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| Study on the medication rule of traditional chinese medicine in treating chronic insomnia based on data mining |
| LIN Ling1 YUAN Jie2 LIU Dongling2 HAN Zucheng2 LUO Fan1 WANG Ying1 CHEN Jie2 |
1.The First Clinical College, Shaanxi University of Chinese Medicine, Shaanxi Province, Xianyang 712046, China;
2.Department of Encephalopathy, Shaanxi Traditional Chinese Medicine Hospital, Shaanxi Province, Xi’an 710003, China |
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Abstract Objective To summarize the drug rules of traditional Chinese medicine in treating chronic insomnia by data mining. Methods The literatures related to the treatment of chronic insomnia with traditional Chinese medicine from October 2010 to October 2020 were retrieved from CNKI, Wanfang, and VIP databases, the database was constructed by screening prescriptions, and mining was carried out by frequency analysis, association rules and cluster analysis. Results A total of 206 prescriptions were included, involving 193 traditional Chinese medicines. The top five drugs were Suanzaoren, Poria cocos, oyster, keel, and Polygala tenuifolia. The most commonly used categories of traditional Chinese medicine were tranquilizing drugs, deficiency-tonifying drugs, heat-clearing drugs and so on. The common dosage of the top 20 drugs were in accordance with the dosage stipulated in Chinese Pharmacopoeia and Internal Medicine of Traditional Chinese Medicine. The four qi of drug were mainly cold and flat, the five flavors were sweet and bitter, and the meridians were mainly the meridians of the heart, liver, and spleen. The combination of keel and oyster was the most used drug. Unearthed 16 core combinations, 8 new prescriptions by data mining. Conclusion Through excavation and analysis, it can be seen that the pathological factors of chronic insomnia are mainly deficiency, fire, phlegm, and heat. Traditional Chinese medicines such as tranquilizing the mind, tonifying deficiency, clearing away heat, resolving phlegm, and regulating qi are used in the treatment, which provide references for clinical drug use.
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[1] 连萍.柴胡加龙骨牡蛎汤治疗失眠时效性临床观察[J].中西医结合心血管病电子杂志，2020，8（12）：172.
[2] 周清辰，杜广中，岳公雷，等.不同刺激量针刺治疗心脾两虚型失眠症66例临床观察[J].中医杂志，2020，61（15）：1334-1338.
[3] 高和.《国际睡眠障碍分类》（第三版）慢性失眠障碍的诊断标准[J].世界睡眠医学杂志，2018，5（5）：555-557.
[4] 杨茜，方庆霞.针刺五脏俞加膈俞为主穴辨证治疗慢性失眠患者70例临床观察[J].中医杂志，2015，56（20）：1760- 1762.
[5] 裴清华，唐启盛，李侠，等.失眠患者睡眠质量、个性特征及生活质量的研究[J].中华中医药杂志，2017，29（3）：927-929.
[6] Neubauer DN. Chronic insomnia [J]. Continuum（Minneap Minn），2013，19（1 Sleep Disorders）：50-66.
[7] Foley DJ，Monjan AA，Brown SL，et al. Sleep complaints among elderly persons：an epidemiological study of three communities [J]. Sleep，1995，18（6）：425-432.
[8] 李帅，赵远红.中医治疗失眠机制的实验研究进展[J].山东中医杂志，2016，35（6）：570-573.
[9] 中华医学会精神科分会.CCMD-3中国精神障碍分类与诊断标准[M].3版.济南：山东科学技术出版社，2001：118.
[10] 周仲瑛.中医内科学[M].2版.北京：中国中医药出版社，2007：157.
[11] 卢朋，李健，唐仕欢，等.中医传承辅助系统软件开发与应用[J].中国实验方剂学杂志，2012，18（9）：1-4.
[12] 国家药典委员会.中华人民共和国药典[M].北京：中国医药科技出版社，2020.
[13] 房超群，张伦忠，赵曼丽.基于中医传承辅助平台探讨张伦忠治疗中老年郁证经验及组方用药规律[J].中西医结合心脑血管病杂志，2021，19（6）：913-918.
[14] 张修红，陈金雄，郑关毅，等.甘麦芪仙磁石汤联合艾司唑仑片治疗老年慢性失眠心脾两虚证临床观察[J].中国中西医结合杂志，2020，40（6）：666-671.
[15] 赵杰荣，赵书豪，郑伟峰.六味地黄丸合黄连阿胶汤加减治疗老年原发性失眠肝肾阴虚证的临床观察[J].中国实验方剂学杂志，2019，25（20）：94-99.
[16] 付桂玲，刘颖.慢性失眠症中医综合治疗心得[J].世界睡眠医学杂志，2018，5（9）：1022-1025.
[17] 杨建宇，刘白云，刘桂香，等.中华中医药道地药材系列汇讲（17）道地药材酸枣仁的研究近况[J].现代医学与健康研究电子杂志，2020，4（17）：115-118.
[18] Cao JX，Zhang Q，Zhao YY. Hypnotic effect of jujubosides from Semen Ziziphi Spinosae [J]. J Ethnopharmacol，2010， 130（1）：163.
[19] 杨楠，叶晓川.酸枣仁汤的神经药理作用及分子机制研究进展[J].湖北中医药大学学报，2017，19（3）：114-117.
[20] Ghimire S，Kim MS. Jujube （Ziziphus Jujuba Mill.） fruit feeding extends lifespan and increases tolerance to environmental stresses by regulating aging-associated gene expression in Drosophila [J]. Biogerontology，2017，18（2）：263-273.
[21] 陈海洋，安柳，化杜平，等.石菖蒲远志配伍对小鼠睡眠的影响[J].湖北中医杂志，2015，37（10）：13-15.
[22] 冯启光.茯苓有效成分的药理学研究概况探析[J].世界最新医学信息文摘，2015，15（24）：179-180.
[23] 方萍.浅谈中药四气现代药理学研究[J].浙江中医学院学报，2000（4）：73.
[24] 刘雅倩，黄泳.陈宝田从心肝论治失眠[J].河南中医，2020，40（7）：1026-1029.
[25] 余晓晓，陈颖异，潘光强.龙骨牡蛎配伍治疗心身疾病三则[J].浙江中医杂志，2020，55（9）：699. |
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