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2022 Vol. 19, No. 29 Published: 2022-10-15

	7	Visual analysis of reaserch on tic disorders treated by traditional Chinese medicine based on CiteSpace
		YAN Yurou1 LUO Changyong2 ZHANG Qiang1 LYU Tiying1 SHOU Songting1 WANG Junhong3
		DOI: 10.20047/j.issn1673-7210.2022.29.01
		Objective To visually analyze the literature related to the treatment of tic disorders with traditional Chinese medicine based on CiteSpace. Methods The literature related to traditional Chinese medicine treatment of tic disorders were retrieved from inception to December 2021 of China National Knowledge Infrastructure. The source journals, authors, institutions, keywords, research hotspots, and trends of the included literature were visualized and analyzed based on the CiteSpace co-occurrence analysis function. Results A total of 1 757 articles were included in the literature, and the journal with the most published literature was the Journal of Traditional Chinese Medicine. The overall trend in the number of articles published in this field in the last 40 years was on the rise, and the author with the most articles was Wang Sumei, and the research institution with the highest centrality was the Dongfang Hospital, Beijing University of Chinese Medicine. Twelve clusters and 15 emergent keywords were formed. Conclusion In recent years, the research on traditional Chinese medicine treatment of tic disorders has been increasing in popularity, and the research content has been deepening. In the future, cooperation and communication should be strengthened, and the research content needs to focus on innovative research on the experience of famous doctors, diverse interventions in traditional Chinese medicine, high-quality randomized controlled studies, and so on.
		2022 Vol. 19 (29): 7-10,20 [Abstract] ( 22 ) HTML (1 KB) PDF (2041 KB) ( 34 )

	11	Visualization analysis of hotspots of research on bone tumor basedon CiteSpace and VOSviewer
		ZHANG Qiang1 TIAN Shengyuan1 LI Qing2
		DOI: 10.20047/j.issn1673-7210.2022.29.02
		Objective To analyze the research hotspots and trends of bone tumor with knowledge graph. Methods CiteSpace and VOSviewer software were used to search the literature related to bone tumor from 2000 to 2020 on Web of Science, and the bibliometric analysis was performed. According to the results, the annual publication volume, cooperation network of countries/regions and institutions, author cooperation network, keyword co-occurrence and clustering, and co-cited literature clustering were drawn and analyzed. Results A total of 2 852 papers were included in the study with a steady increase of publications; a total of 290 authors were included in the author’s cooperation network, represented by Xiao Jianru; a total of 285 institutions were included in institutional cooperation network, represented by Shanghai Jiao Tong University; the keyword clustering showed that research hotspots focused on the fields of osteosarcoma, bone metastases, apoptosis, and other related fields; the co-citation literature clustering showed that the current research focused on proliferation, STAT3, and signaling pathway. Conclusion The visual analysis of knowledge graph indicates that osteosarcoma, bone metastasis and apoptosis are the research hotspots, providing a certain reference for future researches.
		2022 Vol. 19 (29): 11-15 [Abstract] ( 21 ) HTML (1 KB) PDF (2033 KB) ( 24 )

	16	Analysis of Professor Wei Qiping’s medication rules and characteristics in treating optic atrophy
		SHUI Xiaoding1 GONG Xiaohong2 WEI Qiping2 LIAO Liang2 CHEN Tao1 XIA Yanting2
		DOI: 10.20047/j.issn1673-7210.2022.29.03
		Objective To organize and summarize the rules and characteristics of Professor Wei Qiping’s medication for optic atrophy based on data mining. Methods From January 2015 to April 2022, the prescriptions of traditional Chinese medicine used by Professor Wei Qiping for the treatment of optic atrophy were collected. The frequency, efficacy, four nature, five flavours, and channel tropism of traditional Chinese medicine for optic atrophy were analyzed. Association rules, cluster analysis, and factor analysis were used to explore potential medication rules. Results A total of 692 prescriptions and 212 traditional Chinese medicine were included. The most commonly used traditional Chinese medicines were Angelicae Sinensis Radix, Aurantii Fructus, Lycii Fructus; reinforcing-deficiency drugs, superficies-relieving drugs, and regulating qi-flowing drugs ranked the top three in the category of drugs. Drug properties were mostly plain; the taste of drug was mostly sweet, bitter, and pungent; the channel tropism were mainly liver and spleen channels. Eight core drug combinations were obtained by cluster analysis. A total of six common factors were extracted by factor analysis. Conclusion In the treatment of optic atrophy, Professor Wei Qiping attaches great importance to dispersing stagnated liver qi for relieving qi stagnation, while taking into account resolving phlegm and promoting blood circulation, nourishing blood and strengthening spleen.
		2022 Vol. 19 (29): 16-20 [Abstract] ( 21 ) HTML (1 KB) PDF (1774 KB) ( 28 )

	21	Analysis of the effect of FoxM1 expression on the proliferation and invasion related signaling pathways in intrahepatic cholangiocarcinoma based on GSEA
		LIU Lingyun* MAO Han* HUANG Peilu CHEN Shule
		DOI: 10.20047/j.issn1673-7210.2022.29.04
		Objective To compare and analyze the effects of FoxM1 expression on the proliferation and invasion-related cell signaling pathways in intrahepatic cholangiocarcinoma (ICC), and to reveal the molecular mechanism of its occurrence and development. Methods The mRNA data of 36 patients with ICC were downloaded from the TCGA database and divided into the high expression group and the low expression group according to the median of the overall FoxM1 expression value. The gene set enrichment analysis (GSEA) software was used for biological analysis. Informatics analysis to find possible differentially expressed genes between the high and low expressions of FoxM1 and related signal pathways that affect them. Real-time PCR (RT-PCR) was used to verify and compare the expression relationship of FoxM1 and P53 mRNA in ICC cell lines. Results GSEA analysis showed that there were significant differences in the expression of common gene signaling pathways such as P53 and MYC signaling pathways in the high FoxM1 expression group, while there were significant differences in the expression of FOXO signaling pathways in the low FoxM1 expression group (all FDR-Q values < 0.250). Rt-PCR results showed that the expression of P53 mRNA in HCC-9810-FOXM1 cells up-regulated by lentivirus transfection was significantly higher than that in control cells. The mRNA level of P53 in SSP-25-shFOXM1 cells down-regulated by FoxM1 was significantly lower than that in control cells (P < 0.000 1). Conclusion FoxM1 may play a broad role in the development of ICC and other different stages of evolution. Expression of FoxM1 may be related to P53, and FoxM1 in ICC may affect the P53 signaling pathway.
		2022 Vol. 19 (29): 21-24,33 [Abstract] ( 16 ) HTML (1 KB) PDF (874 KB) ( 47 )

	25	Study on the medication rule of traditional Chinese medicine compound for breast cancer based on national patent
		LI Xiaofeng1 LI Jianhui2 BIAN Jingqi3 SONG Aiying4
		DOI: 10.20047/j.issn1673-7210.2022.29.05
		Objective To analyze the national patented compound for the treatment of breast cancer, and to provide references for clinical prescription. Methods All patent granted by the State Intellectual Property Office was retrieved. Excel was used to establish a database, the frequency of traditional Chinese medicine, four qi, five flavor, and meridian were analyzed, SPSS Modeler 18.0 and SPSS Statistics 26.0 were used to analyze association rules, complex networks, and cluster analysis. Results A total of 154 patents were included, involving 499 kinds of traditional Chinese medicine, high frequency drugs were astragalus, angelica, etc.; four qi was mainly cold, five taste was mainly bitter, return to the liver meridian; high frequency medicine had astragalus-angelica; association rules included dangshen-astragalus, etc.; cluster analysis found four combinations of traditional Chinese medicine. Conclusion The treatment of breast cancer with traditional Chinese medicine compound focuses on nourishing deficiency, regulating liver and regulating qi, and fighting cancer.
		2022 Vol. 19 (29): 25-28 [Abstract] ( 19 ) HTML (1 KB) PDF (936 KB) ( 18 )

	29	Construction of a prognostic model for elderly patients with heart failure with preserved ejection fraction based on geriatric nutritional risk index
		ZHANG Mingyang WANG Zuoxiang GU Yiyu JIANG Tingbo
		DOI: 10.20047/j.issn1673-7210.2022.29.06
		Objective To explore the value of geriatric nutritional risk index (GNRI) in evaluating the prognosis of elderly patients with heart failure with preserved ejection fraction (HFpEF), and to establish a nomogram model to predict the prognosis of elderly patients with HFpEF. Methods A total of 135 patients diagnosed with HFpEF in the First Affiliated Hospital of Soochow University from January 2018 to January 2020 were retrospectively included. The patients were divided into case group (44 cases) and control group (91 cases) according to whether major adverse cardiovascular events (MACE) occurred within a year. The clinical data of patients were collected, GNRI was calculated, and multivariate logistic regression was used to analyze the risk factors of poor prognosis in elderly patients with HFpEF. R software was used to construct a nomogram model to predict the occurrence of MACE in patients within a year. Results The age, the ratio of NYHA grade ≥ Ⅲ, the proportion of diabetes, creatinine, high-sensitivity troponin T, N-terminal brain natriuretic peptide precursor, and pulmonary artery pressure of the case group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05); while the hemoglobin, albumin and GNRI were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05). Multivariate logistic regression analysis showed that the ratio of NYHA grade ≥ Ⅲ at admission (OR = 4.213, 95%CI: 1.476 to 12.022) and diabetes (OR = 3.282, 95%CI: 1.198 to 8.990) were the risk factors for the occurrence of MACE within a year in elderly patients with HFpEF (OR > 1, P ＜ 0.05); while higher GNRI (OR = 0.919, 95%CI: 0.853 to 0.990) was a protective factor for the occurrence of MACE in elderly patients with HFpEF within a year (OR < 1, P ＜ 0.05). The area under the ROC curve of the Nomogram model constructed based on GNRI was 0.816 (95%CI: 0.734 to 0.897, P ＜ 0.01). Conclusion NYHA grade ≥ Ⅲ at admission and diabetes mellitus are independent risk factors for MACE within a year in elderly patients with HFpEF, and higher GNRI is a protective factor. The nomogram model constructed in this study has a good predictive value for the prognosis of elderly HfpEF patients within a year.
		2022 Vol. 19 (29): 29-33 [Abstract] ( 25 ) HTML (1 KB) PDF (910 KB) ( 37 )

	34	Research progress on the mechanism of xanthohumol, the active ingredient of hops, in the treatment of osteoporosis
		ZHAO Yifan1 LIU Tianpeng1 ZHAO Shaochuan1 RUI Chen1 YANG Feng2
		DOI: 10.20047/j.issn1673-7210.2022.29.07
		Xanthohumol (XN) is a special flavonoid in hops, which can promote osteoblast differentiation and inhibit osteocbast (OB) differentiation, and regulate osteoclast (OC) metabolism. In this paper, literatures related to the involvement of xanthohumol in OB and OC differentiation and related signal pathways were analyzed by searching CNKI, VIP, Wanfang, PubMed and other databases in the last 10 years. The results showed that XN could up-regulate the expression of Runx2 and promote the proliferation and differentiation of OB. In addition, the expression of PPARγ was down-regulated, and the differentiation of adipocytes was inhibited, thus regulating the balance of osteogenic and adipogenic differentiation. Meanwhile, XN can also promote the production of antioxidants in vivo by up-regulating Nrf2 expression, thus reducing the damage of oxidative stress to OB. In addition, XN inhibited NF-κB, Ca2+/NFATc1, MAPK and other pathways, and inhibited OC differentiation and maturation. This review further clarified the mechanism of XN regulating bone metabolism, and provided a new target for the development of drugs for the prevention and treatment of osteoporosis.
		2022 Vol. 19 (29): 34-37,45 [Abstract] ( 22 ) HTML (1 KB) PDF (620 KB) ( 124 )

	38	The role of microRNA in the diagnosis and treatment of diffuse large B-cell lymphoma
		ZHANG Hanyu1 LI Jingdong2
		DOI: 10.20047/j.issn1673-7210.2022.29.08
		MicroRNA(miRNA) is a class of endogenous, widely distribute, and non-coding RNAs with a length of 20 to 24 nucleotides, which is widely present in body fluids. miRNA is involved in various signaling pathways and the regulation of target genes in malignant tumors, and plays an important role in the occurrence, development, invasion and metastasis of tumors. The pathogenesis of diffuse large B-cell lymphoma (DLBCL) is complex and still unclear. Exploring the role of miRNA in the development, treatment and prognosis of DLBCL is of great significance for the development of new drugs and the discovery of new prognostic indicators.
		2022 Vol. 19 (29): 38-41,49 [Abstract] ( 23 ) HTML (1 KB) PDF (632 KB) ( 41 )

	42	Research progress of traditional Chinese medicine regulating intestinal flora in the treatment of atopic dermatitis
		MA Xuening YANG Suqing YUAN Rui
		DOI: 10.20047/j.issn1673-7210.2022.29.09
		Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by severe itching and easy recurrence. In recent years, studies have suggested that the imbalance of intestinal flora plays an important role in the occurrence and development of AD. Traditional Chinese medicine plays a therapeutic role by regulating intestinal flora to participate in immune response, metabolism, neuroendocrine regulation, and other ways. Based on the introduction of the role of intestinal flora in the pathogenesis of AD, this paper reviews the research progress of traditional Chinese medicine in the treatment of AD by regulating intestinal flora, in order to provide a basis for the development of new drugs targeting intestinal flora to treat and prevent AD.
		2022 Vol. 19 (29): 42-45 [Abstract] ( 25 ) HTML (1 KB) PDF (563 KB) ( 109 )

	46	Research progress on the effect of non drug intervention on neonatal pain in neonatal intensive care unit
		LIN Ge ZHENG Xueyan
		DOI: 10.20047/j.issn1673-7210.2022.29.10
		With the continuous research of pain nursing and the continuous progress of high-quality nursing, neonatal pain nursing has been paid more and more attention. This article mainly expounds and summarizes the research progress of the effect of non drug intervention on neonatal pain in neonatal intensive care unit, introduces the related concepts and mechanisms of neonatal pain, and analyzes the short-term and long-term adverse consequences of neonatal pain in the intensive care unit. In view of the safety and feasibility of non drug intervention, it focuses on the needs of neonatal and their families, summarizes and analyzes the effects of various non drug interventions on neonatal pain in intensive care unit, including environmental control, body position control, skin contact stimulation of tactile senses, oral stimulation of taste senses, stimulation of auditory senses, and multi sensory stimulation, so as to provide more safe, effective, and convenient prevention and intervention directions for alleviating neonatal pain in intensive care unit.
		2022 Vol. 19 (29): 46-49 [Abstract] ( 20 ) HTML (1 KB) PDF (589 KB) ( 227 )

	50	Canonical correlation analysis of hospice care knowledge and attitude among nurses in department of oncology
		GUAN Qingyan1 YANG Jinhong2 SHAO Han1 SHI Haoning1 AN Hongqing3 YANG Xiao1
		DOI: 10.20047/j.issn1673-7210.2022.29.11
		Objective To understand the relationship between hospice knowledge and attitudes of nurses in oncology department, to provide scientific basis for improving the level of palliative care and positive nursing attitude of nurses. Methods A total of 294 nurses in the oncology department of 10 hospitals in Weifang City, Shandong Province were selected from March to August 2021 by the cluster sampling method. The self-made “nursing staff’s knowledge and attitudes of hospice care knowledge and attitude questionnaire” was used to conduct a questionnaire survey, and the canonical correlation analysis was used to analyze the correlation between their hospice care knowledge and attitudes. Results There were statistically significant differences in the scores of palliative care knowledge scores of oncology nurses with different age, marital status, job title, personal annual income, and seriously ill members in the family (P ＜ 0.05); there were significant differences in palliative care attitudes among nurses in the oncology department of different ages, positions, and seriously ill members at home (P ＜ 0.05). Conclusion Canonical correlation analysis showed that there was a high correlation between nursing staff’s knowledge and attitude, and the more comprehensive and solid the knowledge of hospice care was, the more positive the attitude of hospice care was. Management of pain and other symptoms, and psychosocial support of patients and their families were the main indicators of knowledge. The main indicators were the interests of hospice patients, the need for family support, and the caregivers’ attitudes towards fear and anxiety.
		2022 Vol. 19 (29): 50-54,64 [Abstract] ( 19 ) HTML (1 KB) PDF (1055 KB) ( 113 )

	55	Construction of postoperative fecal soiling risk assessment questionnaire for children with hirschsprung’s disease based on Delphi method
		QIN Huaxing1 HUANG Qiuhuan2 LYU Changheng1 HUANG Xiujuan1 WANG Lisi3 MENG Zhiqiong3
		DOI: 10.20047/j.issn1673-7210.2022.29.12
		[Abstract] Objective To construct a post-operative fecal risk assessment questionnaire (hereinafter referred to as “assessment questionnaire”) for children with hirschsprung’s disease (HSCR), and to provide a reference for early identification and intervention of high-risk groups of fecal soiling after HSCR. Methods Based on failure mode and effect analysis, from October 2020 to March 2021, a draft evaluation questionnaire was constructed through literature reading and group discussion, and then the first draft of the evaluation questionnaire was formed through an expert group discussion meeting. Finally, the Delphi method was used to conduct two rounds of correspondence to 16 experts in pediatric surgery-related fields, and the final draft of the evaluation questionnaire was initially established. Results In the two rounds of expert consultation, the recovery rate of the questionnaire was 100%, the authority coefficient was 0.925, 0.928, and the Kendall harmony coefficient was 0.318, 0.352 (P ＜ 0.001). The final evaluation questionnaire includes four dimensions (primary indicators) and 15 items (secondary indicators). Conclusion The evaluation questionnaire constructed based on the Delphi method has good scientificity, reliability and comprehensiveness. To a certain extent, it can be used as an evaluation tool for the high-risk population of fecal soiling after HSCR, and has important guiding significance for the management of such populations.
		2022 Vol. 19 (29): 55-59 [Abstract] ( 21 ) HTML (1 KB) PDF (674 KB) ( 27 )

	60	Qualitative study on the current status of medication safety in chronic disease patients with long-term medication prescriptions from the perspective of general practitioners
		CHEN Yanxiang1,2 FENG Zhengwen1 HU Yongqiang2 LI Hui1 DU Juan1
		DOI: 10.20047/j.issn1673-7210.2022.29.13
		Objective To explore the cognition and influencing factors of general practitioners in Beijing urban areas on the current situation of medication safety for chronically ill patients with long-term medication prescriptions, and to put forward reasonable suggestions for formulating medication safety interventions for chronically-ill patients with long-term medication prescriptions in the future. Methods Using the objective sampling method, 16 general practitioners (numbered A to P) from mne community health service centers in Chaoyang District, Beijing were selected as the research subjects. Using the method of one-on-one in-depth interviews, 16 general practitioners were interviewed according to the interview outline from March to June 2021. The content analysis method was used to organize and analyze the data and summarize the interview topics. Results After collating and analyzing the interview data, three themes were extracted. ①There were 10 common medication errors in patients with chronic diseases, such as increasing or decreasing the dose of medication by themselves, repeated medication, wrong medication time and wrong medication method during taking medication. ②The influencing factors that lead to drug safety problems in patients were mainly four aspects including medical staff, patients, families and policy-related factors: doctors’ lack of health education to patients and untimely follow-up; patients’ lack of knowledge and attention to drug use knowledge and skills; timely; insufficient participation of family members; untimely supply of some long-term mediation prescription drugs leads to interruption of patients’ medication and inconsistent specifications and quantities of drugs prescribed by various pharmaceutical factory directors, which indirectly affects the safety of patients’ medication. ③Various measures should be taken to improve the safety of patients’ medication. The main measures include strengthening medication safety education for patients, regular follow-up visits, and encouraging family members to participate and support. Conclusion The drug safety problem of chronically ill long-term mediation prescription patients is prominent, and the collaborative role of the family doctor’s service team should be brought into full play, and patients and family members should be encouraged to participate in drug management. The policy guarantees the unification of the supply of some long-prescription drugs and the number of drugs in each box, improves patient compliance with medication, improves patient medication safety, and promotes the further implementation of the long-prescription policy.
		2022 Vol. 19 (29): 60-64 [Abstract] ( 19 ) HTML (1 KB) PDF (738 KB) ( 157 )

	65	Attitudes toward premarital sexual behavior and their relationship with self-efficacy among medical students
		WANG Chuanming1 JI Shunxin2 YU Qinming3
		DOI: 10.20047/j.issn1673-7210.2022.29.14
		Objective To explore the attitude of medical students to premarital sexual behavior and its relationship with self-efficacy, and to provide a theoretical basis for their sexual health education and intervention. Methods From September 6 to 12, 2021, the self-compiled college students’ attitude towards premarital sexual behavior and Wang Caikang’s revised general self-efficacy scale (GSES) were used. From four representative medical colleges in Northeast China, with the class as the basic unit, a cluster random sampling method was used to select 1 697 medical students for a questionnaire survey. Results There were statistically significant differences in the scores of premarital sexual behavior attitude scores among medical students of different genders, grades, and places of origin (P ＜ 0.05). The correlation results showed that the three dimensions and total scores of medical students’ attitude towards premarital sexual behavior were positively correlated with self-efficacy (r > 0, P ＜ 0.01). Linear regression showed that self-efficacy could positively predict each dimension and total score of medical students’ attitude towards premarital sexual behavior (P ＜ 0.01). Conclusion The attitude towards premarital sexual behavior of medical students is at a moderate level, and there are certain internal differences; self-efficacy is an important variable that affects medical students’ attitude toward premarital sexual behavior.
		2022 Vol. 19 (29): 65-68 [Abstract] ( 14 ) HTML (1 KB) PDF (583 KB) ( 57 )

	69	Investigation and analysis of outpatients’ medical experience in general hospital based on service quality model
		BAO Juan SHA Rui MEI Guangliang YAO Yun
		DOI: 10.20047/j.issn1673-7210.2022.29.15
		Objective To explore the medical experience of outpatients’ in general hospital based on service quality (SERVQUAL) model. Methods From October to November 2020, outpatients, in general hospital were selected and the revised SERVQUAL model was used to develop the SERVQUAL questionnaire for outpatient service. A total of 70 questionnaires were distributed in the medical and surgical areas of general hospital, respectively; 35 questionnaires were distributed in obstetrics and gynaecology, and paediatric clinics areas, respectively, a total of 210 questionnaires were distributed, and the recovered effective scales were analyzed. Results In this study, 207 questionnaires were actually collected, among which 204 questionnaires were valid, with an effective recovery rate of 98.55%. Of the 204 outpatients surveyed, 64 were the first to visit general hospital, and 140 chose to visit general hospital because of high technical level. The expected scores of six dimensions of the SERVQUAL questionnaire for outpatients were all higher than the actual medical experience scores, and the expected scores of 20 items under six dimensions were all higher than the actual medical experience scores, and the differences were statistically significant (P ＜ 0.05). Conclusion There is a gap between outpatient experience and expected service quality in general hospital, which affects patients’ medical experience and should be paid attention to in future work.
		2022 Vol. 19 (29): 69-72 [Abstract] ( 20 ) HTML (1 KB) PDF (598 KB) ( 118 )

	73	Analysis of influencing factors of cancer-related fatigue in postoperative patients with thyroid carcinoma based on structural equation model
		LU Ying1 KOU Meihong2 LI Jinhua1 FAN Boqiang3 XIA Yanyan4
		DOI: 10.20047/j.issn1673-7210.2022.29.16
		Objective To explore the influencing factors of cancer-related fatigue in postoperative patients with thyroid carcinoma (TC) based on structural equation model. Methods A total of 120 postoperative patients with TC admitted to Jiangsu Provincial People’s Hospital from February 2020 to February 2021 were selected. The cancer fatigue scale (CFS) was used to evaluate the level of cancer-related fatigue in all patients at one month after surgery. Baseline data questionnaire was designed and the differences in CFS scores of patients with different baseline characteristics were compared, and the influencing factors of cancer-related fatigue in postoperative patients with TC were analyzed. Results A total of 120 questionnaires were distributed in this study, and 120 were successfully recovered with a successful recovery rate of 100%. The CFS score of 120 postoperative patients with TC was (28.61±14.53) points. The CFS score of high school or technical secondary school and above patients was higher than that of middle school and below patients, and the difference was statistically significant (P ＜ 0.05). The CFS scores of self-efficacy, social support, family function, and anxiety of 120 postoperative patients with TC were (81.17±26.42), (52.35±16.14), (150.33±44.23), and (61.20±18.75) points, respectively. Multiple linear regression results showed that self-efficacy (X1), social support (X2), family function (X3), anxiety (X4), and education level (X5) were the influencing factors of cancer-related fatigue in postoperative patients with TC. The equation was Y= 37.340-0.117X1-0.258X2+0.107X3+0.046X4+0.476X5 (F = 7 082.316, R2 = 0.997, adjusted R2 = 0.997, P ＜ 0.05). The level model of cancer-related fatigue in postoperative patients with TC was established, the results showed that the total effects of self-efficacy, social support, family function, anxiety, and education level on cancer-related fatigue of postoperative patients with TC were -0.049, -0.135, 0.061, 0.015, and 0.198, respectively. The goodness of fit of the model was in line with the reference standard, and the fit of the model was good with the data (P ＜ 0.05). Conclusion The level of cancer-related fatigue in postoperative patients with TC is affected by self-efficacy, social support, family function, anxiety, education level, and other factors, which should be paid attention to and targeted intervention should be given in clinical practice.
		2022 Vol. 19 (29): 73-76,89 [Abstract] ( 14 ) HTML (1 KB) PDF (1042 KB) ( 39 )

	77	Analysis of influencing factors of recurrence in elderly patients with depression
		WU Tingting1 LOU Yongao2 SHEN Cuizhen1
		DOI: 10.20047/j.issn1673-7210.2022.29.17
		Objective To investigate the influencing factors of relapse in elderly patients with depression. Methods A total of 220 elderly patients with depression who were admitted to Ningbo Kangning Hospital, Zhejiang Province from February 2019 to February 2020 were selected as the research subjects. After a year of follow-up, the patients were divided into recurrence group (90 cases) and non-relapse group (130 cases) according to the follow-up results. The gender, age, marital status, onset form, family history, associated physical diseases, cognitive dysfunction, treatment compliance, major life events, sleep disturbances, the number of onsets, and the total course of the disease were compared between the two groups. Multivariate unconditional logistic regression analysis was used to observe the risk factors affecting the recurrence of depression in the elderly. Results There were statistically significant differences in marital status, onset form, family medical history, associated physical disease, cognitive dysfunction, treatment compliance, major life events, sleep disturbance, and incidence of disease between the two groups (P ＜ 0.05). Stepwise regression analysis was performed by multivariate unconditional logistic regression, associated with physical disease (OR = 3.934, 95%CI: 2.706-5.159), cognitive impairment (OR = 2.336, 95%CI: 1.561-3.118), treatment compliance (OR = 3.458, 95%CI: 2.330-4.568), major life events (OR = 5.440, 95%CI: 3.987-6.896), and sleep disturbance (OR = 1.989, 95%CI: 1.268-2.721) were risk factors for relapse in elderly patients with depression (P ＜ 0.05). Conclusion Relapse in elderly patients with depression is common in clinical practice, accompanied by physical disease, cognitive dysfunction, treatment compliance, major life events, and sleep disturbance are risk factors for relapse, and targeted interventions should be taken to reduce the relapse rate.
		2022 Vol. 19 (29): 77-80 [Abstract] ( 21 ) HTML (1 KB) PDF (532 KB) ( 125 )

	81	Psychological crisis state and related factors in patients with viral hepatitis after liver biopsy
		FANG Fang LI Shuang▲ DIAO Lingling KONG Wanru WANG Jie
		DOI: 10.20047/j.issn1673-7210.2022.29.18
		Objective To observe the psychological crisis state of patients with viral hepatitis after liver biopsy and to analyze its related risk factors. Methods A total of 107 patients with viral hepatitis who received liver biopsy in the First Affiliated Hospital of Nanjing Medical University from October 2018 to October 2021 were selected. All patients received investigation of psychological crisis vulnerability scale (PCVS) at three weeks after puncture. The patients’ baseline data were investigated, and the differences in PCVS scores of patients with different baseline characteristics were compared, and the scores of medical coping style questionnaire (MCMQ), psychological resilience scale (CD-RISC), and perceived social support scale (PSSS) were evaluated, and the influencing factors of psychological crisis state in patients with liver biopsy were further analyzed. Results A total of 107 questionnaires were distributed and 107 were recovered with a recovery rate of 100%. The PCVS score of 107 patients with liver biopsy was (74.24±12.81) points, and the PCVS score of patients with puncture complications was higher than that of patients without puncture complications (P ＜ 0.05). PCVS score was positively correlated with patient surrender and avoidance (r ＞ 0, P ＜ 0.05), and negatively correlated with face, psychological resilience, and social support (r ＜ 0, P ＜ 0.05). The results of multiple linear regression analysis showed that puncture complications (X1), avoidance (X3), face (X4), resilience (X5), and social support level (X6) were the influencing factors of psychological crisis in patients with liver puncture biopsy, and the equation was as follows: Y=130.664+10.572X1+0.815X3-1.475X4-0.531X5-0.185X6 (F = 147.812, R2 = 0.899, adjusted R2 = 0.893, P ＜ 0.05). Conclusion The psychological crisis of patients with liver biopsy may be affected by puncture complications, coping modes, psychological resilience and social support.
		2022 Vol. 19 (29): 81-84 [Abstract] ( 17 ) HTML (1 KB) PDF (588 KB) ( 109 )

	85	Mesh meta analysis of the intervention effects of health education models in stroke patients
		MA Xiaolin ZHONG Hua ZHU Lili YANG Xiaoyang ZENG Qiuxia ZHANG Fuqing
		DOI: 10.20047/j.issn1673-7210.2022.29.19
		Objective To explore the intervention effects of different health education models in stroke patients by mesh meta analysis, so as to provide a reference for stroke patients to choose the best health education model. Methods Cochrane Library, PubMed, Embase, Web of Science, MEDLINE, CBM, CNKI, VIP, and Wanfang Data were searched for randomized controlled trials on the efficacy of different health education modes in stroke patients from the inception to May 2021. Data were extracted and methodological quality was evaluated, and the mesh meta analysis was performed by Stata 15.1. Results A total of 19 literatures were included, involving 1 642 stroke patients. Mesh meta analysis showed that, compared with the control group, the enabling health education model had the best effect on improving the Barthel index of patients (SMD = 1.46, 95%CI: 1.21-1.77, P ＜ 0.05). Health action process approach (HAPA) education model had the best effect in improving the scores of Spanish stroke-specific quality-of-life (SMD = 0.000 01, 95%CI: 0-0.02, P ＜ 0.05) and health-promoting life style profile Ⅱ (SMD = 0.000 01, 95%CI: 0-10.04, P ＜ 0.05). The Green health education model had the best effect on motor function Fugl-Meyer assessment scale (SMD = 2.058, 95%CI: 1.960-3.410, P ＜ 0.05). Conclusion The enabling health education model, Green education model, and HAPA model can improve patients’ living ability, quality of life and motor function, achieve the purpose of health promotion, and have the value of promotion.
		2022 Vol. 19 (29): 85-89 [Abstract] ( 21 ) HTML (1 KB) PDF (1122 KB) ( 46 )

	90	Clinical effect of acupuncture assisted Citalopram Hydrobromide in the treatment of elderly patients with post-stroke insomnia and depression
		ZHOU Xueping CAO Lijuan YAN Pingkang
		DOI: 10.20047/j.issn1673-7210.2022.29.20
		Objective To explore the clinical effect of acupuncture assisted Citalopram Hydrobromide in the treatment of elderly patients with post-stroke insomnia and depression. Methods A total of 78 elderly patients with post-stroke insomnia and depression admitted to Jinhua Second Hospital, Zhejiang Province from May 2019 to June 2021 were selected and divided into control group (Citalopram Hydrobromide Tablets) and experimental group (acupuncture assisted Citalopram Hydrobromide Tablets) by random number table method, with 39 cases in each group. After continuous treatment for four weeks, the efficacy of the two groups was evaluated. The depression grade, sleep quality, and serological indexes of the two groups before and after treatment were counted, and the incidence of adverse reactions in the two groups was recorded. Results The efficacy of the experimental group was better than that of the control group, and the difference was statistically significant (P ＜ 0.05). After treatment, the scores of Hamilton depression scale and Pittsburgh sleep quality index in the two groups were lower than those before treatment, and the experimental group was lower than the control group, and the differences were statistically significant (P ＜ 0.05). After treatment, the levels of 5-hydroxytryptamine and brain-derived neurotrophic factor in the two groups were higher than those before treatment, and the experimental group was higher than the control group, and the differences were statistically significant (P ＜ 0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Acupuncture assisted Citalopram Hydrobromate has a definite effect on elderly patients with insomnia and depression after stroke, which can improve the sleep disorder and depression tendency of patients, with good safety, and can be applied in clinical practice.
		2022 Vol. 19 (29): 90-93 [Abstract] ( 18 ) HTML (1 KB) PDF (564 KB) ( 44 )

	94	Effect of high definition transcranial direct current stimulation combined with Fluoxetine Hydrochloride in the treatment of post-stroke patients with depression with sleep disorders
		HAN Li
		DOI: 10.20047/j.issn1673-7210.2022.29.21
		Objective To analyze the clinical effect of high definition transcranial direct current stimulation (HD-tDCS) combined with Fluoxetine Hydrochloride in patients with post-stroke depression (PSD) and sleep disorders. Methods A total of 87 PSD patients with sleep disorders admitted to Hangzhou Seventh People’s Hospital from March 2019 to December 2021 were selected as the research subjects and divided into treatment group (44 cases) and control group (43 cases) by random number table method. Both groups received routine basic treatment and psychological intervention, the control group was additionally treated with Fluoxetine Hydrochloride, and the treatment group was combined with HD-tDCS based on the control group, both groups were treated for four weeks. The Hamilton depression scale (HAMD) score, the degree of neurological deficit, the Pittsburgh sleep quality index (PQSI), and the living ability were compared between the two groups before and after treatment. The adverse reactions of the two groups during the treatment period were observed. Results After treatment, scores of HAMD, Chinese stroke scale (CSS), and PQSI in two groups were lower than those before treatment, and Barthel index was higher than that before treatment. Teh 8 scores of HAMD and CSS, and PQSI in the treatment group were lower than those in the control group, and Barthel index was higher than that in the control group, and the differences were statistically significant (P ＜ 0.05). During the treatment, the liver and kidney function and blood routine examination results of the two groups were normal, and there were no serious adverse events. Conclusion HD-tDCS combined with Fluoxetine Hydrochloride in the treatment of PSD patients with sleep disorders can significantly improve the mood and sleep quality of patients, promote the improvement of neurological deficits, improve the ability of life, and has good safety.
		2022 Vol. 19 (29): 94-96,100 [Abstract] ( 23 ) HTML (1 KB) PDF (604 KB) ( 129 )

	97	Deficiency status of vitamin A and vitamin D in children with recurrent upper respiratory tract infection and their relationship with immune function
		PENG Tianchuan YU Mei▲
		DOI: 10.20047/j.issn1673-7210.2022.29.22
		Objective To investigate the deficiency status of vitamin A and vitamin D in children with recurrent upper respiratory tract infection and their relationship with immune function. Methods A total of 79 children with recurrent upper respiratory tract infection who were admitted to People’s Hospital of Chongqing Banan District from May 2019 to January 2022 were selected as the research group, and 75 healthy children who underwent physical examination during the same period were selected as the control group. Levels of vitamin A and vitamin D in both groups were detected by high performance liquid chromatography; the deficiency status of vitamin A and vitamin D in children with recurrent upper respiratory tract infection was counted; levels of vitamin A and Vitamin D in two groups were compared; immune functions (CD3+, CD4+, CD8+, CD4+/CD8+, immunoglobulin [Ig] A, IgG, and IgM) were compared between two groups; the correlation between vitamin A and vitamin D and immune function in children with recurrent upper respiratory tract infection were analyzed. Results Among the 79 children with recurrent upper respiratory tract infection, 55 cases (69.62%) of normal vitamin A, 12 cases (15.19%) of suspected subclinical deficiency, 7 cases (8.86%) of subclinical deficiency, and 5 cases (6.33%) of clinical deficiency; vitamin D was sufficient in 59 cases (74.68%), insufficient in 13 cases (16.46%), and deficient in 7 cases (8.86%). The levels of vitamin A and vitamin D in study group were lower than those in control group (P < 0.05). The levels of CD3+, CD4+, CD4+/CD8+, IgA, IgG, and IgM in study group were lower than those in control group (P ＜ 0.05), while CD8+ in study group was higher than that in control group (P ＜ 0.05). The levels of vitamin A and vitamin D in children with recurrent upper respiratory tract infection were positively correlated with the levels of CD3+, CD4+, CD4+/CD8+, IgA, IgG, and IgM (r ＞ 0, P < 0.05); while negatively correlated with CD8+ (r ＜ 0, P ＜ 0.05). Conclusion The deficiency status of vitamin A and vitamin D in children with recurrent upper respiratory tract infection still needs to be improved, and their vitamin A and vitamin D levels are closely related to immune function, which can assist in determining the deficiency status of vitamin A and vitamin D.
		2022 Vol. 19 (29): 97-100 [Abstract] ( 24 ) HTML (1 KB) PDF (556 KB) ( 29 )

	101	Analysis of risk factors for ovarian cancer risk in middle-aged and elderly female with rheumatoid arthritis
		HUANG Zhaowei1 Ling Yi2 Tan Linlin3 HUANG Fangqin1 WANG Lu1 MA Wukai2
		DOI: 10.20047/j.issn1673-7210.2022.29.23
		Objective To study the risk factors of ovarian cancer risk in middle-aged and elderly women with rheumatoid arthritis (RA). Methods A total of 180 middle-aged and elderly (age ≥40) female RA patients (RA group) admitted to the Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine from October 2019 to December 2020 and 80 healthy middle-aged and elderly females (healthy group) were randomly selected. The general conditions of subjects and ovarian cancer risk-related indicators of RA patients were recorded. The absolute value of T lymphocyte subsets of RA patients were detected. The levels of CA125 in the two groups were compared. The RA group was divided into 31 cases of CA125 positive group and 149 cases of CA125 negative group according to whether CA125 was abnormal or not. The correlation between the elevation of CA125 in RA patients and human epididymal protein 4 (HE4) and T cell subsets was analyzed. Results The CA125 level in the RA group was higher than that in the healthy group (P ＜ 0.05). The levels of HE4 and CD8+ T cells in CA125-positive patients were significantly higher than those in CA125-negative patients (P ＜ 0.05). Logistic regression analysis showed that HE4 (OR = 1.117, 95%CI:1.052-1.185) and CD8+ T cells (OR = 1.499, 95%CI:1.213-1.851) were independent risk factors for CA125 positivity in RA patients (P ＜ 0.05). Conclusion Middle-aged and elderly female RA patients are prone to CA125 positivity. CA125 positivity is closely related to the levels of HE4 and CD8+ T cells, which may indicate an increased risk of ovarian cancer in CA125-positive RA patients. Clinically, the risk of ovarian cancer in this population should be fully paid attention to and timely investigation should be carried out.
		2022 Vol. 19 (29): 101-104,125 [Abstract] ( 20 ) HTML (1 KB) PDF (891 KB) ( 33 )

	105	Effect of intratracheal radiotherapy in the treatment of advanced non-small cell lung cancer
		LIAO Chen ZHENG Beibei CUI Heqing LIU Zhiyuan HONG Mei▲
		DOI: 10.20047/j.issn1673-7210.2022.29.24
		Objective To evaluate the efficacy and adverse events of intratracheal radiotherapy combined with external irradiation in the treatment of advanced non-small cell lung cancer. Methods A total of 60 patients with stage Ⅲa to Ⅳ non-small cell lung cancer treated in Nanjing Chest Hospital from July 2016 to December 2019 were selected as the research objects. According to the random number table method, they were divided into experimental group and control group. A total of 29 patients in the experimental group were treated with endotracheal radiotherapy + external irradiation (endotracheal radiotherapy DT 10 Gy / 2 f + external irradiation DT 55-56 Gy), and 31 patients in the control group were treated with conventional external chest irradiation intensity modulated radiotherapy DT 60 Gy/30 f. After treatment, the short-term efficacy, 1-year local control rate and the incidence of adverse reactions were compared between the two groups. Results There was no significant difference in objective remission rate between the two groups at one month after radiotherapy (P ＞ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). The 1-year survival rate of the experimental group was higher than that of the control group after 12 months follow-up (P ＜ 0.05). Conclusion For patients with locally advanced non-small cell lung cancer,endotracheal radiotherapy combined with external irradiation can stabilize the short-term efficacy while reducing the dose of external chest irradiation, help to reduce the incidence of adverse reactions such as radiation pneumonia and radiation esophagitis, and the 1-year survival rate is high.
		2022 Vol. 19 (29): 105-108 [Abstract] ( 21 ) HTML (1 KB) PDF (622 KB) ( 19 )

	109	Analysis of Professor Cui Yinglin’s theory of treating apoplexy by stage based on “new and long phlegm”
		PANG Botong1 NAN Songhua1 CHEN Fangfang1 GE Wenjing1 CUI Yinglin2
		DOI: 10.20047/j.issn1673-7210.2022.29.25
		The second National famous traditional Chinese medicine Professor Cui Yinglin believes that phlegm pathogen is an important factor in the formation, change and prognosis of apoplexy. However, phlegm pathogen itself also changes with the course of apoplexy. Therefore, he proposed the academic idea of “treating by stages based on the new and long phlegm”. He believes that the treatment of apoplexy should start from the new and long phlegm, and according to the specific course of the disease and the different concurrent disease, stage treatment. At the same time, he also original Xingnao Emena Decoction, Kangyi Capsules and so on, applied in clinical, curative effect is very good. The author has the honor to be the successor of Professor Cui’s academic thought. In the course of learning from teachers, the author sorted out Professor Cui’s academic thought of “treating by stages based on the new and long phlegm” and its academic origins. The etiology, pathogenesis and characteristics of “phlegm-induced apoplexy” were summarized. The clinical medication experience of “phlegm-induced apoplexy” was summarized to provide theoretical basis for the treatment of apoplexy with traditional Chinese medicine.
		2022 Vol. 19 (29): 109-113 [Abstract] ( 22 ) HTML (1 KB) PDF (748 KB) ( 18 )

	114	Analysis of the theoretical basis of Yishen Jiedu Tongluo Method in the treatment of multiple sclerosis based on image thinking
		DING Wenjing WANG Zhongmin REN Jiayan WANG Xiang SHANG Xiaoling
		DOI: 10.20047/j.issn1673-7210.2022.29.26
		Traditional Chinese medicine image thinking is the core thinking method to understand traditional Chinese medicine theory and guide clinical application. Using image thinking to distinguish and treat multiple sclerosis (MS) is the development and continuation of traditional Chinese medicine clinical diagnosis and treatment, inheritance and innovation. This paper analyzes the pathogenesis and clinical treatment of MS based on image thinking, and fully interprets the application of image thinking in the syndrome differentiation and treatment of MS, including “taking images abstracting from viewing”, “comparing images with categories” , and “taking images to understand the meaning”. Using the image thinking to summarize the symptoms and functional characteristics of MS, it is proposed that the clinical symptom of MS in traditional Chinese medicine is “flaccidity”. Combined with the original thinking of traditional Chinese medicine, it is concluded that “poison” is the key pathogenesis of MS. To guide the clinical treatment of MS with “flaccidity” and “poison”, and to use the method of “benefiting kidney, removing toxicity substance, and dredging collateral” is the extension and expansion of syndrome differentiation and diagnosis, which is of great significance to guide clinical practice and promote theoretical research and innovation.
		2022 Vol. 19 (29): 114-117 [Abstract] ( 23 ) HTML (1 KB) PDF (662 KB) ( 23 )

	118	Professor Zhou Jian’s experience in treating Graves’ ophthalmopathy from liver and lung theory
		GAO Miaoran1 HUANG Sheng2 YAN Xiaoling3 SUN Wu1 LI Shimeng1 SHI Suisui1 LUO Xianke1 ZHOU Jian3
		DOI: 10.20047/j.issn1673-7210.2022.29.27
		Graves’ ophthalmopathy (GO) is a common disease in the department of ophthalmology and thyroidology. Because it causes ocular changes, the patient’s appearance is affected at least, the patient’s vision is impaired at most, and the patient’s quality of life is significantly affected, clinical treatment is more difficult. Professor Zhou Jian believes that liver and lung qi disorders are the important pathogenesis of GO. He is good at treating GO by syndrome differentiation and staging based on the rise and fall theory of liver and lung qi. He has clear clinical ideas and accurate medication. This article summarizes Professor Zhou Jian’s experience in long-term syndrome differentiation treatment of GO, and expounds the typical clinical cases, in order to provide reference for traditional Chinese medicine treatment of GO.
		2022 Vol. 19 (29): 118-121 [Abstract] ( 23 ) HTML (1 KB) PDF (654 KB) ( 14 )

	122	Summary of Professor Yin Kejing’s experience in treating elderly gynecomastia with Zishen Huatan Method
		CHEN Lijie1 MA Yuyu1 XU Weiwei1 DU Xu1 YIN Kejing2
		DOI: 10.20047/j.issn1673-7210.2022.29.28
		The incidence of elderly gynecomastia is on the rise. If not treated in time, it may develop into male breast cancer. Through the observation of clinical records, Professor Yin Kejing summes up that the pathogenesis of the disease is based on deficiency of root cause and excess of manifestation. The deficiency of root cause is lack of kidney essence, and excess of manifestation is mainly phlegm and blood stasis. Combined with the pathological basis of phlegm and blood stasis deficiency in the elderly, he establishs the method of Zishen Huatan Method. The treatment emphasizes on nourishing kidney essence, removing phlegm and blood stasis mainly, Semen Cuscutae, Herba Epimedii, Radix Morindae Officinalis, etc. are most used to tonifying kidney yang, unprocessed Radix Rehmanniae Recens, Rhizoma Polygonati, etc. are most used to tonifying kidney yin, Rhizoma Alismatis, Semen Sinapis Albae, Salvia chinensia Benth, etc. are most used to remove phlegm and blood stasis, manifestation and root cause are treated simultaneously, clinical effect is remarkable, which is worthy of promotion.
		2022 Vol. 19 (29): 122-125 [Abstract] ( 22 ) HTML (1 KB) PDF (653 KB) ( 26 )

	126	Clinical effect of Xuanfei Zhisou Mixture in the treatment of post infectious cough of wind evil invading lung type#br#
		SUN Ning1 LI Qian2▲ SHI Lei3 YANG Yang1 SONG Minping4
		DOI: 10.20047/j.issn1673-7210.2022.29.29
		[Abstract] Objective To observe the clinical effects of Xuanfei Zhisou Mixture in the treatment of post infectious cough (wind evil invading lung type) and the impacts on inflammation. Methods From October 2021 to March 2022, 102 cases with post infectious cough（wind evil invading lung type） were enrolled in the First Hospital of Integrated Traditional Chinese and Western Medicine of Beijing, and they were divided into control group and obseruation group according to the random number table method, with 51 cases in each group. The control group received Suhuang Zhike Capsules, the obseruation group received Xuanfei Zhisou Mixture. All treated for seven days. The clinical efficacy, traditional Chinese medicine syndrome score and inflammatory factor C-reactive protein (CRP), interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α) in sputum before and after treatment were compared between the two groups, and the adverse reactions of the two groups were recorded. Results After treatment, the scores of traditional Chinese medicine symptoms in the two groups were decreased, and the cough score in the observation group was lower than that in the control group (P ＜ 0.05); there were no significant differences in the scores of choking, itching, coughing, and exacerbation of cough when exposed to wind between the two groups (P ＞ 0.05). After treatment, the levels of CRP, IL-8 and TNF-α in the two groups were decreased, and the level of IL-8 in the observation group was lower than that in the control group (P ＜ 0.05); and there were no significant differences in CRP and TNF-α between the two groups (P ＞ 0.05). There was no significant difference in clinical efficacy between the two groups (P ＞ 0.05). There were no obvious adverse reactions in the two groups. Conclusion Xuanfei Zhisou Mixture is effective and safe in treating post infectious cough (wind evil invading lung type), and is worthy of widely clinical use.
		2022 Vol. 19 (29): 126-129 [Abstract] ( 22 ) HTML (1 KB) PDF (577 KB) ( 19 )

	130	Clinical effect of Cangfu Daotan Decoction in the treatment of obese polycystic ovary syndrome with phlegm-damp internal resistance syndrome
		SHAN Ke GAO Hui
		DOI: 10.20047/j.issn1673-7210.2022.29.30
		Objective To explore and analyze the clinical effect of Cangfu Daotan Decoction in the treatment of obesity-type polycystic ovary syndrome (PCOS) with phlegm-damp internal resistance syndrome. Methods A total of 120 obese PCOS patients with phlegm-humidity internal resistance syndrome admitted to Liaocheng Hospital of Traditional Chinese Medicine in Shandong Province from January 2019 to January 2021 were selected and they were divided into observation group and control group according to the random number table method, with 60 cases in each group. The control group was treated with Metformin Hydrochloride Enteric-coated Tablets, on the basis of the control group, the observation group was treated with Cangfu Daotan Decoction, both groups were treated for three months. The clinical efficacy, body mass index (BMI), glucose metabolism index, lipid metabolism index, and ovulation before and after treatment were compared between the two groups. Results The total effective rate and ovulation rate of the observation group were higher than those of the control group (P ＜ 0.05). After treatment, the values of BMI, fasting insulin, fasting blood glucose, total cholesterol, triacylglycerol, and low density lipoprotein cholesterol in the two groups were lower than those before treatment, and observation group were lower than those in the control group, the high density lipoprotein cholesterol was increased than those befere treatment, and the observation group was higher than those in the control group (P ＜ 0.05). Conclusion Cangfu Daotan Decoction in the treatment of obese PCOS with phlegm-damp internal resistance syndrome patients can have a good clinical effect, can effectively reduce the patient’s BMI value, adjust the glucose and lipid metabolism indicators, and can also promote and improve ovulation to a certain extent.
		2022 Vol. 19 (29): 130-133,143 [Abstract] ( 21 ) HTML (1 KB) PDF (742 KB) ( 33 )

	134	Distribution of clinical symptoms and syndrome in enthyroid Hashimoto thyroiditis patients
		XU Shoujing1 QI Shuo2 SHANG Jianwei3 HU Rui3 CHEN Xiaoheng3 YAO Simiao1 DING Zhiguo2
		DOI: 10.20047/j.issn1673-7210.2022.29.31
		Objective To explore the distribution of clinical symptoms and syndrome in enthyroid hashimoto thyroiditis (HT) patients. Methods Enthyroid HT patients treated in the Department of Thyroid, Dongzhimen Hospital and Sun Simiao Hospital of Beijing University of Chinese Medicine from December 2020 to December 2021 were selected, the four diagnosis information of them was collected by traditional Chinese medicine symptom scale, and statistical analysis and cluster analysis were carried out by SPSS software. Results A total of 267 cases of enthyroid HT were collected in this study. After standardizing the name, 52 traditional Chinese medicine symptoms and signs with a frequency of more than 10% were screened. The most common symptoms were irritability (73.03%), fatigue (69.66%), memory loss (62.17%), anxiety (61.80%), pharyngeal foreign body sensation (54.68%), dry mouth (51.31%), palpitation (50.56%), depression and sadness (50.19%), the most common sign was goiter (68.16%); eight tongue signs with frequency greater than 10% were screened, the most common tongue signs were white fur (71.16%), thin fur (61.05%) and teeth-printed tongue (31.09%); three pulse types with frequency greater than 10% were screened,the most common pulse was stringy pulse (34.83%). After cluster analysis, three traditional Chinese medicine syndrome types were obtained: stagnation of liver qi, phlegm-dampness due to spleen deficiency; Stagnation of heat in liver channel, deficiency of spleen and phlegm coagulation; deficiency of spleen and kidney, syndrome of deficiency of both yin and Yang. Conclusion This study shows that enthyroid Hashimoto thyroiditis can be divided into three types: stagnation of liver qi, phlegm-dampness due to spleen deficiency at the beginning; the middle stage of the disease is stagnation of liver qi, syndrome of phlegm-dampness due to spleen deficiency; the disease is characterized by deficiency of spleen and syndrome of kidney and deficiency of both yin and Yang.
		2022 Vol. 19 (29): 134-138 [Abstract] ( 22 ) HTML (1 KB) PDF (1474 KB) ( 254 )

	139	Xie Haizhou’s academic thought of “mental disorders” in treating child autism
		WANG Bo ZHANG Huadong
		DOI: 10.20047/j.issn1673-7210.2022.29.32
		Child autism is a neurological developmental disorder that falls under the category of mental disorders. Professor Xie Haizhou holds that mental disorders are caused by deficiency of kidney essence， deficiency of blood and qi, absence of nourishment, obstruction of phlegm and blood stasis, and obscuring the clearance of consciousness, which have important reference value for the treatment of autism in children. Treatment of the brain is the key to the treatment of autism in children, special treatment measures such as invigorating the kidney, nourishing the qi, nourishing the blood， eliminating phlegm, and removing blood stasis can be applied according to the etiology and pathogenesis of autism. For children with sudden self-mutilation, mania, convulsions, syncope, and other emergencies, priority should be given to the application of drugs to alleviate the emergencies, quickly calm the children’s mind and stabilize their mood, first standard, then both the original and the specimen.
		2022 Vol. 19 (29): 139-143 [Abstract] ( 26 ) HTML (1 KB) PDF (857 KB) ( 107 )

	144	Effect of cardiac rehabilitation training in cardiovascular clinic on cardiac function after pacemaker implantation
		TU Yanmei1 ZHANG Jing2 WANG Qiuchi1▲ ZHU Ye3
		DOI: 10.20047/j.issn1673-7210.2022.29.33
		Objective To explore the effect of cardiac rehabilitation training program in cardiovascular clinic on the improvement of cardiac function after pacemaker implantation. Methods A total of 100 patients who underwent pacemaker implantation in Jiangsu Subei People’s Hospital from January 2018 to January 2021 were selected, the patients with different rehabilitation training data were divided into groups by propensity score matching method. The 42 cases in the control group received routine rehabilitation nursing, and 42 cases in the outpatient group received cardiac rehabilitation training in cardiovascular clinic, they were followed up for three months. Cardiac function, exercise endurance, performance rate of functional exercise, and upper limb mobility were compared between the two groups after implantation. Results The left ventricular ejection fraction and 6-minute walking distance of the outpatient group at three months after operation were higher than those of the day after operation and the control group at three months after operation (P ＜ 0.05). The number of execution days and the implementation rate of functional exercise in the outpatient group were higher than those in the control group (P ＜ 0.05). The angles of extension, forward flexion, external flexion and adduction in the two groups three months after operation were higher than those seven days after operation, and the outpatient group was higher than that in the control group (P ＜ 0.05). Conclusion Cardiac rehabilitation training in cardiovascular clinic for patients after cardiac pacemaker implantation can effectively improve cardiac ejection function, improve exercise endurance and functional exercise execution, and promote upper limb function recovery.
		2022 Vol. 19 (29): 144-147,156 [Abstract] ( 24 ) HTML (1 KB) PDF (695 KB) ( 36 )

	148	Application effect of the concept of enhanced recovery after surgery based on standardized pain management in the intervention of early out-of-bed for elderly patients with hip fracture
		DING Liumin1 GAO Jing2 XU Peilan3
		DOI: 10.20047/j.issn1673-7210.2022.29.34
		Objective To explore the clinical application effect of enhanced recovery after surgery based on standardized pain management in early out-of-bed activities of elderly patients with hip fracture. Methods According to the principle of randomized controlled study, 84 elderly patients with hip fracture peformed artificial hip replacement in Xinjiang Uygur Autonomous Region People’s Hospital from January 2019 to December 2020 were selected and divided into control group and observation group by random number table method, with 42 cases in each group. The control group was given standardized pain management nursing, and the observation group was given the early out-of-bed intervention of concept of enhanced recovery after surgery based on standardized pain management in the control group. The visual analogue scores before operation, the day after surgery, the 1st, 3rd, 5th day, and the one week after surgery; the changes of hip function score before operation, two weeks, one month and three months after operation; first time out of bed, mean length of hospital stay, satisfaction and complications were compared between the two groups. Results The pain scores of the two groups before operation, postoperative the 1st, 3rd, 5th and one week after operation were compared. The overall analysis showed that there were statistically significant differences in the comparison between groups, time points and interaction (P ＜ 0.05). There were statistically significant differences between the two groups at each time point (P ＜ 0.05), and the visual analogue scores of the observation group were lower than those of the control group at each time point after surgery, and the differences were statistically significant (P ＜ 0.05). The hip function scores of the two groups before operation, two weeks, one month, and three months after operation were compared. The overall analysis showed that there were statistically significant differences in the comparison between groups, time points and interaction (P ＜ 0.05). Further pairwise comparison showed that there were significant differences between the two groups at each time point(P ＜ 0.05), the change of hip function scores at each time point after surgery in the observation group was higher than that in the control group, and the differences were statistically significant(P ＜ 0.05). The first time out of bed and the average length of hospital stay in the observation group were lower than those in the control group, the satisfaction was higher than that in the control group, and the total incidence of complications such as constipation, pulmonary infection, urinary tract infection and deep vein thrombosis of lower limbs was lower than that in the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Enhanced recovery after surgery based on pain management can reduce pain in elderly patients with hip fracture, shorten the first time of getting out of bed, improve hip function, reduce the incidence of postoperative complications, and promote early rehabilitation after joint replacement.
		2022 Vol. 19 (29): 148-152,178 [Abstract] ( 25 ) HTML (1 KB) PDF (864 KB) ( 38 )

	153	Effect of touch care combined with white noise intervention on neonatal sleep and nervous system development
		FU Jia CHENG Gongmei FAN Rui▲ JIN Na HE Jiaojiao YAN Jie
		DOI: 10.20047/j.issn1673-7210.2022.29.35
		Objective To explore the effect of touch care combined with white noise intervention on neonatal sleep and nervous system development. Methods A total of 92 newborns in Department of Pediatric, Xijing Hospital, the First Affiliated Hospital of Air Force Military Medical University of the Chinese People’s Liberation Army from July 2019 to December 2021 were selected. The patients were divided into experimental group and control group, with 46 newborns in each group. The control group received white noise intervention, and the experimental group received touch care on the basis of control group. The sleep quality, growth and development, and neurobehavior of two groups were compared. Results After the intervention, the crying times of two groups were less than those before intervention, and those in experimental group was less than those in control group (P < 0.05); the maximum duration of crying in two groups were shorter than that before intervention, and that in experimental group was shorter than that in control group (P < 0.05). The body length, body weight, and head circumference of two groups were greater than those before intervention, and those in experimental group were greater than those in control group (P < 0.05). The scores of active muscle tension, behavioral ability, passive muscle tension, original reflex, and general response in two groups were higher than those before intervention, and those in experimental group were higher than those in control group (P < 0.05). Conclusion Touch care combined with white noise intervention can improve the growth and development of newborns, and improve sleep quality and neural behavior of newborns.
		2022 Vol. 19 (29): 153-156 [Abstract] ( 24 ) HTML (1 KB) PDF (557 KB) ( 61 )

	157	Application of different supine positions in ventilation therapy for acute exacerbation of chronic obstructive pulmonary disease
		DU Fengyan ZHANG Yun WANG Dongli LU Yumei▲
		DOI: 10.20047/j.issn1673-7210.2022.29.36
		Objective To explore the application of different supine positions in the ventilation treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods A total of 102 AECOPD patients who received mechanical ventilation in Nantong Third People’s Hospital of Jiangsu Province from July 2017 to June 2020 were selected. The patients were divided into control group and observation group by random number table method, with 51 cases in each group. Both groups were given routine mechanical ventilation nursing, while the control group was given conventional supine position intervention, and the observation group was given prone position ventilation position intervention. The differences between the two groups of oxygenation index (PaO2/FiO2), pH value, positive end-expiratory pressure (PEEP), dynamic lung compliance (Cdyn), and the degree of recovery were observed and compared before and after the intervention for 72 h. Results After 72 h of intervention, the PEEP and Cdyn of the two groups were higher than those before the intervention, while those of the observation group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). After 72 h of intervention, the PaO2/FiO2 and pH values of the observation group were higher than those before the intervention, while those of the observation group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). After 72 h of intervention, the acute physiology and chronic health evaluation score system score of the observation group was lower than that before the intervention, while the observation group was lower than the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Mechanical ventilation in prone position can improve oxygenation index and blood gas analysis value, significantly improve lung compliance, and reduce the severity of the patient’s condition.
		2022 Vol. 19 (29): 157-160 [Abstract] ( 19 ) HTML (1 KB) PDF (559 KB) ( 18 )

	161	Application effect of incentive nursing intervention in patients undergoing endoscopic variceal ligation
		JIN Xiaoxiao WU Jianjiang WANG Huiqin
		DOI: 10.20047/j.issn1673-7210.2022.29.37
		Objective To evaluate the application effect of incentive nursing intervention in patients who received endoscopic variceal ligation. Methods A total of 106 patients with moderate to severe esophageal varices admitted to the First Affiliated Hospital Xinjiang Medical University from October 2019 to October 2020 were included, and all patients received endoscopic variceal ligation. Patients were divided into incentive group (53 cases) and control group (53 cases) by random number table method, the control group was given traditional nursing mode, while the incentive group was given incentive nursing mode. The scores of self-rating anxiety scale (SAS), self-rating depression scale (SDS), Memorial University of Newfoundland happiness (MUNSH) scale, and quality of life questionnaire (QLQ-C30) were compared between the two groups. Results After nursing, the scores of SDS and SAS in the two groups were lower than those before nursing, and the incentive group was lower than the control group (P ＜ 0.05). The MUNSH scale scores of the two groups were higher than those before nursing, and the incentive group were higher than those of the control group (P ＜ 0.05). The improvement levels of the five quality of life indicators of the QLQ-C30 scale in the two groups were higher than those before nursing, and the score of the incentive group was higher than that of the control group (P ＜ 0.05). Conclusion For these patients undergoing endoscopic variceal ligation, the use of incentive intervention can enhance self-awareness and happiness, improve their negative emotions, promote the improvement of treatment confidence, and improve their quality of survival, which has further clinical value.
		2022 Vol. 19 (29): 161-164 [Abstract] ( 20 ) HTML (1 KB) PDF (573 KB) ( 74 )

	165	Effect of optimized nutritional pathway on gastrointestinal function and immune indexes after colorectal cancer surgery
		XIONG Lancai LUO Jiong XU Xiaowei
		DOI: 10.20047/j.issn1673-7210.2022.29.38
		Objective To investigate the effect of optimized nutritional pathway on gastrointestinal function and immune indexes after colorectal cancer (CRC) surgery. Methods A total of 136 patients with CRC who underwent radical resection in the First People’s Hospital of Lianyungang, Jiangsu Province from April 2018 to May 2021 were selected. According to the random number table method, the patients were divided into routine group (n = 68, with routine nutritional care) and optimization group (n = 68, with optimized nutritional path), the recovery time of gastrointestinal function, immune indexes, postoperative nutritional risk score, and incidence of complications were compared between the two groups. Results The time of bowel sounds, time of first anal exhaust, time of first defecation, time of first eating, time of resuming normal eating, and incidence of complications in the optimization group were lower than those in the conventional group (P ＜ 0.05). The levels of CD4+, CD8+, and CD4+/CD8+ in the two groups at seven days postoperative were lower than those at one day before operation, and the levels of CD4+ and CD4+/CD8+ in the optimization group were higher than those in the conventional group, and the level of CD8+ was lower than that in the conventional group (P ＜ 0.05). The nutritional risk scores of the two groups at seven days after operation were lower than those at enrollent, and the optimization group was lower than the conventional group (P ＜ 0.05). Conclusion The optimized nutritional pathway in CRC is helpful to improve gastrointestinal function, immune indicators and nutritional level, and reduce the risk of postoperative complications.
		2022 Vol. 19 (29): 165-168 [Abstract] ( 12 ) HTML (1 KB) PDF (543 KB) ( 71 )

	169	Application effect of improved cluster nursing in patients with chronic obstructive pulmonary disease and respiratory failure
		LIN Huan JI Ting▲
		DOI: 10.20047/j.issn1673-7210.2022.29.39
		Objective To explore the role of improved cluster nursing in patients with chronic obstructive pulmonary disease and respiratory failure. Methods A total of 84 patients with chronic obstructive pulmonary disease and respiratory failure admitted to Nanjing First Hospital from July 2020 to July 2021 were selected. They were divided into routine group (42 cases, routine nursing) and study group (42 patients, routine + improved cluster nursing) by random number table method. The nursing comfort level, hospital anxiety and depression scale (HADS) score, quality of life measurement scale (QLQ-30), nursing adverse events, and Newcastle satisfaction with nursing scale (NSNS) score were compared between the two groups. Results The nursing comfort level and NSNS score of the study group were higher than those of the routine group, and the differences were statistically significant (P ＜ 0.05). After nursing, the HADS scale scores of the two groups were lower than those before nursing, while that of the research group was lower than that of the routine group, and the differences were statistically significant (P ＜ 0.05). After nursing, the QLQ-30 scores of the two groups were higher than those before nursing, while that of the research group was higher than that of the routine group, and the differences were statistically significant (P ＜ 0.05). The total incidence of nursing adverse events in the study group was lower than that in the routine group, and the difference was statistically significant (P ＜ 0.05). Conclusion Improved bundled care is beneficial for improving patient comfort, quality of life and satisfaction, and is also safe.
		2022 Vol. 19 (29): 169-172 [Abstract] ( 22 ) HTML (1 KB) PDF (552 KB) ( 62 )

	173	Effects of discharge preparation service strategy combined with personalized nursing management mode on discharge guidance quality, discharge readiness, and psychological state of IBD patients
		SU Miaomiao1 LIU Jun1 LIU Jie2 LIU Hui1▲
		DOI: 10.20047/j.issn1673-7210.2022.29.40
		Objective To explore the effects of discharge preparation service strategy combined with personalized nursing management mode on discharge guidance quality, discharge readiness, and psychological state of inflammatory bowel disease (IBD) patients. Methods A total of 200 IBD patients admitted to the First Affiliated Hospital of Military Medical University of the Chinese People’s Liberation Army from October 2018 to March 2021 were selected as the research objects. According to the random number table method, they were divided into control group and observation group, with 100 cases in each group. The control group adopted the personalized nursing management mode intervention, and the observation group adopted the discharge preparation service strategy on this basis. The discharge guidance quality, discharge readiness, self-rating anxiety scale (SAS), and self-rating depression scale (SDS) of two groups were compared. Results After intervention, the scores of instruction content and instruction skills in two groups were higher than those before intervention, and those in observation group were higher than those in control group (P < 0.05). The scores of self condition, disease knowledge, coping ability, and social support in two groups were higher than those before intervention, and those in observation group were higher than those in control group (P < 0.05). The scores of SAS and SDS of two groups were lower than those before intervention, and those in observation group were lower than those in control group (P < 0.05). Conclusion The application of discharge preparation service strategy combined with personalized nursing management mode in IBD patients can improve the quality of discharge guidance, discharge readiness and psychological state, which is worthy of promotion.
		2022 Vol. 19 (29): 173-176 [Abstract] ( 26 ) HTML (1 KB) PDF (549 KB) ( 23 )

	177	Intervention effect of humanistic care theory in nursing of patients with enhanced MRI examination
		PANG Yanhong MA Jiaqin TANG Donge
		DOI: 10.20047/j.issn1673-7210.2022.29.41
		Objective To explore the intervention effect of humanistic care theory in nursing of patients with enhanced magnetic resonance imaging (MRI) examination. Methods A total of 100 patients who underwent enhanced MRI examination in Bozhou People’s Hospital of Anhui Province were selected, including 49 patients who were examined from February 2020 to February 2021 as the control group, and 51 patients who were examined from March 2021 to March 2022 as the observation group. The control group adopted routine nursing, and the observation group adopted humanistic care theory. The scores of self-rating depression scale (SDS) and self-rating anxiety scale (SAS) before and after nursing were compared; the coordination and image quality of two groups were compared. Results After nursing, the SAS and SDS scores of two groups were lower than those after nursing, and those in observation group were lower than those in control group, and the differences were statistically significant (P < 0.05). The coordination of observation group was better than that of control group, and the difference was statistically significant (P < 0.05). The image pass rate of observation group was higher than that of control group, and the difference was statistically significant (P < 0.05). Conclusion Humanistic care intervention for patients receiving enhanced MRI examination can improve the coordination of patients, reduce anxiety, depression, and other emotions.
		2022 Vol. 19 (29): 177-180 [Abstract] ( 21 ) HTML (1 KB) PDF (574 KB) ( 32 )

	181	A case report of resorption of lumbar disc herniation
		ZHOU You1 FENG Minshan2 HAN Tao2 YUE Guang3 PAN Junjun4 ZHU Liguo2▲
		DOI: 10.20047/j.issn1673-7210.2022.29.42
		With the progress of imaging technology, the phenomenon of lumbar disc herniation and reabsorption has been paid attention to by peers in the industry. Its clinical presentation is also different. At present, two different clinical manifestations of intervertebral discs at different lumbar levels in the same patient are rarely reported. The patient presented to the clinic because of recurrent low back pain and cold sensation in the left lower extremity. Imaging data showed that the L3-4 huge prolapse occurred significant reabsorption phenomenon, and the L4-5 protrusion calcified. After diagnosis of lumbar disc herniation, the patient was treated with Chinese medicine Spinal Ⅱ Prescription orally, and the symptoms were significantly improved. Through the analysis of this case, this paper reveals the influence of the shape of herniated intervertebral disc and its surrounding environment on the reabsorption, deepen the understanding of the diversity and complexity of the phenomenon of intervertebral disc reabsorption, and explore the effective treatment plan of traditional Chinese medicine conservative treatment for the possible reabsorption phenomenon in lumbar intervertebral disc herniation.
		2022 Vol. 19 (29): 181-184 [Abstract] ( 24 ) HTML (1 KB) PDF (1206 KB) ( 107 )

	185	Experience report of a case of Charcot joint treated with artificial knee arthroplasty
		XU Yilang1 XU Shuchai2 HUANG Shunying1 LIU Yan2 CHENG Zhian2
		DOI: 10.20047/j.issn1673-7210.2022.29.43
		Charcot arthropathy is a chronic progressive joint disease caused by nociceptive loss secondary to neurological disorders, it is a group of rare clinical diseases characterized by sensory, motor, and autonomic nerve damage, severe joint destruction, instability, and osteoporosis. In this paper, a patient with Charcot joint underwent artificial knee arthroplasty in Guangdong Hospital of Traditional Chinese Medicine due to “knee pain with limited mobility”, postoperative complications such as “periprosthetic fracture” and “periprosthetic infection” occurred. After prosthesis revision, extension of external fixation time, strengthening anti-infection, and other treatments, satisfactory results are obtained. This article summarizes the key points of Charcot joint surgery and postoperative rehabilitation through case review, in order to improve clinicians’ understanding of Charcot joint.
		2022 Vol. 19 (29): 185-188 [Abstract] ( 13 ) HTML (1 KB) PDF (1407 KB) ( 57 )

	189	Investigate the research status of sicca syndrome based on National Natural Science Foundation of China
		GUO Zilin1 TANG Xiaopo1▲ ZHOU Xinyao1 XU Haodong1 LI Yanting1 ZHANG Yi2
		DOI: 10.20047/j.issn1673-7210.2022.29.44
		Objective To analyze the research status and improvement direction based on the funding of sicca syndrome (SS) project by National Natural Science Foundation of China (NSFC). Methods From January 2000 to December 2021, all funded projects with SS in their titles, abstracts or keywords were collected from the NSFC website, Mace Medical, LetPub, and Home for researchers. Information such as project type, funding amount, supporting unit, responsible person, discipline code, keywords, and achievement transformation were extracted and analyzed by descriptive statistical method. Results From 2000 to 2021, NSFC funded 88 SS projects, including general projects, youth science funds projects, regional science funds projects, and emergency management projects. In 2003, the SS field received NSFC funding for the first time. Since then, although the number and funding of the projects had fluctuated, the overall trend was on the rise. From 2010 to 2019, the number, amount, and achievement transformation of SS funded projects were lower than those of rheumatoid arthritis and systemic lupus erythematosus. Among the 11 supporting institutions that had approved projects more than three times, Peking University was in the leading position in terms of the number of approved projects and funding. The research direction of SS project was wide, and the angle of entry was diverse. The keywords was repetition rate low, and the high-frequency terms were cell, cytokine, and pathway. Conclusion NSFC funding is of great significance to SS, but the current clinical demand is large, and the advantages of traditional Chinese medicine are not fully reflected. In the future, it should pay attention to innovation and multidisciplinary intersection, implement the guideline consensus and big data platform as soon as possible, and lead the development of SS clinical research.
		2022 Vol. 19 (29): 189-192，封三 [Abstract] ( 18 ) HTML (1 KB) PDF (1761 KB) ( 90 )

	193	Progress and future prospects of diagnosis-related groups in China during “the 13th Five-Year Plan” to deepen the reform of the medical system
		TANG Jiaji
		DOI: 10.20047/j.issn1673-7210.2022.29.45
		During the “13th Five-Year Plan” period of medical reform, Chinese diagnosis-related groups (DRG) payment system reform achieved remarkable pilot results, and eight mainstream diagnosis-related groups (DRG) versions appeared successively. As a master, China healthcare security diagnosis related groups has initially formed a DRG payment system with Chinese characteristics. In the future, it needs to consolidate the coding system to help improve the grouping scheme, and strengthen the design of supporting system and the construction of evaluation system. DIP payment will coordinate with DRG to promote the reform and expansion of payment methods. Public hospitals should effectively develop and utilize DRG tools, strengthen cost awareness, and make concerted efforts in medical insurance management, performance management, medical management, nursing management, etc., so as to stimulate clinical endogenous dynamics and form a DRG-based three-dimensional hospital management system supported by information technology.
		2022 Vol. 19 (29): 193-封三 [Abstract] ( 23 ) HTML (1 KB) PDF (664 KB) ( 164 )

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