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Efficacy of self-made Shengqing Yizhi Decoction in the treatment of mild vascular cognitive impairment after cerebral infarction with qi deficiency and phlegm obstruction syndrome |
LI Fuhai1 WANG Xuehong1 LIU Ling2 ZHANG Xiaoguang1 CAO Haifang1 LI Xiangyang1 ZHAO Hanqing2 |
1.Department of Cerebral Diseases, Yixian Hospital of Traditional Chinese Medicine, Hebei Province, Yixian 074200, China;
2. College of Traditional Chinese Medicine, Hebei University, Hebei Province, Baoding 071000, China |
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Abstract Objective To investigate the clinical efficacy of self-made Shengqing Yizhi Decoction in treating patients with mild vascular cognitive impairment after cerebral infarction with qi deficiency and phlegm obstruction syndrome. Methods A total of 172 patients with mild vascular cognitive impairment after cerebral infarction of qi deficiency and phlegm-blocked type in the Department of Cerebral Diseases, Yixian Hospital of Traditional Chinese Medicine of Hebei Province from January 2021 to October 2021 were selected as the research objects, and they were divided into control group and treatment group by random number table method, with 86 cases in each group. The control group was given Niergoline, Citicoline and Oxacetam Capsules for oral treatment. In the treatment group, self-made Shengqing Yizhi Decoction was added to based on the control group. The total treatment course of both groups was three months. The changes of traditional Chinese medicine syndromes and cognitive level were compared between the two groups before and after treatment. Results During the experiment, five patients in the control group fell off. After treatment, the total scores of traditional Chinese medicine syndrome in both groups were lower than those before treatment, and the treatment group was lower than the control group, the differences were statistically significant (P < 0.05). After treatment, the mini-mental state examination scores and montreal cognitive assessment scores of the two groups were higher than those before treatment, and the treatment group was higher than the control group, the differences were statistically significant (P < 0.05). Conclusion Shengqing Yizhi Decoction made at home mixed with western medicine is considerably more successful in treating vascular cognitive impairment than oral western medicine alone.
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[1] 朱帅,张一英,向芳,等.脑卒中高危人群缺血性脑卒中3年发病影响因素COX回归分析[J].中国慢性病预防与控制,2022,30(2):134-137.
[2] 臧艳静,郑宏伟,崔泽岩.基于血清学指标的脑梗死患者预后列线图预测模型的建立与评估[J].中华老年心脑血管病杂志,2022,24(3):277-280.
[3] 张帅康.《卒中后认知障碍管理专家共识2021》发布[N].人民政协报,2021-07-21.
[4] Du Y,Zhang L,Liu W,et al. Effect of acupuncture treatment on post-stroke cognitive impairment:A randomized controlled trial [J]. Medicine,2020,99(51):e23803.
[5] 杨帆,李兴义,满劲进,等.卒中后认知障碍早期预测因素的研究进展[J].神经损伤与功能重建,2022,17(4):218- 221.
[6] Casolla B,Caparros F,Cordonnier C,et al. Biological and imaging predictors of cognitive impairment after stroke:a systematic review [J]. J Neurol,2019,266(11):2593-2604.
[7] Tu J,Wang LX,Wen HF,et al. The association of different types of cerebral infarction with post-stroke depression and cognitive impairment [J]. Medicine,2018,97(23):e10919.
[8] 吴晓君.丁苯酞治疗急性脑梗死后轻度血管性认知功能障碍的疗效观察[J].中国现代药物应用,2022,16(4):133- 135.
[9] Kalaria RN,Akinyemi R,Ihara M. Stroke injury,cognitive impairment and vascular dementia [J]. Biochim Biophys Acta,2016,1862(5):915-925.
[10] 邓美霞,王敏,潘政,等.脑动脉狭窄与血管性认知障碍的相关性研究进展[J].疑难病杂志,2022,21(3):317- 320,324.
[11] 李福海,赵汉青,王雪红,等.“运脾化浊”思想的临证运用[J].中国医药导报,2021,18(32):143-146.
[12] 中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组.中国各类主要脑血管病诊断要点2019[J].中华神经科杂志2019,52(9):710-715.
[13] 中国医师协会神经内科分会认知障碍专业委员会,《中国血管性认知障碍诊治指南》编写组.2019年中国血管性认知障碍诊治指南[J].中华医学杂志,2019,99(35):2737-2744.
[14] 董强,郭起浩,罗本燕,等.卒中后认知障碍管理专家共识[J].中国卒中杂志,2017,12(6):519-531.
[15] 中华中医药学会.中医内科常见病诊疗指南西医疾病部分[M].北京:中国中医药出版社,2008:306-307.
[16] 张伯礼,吴勉华.中医内科学[M].北京:中国中医药出版社,2017:127-134.
[17] Folstein MF,Folstein SE,McHugh PR.“Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician [J]. J Psychiatr Res,1975,12(3):189- 198.
[18] Nasreddine ZS,Phillips NA,Bédirian,et al. The Montreal Cognitive Assessment,MoCA:a brief screening tool for mild cognitive impairment [J]. J Am Geriatr Soc,2005,53(4):695-699.
[19] 李长琳,夏源,戴恩云.养阴和瘀通窍汤辅助治疗非痴呆型血管性认知功能障碍的疗效及对大脑及椎底动脉血流流速的影响[J].齐齐哈尔医学院学报,2021,42(15):1311-1314.
[20] 吴俊睿,明淑萍,柯珂,等.从痰瘀互结论治血管性认知功能障碍[J].中西医结合研究,2022,14(2):119-121, 128.
[21] 杨凤珍,刘宗莲,张小平,等.基于路志正医案数据挖掘现代疾病内伤湿浊病机与治法研究[J].中华中医药杂志,2017,32(9):4252-4255.
[22] 苏凤哲.路志正升阳除湿法临床应用探讨[J].世界中西医结合杂志,2014,9(6):580-582.
[23] 杨惠卿,房玲,侯震,等.路志正化浊通络畅气机方对痰瘀阻络型脑梗死恢复期患者血脂影响[J].世界中西医结合杂志,2018,13(9):1294-1297.
[24] 周育平.路志正升阳除湿法运用特点[J].中医杂志,2016, 57(9):731-733.
[25] 刘喜明,路洁,苏凤哲,等.路志正教授调理脾胃治疗疑难病证的学术思想研究之三——路志正教授调理脾胃的理论核心“持中央,运四旁”[J].世界中西医结合杂志,2010,5(6):471-347,475.
[26] 李怀芝,罗良,杨金萍.《东垣试效方》内科中的风药运用[J].山东中医药大学学报,2022,46(1):14-19.
[27] 闵冬雨,刘勇明,贾连群,等.从脾论治血管性痴呆钩玄简[J].辽宁中医药大学学报,2018,20(2):4.
[28] 张鹤,白宇宁,刘绍能,等.现代医学视角下中医“脾主运化”探析[J].北京中医药,2022,41(2):179-181. |
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