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| Research progress of HSPB5 |
| FU Jia LI Shiqi ZHAO Xiaoting ZHENG Xiaodong |
| Department of Genetics and Cell Biology, Harbin Medical University (Daqing), Heilongjiang Province, Daqing 163319, China |
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Abstract HSPB5 is a protein with a highly conserved crystal structure, which exists in the form of dynamic oligomers in vivo. HSPB5 expression is regulated by various physiological and pathological factors, such as increased expression under heat stress, and its activity is regulated by various post-translational modifications such as phosphorylation, acetylation, and glycosylation. Under physiological conditions, HSPB5, as a chaperone-like protein can reduce the aggregation of misfolded proteins, and can also interact with various proteins to inhibit apoptosis. Under pathological conditions, HSPB5 can also affect multiple disease processes, such as Alzheimer’s disease, cardiomyopathy, tumor, and hypoxia, etc. This paper briefly reviews the role and the mechanism of HSPB5 in physiological and pathological conditions states. Regulating the expression level and activity of HSPB5 may serve as a new therapeutic strategy for a variety of diseases.
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