Discussion on the relevant factors of metastasis of triple negative breast cancer from the perspective of traditional Chinese medicine syndrome types
MEI Heting1 LU Wenping2 ZHUO Zhili2 WANG Yanan1 ZHANG Dongni2 WU Xiaoqing2 CUI Yongjia2
1.Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China;
2.Department of Oncology, Guang’anmen Hospital, Beijing 100053, China
Abstract Objective To explore the relevant factors of metastasis of triple negative breast cancer (TNBC) from the perspective of traditional Chinese medicine syndrome types. Methods A retrospective analysis was performed on the clinical data of 133 patients with complete medical records who were treated for the first time in Guang’anmen Hospital from June 2019 to January 2022. They had received western standardized treatment and had no history of traditional Chinese medicine treatment. Patients were divided into metastatic group (20 cases) and non-metastatic group (113 cases) according to whether metastasis had occurred at the time of visit. Logistic regression analysis was used to explore the related factors of TNBC metastasis. Results There were significant differences in traditional Chinese medicine syndrome type, operation type, T stage and N stage between the two groups (P ＜ 0.05). Multivariate regression showed spleen and stomach weakness (OR = 6.617, 95%CI:1.037-42.202), tumor size (T＞5 cm, OR = 14.512, 95%CI:1.797-117.185) and lymph node metastasis (0＜N≤3, OR = 0.086, 95%CI:0.007-0.990) were independent risk factors for metastasis (P ＜ 0.05). Conclusion The syndrome type-PWXR syndrome、T and N were independent relevant factors leading to metastasis，and treatment should take care of the spleen and stomach in order to secure the organs.
MEI Heting1 LU Wenping2 ZHUO Zhili2 WANG Yanan1 ZHANG Dongni2 WU Xiaoqing2 CUI Yongjia2. Discussion on the relevant factors of metastasis of triple negative breast cancer from the perspective of traditional Chinese medicine syndrome types[J]. 中国医药导报, 2022, 19(33): 104-107.
