啤酒花活性成分黄腐酚治疗骨质疏松症的机制研究进展

doi:10.20047/j.issn1673-7210.2022.29.07

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Abstract Xanthohumol (XN) is a special flavonoid in hops, which can promote osteoblast differentiation and inhibit osteocbast (OB) differentiation, and regulate osteoclast (OC) metabolism. In this paper, literatures related to the involvement of xanthohumol in OB and OC differentiation and related signal pathways were analyzed by searching CNKI, VIP, Wanfang, PubMed and other databases in the last 10 years. The results showed that XN could up-regulate the expression of Runx2 and promote the proliferation and differentiation of OB. In addition, the expression of PPARγ was down-regulated, and the differentiation of adipocytes was inhibited, thus regulating the balance of osteogenic and adipogenic differentiation. Meanwhile, XN can also promote the production of antioxidants in vivo by up-regulating Nrf2 expression, thus reducing the damage of oxidative stress to OB. In addition, XN inhibited NF-κB, Ca2+/NFATc1, MAPK and other pathways, and inhibited OC differentiation and maturation. This review further clarified the mechanism of XN regulating bone metabolism, and provided a new target for the development of drugs for the prevention and treatment of osteoporosis.

Key words： Xanthohumol Osteoporosis Osteoblast Osteoclast Mechanism

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	ZHAO Yifan1 LIU Tianpeng1 ZHAO Shaochuan1 RUI Chen1 YANG Feng2

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ZHAO Yifan1 LIU Tianpeng1 ZHAO Shaochuan1 RUI Chen1 YANG Feng2. Research progress on the mechanism of xanthohumol, the active ingredient of hops, in the treatment of osteoporosis[J]. 中国医药导报, 2022, 19(29): 34-37,45.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2022.29.07 OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I29/34

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