肌球蛋白轻链激酶3基因在心脏疾病中的研究进展

doi:10.20047/j.issn1673-7210.2022.33.13

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Abstract Myosin light chain kinase (MYLK) 3 gene is a member of the MYLK family, which is mainly expressed in myocardial tissue. Its protein product, cardiac MYLK, plays an important role in cardiac development, cardiac contraction, and sarcomeric tissue formation. When its expression is reduced or absent, it can affect myocardial formation and development, leads to congenital heart disease, heart hypertrophy, dilated heart disease, and other heart diseases. The discovery of MYLK3 gene makes the clinical further understanding of heart diseases from the gene level, which may provide a new theoretical basis and therapeutic target for the diagnosis and treatment of heart diseases. This article reviews the structure and function of MYLK3 gene and its research progress in heart disease.

Key words： Myosin light chain kinase 3 Cardiac myosin light chain kinase Heart disease

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	ZENG Jing LIU Xiaoyang BAI Yang WANG Dawei▲

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ZENG Jing LIU Xiaoyang BAI Yang WANG Dawei▲. Research progress of myosin light chain kinase 3 gene in heart disease[J]. 中国医药导报, 2022, 19(33): 63-65,87.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2022.33.13 OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I33/63

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