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| Clinical effect of Shengjiang Decoction combined with Banxia Houpu Decoction in the treatment of subclinical hypothyroidism of Hashimoto thyroiditis with liver depression and spleen deficiency |
| ZHANG Chen LI Jing SHANG Juju |
| Department of Endocrinology, Beijing Hospital of Chinese Medicine, Capital Medical University, Beijing 100010, China |
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Abstract Objective To investigate the clinical effect of Shengjiang Decoction combined with Banxia Houpu Decoction in the treatment of subclinical hypothyroidism of Hashimoto thyroiditis with liver depression and spleen deficiency. Methods From February to May 2022, 64 patients with subclinical hypothyroidism of Hashimoto thyroiditis with liver stagnation and spleen deficiency who visited Department of Endocrinology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University were selected as research objects. They were divided into treatment group and control group according to the random number table method, with 32 cases in each group. The control group was given Levothyroxine Sodium Tablets, and the treatment group was given Shengjiang Decoction combined with Banxia Houpu Decoction, the duration of treatment was four weeks. The clinical symptoms of the two groups were compared, the clinical symptom score, serum thyroid thyroid-stimulating hormone (TSH), thyroglobulin antibody (TGAb), and thyroid peroxidase antibody (TPOAb) before and after treatment were compared between two groups. Results The clinical efficacy of treatment group was better than that of control group, and the difference was statistically significant (P ＜ 0.05). After treatment, the scores of fatigue, insomnia, abnormal defecation, and emotional irritability or depression in treatment group were lower than those before treatment, and the scores in treatment group were lower than those in control group, and the differences were statistically significant (P ＜ 0.05). After treatment, the levels of TSH in two groups were lower than those before treatment, and the differences were statistically significant (P ＜ 0.05); the levels of TPOAb and TGAb in treatment group were lower than those before treatment, and the levels of TPOAb and TGAb in treatment group were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion The treatment of Shengjiang Decoction combined with Banxia Hopu Decoction can effectively improve the clinical symptoms, TSH, TPOAb, and TGAb of subclinical hypothyroidism of Hashimoto thyroiditis with liver stagnation and spleen deficiency, and improve the thyroid function.
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