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| Correlation between vaginal microbiota and cervical precancerous lesions |
| HAN Buwei1 LIU Yang1 HE Hui1 GONG Yi2 LIU Ning1 ZHOU Lina1 HAO Xinying1 LIU Li3 |
1.Graduate School of Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150040, China;
2.Department of Traditional Chinese Medicine, Beilun Branch, the First Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang Province, Ningbo 315000, China;
3.Ward Two, Department of Gynecology, the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150040, China |
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Abstract The female reproductive tract has a microbiome that lives in symbiosis with the human body, Lactobacillus is usually the dominant bacterium, this genus plays an important role in maintaining the health of the female reproductive tract. Dysregulation of reproductive tract microbiota may promote the development of human papillomavirus (HPV) infection and cervical intraepithelial neoplasias (CIN), and eventually lead to cervical malignancy. As the severity of CIN increases, depletion of dominant Lactobacillus increases, which may negatively affect the rate of disease regression, for example, leading to a pro-inflammatory environment that increases the expression of HPV E6 and E7 oncogenes and proliferation of malignant cells. This paper reviews the correlation between the composition of vaginal microbiota and the occurrence and development of cervical cancer, in order to better understand the influence of the microbiota on cervical cancer, which may contribute to explore new diagnostic or prognostic microbial markers of cervical cancer, and seek new prevention or treatment drug targets.
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