patients with craniocerebral injury improves patient self-management and neurological recovery outcomes and reduces complications.
		2022 Vol. 19 (33): 164-167 [Abstract] ( 23 ) HTML (1 KB) PDF (578 KB) ( 126 )

	168	Effect of affective intervention with edutainment model of care on limb recovery and pain after orthopedic surgery for children with pediatric developmental dysplasia of hip
		SUN Lei JIN Wei WANG Nan
		DOI: 10.20047/j.issn1673-7210.2022.33.38
		Objective To investigate the effect of edutainment model of care with affective intervention on postoperative limb recovery and pain in children with pediatric developmental dysplasis of hip (DDH) after orthopedic surgery. Methods Three hundred children with DDH treated by orthopaedic surgery in the Department of Pediatric Orthopaedics of Beijing Jishuitan Hospital from November 2019 to November 2021 were selected and divided into control group and observation group by using the coin toss method, with 150 cases. The control group was given conventional affective care, the observation group was given the edutainment model of care under affective intervention, both for three months continuously. The limb recovery (evaluation of lower limb function scale in simple Fugl-Meyer assessment [FAM]), pain condition (evaluation of visual analog scale [VAS]) before and after operation and postoperative complications were compared between two groups. Results At three months of intervention, the lower limb FAM scores in both groups were higher than before the intervention, while that in the observation group was higher than that in the control group, and the differences were statistically significant (P ＜ 0.05). At three months of intervention, the VAS scores in both groups were lower than before the intervention, while that in the observation group was lower than that in the control group, and the differences were statistically significant (P ＜ 0.05). There was no statistically significant difference in the complication rate between the two groups (P ＞ 0.05). Conclusion Teaching in fun nursing mode under emotional intervention can promote the recovery of limbs and reduce pain of children with DDH after orthopedic surgery.
		2022 Vol. 19 (33): 168-171 [Abstract] ( 29 ) HTML (1 KB) PDF (592 KB) ( 29 )

	172	Practice of follow-up nutrition nursing program in patients with non-small cell lung cancer undergoing chemotherapy
		BAI Lina TAO Zhenwen AN Runhua WANG Guochao GUO Wenjuan
		DOI: 10.20047/j.issn1673-7210.2022.33.39
		Objective To analyze the practice of follow-up nutrition nursing program in patients with non-small cell lung cancer (NSCLC) after chemotherapy. Methods A total of 150 patients with NSCLC during chemotherapy treated in Shanxi Provincial Cancer Hospital from March 2019 to February 2021 were selected. According to the random number table method, they were divided into control group and observation group, with 75 cases in each group. The control group implemented the routine diet nursing scheme, and the observation group implemented the follow-up nutrition nursing scheme, the nutritional indexes (total protein [TP], albumin [Alb], hemoglobin [Hb]) and anthropometric indexes (body mass index [BMI], middle arm muscle circumference [MAMC], and triceps brachii thickness skin fold [TSF]) were compared between the two groups before and after 12 weeks of nursing, and the degree of adverse reactions to chemotherapy of patients was counted. Results After 12 weeks of nursing, TP, Alb, and Hb in both groups were lower than those before nursing, but the observation group was higher than the control group (P ＜ 0.05); after 12 weeks of nursing, the BMI, MAMC, and TSF of the control group were lower than those before nursing (P ＜ 0.05), there were no significant differences in BMI, MAMC, and TSF between the observation group and the observation group before nursing for 12 weeks (P ＞ 0.05), and the BMI, MAMC and TSF of the observation group were higher than those of the control group (P ＜ 0.05); the adverse reactions of appetite loss, vomiting, and diarrhea in the observation group were lower than those in the control group (P ＜ 0.05). Conclusion The follow-up nutrition nursing scheme can significantly improve the nutritional status of NSCLC patients during chemotherapy and reduce the their adverse reactions of chemotherapy.
		2022 Vol. 19 (33): 172-175 [Abstract] ( 25 ) HTML (1 KB) PDF (546 KB) ( 126 )

	176	A case report and literature review of gallbladder metastasis of clear cell renal cell carcinoma
		ZHU Shanfei YUAN Wei DU Yongliang WU Fan YAN Yong WANG Bailin
		DOI: 10.20047/j.issn1673-7210.2022.33.40
		Clear cell renal cell carcinoma (ccRCC) is the most common pathological type of renal cell carcinoma (RCC), accounting for about 3%-5% of adult malignant tumors. RCC is mainly with vascular metastasis, which is common in organs or tissues such as lung, liver, bone, adrenal gland, and brain, but it is very rare that RCC metastasis to gallbladder. This report retrospectively analyzed the case data of a patient with gallbladder metastasis found eight years after radical resection of left ccRCC in the Department of Hepatobiliary Surgery of Guangzhou Red Cross Hospital Jinan University in January 2021. The patient was found to have gallbladder space occupying lesions and right lung nodules (no cancer cells were found in the nodule by out-of-hospital biopsy before) after admission. The lesion was pathologically confirmed as ccRCC gallbladder metastasis during subsequent laparoscopic radical gallbladder cancer surgery. However, after two months’ follow-up, a new nodule was found in the left lung, and was pathologically confirmed to be metastatic ccRCC, which was intervened by delivering Sunitinib. After 15 months’ follow-up, there was no recurrence of primary or other tumors, except for the progression of lung metastases. Preoperative diagnosis of ccRCC gallbladder metastasis based on clinical symptoms, signs and imaging data is challenging, which should be further proved by pathological examination. Therefore, the current report aimed to help better understanding the disease via reviewing the corresponding literature including imaging, pathological features, diagnosis, treatment, and prognosis.
		2022 Vol. 19 (33): 176-179,192 [Abstract] ( 30 ) HTML (1 KB) PDF (1495 KB) ( 182 )

	180	One case of ventricular aneurysm after acute myocardial infarction treated by benefiting qi and activating blood circulation, cooling blood and generating muscle
		LI Yan1 LI Yuxuan1 LI Peng1 LI Dong1 CUI Xiaoyun1 LIU Jing1 LU Jinjin1 LIN Qian2
		DOI: 10.20047/j.issn1673-7210.2022.33.41
		Ventricular aneurysm (VA) is one of the common complications of acute myocardial infarction, which seriously affects the prognosis of patients. In addition to surgery, there is still a lack of targeted treatment of VA in clinic. This paper reports a case of VA patient treated by traditional Chinese medicine after acute myocardial infarction. The patient underwent emergency percutaneous coronary intervention due to “coronary heart disease acute extensive anterior myocardial infarction”. Postoperative cardiac ultrasound indicated the formation of apical VA, accompanied by palpitation, upset, fatigue, dry mouth, and difficulty in sleeping and other symptoms. The author combined tongue syndrome differentiation as qi deficiency and blood stasis, phlegm and heat disturbing the heart. After the treatment of western medicine combined with benefiting qi for activating blood circulation, cooling blood and generating muscle, the patient’s symptoms improved and the VA disappeared. It is suggested that the treatment of VA by benefiting qi for activating blood circulation, cooling blood and generating muscle has a better effect. In this paper, the traditional Chinese medicine treatment to review the analysis, explore its theory, in order to broaden the treatment of this disease, and explore the advantages of traditional Chinese medicine treatment of this disease.
		2022 Vol. 19 (33): 180-183 [Abstract] ( 25 ) HTML (1 KB) PDF (598 KB) ( 29 )

	184	A case report and literature review of primary hyperparathyroidism with renal calculi as the first symptom
		HE Yongmao1 SHAO Minghai1 LAN Tianying2 WANG Chen3 YE Chaoyang4
		DOI: 10.20047/j.issn1673-7210.2022.33.42
		[Abstract] This paper reports a case of primary hyperparathyroidism (PHPT) with kidney calculi as the main symptom. This patient had a history of dry mouth polydipsia and polyuria for more than 20 years, which was not properly diagnosed and treated. In this case, the main symptoms of renal stone obstruction were low back pain, abdominal distension, nausea and vomiting, gross hematuria, etc. After lefe parathyroidectomy, PHPT was clearly diagnosed by pathology. After laser lithotripsy, drug therapy, and parathyroid adenoma resection, blood calcium, urine and renal function were recovered, small calculi were left in both kidneys, and parathyroid hormone (PTH) was still elevated after operation, and returned to normal two months after operation. Renal and parathyroid imaging, renal function, serum calcium, PTH, and urinary calcium levels were followed up. The diagnosis of PHPT includes qualitative and locational diagnosis, laboratory examination makes qualitative diagnosis, and imaging examination is used for localization and quantification. In terms of treatment, medical treatment can alleviate the hypercalcemia emergency, and surgical treatment is the first choice for the complete cure of PHPT, the surgical method was selected according to the location and number of lesions, intraoperative PTH monitoring is beneficial to improve the cure rate, if PTH and serum calcium are still elevated during postoperative follow-up, secondary hyperparathyroidism should be considered first, and the possibility of incomplete surgery or recurrence should be excluded.
		2022 Vol. 19 (33): 184-187 [Abstract] ( 23 ) HTML (1 KB) PDF (1066 KB) ( 35 )

	188	Research status of systemic lupus erythematosus based on the National Natural Science Foundation of China from 2010 to 2020
		WU Shiya1 ZHOU Xinyao2 XU Haodong2 GUO Zilin2 CHENG Zengyu2 LI Yanting2 TANG Xiaopo2
		DOI: 10.20047/j.issn1673-7210.2022.33.43
		Objective To discuss the research status of the disease by analyzing the 2010—2020 National Natural Science Foundation of China (NSFC) related projects for systemic lupus erythematosus (SLE). Methods Through NSFC Project query (V2.0 official version) and LetPub latest science Fund query system, SLE related projects from 2010 to 2020 were searched comprehensively, and the category, quantity, amount and supporting unit of the approved projects were analyzed retrospectively. Results From 2010 to 2020, a total of 405 SLE related projects were funded with a total amount of 159.84 million yuan. The supporting units were mainly comprehensive colleges and Western medicine colleges. The top three first-level disciplines in the number of approved projects were medical immunology, skin and its accessories, and urinary system. The keyword-cloud showed that pathogenesis, mesenchymal stem cells, microRNA, signaling pathways and regulatory T-cells were the top five in frequency. Conclusion NSFC’s fund for SLE has increased steadily, mainly focus on mesenchymal stem cells, microRNA, and signaling pathways to conduct SLE pathogenesis in-depth research.However, there are some problems such as low degree of interdisciplinary,single type of test animals and insufficient research in the field of traditional Chinese medicine.
		2022 Vol. 19 (33): 188-192 [Abstract] ( 26 ) HTML (1 KB) PDF (1592 KB) ( 164 )

	193	Research on the optimization strategy of network ideology in public hospitals
		WANG Lei1 DU Mengkai1 HUA Lei2 YUE Xiaolin2
		DOI: 10.20047/j.issn1673-7210.2022.33.44
		This study focuses on the new challenges faced by public hospitals’ network ideology work, and demonstrates the importance of public hospitals’ network ideology work in accordance with the requirements of age. This paper analyzes the main problems of public hospital network ideology work, such as the implementation of responsibility is tight on upper layer and loose in lower layer, the position management needs to be optimized urgently, and the ability of early warning and judgment is insufficient. Problem-oriented, it is clear that the network ideology of public hospitals should follow the principles of unified leadership, safety first, and correct orientation. This paper puts forward the strategies to promote the continuous optimization of public hospital network ideology work from four aspects: compaction of the responsibility of public hospital network ideology work, strengthening the management of public hospital network ideology position, improving the risk prevention ability of public hospital network ideology, and making good use of normalized performance evaluation and accountability.
		2022 Vol. 19 (33): 193-196 [Abstract] ( 25 ) HTML (1 KB) PDF (646 KB) ( 186 )

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