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2022 Vol. 19, No. 31 Published: 2022-11-05

	5	Effects of Cuscutae Semen-Lycii Fructus on proliferation and apoptosis in Triperygium wilfordii multiglucoside induced spermatocytic dysfunction model of spermatogonium
		WANG Jisheng BAO Binghao DENG Sheng FENG Junlong LI Haisong
		DOI: 10.20047/j.issn1673-7210.2022.31.01
		Objective To investigate the ameliorative effect and mechanism of couplet medicines traditional Chinese medicine of Cuscutae Semen-Lycii Fructus on proliferation and apoptosis of spermatogenic dysfunction induced by Tripterygium wilfordii multiglucoside. Methods Twenty SPF 6-week-old (200±20) g male SD rats were divided into blank group, Tripterygium wilfordii multiglucoside group, L-carnitine group, and couplet medicines group by the random number table method, with five rats in each group, and were used to prepare drug-containing serum. Spermatogonium were divided into blank group, model group, L-carnitine group, and couplet medicines group. The blank group was treated with 10% blank rat serum, the model group, L-carnitine group, and couplet medicines group were firstly treated with 10% Tripterygium wilfordii multiglucoside intragastric administration of drug-containing serum to prepare spermatogenic dysfunction model, and then L-carnitine group and couplet medicines group were treated with 10% drug-containing serum of L-carnitine and Cuscutae Semen-Lycii Fructus respectively. The changes of cell proliferation, apoptosis, ultrastructure and mitochondrial membrane potential were observed. Results Compared with blank group, the apoptosis rate of model group was significantly increased (P ＜ 0.01). Compared with the model group, the apoptosis rate of the couplet medicines group was significantly decreased (P ＜ 0.01). Compared with blank group, the percentage of cells in G0/G1 and G2/M phase in model group was significantly decreased, and the percentage of cells in S phase was significantly increased (P ＜ 0.05 or P ＜ 0.05). Compared with the model group, the percentage of cells in G0/G1 and G2/M phases was significantly increased, and the percentage of cells in S phase was significantly decreased in the couplet medicines group (P ＜ 0.01). Compared with the blank group, the mitochondrial membrane potential in the model group was significantly increased (P ＜ 0.01). Compared with the model group, the mitochondrial membrane potential in the couplet medicines group was significantly decreased (P ＜ 0.01). In the blank group, the morphology and structure of the organelles were normal, while in the model group, the cell membrane was ruptured in a large area, the density of the cell matrix was decreased in a large area, and vacuolation was observed. The cell membrane structure of L-carnitine group and couplet medicines group was intact, and the mass density of cell matrix was normal. Conclusion Cuscutae Semen-Lycii Fructus can regulate spermatogenic function of spermatogonium, which may be related to the regulation of cell proliferation, apoptosis, cell cycle and mitochondrial membrane potential.
		2022 Vol. 19 (31): 5-9 [Abstract] ( 15 ) HTML (1 KB) PDF (0 KB) ( 12 )

	10	Diagnostic value of CT features in different pathological subtypes of lung adenocarcinoma
		ZHANG Pengju1 LI Tianran1 LI Wenping2 XU Jinhuan2 ZHAO Shaohong2▲
		DOI: 10.20047/j.issn1673-7210.2022.31.02
		Objective To investigate the diagnostic value of the CT features of pure ground-glass nodules (pGGN) in different pathological subtypes lung adenocarcinoma, and to provide imaging support for the management and treatment of pGGN. Methods The clinical data of 215 patients (236 nodules) with pGGN ≤2 cm in diameter and pathologically confirmed early lung adenocarcinoma at the First Medical Center of General Hospital of the Chinese People’s Liberation Army from January to December 2019 were analyzed. According to the pathological subtypes of pGGN, they were divided into preinvasive lesions-minimally invasive adenocarcinoma group (117 nodules), lepidic predominant adenocarcinoma group (77 nodules), and non-lepidic predominant adenocarcinoma group (42 nodules). The clinical features and CT features of the three groups were compared; receiver operating characteristic curves of diameter, CT value, and combined detection were drawn to predict the diagnostic efficacy of invasive predominant adenocarcinoma. Results There were significant differences in lobulation, spiculation, vascular changes, diameter, and CT value among three components (P ＜ 0.05). Diameter and CT value were positively correlated with pathological subtype (r ＝ 0.302, 0.352, P ＜ 0.05). Lobulation, vascular changes, diameter, and CT value were the influencing factors of invasive pulmonary adenocarcinoma (OR ＞ 1, P ＜ 0.05). The area under the curve of invasive predominant adenocarcinoma diagnosed by the combined detection of diameter and CT value was greater than that detected by each index alone. Conclusion The CT features of pGGN are related to its pathological subtype to some extent. Attention should be paid to morphological changes such as lobulation, spiculation, and vascular changes.
		2022 Vol. 19 (31): 10-13,21 [Abstract] ( 10 ) HTML (1 KB) PDF (0 KB) ( 8 )

	14	Effect of bone marrow mesenchymal stem cells on the senescence of K562 cells and the Raf/MEK/ERK signaling pathway
		ZHOU Wen ZHOU Yue TANG Ziyun HE Siyue LIU Xiaohu BI Ziying LI Minrui YANG Nan
		DOI: 10.20047/j.issn1673-7210.2022.31.03
		Objective To investigate the effect of bone marrow mesenchymal stem cells (BMSCs) on the senescence of chronic myeloid leukemia K562 cells and Raf/MEK/ERK signaling pathway. Methods BMSCs were isolated from the bone marrow of 30 C57BL/6J male mice with SPF grade of 6-8 weeks and body weight of 20-30 g. The expression of surface antigens CD29, CD244, and CD45 was detected by flow cytometry. After induction with adipogenic and osteogenic differentiation inducing fluid, the differentiation ability was identified by oil red O and alizarin red staining. BMSCs and K562 cells were cultured at the ratios of 1∶4, 1∶2, 1∶1, and 2∶1 for 24, 48, and 72 h, respectively. The co-culture time and cell ratio with the lowest proliferation rate of K562 cells were selected as the BMSCs group, and the conventional cultured K562 cells were used as the control group for subsequent experiments. SA-β-Gal staining was used to detect the senescence of cells in the two groups, and Western blot was used to detect the protein expressions of p16INK4a, p-Raf, p-MEK, and p-ERK in the two groups. Results The positive expression rates of BMSCs surface markers CD29, CD44, and CD45 were 89.18%, 87.65%, and 1.16%, respectively. BMSCs successfully differentiated into adipocytes and osteocytes in vitro. When the ratio of BMSCs to K562 cells was 1∶2, 1∶1, and 2∶1, the proliferation rates of K562 cells at each time point of co-culture were lower than those of the control group at the same time point, and the proliferation rates of K562 cells at each time point with the ratio of 2∶1 were lower than those of the control group at the same time point (P ＜ 0.05). When the ratio of BMSCs to K562 cells was 2∶1, the proliferation rate of K562 cells after co-culture for 48 h was lower than those after co-culture for 24 and 72 h (P ＜ 0.05). The positive rate of senescent cells and the protein expression of p16INK4a in BMSCs group were higher than those in control group, while the protein expression levels of p-Raf, P-MEK, and p-ERK were lower than those in control group (P ＜ 0.01). Conclusion BMSCs can induce senescence in K562 cells, and the mechanism may be related to Raf/MEK/ERK signaling pathway.
		2022 Vol. 19 (31): 14-17 [Abstract] ( 12 ) HTML (1 KB) PDF (0 KB) ( 9 )

	18	Study on the medication rule of traditional chinese medicine in treating chronic insomnia based on data mining
		LIN Ling1 YUAN Jie2 LIU Dongling2 HAN Zucheng2 LUO Fan1 WANG Ying1 CHEN Jie2
		DOI: 10.20047/j.issn1673-7210.2022.31.04
		Objective To summarize the drug rules of traditional Chinese medicine in treating chronic insomnia by data mining. Methods The literatures related to the treatment of chronic insomnia with traditional Chinese medicine from October 2010 to October 2020 were retrieved from CNKI, Wanfang, and VIP databases, the database was constructed by screening prescriptions, and mining was carried out by frequency analysis, association rules and cluster analysis. Results A total of 206 prescriptions were included, involving 193 traditional Chinese medicines. The top five drugs were Suanzaoren, Poria cocos, oyster, keel, and Polygala tenuifolia. The most commonly used categories of traditional Chinese medicine were tranquilizing drugs, deficiency-tonifying drugs, heat-clearing drugs and so on. The common dosage of the top 20 drugs were in accordance with the dosage stipulated in Chinese Pharmacopoeia and Internal Medicine of Traditional Chinese Medicine. The four qi of drug were mainly cold and flat, the five flavors were sweet and bitter, and the meridians were mainly the meridians of the heart, liver, and spleen. The combination of keel and oyster was the most used drug. Unearthed 16 core combinations, 8 new prescriptions by data mining. Conclusion Through excavation and analysis, it can be seen that the pathological factors of chronic insomnia are mainly deficiency, fire, phlegm, and heat. Traditional Chinese medicines such as tranquilizing the mind, tonifying deficiency, clearing away heat, resolving phlegm, and regulating qi are used in the treatment, which provide references for clinical drug use.
		2022 Vol. 19 (31): 18-21 [Abstract] ( 15 ) HTML (1 KB) PDF (0 KB) ( 11 )

	22	Effect of Xuebijing Injection on expression of apoptosis-related microRNAs in alveolar type Ⅱ epithelial cells of cardiopulmonary bypass-induced acute lung injury rats
		XU Zhaojun1 ZHANG Shengkang1 ZHANG Yi1 ZHOU Daiyong1 SONG Lan2
		DOI: 10.20047/j.issn1673-7210.2022.31.05
		Objective To study the effect of Xuebijing Injection on the expression of apoptosis-related microRNA (miRNA) in alveolar typeⅡepithelial cells of cardiopulmonary bypass -induced acute lung injury rats. Methods The candidate miRNAs related to apoptosis of alveolar type Ⅱ epithelial cells were screened by bioinformatics technology; 30 male SD rats (20 to 22 weeks old, body weight 450 to 500 g) were divided into three groups according to the random number table method. Sham operation group, cardiopulmonary bypass group and Xuebijing group. In the sham operation group, 4 ml/kg of normal saline was injected intraperitoneally two hours before the arterial and venous puncture, and in the cardiopulmonary bypass group two hours before the cardiopulmonary bypass. In Xuebijing group, 4 ml/kg of Xuebijing Injection was injected intraperitoneally two hours before cardiopulmonary bypass, and the rats were sacrificed by bloodletting four hours after cardiopulmonary bypass, and lung tissue samples were taken. Lung wet/dry weight ratio (W/D) and alveolar injury quantitative assessment index (IQA) were used to evaluate the degree of lung injury. The effect of Xuebijing Injection on the expression of candidate miRNAs in alveolar type Ⅱ epithelial cells of cardiopulmonary bypass-induced acute lung injury was observed by RT-PCR. Results Five miRNAs related to apoptosis of alveolar type Ⅱ epithelial cells were screened by bioinformatics analysis rno-miR-17-5p, rno-miR-34a-5p, rno-miR-26a-5p, rno-miR-21a-5p, and rno-miR-375-3p. Compared with Sham operation group, W/D and IQA increased in cardiopulmonary bypass group, and the difference was statistically significant (P ＜ 0.05) Compared with the cardiopulmonary bypass group, the W/D and IQA of the Xuebiying group were significantly decreased, and the differences were statistically significant (P ＜ 0.05). The expression of miRNA-17-5p in alveolar typeⅡepithelial cells of cardiopulmonary bypass group was lower than that of sham operation group,and the difference was statistically significant (P ＜ 0.05), while the expression of miRNA-34a-5p was up-regulated (P ＜ 0.05); Compared with the cardiopulmonary bypass group, the expression of miRNA-17-5p in alveolar typeⅡepithelial cells in the XBJ group was up-regulated, and the difference was statistically significant(P ＞ 0.05), while the expression of miR-34a-5p was down- regulated, but there was no statistical difference between the two groups (P ＞ 0.05). Conclusion Xuebijing Injection may play a therapeutic role in the treatment of cardiopulmonary bypass-induced acute lung injury by up-regulating miRNA-17- 5p, and initially reveal the molecular mechanism of Xuebijing injection in the treatment of CPB-Induced acute lung injury.
		2022 Vol. 19 (31): 22-26,43 [Abstract] ( 12 ) HTML (1 KB) PDF (0 KB) ( 9 )

	27	Data mining-based acupuncture point selection pattern study for postherpetic neuralgia
		GUO Chenqi1 ZHANG Jianfeng1 ZHANG Yu2
		DOI: 10.20047/j.issn1673-7210.2022.31.06
		Objective To analyze the rules of acupuncture point selection patterns for postherpetic neuralgia (PHN) using data mining techniques. Methods The clinical literature on the treatment of PHN with acupuncture therapy was searched from China Knowledge Network, VIP, Wanfang, and China Biomedical Literature Database from its establishment to December 2021 to establish a database of selected acupuncture point prescriptions, and data mining was performed using SPSS statistical software to analyze the patterns of acupuncture point dispensing. Results A total of 276 acupuncture prescriptions involving 91 acupoints were included, and the most frequently used acupoints were āshì and jiájǐ; the meridians with the most selection were the gallbladder, spleen, and stomach meridians; the combination of acupoints with the highest correlation corresponded to the frequency of selection; through cluster analysis, five clusters could be obtained. Conclusion Acupuncture treatment for PHN is based on āshì acupuncture point and jiájǐ acupuncture point, and acupuncture points are taken according to the site of skin lesion following the meridian, focusing on the combination of local and distal acupuncture points, together with dialectical evidence, in order to achieve the effect of clearing liver and fire, strengthening spleen and dispelling dampness, clearing heat and detoxifying.
		2022 Vol. 19 (31): 27-30 [Abstract] ( 13 ) HTML (1 KB) PDF (0 KB) ( 8 )

	31	Influencing factors of mismatch repair gene expression in hepatitis B virus-associated hepatocellular carcinoma
		GAO Yuxue NING Qiqi CAI Yuying GUAN Yuanyue YANG Pengxiang CHEN Dexi
		DOI: 10.20047/j.issn1673-7210.2022.31.07
		Objective To investigate the influencing factors of mismatch repair gene(MMR) expression in hepatitis B virus (HBV)-associated hepatocellular carcinoma. Methods The MMR immunohistochemical results of 125 patients with HBV-associated hepatocellular carcinoma admitted to Beijing Youan Hospital, Capital Medical University from December 2019 to June 2021 were retrospectively analyzed. The patients were divided into deficiency MMR (dMMR) group (18 cases) and proficiency MMR (pMMR) group (107 cases). The influencing factors of dMMR in patients with HBV-associated hepatocellular carcinoma were further analyzed. Results The deletion of dMMR group included the loss of MutL homologue 1 (MLH1)/postmeiotic protein isolate 2 (PMS2) expression (4 cases), the loss of MLH1 expression (1 case), the loss of MutS protein homologue 2 (MSH2) /PMS2 expression (1 case), and the loss of PMS2 expression (12 cases). The necrosis rate, microvascular invasion rate, glutamic-oxaloacetic transaminase level, and abnormal prothrombin level in dMMR group were lower than those in pMMR group, and the differences were statistically significant (P ＜ 0.05). There were significant differences in differentiation degree, Edmondson grade, and P53 protein intensity between the two groups (P ＜ 0.05). The results of multivariate analysis showed that Edmondson grade and glutamic-oxaloacetic transaminase level were independent influencing factors of dMMR (P ＜ 0.05). Conclusion dMMR is a low-frequency event in HBV-associated hepatocellular carcinoma, which is related to Edmondson grade and glutamic-oxaloacetic transaminase level, and may be an effective target for the treatment of the disease.
		2022 Vol. 19 (31): 31-34,48 [Abstract] ( 27 ) HTML (1 KB) PDF (0 KB) ( 14 )

	35	Investigate of the mechanism of the influence of myeloid-derived suppressor cells on chronic colitis associated carcinogenesis through immunometabolic pathways
		HE Shanquan1 CHEN Xue1 LI Weidong2
		DOI: 10.20047/j.issn1673-7210.2022.31.08
		Myeloid-derived suppressor cells (MDSC) form an immunosuppressive microenvironment that affects the progression of chronic colitis associated carcinogenesis (CAC). In the inflammatory state, abnormal mitochondrial metabolism and hypoxia participate in the regulation of MDSC and affect the progression of CAC. Adenosine 5’-monophosphate- activated protein kinase (AMPK) activation inhibits hypoxia inducible factor-1αregulation of MDSC. This article intends to explore how MDSC regulates and affects the carcinogenesis of chronic colitis from the pathway of inflammatory immune metabolism, in order to provide clues and evidence for the prevention and treatment of colorectal cancer.
		2022 Vol. 19 (31): 35-38,56 [Abstract] ( 12 ) HTML (1 KB) PDF (0 KB) ( 8 )

	39	Research progress on the mechanism of traditional Chinese medicine regulating autophagy in Alzheimer’s disease
		MA Hongyue1 PIAO Zhongyuan2 SONG Lin3 CHU Wei1 ZHENG Yuanwu3
		DOI: 10.20047/j.issn1673-7210.2022.31.09
		With the aging of the world population, the mortality rate of Alzheimer’s disease (AD) is increasing year by year, and the prevention and treatment of AD is extremely urgent. Autophagy has become a hotspot of medical research in recent years, and more and more studies have shown that autophagy has made great progress in the prevention and treatment of AD. At the same time, researchers have found that traditional Chinese medicine can delay the progression of AD by regulating autophagy. Traditional Chinese medicine monomer dendrobium nobile lindl alkaloid, crocetin, curcumin, and geniposide, and traditional Chinese medicine compound Fuzheng Quxie Prescription, Tiaoxin Prescription, and Tiantai No.1 have the effect of activating autophagy and interfering with AD, while traditional Chinese medicine monomer Icariin Ⅱ, acorus Tatarinowii Volatile Oil combined with total ginsenoside, flavone monomer of jujube seed, resveratrol, and modified Dioscorea Pill in traditional Chinese medicine can inhibit autophagy interfere with AD. More and more attention has been paid to the study of monomer and compound of traditional Chinese medicine. This article reviews the research progress of traditional Chinese medicine regulating autophagy in the prevention and treatment of AD, hoping to provide beneficial reference for traditional Chinese medicine in the prevention and treatment of AD.
		2022 Vol. 19 (31): 39-43 [Abstract] ( 16 ) HTML (1 KB) PDF (0 KB) ( 7 )

	44	Research progress of mesenchymal stem cells in the treatment of ankylosing spondylitis
		LIU Donghan1 TAN Longwang2 ZHU Yu3
		DOI: 10.20047/j.issn1673-7210.2022.31.10
		Ankylosing spondylitis is an autoimmune disease with a high clinical incidence. It is characterized by abnormal ossification and rigidity of the spine and sacroiliac joints, and with the further development of the disease, the patient’s quality of life is dramatically reduced. At present, the treatment of this disease is still a difficult problem in clinic. Considering the limitations of existing therapies (nonsteroidal anti-inflammatory drugs, glucocorticoids, antirheumatics, and biologic drugs), it is necessary to seek a treatment pathway with fewer side effects and higher potential. With the development of stem cell theory and technology, mesenchymal stem cells may be a new way to treat ankylosing spondylitis. This article reviews the basic and clinical research of mesenchymal stem cells in the treatment of ankylosing spondylitis in recent years, in order to provide new ideas for future research and application.
		2022 Vol. 19 (31): 44-48 [Abstract] ( 12 ) HTML (1 KB) PDF (0 KB) ( 12 )

	49	Research progress in Chinese medicine treatment of cancer pain
		WANG Yuru1 LIU Zhaidong2
		DOI: 10.20047/j.issn1673-7210.2022.31.11
		Cancer pain is a common symptom of tumor patients, which is caused by the pressure or invasion of tumor on surrounding tissues, surgery, chemotherapy, and other treatment means or combined with another disease, which seriously affects the quality of life of tumor patients and interferes with the process and effectiveness of anti-tumor treatment. Western medicine treatment for cancer pain is not ideal for pain control due to its side effects, addiction, and drug resistance. Traditional Chinese medicine, acupuncture and moxibustion, acupuncture point injection, and other Chinese medicine means are widely used in clinical practice because of their high safety, low side effects and convenient application. This paper reviews the research progress of Chinese medicine in the treatment of cancer pain in recent years.
		2022 Vol. 19 (31): 49-52 [Abstract] ( 21 ) HTML (1 KB) PDF (0 KB) ( 9 )

	53	Research progress of traditional Chinese medicine in the treatment of chronic atrophic gastritis
		GU Wenshu YANG Wenchen WANG Ting LI Yinghao ZHONG Fengyu TANG Meiwen
		DOI: 10.20047/j.issn1673-7210.2022.31.12
		Chronic atrophic gastritis (CAG) is a common and prevalent disease in splenogastroenterology. It is mainly characterized by atrophy of the epithelium and glands of the gastric mucosa, and is accompanied by intestinal chemosis or heterogeneous hyperplasia. Compared with the low eradication rate and adverse effects such as abdominal pain and constipation brought about by allopathic treatment in Western medicine, traditional Chinese medicine treatment characterized around a holistic concept and discriminative treatment has demonstrated great advantages. The literature related to the treatment of CAG by traditional Chinese medicine in recent years has been compiled and reviewed in terms of traditional Chinese medicine disease name, etiology and pathogenesis, identification and classification, and traditional Chinese medicine treatment, etc. The treatment rules and prescriptions of CAG under the guidance of traditional Chinese medicine theory have been systematically explained, and traditional Chinese medicine characteristic therapies such as acupuncture, acupuncture point embedding, auricular pressure bean, traditional Chinese medicine conditioning, and body identification have been summarized. It is easy to find that traditional Chinese medicine has the unique advantages of simplicity, convenience, inexpensiveness, experimentation, and effectiveness, however, there are still shortcomings in the modern development of traditional Chinese medicine. It is now reviewed into a paper to provide reference for clinical treatment, with a view to promoting the further development of traditional Chinese medicine.
		2022 Vol. 19 (31): 53-56 [Abstract] ( 20 ) HTML (1 KB) PDF (0 KB) ( 8 )

	57	Research progress of autophagy in sepsis muscle atrophy
		LIN Dawei WU Jin JIANG Peng▲
		DOI: 10.20047/j.issn1673-7210.2022.31.13
		Sepsis muscle atrophy is one of the serious complications of sepsis, which seriously affects the motor system and respiratory function. Studies have shown that sepsis can induce muscle atrophy through a variety of pathways, including muscle protein metabolism disorders, mitochondrial damage, inflammation, and so on. Autophagy is an important pathway of substance metabolism. Normally, autophagy protects cells by degrading harmful substances in cells. But the disease process can have different effects. At present, the advantages and disadvantages of autophagy on sepsis muscular atrophy are still controversial. Autophagy can promote muscle atrophy through metabolic pathways, and also inhibit muscle atrophy through mitochondrial autophagy and other pathways. This review aims to explore the effect of autophagy on sepsis muscle atrophy and provide new ideas for clinical treatment.
		2022 Vol. 19 (31): 57-60,77 [Abstract] ( 15 ) HTML (1 KB) PDF (0 KB) ( 8 )

	61	Research progress of traditional Chinese medicine medical technology in the treatment of type 2 diabetes mellitus
		WEI Le GUO Fengqin WEI Yusuo ZHAO Xiaoming
		DOI: 10.20047/j.issn1673-7210.2022.31.14
		This paper summarizes the pathogenesis of type 2 diabetes mellitus and the clinical research progress of traditional Chinese medicine medical technology in the treatment of type 2 diabetes mellitus in recent years, in order to provide theoretical reference and treatment ideas for the clinical application of traditional Chinese medicine medical technology in the treatment of type 2 diabetes mellitus, and gives play to the advantages of non-drug therapy with safety and no side effects. In the treatment of type 2 diabetes mellitus, the techniques of traditional Chinese medicine mainly include acupuncture, massage, moxibustion, and minimally invasive techniques of traditional Chinese medicine, while the other techniques are seldom used. Traditional Chinese medicine medical techniques can reduce blood glucose by promoting insulin secretion, improving insulin resistance, correcting lipid metabolism disorder, regulating sympathetic nerve function in islet and other mechanisms, and improve the clinical symptoms of type 2 diabetes mellitus patients.
		2022 Vol. 19 (31): 61-64 [Abstract] ( 19 ) HTML (1 KB) PDF (0 KB) ( 7 )

	65	Research status of arthroscopic anterior cruciate ligament reconstruction
		FAN Bingyang1 HE Hairong2 YUAN Lingwei2 WU Jinqiu2
		DOI: 10.20047/j.issn1673-7210.2022.31.15
		In recent years, the injury of anterior cruciate ligament (ACL) has increased year by year, and it has become a common sports injury. Arthroscopic ACL reconstruction is a widely accepted treatment method, but there are still controversies in the selection of surgical timing, surgical reconstruction method, graft, fixation method, and so on. In this paper, the relevant literature at home and abroad is reviewed, and the research status of arthroscopic ACL reconstruction is reviewed for clinical reference.
		2022 Vol. 19 (31): 65-68,87 [Abstract] ( 18 ) HTML (1 KB) PDF (0 KB) ( 8 )

	69	Application and evaluation of the flipped classroom based on micro-video class in experimental teaching of the foundation of clinical laboratory medicine
		LI Dan1 ZHOU Xiaodong1 DUAN Jiahui1 PENG Kejun1 ZHOU Xinge1 SU Yang2 HUANG Xiaotian2 ZHANG Juan2
		DOI: 10.20047/j.issn1673-7210.2022.31.16
		Objective To improve students’ operational and practical ability in the foundation of clinical laboratory medicine, the flipped classroom based on micro-video class was hold in experimental teaching of the foundation of clinical laboratory basic experiment teaching and its application effect was evaluated. Methods In 2022, 87 students in the Second Grade of the undergraduate medical laboratory technology of Chengdu Medical College were divided into experimental group (29 students) and control group (58 students), according to student ID. The students in experimental group were hold with the teaching model of flipped classroom based on micro-video class, while the students in control group were hold with the traditional teaching model. The experimental test, questionnaire survey and student interviews were taken to evaluate the implementation effect. Results The scores of experimental test and questionnaire survey about satisfaction, stimulating learning enthusiasm, improving operational ability, enhancing ability of autonomous learning, problem-analyzing and solving in experimental group were higher than those in control group (P ＜ 0.05). The above results were confirmed by student interviews. Conclusion Compared with traditional teaching model, the teaching model of flipped classroom based on micro-video class consolidates the students’ operational and practical ability, and also improves the teachers’ comprehensive teaching ability. The goal of both teaching and learning growing together is achieved, it appears a useful teaching mode worth to promote in experimental teaching of medical course.
		2022 Vol. 19 (31): 69-72 [Abstract] ( 22 ) HTML (1 KB) PDF (0 KB) ( 11 )

	73	Application of MCAT teaching mode integrating curriculum ideological and political ideas in basic nursing courses
		CHEN Feier1 ZHU Jiafu2 JIN Xiaofeng1
		DOI: 10.20047/j.issn1673-7210.2022.31.17
		Objective To explore the application effect of MCAT teaching mode integrating curriculum ideological and political ideas in basic nursing courses. Methods From March 2020 to January 2021, two classes of students majoring in nursing in Zhejiang Industry Polytechnic College were selected as the research objects. There were 52 students in one class as experimental group, and 53 students in the other class as control group. The control group carried out conventional course ideological and political teaching, and the experimental group carried out MCAT teaching mode integrating curriculum ideological and political concept on the basis of the control group. The scores of students’ ideological and political knowledge, faith and behavior, humanistic care ability, professional identity, and critical thinking ability were compared between the two groups before and after implementation. Results After the implementation, the knowledge awareness rate, belief accuracy rate and behavior formation rate of the experimental group were higher than those before the implementation, and the experimental group was higher than the control group, and the differences were statistically significant (P ＜ 0.05). After the implementation, the scores of each dimension and total score of humanistic care ability in the experimental group were higher than those before the implementation, and the experimental group was higher than the control group, and the differences were statistically significant (P ＜ 0.05). After the implementation, the scores of professional identity and critical thinking in the experimental group were higher than those before the implementation, and the experimental group was higher than the control group, and the differences were statistically significant (P ＜ 0.05).Conclusion The MCAT teaching mode integrated with the ideological and political concept of the curriculum is helpful to improve the teaching quality of basic nursing and cultivate students’ professional quality.
		2022 Vol. 19 (31): 73-77 [Abstract] ( 20 ) HTML (1 KB) PDF (0 KB) ( 8 )

	78	Application effect of the flipped classroom based on MOOC in the teaching of perioperative nursing in the pediatric congenital heart disease
		LIU Hui1 ZHANG Guoming2 HE Liyun1▲
		DOI: 10.20047/j.issn1673-7210.2022.31.18
		Objective To explore the classroom teaching effect of massive open online course (MOOC) combined with flipped classroom teaching method in perioperative nursing teaching of children with congenital heart disease. Methods A total of 90 nursing students who received perioperative nursing teaching for children with congenital heart disease in the First Affiliated Hospital of Xinjiang Medical University from April 2020 to August 2021 were selected and they were divided into the control group and the observation group by random number table method, with 45 students in each group. The control group was given the conventional teaching method, while the observation group was given the teaching based on the situation of “MOOC plus flipped classroom” on the basis of the control group. Both groups were taught for four consecutive months. The results of teaching content assessment and nursing students’ satisfaction with teaching methods were compared between the two groups. Results The basic concept theory score and case comprehensive analysis score of the observation group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). The proportion of nursing students in the observation group who were able to find information independently, take the initiative to speak, clear their personal views, cooperate well with students and/or teachers, and think they performed well were higher than that in the control group, and the differences were statistically significant (P ＜ 0.05). The scores of learning effect in improving the learning interest in learning, improving the learning enthusiasm and initiative, improving the difficult content understanding, deepen the study content, deepening the knowledge system construction, improving self-learning ability, improving the classroom atmosphere, better embodiment of the abstract knowledge in the observation group were higher than control group, the differences were statistically significant (P ＜ 0.05). The subjective satisfaction of nursing students in the observation group was significantly higher than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The teaching based on “MOOC plus flipped classroom” during the perioperative nursing teaching of children with congenital heart disease can achieve better results. The self-learning performance of nursing students is good, and the learning effect has obvious advantages, subjective satisfaction with the teaching method is high.
		2022 Vol. 19 (31): 78-82 [Abstract] ( 20 ) HTML (1 KB) PDF (0 KB) ( 9 )

	83	Evaluation on the effect of advanced simulated human tracheal intubation situational simulation teaching method in standardized training and teaching of traditional Chinese medicine specialty
		DING Lingling WANG Qi KE Hai NING Jiaqi
		DOI: 10.20047/j.issn1673-7210.2022.31.19
		Objective To evaluate the effect of advanced simulation teaching method on airway intubation and airway management in standardized training of traditional Chinese medicine. Methods A total of 80 standardized training physicians of traditional Chinese medicine were divided into the traditional teaching method group (group C) and the advanced simulation teaching method group (group A), with 40 people in each group. Group C was taught with traditional teaching method combined with ordinary simulated person, and group A was taught with Gaumard S1030 high-end simulated person based on group C. Before the training, a thorough investigation and theoretical examination were conducted. After the training, a theoretical and practical examination was conducted, and the course satisfaction was investigated. Results Before training, there was no significant difference in the investigation results of the two groups (P ＞ 0.05). After training, the theoretical test scores and practical test scores of the two groups were higher than those before teaching, and group A was higher than group C (P ＜ 0.05). The passing rate of the first examination and the success rate of the first intubation in group A were higher than those in group C (P ＜ 0.05), and the operation time of intubation was shorter than that in group C (P ＜ 0.05). The course satisfaction of group A was higher than that of group C (P ＜ 0.05). Conclusion Advanced simulation teaching method can improve the students’ ability of airway management and course satisfaction.
		2022 Vol. 19 (31): 83-87 [Abstract] ( 18 ) HTML (1 KB) PDF (0 KB) ( 11 )

	88	Analysis on the construction effect of “double-qualified” teaching staff in local undergraduate colleges
		KONG Lingyu MAO Chun GUAN Siyu▲
		DOI: 10.20047/j.issn1673-7210.2022.31.20
		Objective To explore the construction mechanism of “double-qualified” teaching staff in local undergraduate universities. Methods The nursing department was selected as the pilot. In September 2016, 47 nursing teachers and 65 students who look for final-year bachelor from the Department of Medicine, Hubei University of Arts and Sciences were selected by cluster sampling method. Since January 1, 2017 intervention measures for teachers have been implemented to implement the “four modernizations” construction mechanism. In 2019, statistical analysis was conducted on the basic situation of teachers, students’ evaluation of teaching effects and evaluation results of teaching satisfaction before and after intervention. Results After the intervention, the quality of double teachers, professional title structure, scientific research projects, and paper publication indexes were higher than those before the intervention, and the differences were statistically significant (P ＜ 0.05). The students’ recognition rate of each content of the teaching effect after intervention reached 76.92% to 90.77%; the teaching satisfaction after intervention was higher than that before intervention (P ＜ 0.05). Conclusion The adoption of the “four modernizations” mechanism to build the “double-qualified” nursing teaching staff in local undergraduate colleges can improve the basic situation of the teaching staff, improve the overall quality of the teaching staff, improve the teaching level of the teachers, and realize the long-term development of the teaching staff in local application-oriented undergraduate colleges, which is worth learning from peers.
		2022 Vol. 19 (31): 88-91 [Abstract] ( 18 ) HTML (1 KB) PDF (0 KB) ( 8 )

	92	Activation and exhaustion of CD8+ memory T cells in human immunodeficiency virus infected patients after anti-retroviral therapy
		QIU Wenhao1 XIONG Runsong2 LIU Xian3 WU Yuerong4 XIAO Jian3
		DOI: 10.20047/j.issn1673-7210.2022.31.21
		[Abstract] Objective To investigate the level of activation and exhaustion of CD8+ memory T cells (Tm) in human immunodeficiency virus (HIV) infected patients after anti-retroviral therapy (ART). Methods From January to February 2022, 62 HIV-infected patients (divided into incomplete immune reestablishment group [22 cases] and complete immune reestablishment group [40 ceaes] after ART treatment and 12 healthy subjects were selected in Guigang Center for Disease Control and Prevention, Guangxi. The activation and depletion levels of CD8+Tm cells in HIV-infected patients were detected. Results The expression levels of CD38, HLA-DR, and 2B4 in CD8+Tm cells in the incomplete immune reestablishment group and complete immune reestablishment group were higher than those in the healthy group (P ＜ 0.05). The expression of 2B4 in CD38+HLA-DR+CD8+Tm cells in immune reestablishment group and complete immune-reestablishment group were significantly higher than that in healthy group (P ＜ 0.05). There was a positive correlation between CD38 and HLA-DR expression in CD8+Tm cells of HIV-infected patients (r = 0.634 6, P ＜ 0.05). Conclusion Although the HIV infected patients received the treatment of CD8+Tm cells after art, the activation of CD8+Tm cells still increased, which led to the overexpression of immune exhaustion molecules and the suppression of immune function.
		2022 Vol. 19 (31): 92-95,116 [Abstract] ( 18 ) HTML (1 KB) PDF (0 KB) ( 7 )

	96	Effect of exercise prescription training based on cardiopulmonary exercise test in elderly patients with chronic obstructive pulmonary disease
		LUO Na1 YU Guangyang2 CHEN Lingling1▲
		DOI: 10.20047/j.issn1673-7210.2022.31.22
		Objective To investigate the effect of exercise prescription training based on cardiopulmonary exercise test in elderly patients with chronic obstructive pulmonary disease (COPD). Methods A total of 128 elderly patients with COPD admitted to Huaian First Hospital Affiliated to Nanjing Medical University from November 2019 to November 2021 were selected and divided into control group (64 cases) and experimental group (64 cases) by random number table method. The control group was given routine nursing, while the experimental group was given exercise prescription training based on cardiopulmonary exercise test on the baseic of control group. Both groups were intervened for six weeks. The changes of exercise endurance, lung function, and quality of life before and after intervention were compared between the two groups. Results After intervention, the six-minute walking test, exercise duration, maximum exercise power, forced vital capacity (FVC), forced expiratory volume in one second (FEV1), and FEV1/FVC in the two groups were higher than those before intervention, and the experimental group was higher than that in the control group (P ＜ 0.05). After intervention, the symptoms, activity limitation, and disease scores of St.George’s respiratory questionnaire in the two groups were lower than those before intervention, and the experimental group was lower than the control group (P ＜ 0.05). Conclusion In elderly patients with COPD, exercise prescription training based on cardiopulmonary exercise test can improve exercise endurance, promote the recovery of lung function and improve the quality of life.
		2022 Vol. 19 (31): 96-99 [Abstract] ( 21 ) HTML (1 KB) PDF (0 KB) ( 10 )

	100	Effects of cognitive behavioral therapy on mental state, sleep status, and cardiac function in patients with chronic heart failure complicated with anxiety and depression
		WANG Jiawei1 WU Yechen2 ZHANG Yanping1 YANG Fan1 WANG Chunmei1 SUN Bingyan1 ZHANG Zheng2 ZHAO Yingyu2
		DOI: 10.20047/j.issn1673-7210.2022.31.23
		Objective To study the effects of cognitive behavioral therapy on mental state, sleep status, and cardiac function in patients with chronic heart failure complicated with anxiety and depression. Methods A total of 160 patients with chronic heart failure complicated with anxiety and depression admitted in Qinhuangdao Jungong Hospital of Hebei Province from January 2020 to December 2021 were selected, they were divided into control group and observation group by random number table method, with 80 patients in each group. Both groups received symptomatic drug therapy and Sakobactri Valsartan Sodium Tablets, the control group received conventional psychological intervention on this basis, and the observation group received cognitive behavioral therapy. The psychological state, sleep quality, and cardiac function indexes before and after intervention were compared between the two groups. Results After intervention, the scores of Hamilton anxiety scale, Hamilton depression scale, and Pittsburgh sleep quality index in two groups were lower than those before intervention, and observation group was lower than control group (P ＜ 0.05). After intervention, left ventricular end-diastolic dimension and left ventricular end-systolic diameter in two groups were lower than those before intervention, and observation group was lower than control group (P ＜ 0.05); left ventricular ejection fraction in two groups were higher than those before intervention, and observation group was higher than control group (P ＜ 0.05). After intervention, brain natriuretic peptide, cardiac troponin I, and creatine kinase isoenzyme MB in two groups were lower than those before intervention, and observation group was lower than control group (P ＜ 0.05). Conclusion Based on the drug control, the comprehensive management mode combined with cognitive behavioral therapy for patients with chronic heart failure complicated with and anxiety and depression during rehabilitation has positive effects on patients’ quality of life, myocardial indicators, and disease control, which is worth promoting.
		2022 Vol. 19 (31): 100-103 [Abstract] ( 17 ) HTML (1 KB) PDF (0 KB) ( 9 )

	104	Effect of neuromuscular electrical stimulation on muscle strength and prognosis of mechanically ventilated patients in intensive care unit
		DANG Hui1 CHEN Jun2 CHEN Weirong1 LI Jianming1 YANG Feifei1
		DOI: 10.20047/j.issn1673-7210.2022.31.24
		Objective To investigate the effect of neuromuscular electrical stimulation (NMES) on muscle strength and prognosis of mechanically ventilated patients in intensive care unit (ICU). Methods A total of 106 patients admitted to ICU of Danzhou People’s Hospital of Hainan Province from January 2020 to December 2021 were selected, and they were divided into two groups according to the random number table method. The control group (53 cases) received routine symptomatic treatment and rehabilitation training, and observation group (53 cases) received NMES on the basis of control group. The mechanical ventilation time, ICU stay time, and hospital stay were compared between two groups; the grip strength, medical research council manual muscle test (MRC) score, acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ) score, and Barthel index were compared between two groups on the 3rd day of ICU admission and on the day of ICU exit; the incidence of ICU-acquired myasthenia (ICU-AW) and the mortality within 28 days were compared between two groups. Results The mechanical ventilation time, ICU stay time, and hospital stay in the observation group were shorter than those in control group (P ＜ 0.05). On the day of ICU exit, the grip strength, MRC score and Barthel index in both groups were higher than those on the 3rd day of ICU admission, and observation group was higher than control group (P ＜ 0.05); APACHE Ⅱ score in both groups were lower than those on the 3rd day of ICU admission, and observation group was lower than control group (P ＜ 0.05). On the day of ICU exit, the incidence of ICU-AW and mortality within 28 days in observation group were lower than those in control group (P ＜ 0.05). Conclusion NMES can effectively improve the muscle strength of ICU patients with mechanical ventilation, reduce the incidence and mortality of ICU-AW, and improve the prognosis of patients.
		2022 Vol. 19 (31): 104-107 [Abstract] ( 12 ) HTML (1 KB) PDF (0 KB) ( 10 )

	108	Effect of prophylactic ileal double-lumen and single-lumen stoma on the patients after laparoscopic low rectal cancer resection
		WANG Bojun1 WU Xiaohong1 JIANG Yi2
		DOI: 10.20047/j.issn1673-7210.2022.31.25
		Objective To investigate the effects of prophylactic ileal double-lumen and single-lumen stoma on the patients after laparoscopic low rectal cancer resection. Methods A total of 86 patients with low rectal cancer in Yixing Hospital Affiliated to Jiangsu University were selected from January 2016 to November 2021 for this prospective study. They were divided into single-lumen stoma group (43 cases, single-lumen stoma) and double-lumen stoma group (43 cases, double-lumen stoma) by random number table method. The perioperative conditions, postoperative complications, and diversion colitis (DC) of stage Ⅰ and Ⅱ operation in the two groups were analyzed. Results In the double-lumen stoma group, three cases were lost to follow-up, and 40 cases were finally included in the study. There were no significant differences between the two groups in duration of stage Ⅰ operation, intraoperative blood loss of stageⅠ operation, exhaust time of stage Ⅰ operation, hospital stay of stage Ⅰ operation, time between stage Ⅰ operation and stage Ⅱ operation, intraoperative blood loss of stage Ⅱ operation, total incidence of complications of both two stage operation, and DC occurrence within six months after stage Ⅱ operation (P ＞ 0.05). The operation time of stage Ⅱ in double-lumen stoma group was longer than that in single-lumen stoma group, and the difference was statistically significant (P ＜ 0.05). There was a significant difference in different level DC occurrence between the two groups within three months after stage Ⅰ operation (P ＜ 0.05). Conclusion Prophylactic ileal double-lumen and single lumen stoma after laparoscopic low rectal cancer resection are both feasible and safe, but double-lumen can better reduce the incidence of DC and shorten the operation time of stage Ⅱ operation.
		2022 Vol. 19 (31): 108-111 [Abstract] ( 17 ) HTML (1 KB) PDF (0 KB) ( 17 )

	112	Experience of Professor Tang Xudong in treating chronic lymphocytic leukemia based on the principle of “attacking toxin and resolving hard mass, strengthening and consolidating body resistance”
		LIU Jian1 LI Rui1 MAO Yue1 JIN Nan1 JIANG Peizhen2 TANG Xudong2
		DOI: 10.20047/j.issn1673-7210.2022.31.26
		Chronic lymphocytic leukemia is a type of chronic B cell lymphoproliferative disease, which is more common in the elderly. In recent years, the incidence of chronic lymphocytic leukemia is increasing, and many patients simply use western medicine chemotherapy, its effect is not ideal, and side effects happen a lot, high recurrence rate and mortality. Professor Tang Xudong is good at diagnosis and treatment of chronic lymphocytic leukemia from the perspective of integrated traditional Chinese and western medicine, the effect is remarkable, quite experienced. Professor Tang mostly treats chronic lymphocytic leukemia from the treatment idea of “attacking toxin and resolving hard mass, strengthening and consolidating body resistance”. In the early stage, “attacking toxin and resolving hard mass” is used as the method to break blood and remove blood stasis, disinfect and resolve hard mass, and remove pathogenic qi. In the middle stage, the method of “strengthening and consolidating body resistance” is used to consolidat body resistance and strengthen vital qi, help the pathogenic qi go out. In the later stage, “benefiting qi and nourishing yin” is the main method, benefiting qi and consolidating body resistance, nourishing yin, and promoting fluid production, and replenishing the vital qi of the body damaged by diseases. Professor Tang to “attacking toxin and resolving hard mass, strengthening and consolidating body resistance” for treating chronic lymphocytic leukemia, in the treatment of before, during, and after use of traditional Chinese medicine treatment, at the same time of removing pathogenic qi, take care of the vital qi of the injured human body and treat and use the medicine flexibly according to the clinical symptoms and related syndrome of the patients, which has achieved good results, which is worth learning and reference.
		2022 Vol. 19 (31): 112-116 [Abstract] ( 22 ) HTML (1 KB) PDF (0 KB) ( 11 )

	117	Influence of music treatment based on syndrome differentiation with point selection by midday-midnight flowing of qi-bloodpoint on anxiety and quality of life in patients with acute cerebral infarction
		QU Yueqing WU Xiaoping DING Yanbing
		DOI: 10.20047/j.issn1673-7210.2022.31.27
		Objective To explore the influence of music treatment based on syndrome differentiation with point selection by midday-midnight flowing of qi-bloodpoint on anxiety and quality of life in patients with acute cerebral infarction. Methods A total of 76 patients with acute cerebral infarction complicated with anxious neurosis hospitalized in Hubei Provincial Hospital of Traditional Chinese Medicine from January to December 2021 were selected and divided into observation group (38 cases) and control group (38 cases) according to the random number table method. Both groups were treated with the basic treatment, rehabilitation, and nursing routine, and the observation group was treated with music treatment based on syndrome differentiation with point selection by midday-midnight flowing of qi-bloodpoint. After 14 days of intervention, Hamilton anxiety scale (HAMA), self-rating anxiety scale (SAS), short form 36 (SF-36) scores, and sleep electroencephalogram parameters were compared between the two groups before and after intervention. Results After intervention, HAMA and SAS scores of the two groups were lower than those before intervention, and the observation group was lower than the control group, and the differences were statistically significant (P ＜ 0.05). After intervention, the scores of body pain, physical function, and emotional function in SF-36 of the two groups were higher than those before intervention, the scores of overall health, vitality, social function, and mental health in the observation group were higher than those before intervention, the scores of body pain, physical function, general health, vitality, social function, emotional function, and mental health in the observation group were higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). After intervention, the sleep latency, awakening time of the two groups were lower than those before intervention, and the total sleep time was longer than those before treatment, the awakening times of observation group were lower than those before intervention, the sleep latency, awakening time, and awakening times of the observation group were lower than those of the control group, and the total sleep time was longer than that of the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Music treatment based on syndrome differentiation with point selection by midday-midnight flowing of qi-bloodpoint can improve the sleep quality of patients with acute cerebral infarction, effectively improve the anxiety and quality of life of these patients, and the clinical effect is significant.
		2022 Vol. 19 (31): 117-121 [Abstract] ( 21 ) HTML (1 KB) PDF (0 KB) ( 9 )

	122	Summary of Professor Xiong Shaoquan’s experience in the treatment of refractory chemo-therapy-induced thrombocytopenia in patients with malignant tumors with “Sanwei Shenghuo Dan”
		LUO Yingzhe LI Ru XIONG Shaoquan HE Lifang HUANG Xingmei WU Guoyu
		DOI: 10.20047/j.issn1673-7210.2022.31.28
		Due to repeated chemotherapy in patients, refractory chemo-therapy-induced thrombocytopenia is a side effect of chemotherapy, which manifests as irreversible bone marrow hematopoietic dysfunction. Routine use of platelet-promoting factors such as recombinant human thrombopoietin, interleukin-11 and etc. has been difficult to achieve ideal clinical efficacy. Professor Xiong Shaoquan believes that the internal binding of static blood and poison caused the deficiency of the spleen kidney, and other viscera. Repeated chemotherapy leads to damaging the kidney yin and yin deficiency involving yang which results to the decline of vital gate fire. Therefore, Professor Xiong Shaoquan proposes that the main pathogenesis of this disease is “decline of vital gate fire and the deficiency of both kidney yin and yang” and created the “Sanwei Shenghuo Dan” to treat the disease. “Sanwei Shenghuo Dan” is composed of Aconiti Lateralis Radix Praeparata, Polygonati Rhizoma, Jujubae Fructus. The three herbs are prepared in a ratio of 1∶1∶1. According to the specific situation, “Sanwei Shenghuo Dan” need to be used in addition or subtraction others herbs on the basis of this prescription. On the one hand, replenishing the vital gate fire to strengthen the kidney yang; on the other hand, strengthening zhongzhou to produce the middle qi. When the kidney fire is strong, qi and blood grow, and when the middle qi is sufficient, the qi and blood biochemistry are active and the platelets can be restored to normal. A case study is attached in order to provide new ideas and methods for the clinical prevention and treatment of refractory chemo-therapy-induced thrombocytopenia.
		2022 Vol. 19 (31): 122-125 [Abstract] ( 28 ) HTML (1 KB) PDF (0 KB) ( 14 )

	126	Bibliometric analysis of the study on the international communication of “the Belt and Road” of traditional Chinese medicine
		DU Yawen* CHEN Kedian* CUI Herong LEI Haimin
		DOI: 10.20047/j.issn1673-7210.2022.31.29
		Objective To explore the current situation and main characteristics of the international communication of traditional Chinese medicine “the Belt and Road” through bibliometric analysis. Methods China National Knowledge Infrastructure, VIP database, Wanfang database, China Biomedical Literature Database, CiteSpace, China National Knowledge Infrastructure literature analysis tool, and NoteExpress were used to study the literatures published from January 2013 to June 2021. The status and trends of the field were analyzed qualitatively and quantitatively in terms of year distribution, institutions, authors, funds, subject distribution, and progress analysis, etc. Results Through the analysis of 1 664 included literatures, it was found that the number of literatures published in this field gradually increased, Song Xinyang published the most, and the team cooperation was the most close. The support units were mainly Nanjing University of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Beijing University of Chinese Medicine and other provinces and cities of traditional Chinese medicine colleges, funded by the national social science foundation projects. The main keywords were “the Belt and Road”, “traditional Chinese medicine”, “internationalization”, etc., and there were 12 categories of keyword clustering labels. The research focus was on international cooperation. The research focused on the “the Belt and Road” initiative, and progress had been made in five aspects: policy, resources, public support, science and technology, and trade. Conclusion The development space of “the Belt and Road” international communication research on traditional Chinese medicine is large, and it is advisable to strengthen interdisciplinary cooperation to deepen the research.
		2022 Vol. 19 (31): 126-130,134 [Abstract] ( 21 ) HTML (1 KB) PDF (0 KB) ( 10 )

	131	Professor He Xiaojin’s experience in treating postmenopausal osteoporosis with Xiange Prescription based on collateral disease theory
		YANG Fan1 CAO Jing2
		DOI: 10.20047/j.issn1673-7210.2022.31.30
		Professor He Xiaojin makes good use of collateral disease theory to treat postmenopausal osteoporosis (PMOP), and developed and improved the concept of collateral disease with clinical guiding significance. According to the traditional Chinese medicine treatment principle of treatment based on syndrome differentiation, Professor He believes that the disease of PMOP is located in the bone collaterals, and the pathogenesis is characterized by “the spleen does not governing ascending clear, the kidney essence is deficient, and the blood stasis blocks the collaterals”. Taking “combining tonifying with dredging” as the treatment principle, “raising the spleen and tonifying the kidney, benefiting essence and filling bones, promoting blood circulation for removing obstruction in collaterals” as the treatment method, self-made Xiange Prescription is designed to treat PMOP and the clinical effect is quite good. This paper summarizes and analyzes Professor He’s experience in treating postmenopausal osteoporosis with Xiange Prescription based on collateral disease theory, so as to provide the same way and serve the patients.
		2022 Vol. 19 (31): 131-134 [Abstract] ( 22 ) HTML (1 KB) PDF (0 KB) ( 10 )

	135	Clinical effect of modified Yizi Decoction enema combined with endoscopic sclerotherapy in the treatment of grade Ⅰ-Ⅲ internal hemorrhoids
		YAO Jingjing1 WANG Zaijian2 WU Yong3 LI Huixia2
		DOI: 10.20047/j.issn1673-7210.2022.31.31
		Objective To study the clinical effect of modified Yizi Decoction enema combined with endoscopic sclerotherapy in the treatment of internal hemorrhoids. Methods A total of 100 patients with grade Ⅰ-Ⅲ internal hemorrhoids with bleeding who were hospitalized in Jingdong Yumei Integrated Traditional Chinese and Western Medicine Nephropathy Hospital of Hebei Province from October 2018 to June 2021 were selected. They were divided into two groups, with 50 cases in each group. The control group underwent surgical resection and the experimental group underwent endoscopic sclerosis, and the second day after surgery, modified Yizi Decoction enema was implemented. The length of hospital stay and clinical efficacy were compared between the two groups; the symptom scores and the levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-10 and IL-17 before and after treatment were compared between the two groups. Results The length of hospital stay in experimental group was shorter than that in control group (P ＜ 0.05). After treatment, the scores of bleeding, anal distension discomfort, and pain in two groups were lower than those before treatment, and experimental group was lower than control group (P ＜ 0.05). The total effective rate of experimental group was higher than that of control group (P ＜ 0.05). After treatment, the levels of IL-17 and TNF-α in two groups were lower than those before treatment, and those in experimental group were lower than those in control group (P ＜ 0.05); the level of IL-10 was higher than that before treatment, and that in experimental group was higher than that in control group (P ＜ 0.05). Conclusion Modified Yizi decoction enema combined with endoscopic sclerosis in the treatment of internal hemorrhoids can shorten the length of hospital stay, reduce the symptoms of hematochezia, anal distension discomfort, and pain. It plays an anti-inflammatory effect on inflammatory cytokines such as IL-17, IL-10, and TNF-α, which is worthy of clinical promotion.
		2022 Vol. 19 (31): 135-138 [Abstract] ( 29 ) HTML (1 KB) PDF (0 KB) ( 11 )

	139	Clinical effect of acupuncture in the treatment of patients with bipolar Ⅱ disorder
		LIU Quanliang1 ZHOU Xin2 LI Xiaojuan3 WANG Zhili4 LI Xianzhou5
		DOI: 10.20047/j.issn1673-7210.2022.31.32
		Objective To observe the clinical effect of acupuncture in the treatment of bipolar Ⅱ disorder. Methods A total of 72 patients with bipolar Ⅱ disorder treated in Tangshan Fengrun People’s Hospital of Hebei Province from January 2018 to December 2020 were selected. According to the random number table method, they were divided into control group and observation group, with 36 cases in each group. The control group was treated with Paroxetine Hydrochloride + Lithium Carbonate Sustained-Release Tablets, and observation group was treated with acupuncture on the basis of control group. The two groups were treated for eight weeks, and the clinical efficacy was compared between two groups; the scores of Hamilton depression scale (HAMD), Bech-Rafaelsen mania scale (BRMS) and the levels of total bilirubin (TBil), albumin, and uric acid (UA) before and after treatment were compared between two groups. Results The clinical efficacy of observation group was better than that of control group (P ＜ 0.05). After treatment, the scores of HAMD and BRMS in two groups were lower than those before treatment, and observation group was lower than control group (P ＜ 0.05). After treatment, the levels of TBil and albumin in two groups were higher than those before treatment, and observation group was higher than control group (P ＜ 0.05); the level of UA was lower than that before treatment, and observation group was lower than control group (P ＜ 0.05). Conclusion Acupuncture treatment can effectively improve the mental symptoms of anxiety, mania, and depression in patients with bipolar Ⅱ disorder, and can also improve the sleep quality and life quality of patients, which has clinical significance.
		2022 Vol. 19 (31): 139-142 [Abstract] ( 22 ) HTML (1 KB) PDF (0 KB) ( 9 )

	143	Effect of Danggui Sini Decoction on pain symptoms and quality of life in endometriosis patients of cold coagulation and blood stasis type
		ZHANG Hengduan1 XIANG Jun2 SHU Yunlu1 WEN Xiaowen3▲ HU Zhuyuan3
		DOI: 10.20047/j.issn1673-7210.2022.31.33
		Objective To explore the application effect of Danggui Sini Decoction in endometriosis of cold coagulation and blood stasis type. Methods A total of 120 patients with endometriosis who were treated in Jinhua Maternal and Child Health Hospital from January 2018 to March 2021 were selected, and they were divided into study group (60 cases) and control group (60 cases) by random number table method. The control group was treated with Dinogestrin, and the study group was treated with Danggui Sini Decoction. The clinical efficacy of the two groups were observed, the dysmenorrhea scores, the quality of life scores before and after treatment, and the incidence of adverse reactions of the two groups were compared. Results The clinical efficacy of the study group was better than that of the control group, the dysmenorrhea score of the study group was lower than that of the control group, the scores of quality of life (emotional function, health status, energy) in the study group were higher than those in the control group , the incidence of adverse reactions in the study group was lower than that in the control group, the differences were statistically significant (P ＜ 0.05). Conclusion Danggui Sini Decoction can effectively relieve the pain symptoms of endometriosis patients of cold coagulation and blood stasis type, and is of great significance in improving their quality of life and reducing the incidence of adverse reactions, and is worthy of popularization.
		2022 Vol. 19 (31): 143-145,150 [Abstract] ( 17 ) HTML (1 KB) PDF (0 KB) ( 10 )

	146	Summary of Professor Zhou Yabin’s academic experience in treating coronary heart disease with anxiety after percutaneous coronary intervention
		WEI Lai1 ZHOU Yabin2 SUN Jing2 YANG Jianfei2
		DOI: 10.20047/j.issn1673-7210.2022.31.34
		The clinical incidence of coronary heart disease with anxiety state after percutaneous coronary intervention is increasing year by year, and the effect of traditional Chinese medicine treatment is prominent. Combined with the current lifestyle, Professor Zhou Yabin in combination with the present way of life, believes that internal blockade of phlegm-turbidity, deficiency of qi and blood, and malnutrition of heart spirit are the main pathogenesis of coronary heart disease with anxiety after percutaneous coronary intervention. He puts forward the the treatment principle of invigorating spleen and dissipating phlegm, nourishing heart and tranquillization, tonifying qi and blood, clearly distinguishes between the false and the real, adjust measures to three factors, treats double heart homology, the clinical effect of the treatment of this disease is exact. This article summarizes Professor Zhou Yabin’s clinical experience in the treatment of coronary heart disease with anxiety after percutaneous coronary intervention, in order to provide new ideas for clinical treatment.
		2022 Vol. 19 (31): 146-150 [Abstract] ( 22 ) HTML (1 KB) PDF (0 KB) ( 10 )

	151	Study on the diagnostic value of magnetic resonance cholangiopancreato-graphy combined with diffusion weighted imaging in malignant biliary obstruction
		ZHANG Yaping1 ZHOU Wei2 ZHANG Hongshe1 FENG Haitao1 XU Tao1 BIAN Haishan1 DONG Ning1
		DOI: 10.20047/j.issn1673-7210.2022.31.35
		Objective To explore the diagnostic value of magnetic resonance cholangiopancreatography (MRCP) combined with diffusion weighted imaging (DWI) in malignant biliary obstruction. Methods A total of 100 patients with suspected malignant biliary obstruction treated in Zhuozhou City Hospital of Hebei Province from April to November 2021 were selected. MRCP and MRCP combined with DWI were used for diagnosis respectively. The pathological results were used as the gold standard to evaluate the accuracy of the two diagnostic protocols. Results Among the 100 patients, 59 were malignant and 41 were benign. The 59 malignant lesions included 11 cases of ampullary carcinoma, 23 cases of pancreatic head carcinoma, and 25 cases of cholangiocarcinoma. The accuracy, sensitivity, and specificity of MRCP were 91.00%, 84.75%, and 95.12% respectively; the accuracy, sensitivity, and specificity of MRCP combined with DWI were 98.00%, 96.61%, and 100.00% respectively. Conclusion Compared with MRCP alone, MRCP combined with DWI has higher application value in the diagnosis of malignant biliary obstruction, and can be used as a reference index for the differential diagnosis of malignant lesions.
		2022 Vol. 19 (31): 151-153,158 [Abstract] ( 21 ) HTML (1 KB) PDF (0 KB) ( 11 )

	154	Characterization of acute lung injury/acute respiratory distress syndrome programs in Chinese clinical trial registries
		CHEN Yifan LI Yan GUO Nan LIU Jin ZENG Yanpeng CHEN Yu
		DOI: 10.20047/j.issn1673-7210.2022.31.36
		Objective To explore the characteristics of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) programs registered in Chinese clinical trial registries. Methods Clinical trials of ALI/ARDS registered from the inception of the center to June 30, 2021 were retrieved and the information was counted. Results Ninety-six projects were screened, with the majority of major research units in Shandong and Shanghai (12.50% each), and 79.17% were single-center trials. The 92 projects with defined sample sizes were expected to recruit a total of 23 310 patients, with a sample size range of 9 to 5 000 patients. The types of studies were mostly observational studies (47.92%), interventional randomized controlled trials (42.71%), and registration information such as blinded use and randomization concealment still needs to be improved. 44 (45.83%) studies involved comorbidities. The interventions involved combined Chinese and western medicine treatment, western medicine treatment and non-pharmaceutical treatment, etc. The specimens collected were mainly blood and bronchoalveolar lavage fluid, and the observation indexes included clinically relevant indexes, physical and chemical examinations, and scoring scales. Conclusion There is a lack of registration information in some projects, and the quality of registration needs to be further improved; multi-center and large sample size clinical studies are still needed for a variety of comorbidities and diverse interventions in ALI/ARDS; outcome indicators are abundant and scattered, and attention can be paid to the development and application of core indicator sets to promote the generation of high-quality evidence-based evidence to help improve clinical diagnosis and treatment, and provide reference for future research directions in this field.
		2022 Vol. 19 (31): 154-158 [Abstract] ( 21 ) HTML (1 KB) PDF (0 KB) ( 9 )

	159	Analysis on the management strategy of multi-hospital based on demand side
		HUANG Huihui1 JIA Xiaoxi2 PIAO Yingshi1 TIAN Wei2 XU Yao1 WU Shufen1 LI Qian1
		DOI: 10.20047/j.issn1673-7210.2022.31.37
		The single multi-hospital model of public hospitals may be the development direction of general hospitals. The use of artificial intelligence consulting system to collect patient needs can provide optimization strategies for hospital management. In this paper, the model of “one hospital, three districts” in Beijing Tongren Hospital, Capital Medical University is used as the research sample of a single public hospital with multiple districts, and the analysis showed that patients’ demands included four aspects: homogeneity, accessibility, recognition, and interoperability. Hospital managers can respond to patients’ homogenization expectations through smooth information, improve service accessibility through fine management, build brand consensus and increase hospital recognition, promote the construction of smart hospitals and promote inter-hospital communication to improve patients’ satisfaction.
		2022 Vol. 19 (31): 159-161 [Abstract] ( 20 ) HTML (1 KB) PDF (0 KB) ( 11 )

	162	Application of diversified health education in school-age children with dilated cardiomyopathy
		TANG Chong MA Xinxiu GUO Chunmian▲
		DOI: 10.20047/j.issn1673-7210.2022.31.38
		Objective To explore the value of diversified health education in school-aged children with dilated cardiomyopathy (DCM). Methods Seventy-two school-aged children with DCM admitted to the First Affiliated Hospital of Air Force Military Medical University from January 2019 to June 2020 were selected and divided into observation and control groups of 36 cases each using the random number table method. The control group was implemented conventional health education, while the observation group was implemented diversified health education on this basis. The two groups were followed up for six months to compare the compliance behavior and cardiac function. Results The control group completed follow-up in 36 cases and the observation group completed follow-up in 34 cases. At six-month follow-up, the compliance rate of the observation group was higher than that of the control group, with statistically significant difference (P ＜ 0.05). The left ventricular end-diastolic internal diameter (LVDD) and left atrial end-diastolic anteroposterior diameter (LADD) were lower, and the left ventricular ejection fraction (LVEF) and left ventricular short-axis shortening rate (LVFS) in the two groups were higher than those at the time of enrollment, with statistically significant differences (P ＜ 0.05); while the LVDD and LADD in the observation group were lower than those in the control group, and the LVEF and LVFS in the observation group were higher than those in the control group, with statistically significant differences (P ＜ 0.05). Conclusion Diversified health education can help promote compliance behaviors and improve cardiac function in school-aged children with DCM.
		2022 Vol. 19 (31): 162-165 [Abstract] ( 27 ) HTML (1 KB) PDF (0 KB) ( 9 )

	166	Effectiveness of risk-based care thinking in preventing lower extremity venous thrombosis in patients undergoing continuous hemodialysis
		MA Qing XU Xianrong▲ XU Jing CHEN Lvjing YE Yajun WU Buyun MAO Huijuan
		DOI: 10.20047/j.issn1673-7210.2022.31.39
		Objective To investigate the effectiveness of risk-based care thinking in preventing lower extremity venous thrombosis in patients undergoing continuous hemodialysis. Methods Ninety-two patients who received continuous hemodialysis treatment in the Renal Disease Intensive Care Unit of Jiangsu Provincial People’s Hospital from October 2018 to September 2021 were selected for the study. The envelope method was used to divide the patients into control group and observation group, with 41 cases in each group. Both groups implemented conventional nursing interventions, while the observation group implemented risk-based nursing thinking on this basis. Before and a week after the intervention, venous blood flow velocity, lower extremity swelling, and incidence of lower extremity venous thrombosis were observed and compared. Results After a week of intervention, the whole blood viscosity low cut, whole blood viscosity medium cut, whole blood viscosity high cut, and plasma viscosity in both groups were lower than before the intervention, while those of the observation group were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05). After a week of intervention, the blood flow velocity in femoral and popliteal veins in both groups were higher than before the intervention, while those of the observation group were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05). The incidence of limb swelling and deep vein thrombosis in the observation group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Implementing risk-based care thinking for continuous hemodialysis patients accelerates lower extremity venous blood flow and prevents lower extremity venous thrombosis and limb swelling.
		2022 Vol. 19 (31): 166-169,181 [Abstract] ( 19 ) HTML (1 KB) PDF (0 KB) ( 8 )

	170	Effect of breast seamless management on first lactation time and lactation volume after maternal delivery
		HU Zhenrong SUN Lili ZHANG Jianmei▲
		DOI: 10.20047/j.issn1673-7210.2022.31.40
		Objective To explore the effect of breast seamless management on first lactation time and lactation volume after maternal delivery. Methods A total of 82 parturients who delivered in the Lianyungang Second People’s Hospital, Jiangsu Province from July 2018 to June 2021 were selected as the research objects, puerpera were divided into control group and observation group by envelope method, with 41 cases in each group. The control group was given routine postpartum care, and the observation group was given seamless breast management on this basis. The differences of the first lactation time, serum prolactin, and milk production before intervention, 24 and 48 h after intervention, and the incidence of postpartum breast complications between the two groups were observed and compared. Results The first lactation time in the observation group was better than that in the control group, the difference was statistically significant (P ＜ 0.05). Overall analysis showed that there were significant differences in serum prolactin level and milk production between the two groups, time points and interaction (P ＜ 0.05); further pairwise comparison and intra-group comparison: the serum prolactin and milk production of the two groups at 24 and 48 h after intervention were higher than those before intervention, and the levels at 48 h after intervention were higher than those at 24 h after intervention, and the differences were statistically significant (P ＜ 0.05); comparison between groups: there were statistically significant differences between the two groups at each time point (P ＜ 0.05). The total incidence of the breast complications in the observation group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Breast seamless management after delivery can shorten the first lactation time, improve lactation volume, and reduce the incidence of breast complications.
		2022 Vol. 19 (31): 170-172，封三 [Abstract] ( 12 ) HTML (1 KB) PDF (0 KB) ( 8 )

	174	Analysis of the value of protective restraint combined with empathic care model for inpatients with severe depressive
		ZHU Hongxia1 SONG Yuting1 CHENG Yuanyuan1 GAN Jianguang2
		DOI: 10.20047/j.issn1673-7210.2022.31.41
		Objective To explore the application value of protective restraint combined with empathic care model in hospitalized patients with severe depression. Methods One hundred and fifty patients with major depression admitted to the Department of Clinical Psychology of Shaoxing Seventh People’s Hospital were selected as the observation subjects, and they were divided into observation group and control group by the random number table method, with 75 cases in both group. The psychological status, compliance, life function and adverse events were compared between the two groups. Results The health questionnaire depression scale and Hamilton depression scale scores in the observation group were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05). The compliance rate of the observation group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). After care, the observation scale scores of inpatient nurses in both groups were lower than before care, while those of the observation group were lower than those of the control group, and the differences were statistically significant (P ＜ 0.05). The incidence of adverse events in the observation group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The application of protective restraint combined with empathic care model for inpatients with major depressive disorder can enhance patients’ life functions and compliance behaviors, improve their depression level and restore their self-confidence, and is worth promoting.
		2022 Vol. 19 (31): 174-177 [Abstract] ( 11 ) HTML (1 KB) PDF (0 KB) ( 8 )

	178	Effect of target blood pressure management on nursing effect and prognosis of cerebral aneurysm after interventional surgery
		PAN Xia ZHANG Lingxia▲
		DOI: 10.20047/j.issn1673-7210.2022.31.42
		Objective To observe the effect of target blood pressure management on nursing effect and prognosis of cerebral aneurysm after interventional surgery. Methods A total of 340 patients with cerebral aneurysm who underwent interventional surgery in Nanjing Hospital Affiliated to Nanjing Medical University from January 2018 to December 2020 were selected. According to the random number table method, they were divided into control group and observation group, with 170 cases in each group. The control group received routine blood pressure management, and the observation group received target blood pressure management. The nursing effect and prognosis of the two groups were compared. Results Overall analysis showed that there were statistically significant differences between groups, time points and interactions in the systolic blood pressure and diastolic blood pressure(P ＜ 0.05). Further pairwise comparison, intra-group comparison: the systolic blood pressure and diastolic blood pressure of the two groups one hour before operation and immediately after operation, and immediately after awakening, and one hour after awakening were significantly (P ＜ 0.05); the systolic blood pressure and diastolic blood pressure in the observation group were lower than those in the control group at the same time (P ＜ 0.05). The incidence of unplanned extubation, abnormal fluctuation of blood pressure, rupture of cerebral aneurysm, and cerebral infarction in the observation group were lower than those in the control group (P ＜ 0.05). The hospital stay in the observation group was shorter than that in the control group (P ＜ 0.05). On postoperative day seven, the Glasgow outcome scale scores of the two groups were better than those before operation, and the observation group was better than the control group (P ＜ 0.05). Conclusion Target blood pressure management plays a role in reducing postoperative blood pressure after cerebral aneurysm intervention, reducing the risk of unplanned extubation, abnormal blood pressure fluctuation, cerebral aneurysm rupture, and cerebral infarction, with lower prognosis of neurological deficit and shorter hospital stay.
		2022 Vol. 19 (31): 178-181 [Abstract] ( 13 ) HTML (1 KB) PDF (0 KB) ( 9 )

	182	Effects of holistic diet planning nursing before bed on nocturnal blood glucose and sleep quality in elderly patients with type 2 diabetes mellitus
		ZHOU Xiaoyan1 XU Wei2 CAO Yongjun2
		DOI: 10.20047/j.issn1673-7210.2022.31.43
		Objective To explore the effects of holistic diet planning nursing before bed on nocturnal blood glucose and sleep quality in elderly patients with type 2 diabetes mellitus. Methods From August 2019 to August 2021, 120 elderly patients with type 2 diabetes mellitus in Nantong Hospital of Traditional Chinese Medicine of Jiangsu Province were selected as the research objects, according to the random number table, they were divided into control group and observation group, with 60 cases in each group. The control group received routine nursing, while the observation group received holistic sleep and diet planning nursing. The control of blood glucose level, sleep quality score, and incidence of complications were compared between the two groups before and after intervention. Results Overall analysis showed that there were statistically significant differences in blood glacose between groups, at different time points and interaction (P ＜ 0.05); further pairwise comparison, intra-group comparison after intervention, and comparison at each time point of the two groups were statistically significant (P ＜ 0.05). There were statistically significant differences between the two groups inter-group at each time point (P ＜ 0.05). The sleep quality scores of the two groups were lower than before intervention, and those of the observation group were lower than those of the control group, and the differences were statistically significant (P ＜ 0.05); the total incidence of complications total in the observation group was lower than those in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Holistic bedtime diet planning nursing for elderly patients with type 2 diabetes mellitus can effectively prevent nocturnal hypoglycemia and other complications, improve the quality of sleep, and facilitate the rapid recovery of blood glucose, which is worthy of reference and adoption by various departments.
		2022 Vol. 19 (31): 182-185 [Abstract] ( 17 ) HTML (1 KB) PDF (0 KB) ( 8 )

	186	Application of failure mode and effect analysis in in-hospital transport of critically ill patients in emergency department
		ZHANG Yan YANG Yun XU Fangfang▲
		DOI: 10.20047/j.issn1673-7210.2022.31.44
		Objective To explore the application of failure mode and effect analysis in in-hospital transport of critically ill patients in emergency department. Methods From December 2017 to December 2020, 102 critically ill patients treated in the Department of Emergency, Wuxi Fifth People’s Hospital of Jiangsu Province were selected as the research objects by random sampling. The patients were divided into control group and observation group by random number table, with 51 cases in each group. The control group implemented the routine hospital transport management mode, and the observation group implemented the failure mode and effect analysis management mode on this basis. The risk priority number value of in-hospital transport process, the incidence of transport accidents and the transport effect were observed and compared between the two groups after the intervention. Results After intervention, patients in the observation group had lower risk values than those in the control group without evaluation grading standard, low sense of responsibility, lack of preparation standard, unreasonable first-aid channel, not choosing the best route, and not implementing standard (P ＜ 0.05). The total incidence of asphyxia, arrhythmia, pipe shedding, equipment failure and incomplete supplies in the transport process in the observation group were lower than those in the control group (P ＜ 0.05). The transport time of the observation group was lower than the control group, and the satisfaction of the receiving departments and patients was higher than the control group (P ＜ 0.05). Conclusion Implementing the failure mode and effect analysis in the management of emergency transport patients can effectively reduce the hospital transfer risk value, reduce the incidence of transport adverse events, shorten the hospital transfer time, and improve the satisfaction of patients and receiving departments.
		2022 Vol. 19 (31): 186-189 [Abstract] ( 12 ) HTML (1 KB) PDF (0 KB) ( 9 )

	190	Effect of intervention mode under the concept of time on motor function and quality of life in patients after hypertensive basal ganglia intracerebral hemorrhage surgery
		LI Chenchen ZHOU Weiping▲
		DOI: 10.20047/j.issn1673-7210.2022.31.45
		Objective To explore the effect of intervention mode under the concept of time on motor function and quality of life in patients after hypertensive basal ganglia intracerebral hemorrhage surgery. Methods A total of 110 patients with hypertensive basal ganglia intracerebral hemorrhage treated in Xinhua Hospital Affiliated to Medical College of Shanghai Jiao Tong University from September 2020 to September 2021 were selected. The random numbers generated by computer were divided into observation group and control group, with 55 cases in each group. The control group was given postoperative routine nursing intervention, and the observation group adopted the intervention mode under the concept of time on the basis of the control group, both groups were intervened for three months. The motor function (assessed by Fugl-Meyer motor function score scale), quality of life (assessed by health survey scale 36 [SF-36]), and nursing satisfaction during intervention were compared between the two groups before and three months after intervention. Results After three months of intervention, the Fugl-Meyer score of the two groups were higher than that before intervention, and the observation group was higher than that of the control group, the differences were statistically significant (P ＜ 0.05); the SF-36 scores of the two groups were higher than those before intervention, and the observation group was higher than that of the control group, and the differences were statistically significant (P ＜ 0.05); the overall nursing satisfaction of the observation group was better than that of the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The intervention mode under the concept of time can improve motor function and quality of life in patients after hypertensive basal ganglia intracerebral hemorrhage surgery, and improve the nursing satisfaction.
		2022 Vol. 19 (31): 190-193 [Abstract] ( 15 ) HTML (1 KB) PDF (0 KB) ( 11 )

	194	Effect of interesting health education on the improvement of negative emotions and clinical symptoms in children with allergic purpura
		XIE Kaili1 WANG Erxiao2 LIANG Juan1▲
		DOI: 10.20047/j.issn1673-7210.2022.31.46
		Objective To investigate the effect of interesting health education on the improvement of negative emotions and clinical symptoms in children with allergic purpura. Methods Eighty-six cases of children with allergic purpura admitted to the First Affiliated Hospital of Air Force Military Medical University from January 2018 to March 2021 were selected as study subjects and they were divided into control and observation groups of 43 cases each by the random number table method. Both groups performed conventional nursing interventions, while the observation group implemented interesting health education on the basis of the control group. The clinical symptoms improvement effect, positive and negative affective scale (PANAS), and compliance behavior of the children in both groups were compared. Results The clinical symptoms of purpura, blood in stool, abdominal pain, arthralgia, and gastrointestinal bleeding disappeared time in the observation group were shorter than those in the control group, and the differences were statistically significant (P ＜ 0.05). After the intervention, the negative emotion scores on the PANAS scale in both groups were lower than those before the intervention, while the scores in the observation group were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05); after the intervention, there was no statistically significant difference in the comparison of positive emotions between and within the two groups (P ＞ 0.05). The observation group had a higher rate of compliance with medical diet, good habits, avoidance of allergen exposure, and timely review behavior than the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Interesting health education has a positive effect on the improvement of negative emotions and clinical symptoms in children with allergic purpura, and can enhance their compliance behavior.
		2022 Vol. 19 (31): 194-封三 [Abstract] ( 13 ) HTML (1 KB) PDF (0 KB) ( 10 )

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