中国医药导报

关闭×

中国医药导报

Home

中文

中国医药导报

Forthcoming Articles

Advanced Search

Download Articles

Quick Search


2022 Vol. 19, No. 1 Published: 2022-01-05

	5	Study of curcumin-loaded targeted liposomes in the treatment of myocardial infarction#br#
		HU Dandan YANG Zhihao GAO Yali JIANG Lei WANG Na LIU Xiaoying
		Objective To construction of curcumin-loaded myocardial infarction targeted liposomes (cT-Cur-LIP) modified with anti-cTnI antibody to improve the therapeutic effect of myocardial infarction. Methods The film dispersion method was used to prepare cT-Cur-LIP; the Malvern laser particle size analyzer was used for preparation characterization; the in vitro experiment verified the uptake of cT-Cur-LIP, and the in vivo experiment verified the therapeutic effect of cT-Cur-LIP on myocardial infarction. Results The surface of the prepared cT-Cur-LIP was round and oval. In vitro results showed that the uptake of cT-Cur-LIP was higher than that of Cur and Cur-LIP, and the difference was statistically significant (P ＜ 0.05). In vivo results proved that in the cT-Cur-LIP group, the fibers of cardiomyocytes were arranged uniformly, and the horizontal cytoplasmic stripes were clear, but the local horizontal stripes disappeared. Conclusion cT-Cur-LIP nano-targeted liposomes can effectively target hypoxic myocardium and provide new ideas for the treatment of myocardial infarction.
		2022 Vol. 19 (1): 5-8 [Abstract] ( 95 ) HTML (1 KB) PDF (1288 KB) ( 120 )

	9	Effect of LR12 peptide on intestinal injury in neonatal mice with necrotic enterocolitis by regulating TLR-4/NF-κB signaling pathways#br#
		ZHAN Caixia LIAO Zhenyu HUANG Ruiwen LIU Yinzhi YANG Hui
		Objective To investigate the mechanism of LR12 peptide on intestinal damage in necrotic enterocolitis (NEC) in neonatal mice. Methods A total of 18 SPF C57BL/6 mice (6 females, 12 males), 8 weeks, weight 16-23 g. Sixty pups born after the female rat pregnancy, they were divided into control group, model group, LR12-scr group and LR12 group according to random number table method, with 15 pups in each group. The control group did not take any operation, and the other three groups established NEC model. After successful model construction, lR12-scr group was intraperitoneally injected with 5 mg/kg LR12 scramble, LR12 group was intraperitoneally injected with 5 mg/kg LR12 peptide, control group and model group were intraperitoneally injected with equal dose of solvent once a day for consecutive three days. The indexes of young rats in each group were compared. Results Compared with the control group, clinical symptom score, intestinal histopathological score, the intestinal permeability, the levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β and IL-6 and the protein expressions levels of triggering receptor expressed on myeloid cells-1, TLR-4, MyD88, and NF-κB p65 were increased in the model group, while weight and the expression levels of IκBα were dereased, the differences were statistically significant (P ＜ 0.05). Compared with the model group, clinical symptom score, intestinal histopathological score, the intestinal permeability, the levels of TNF-α, IL-1β, and IL-6 and the protein expression levels of TREM1, TLR-4, MyD88, and NF-κB p65 were decreased in the LR12 group, while weight and the expression level of IκBα were increased, the differences were statistically significant (P ＜ 0.05). There were no statistical signficances in the above indicators between LR12-scr group and model group (P ＞ 0.05). Conclusion LR12 peptide has improved intestinal permeability, reduced intestinal inflammation and injury in NEC neonatal mice, and the mechanism may be related to inhibiting TLR-4/NF-κB signaling pathway activation.
		2022 Vol. 19 (1): 9-12,22 [Abstract] ( 55 ) HTML (1 KB) PDF (936 KB) ( 134 )

	13	Application of multiple linear regression based on LASSO in the prediction model of learning and memory ability in vascular dementia rats#br#
		WANG Yifan XU Hui LEI Guiyue HUANG Xin TIAN Yinkui MENG Nana ZHU Kunjie
		Medical University, Heilongjiang Province, Qiqihar 161000, China [Abstract] Objective To explore a method to predict the learning and memory ability of rats with vascular dementia (VD) by constructing a multiple linear regression model based on LASSO. Methods Forty male clean grade SD rats aged three to five months, weighing (175±25)g, were divided into model group and sham operation group by random number table method with 20 rats in each group. Random number table method was used to select five rats from each group for prediction model validation, and 15 rats from each group for prediction model establishment. The model group was prepared by bilateral common carotid artery occlusion in stages. The common carotid artery was not ligated after isolated in the sham operation group. Morris water maze was used to detect the learning and memory ability (latency) of rats. After 12 weeks of modeling, 42 blood biochemical indexes such as total protein, total bile acid and total cholesterol were detected. The multiple linear regression model between latency and blood biochemical indexes was initially established and the model was tested for multicollinearity. LASSO regression was used to screen the predictors of blood biochemical indexes to further improve the model, and the error rate was calculated to verify the feasibility of the model. Results Compared with sham operation group, latency of model group was significantly prolonged (P ＜ 0.05). Variance inflation factor values of total protein, total bile acid, total cholesterol, and other 26 indexes were more than 10, indicating multicollinearity of the model. LASSO regression screened ten indexes such as total bilirubin, triglyceride, and cholinesterase, and established multiple linear regression model of latency: W = 51.887-0.384x1-0.104x2-0.154x3-4.988x4-1157.079x5-7.308x6+7.639x7+0.183x8-0.025x9+34.528x10 (x1: total protein; x2: total bile acid; x3: total bilirubin; x4: total cholesterol; x5: apolipoprotein A; x6: high density lipoprotein cholesterol; x7: triglyceride; x8: carbon dioxide; x9: cholinesterase; x10: immunoglobulin M) Model correlation coefficient R = 0.852, goodness of fit R2 = 0.725, regression model statistical value F = 5.016, significance P = 0.001, error rate was less than 5%. Conclusion The mathematical prediction model of ten blood biochemical characteristics and latency period established in this study has an obvious linear relationship and a high degree of fitting, which can not only assist in judging the success of replication of experimental VD animal model, but also provide a convenient and fast detection, which is expected to provide a reference for early prediction and intervention of clinical VD patients.
		2022 Vol. 19 (1): 13-17,26 [Abstract] ( 38 ) HTML (1 KB) PDF (888 KB) ( 153 )

	18	Effect and mechanism of miR-195 regulates on proliferation and apoptosis of human breast cancer MCF-7 cells#br#
		LIU Jiaqi1 ZHAI Fengguo1 GAO Jinxia2 LIU Jiawei3 YANG Xudong1 ZHOU Fubo1 LI Mengquan4▲
		Objective To explore the role and mechanism of miR-195 in regulating proliferation and apoptosis of human breast cancer MCF-7 cells (MCF-7). Methods Breast epithelial cells MCF-10A (MCF-10A) and MCF-7 were cultured in vitro. The expression of miR-195 was detected by qRT-PCR. Protein expression of phosphatase magnesium-dependent 1 delta (PPM1D) was detected by Western blot (WB). Transient transfection of MCF-7 was carried out. 3-(4,5- two methyl thiazole -2)-2,5- two phenyl tetrazolium bromide (MTT) method and DNA breakage TdT-mediated-duTP nick end labeling method were used to observe the effect of miR-195 on proliferation and apoptosis of MCF-7. Double luciferase reporter genes were used to verify the relationship between miR-195 and PPM1D. Results The expression of miR-195 in MCF-7 group was lower than that in MCF-10A group, the expression of PPM1D protein in MCF-7 group was higher than that in MCF-10A group, the differences were statistically significant (P ＜ 0.05). The cell viability of miR-195 mimics group was lower than MCF-7 group; miR-195 inhabitor group was higher than MCF-7 group, the differences were highly statistically significant (P ＜ 0.01). The apoptosis rate of miR-195 mimics group was higher than MCF-7 group, the difference was highly statistically significant (P ＜ 0.01); and miR-195 inhabitor group was lower than MCF-7 group, the difference was statistically significant (P ＜ 0.05). Double luciferase reporter gene showed that miR-195 mimics group, which carried the PPM1D gene fragment, the activity of luciferase was lower than MCF-7 group , the difference was statistically significant (P ＜ 0.01). There was no significant difference in luciferase activity between the mir-195 MIMics group containing the mutated PPM1D gene fragment and McF-7 group (P ＞ 0.05). Conclusion miR-195 may regulate the proliferation and apoptosis of breast cancer cells through targeting PPM1D.
		2022 Vol. 19 (1): 18-22 [Abstract] ( 138 ) HTML (1 KB) PDF (1023 KB) ( 128 )

	23	Protective effects of flavonoid of Fructus Kochiae on Paracetamol-induced acute liver injury in mice#br#
		ZHENG Yi LI Hui WU Jin WANG Fang WU Jia CAI Pei
		Objective To observe the protective effects of flavonoid of Fructus Kochiae (FFK) on Paracetamol-induced acute liver injury in mice. Methods Thirty-six one-month old SPF Kunming mice with body weight of (20±2) g were selected, male and female half, they were divided into FFK low-dose, medium-dose, and high-dose groups (75, 150, 300 mg/kg) and positive control group (Bifendate, 150 mg/kg), blank control group (equal amount of normal saline), and Paracetamol model group (equal amount of normal saline), with six mice in each group. After seven days of continuous intragastric administration, the blank control group was intraperitoneally injected with normal saline (0.1 ml/10 g), and the other groups were intraperitoneally injected with Paracetamol (350 mg/kg) to establish acute liver injury model. After 24 hours, glutamic-pyruvic transaminase (GPT) and glutamic-oxaloacetic transaminase (GOT) levels in serum and the contents of lipid peroxides malondialdehyde (MDA) and superoxide dismutase (SOD) in liver tissues were detected, and the histopathological changes of liver tissues were observed by hematoxylin-eosin (HE) staining. Results The GPT, GOT, and MDA in Paracetamol model group were higher than those in blank control group, while SOD was lower than blank control group, the differences were highly statistically significant (P ＜ 0.01). There was no significant difference between FFK low-dose group and Paracetamol model group (P ＞ 0.05). The GPT, GOT and MDA in medium-dose and high-dose FFK groups were lower than those in Paracetamol model group and low-dose FFK group, while SOD was higher than those in Paracetamol model group and low-dose FFK group, with statistical significance (P ＜ 0.05). HE staining results of pathological sections showed different degrees of liver injury in all groups except blank control group. Conclusion A certain does of FFK has a good protective effect on Paracetamol-induced acute liver injury in mice, and its ability to enhance SOD activity in liver tissue and reduce MDA accumulation may be one of the mechanisms of its liver-protecting and lowering enzymes.
		2022 Vol. 19 (1): 23-26 [Abstract] ( 26 ) HTML (1 KB) PDF (1013 KB) ( 22 )

	27	Extraction technology of optimizing Compound Yishen Lishi Granules with orthogonal test method#br#
		QIN Xinhua1 CHEN Juan2 LI Yan1 YOU Pan1 HU Chuanyi2
		Objective To optimize the extraction technology of Compound Yishen Lishi Granules. Methods Single factor and L9(34) orthogonal test were used to optimize the extraction technology of Compound Yishen Lishi Granules. The total flavonoids content, Radix Dipsaci saponin Ⅵ content, naringin content, neohesperidin content and the comprehensive score of extract rate were determined by ultraviolet-visible spectrophotometry and high performance liquid chromatograph, amount of solvent added, the extraction time and times were optimized. Results The optimal extraction process was as follows: addied eight times of water, soaked for 30 minutes, extracted three times, one hour each time. Conclusion The extraction process establishes by this study is stable and feasible, and the quality is controllable, which lays a foundation for the further development of Yishen Lishi Granules.
		2022 Vol. 19 (1): 27-31 [Abstract] ( 38 ) HTML (1 KB) PDF (864 KB) ( 65 )

	32	Effect of androgen on inflammatory response of stromal cells in patients with benign prostatic hyperplasia#br#
		REN Chao YI Faxian HUANG Yong ZHU Xiaojun LI Jianhong
		Objective To investigate the effect of Dihydrotestosterone (DHT) on prostatic stromal cell inflammation in aged benign prostatic hyperplasia (BPH) patients. Methods A total of 20 patients who underwent transurethral resection prostate in the Department of Urology, Affiliated Hospital of Inner Mongolia Medical University from January 2016 to May 2017 were collected. Primary prostatic stromal cells were cultured by tissue block method. The expression of Cytokeratin, Desmin, Vimentin and α -smooth muscle actin (α-SMA) in cultured stromal cells of the third generation were determined by immunohistochemical staining. The third generation of cells were cultured in the same size petri dishes and named as blank group, control group and experimental group. Culture medium with the same concentration and dose was added to the blank group. The control group and experimental group were added with tumor necrosis factor-α (TNF-α) 10 ng/ml, 30 nmol/L DHT was added in the experimental group 5 h later. Then co-culture for 24 h, take 100 μl supernatant from three groups, with 4 rewells in each group. The concentrations of interleukin (IL)-6, IL-8, monocyte chemotactic protein-1 (MCP-1) and basic fibroblast growth factor (bFGF) in each group were detected by enzyme-linked immunosorbent assay. Results Primary prostatic interstitial cells were cultured in vitro. Cytokeratin and Desmin were negatively expressed in the third generation of prostatic interbasal cells. Vimentin and α-SMA were positive. The concentrations of IL-6, IL-8, MCP-1, and bFGF in the control group were higher than those in the blank group, the differences were statistically significant (P ＜ 0.05), while the concentrations of IL-6, IL-8, MCP-1 and bFGF in the experimental group were lower than those in the control group, the differences were statistically significant (P ＜ 0.05). Conclusion DHT has a direct anti-inflammatory effect on prostatic interstitial cells in aged patients with prostatic hyperplasia.
		2022 Vol. 19 (1): 32-34,43 [Abstract] ( 35 ) HTML (1 KB) PDF (831 KB) ( 45 )

	35	Determination of Fluconazole concentration in neonatal plasma by ultra performance liquid chromatography-tandem mass spectrometry#br#
		QIN Dongjie1* LI Ping2* WU Jing1 LIANG Jing3 WEI Yanfei3 JIANG Yongjiang3 YU Qiaoai4 HE Jing2 WANG Honghong2
		Objective To establish a method for rapid determination of Fluconazole concentration in neonatal plasma. Methods Plasma was treated with acetonitrile precipitated protein with phenacetin as internal standard. Chromatographic column: Eclipse Plus C18 RRHD (2.1 mm×100 mm, 1.8 μm); mobile phase: gradient elution of 0.1% formic acid-methanol; flow rate: 0.3 ml/min; injection volume: 1 μl. Electrochemical spray ion source positive ion mode ionization, multi-reaction monitoring mode detection, quantitative analyse the ionization pairs as mass-to-charge ratio (m/z) 307.1→220.0 (Fluconazole) and m/z 180.1→110.0 (phenacetin). Results The method had a good linearity in the range of 0.1001-60.0600 μg/ml, the lower limit of quantification was 0.01 μg/ml, the accuracy were 82.5%-101.2%, and the extraction recoveries were 85.0%-109.0%. Conclusion The method is simple, rapid, accurate, and high sensitive, suitable for determination of Fluconazole concentration in neonatal plasma.
		2022 Vol. 19 (1): 35-38,55 [Abstract] ( 38 ) HTML (1 KB) PDF (1008 KB) ( 68 )

	39	Research progress on the correlation between tumor stem cells and EGFR-TKI resistance mechanism of lung adenocarcinoma#br#
		CHEN Yu1 CHEN Jie2 LI Yajun1▲
		Lung cancer is currently the malignant tumor with the fastest increase in morbidity and mortality. Among them, the epidermal growth factor receptor (EGFR) mutation rate of adenocarcinoma accounts for the highest proportion of lung cancer patients. For such patients, epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) targeted therapy is its main treatment method, which can effectively inhibit the growth of tumor cells with EGFR sensitive mutations. However, acquired drug resistance severely restricts the use of such drugs. Cancer stem cells (CSC) are small part of cells that exist in tumor tissues, which can promote tumor cell growth, invasion and migration, multidirectional differentiation, and resistance to radiotherapy and chemotherapy. The specific targeting of CSC combined with conventional chemotherapy may achieve the goal of stabilizing remission or curing tumors. Therefore, this article reviews recent research progress in the mechanism of acquired drug resistance of CSC and lung adenocarcinoma EGFR-TKI, and provides new strategies and directions for future research.
		2022 Vol. 19 (1): 39-43 [Abstract] ( 98 ) HTML (1 KB) PDF (569 KB) ( 126 )

	44	Research progress of new biomarkers related to acute renal injury#br#
		YUAN Daochuan GONG Xuezhong LIU Jianlian WANG Danjun LI Tonglu
		The incidence of acute renal injury (AKI) is high and critical in clinic, clinically the early diagnosis of AKI based on serum creatinine and urine volume is delayed and insufficient. Clinically, biomarkers with high sensitivity and specificity are needed to facilitate the early diagnosis of AKI, so that measures can be taken to reduce renal injury and protect renal function. Some novel biomarkers closely related to the pathogenesis of AKI are gradually being used for early identification, clinical monitoring and prognosis assessment of AKI. This article focuses on the biological functions, research status and application prospects of AKI-related biomarkers discovered in recent years, such as interleukin 24, liver-type fatty acid binding protein, chitinase 3-like protein 1, microRNA, PARK7, and CDH16.
		2022 Vol. 19 (1): 44-47 [Abstract] ( 131 ) HTML (1 KB) PDF (551 KB) ( 70 )

	48	Research progress on the related structure and function of astrocytes in migraine#br#
		LI Zhijuan LIU Lu LI Bin
		Migraine is a common disability disease in clinic, and its pathogenesis is complicated. Pain hypersensitivity is a reaction of central sensitization. With the deepening of research, glial cells play an important role in the occurrence and development of pain, and astrocytes have a strong activation response in the development and persistence of pain. Astrocytes participate in the occurrence and development of migraine through gap junctions, intersynaptic glutamate, transporters, and inhibition of cortical spreading. This article summarizes the relationship between the structure and function of astrocytes and migraine, and provides a new direction for the research and treatment of migraine.
		2022 Vol. 19 (1): 48-51 [Abstract] ( 115 ) HTML (1 KB) PDF (554 KB) ( 77 )

	52	Research progress on biological activity of selenium polysaccharide#br#
		YU Lei1 LI Chuandi1 DONG Fang2▲ ZHANG Mengyuan3
		Selenium polysaccharide is easy to be absorbed by the human body, with small side effects, and has good effects on antitumor, antioxidation, and improving the body’s immunity, which has become a research hotspot in recent years. In this paper, the biological activities of selenium polysaccharide in immunomodulatory, anti-virus, anti-inflammation, and protective activities are reviewed, which provides an effective theoretical basis for its research and application.
		2022 Vol. 19 (1): 52-55 [Abstract] ( 52 ) HTML (1 KB) PDF (555 KB) ( 116 )

	56	Research progress of hydrotherapy rehabilitation equipment and its application to military training injuries#br#
		WANG Ning HU Xi WANG Wei
		Hydrotherapy rehabilitation technology is an effective treatment technology and method in rehabilitation treatment, and is increasingly valued in clinic. Hydrotherapy rehabilitation technology is of great significance to the rehabilitation and prognosis of patients with military training injuries, but there are few practices and researches on hydrotherapy rehabilitation equipment, and equipment operation lacks unified technical evaluation standards and maintenance system. This paper reveiewes the hydrotherapy rehabilitation equipment application status and research progress both at home and abroad, analyzes the hydrotherapy rehabilitation equipment application in military training injuries advantages and development difficulties at present, combining the present situation of the military training injuries and the actual application, proposes the hydrotherapy rehabilitation equipment application prospect for the future, thinks military servicemen of effective rehabilitation.
		2022 Vol. 19 (1): 56-59 [Abstract] ( 185 ) HTML (1 KB) PDF (551 KB) ( 73 )

	60	Analysis of course objective attainment based on the mixed teaching mode in systematic anatomy course#br#
		LI Xiu YONG Liujun SHI Zhao XIAO Li LIU Chang LI Jian
		Objective To formulate the teaching objective of systematic anatomy course and assessment methods of online and offline mixed mode, and to analyze the objective achievement degree in order to guide the continuous improvement of systematic anatomy course. Methods The mixed teaching mode of systematic anatomy was constructed, and 848 students majoring in clinical medicine in Chengdu Medical College of grade 2019 were selected as the research objects. Statistical analysis was conducted on the students’ daily grades, final grades, and satisfaction with teaching effects to evaluate the objective achievement degree of systematic anatomy course. Results The objective achievement degree of direct evaluation values of systematic anatomy course was 0.78, and the objective achievement degree of indirect evaluation values of systematic anatomy course was 0.88. Conclusion In the mixed teaching mode, the objective achievement degree of systematic anatomy course is achieved satisfactorily, especially the ideological and political objectives, which provides a basis for the improvement of the teaching quality of systematic anatomy in the mixed teaching mode.
		2022 Vol. 19 (1): 60-63 [Abstract] ( 78 ) HTML (1 KB) PDF (609 KB) ( 91 )

	64	Discussion on the teaching of integrated traditional Chinese and Western medicine tumor course#br#
		LU Dianrong1 LANG Senyan2 YU Chenchen2 ZHANG Qing2 ZHU Shijie1
		The incidence of malignant tumor is increasing year by year in China, which is the primary cause of death of residents, and the situation of tumor prevention and control is grim. The tumor prevention and treatment comprehensive model of integrated traditional Chinese and Western medicine has been widely recognized in China, and a large number of specialized doctors of integrated traditional Chinese and Western medicine are urgently needed. However, the basic education and teaching program of traditional Chinese and Western medicine specialty can not adapt to the development of this specialty. Colleges and universities of traditional Chinese medicine should adjust their teaching mode in time and adopt specialized teaching suitable for the practical operation of the oncology specialty of integrated traditional Chinese and Western medicine at present. This paper describes how to improve the teaching quality and level of integrated Chinese and Western medicine tumor course from the aspects of optimizing teaching coursesfrom three aspects of optimizing teaching courses, cultivating evidence-based medicine thinking, expanding teaching ideas and developing diversified teaching modes，in order to cultivate more high-quality talents of integrated Chinese and Western medicine cancer prevention and treatment under the new situation.
		2022 Vol. 19 (1): 64-67 [Abstract] ( 108 ) HTML (1 KB) PDF (612 KB) ( 52 )

	68	Application effect of multi-disciplinary team combined with case-based learning in standardized training of residents in radiation oncology#br#
		LI Chongyi XIONG Yanli GENG Mingying ZHU Xiaoju LI Mengxia DAI Nan
		Objective To explore the efficacy of multi-disciplinary team (MDT) combined with case-based learning (CBL) in standardized training of residents in radiation oncology. Methods From August 2016 to August 2019, a total of 56 residents were selected from Daping Hospital, Army Medical University for standardized resident training in radiation oncology, according to the random number table method, they were divided into innovative teaching group and traditional teaching group, with 28 residents in each group. Innovative teaching group adopted MDT+CBL teaching mode, while traditional teaching group adopted department rotation+CBL teaching mode. The results of theory assessment, practice assessment and related questionnaire were compared between two groups. Results There was no statistical significance in objective questions scores of theory assessment between two groups (P > 0.05); the results of subjective questions scores of theory assessment and practice scores in innovative teaching group were higher than those in traditional teaching group (P < 0.05). The scores of interest, initiative, knowledge acceptance, and teamwork by training physicians in innovative teaching group were higher than those in traditional teaching group (P < 0.05). The evaluation scores of patients, teachers, and nursing staff in innovative teaching group on the evaluation of standardized training physicians were higher than those in traditional teaching group; and the evaluation scores of training teachers and training bases by training physicians in standardized training group were higher than those in traditional teaching group (P < 0.05). Conclusion MDT+CBL teaching mode can improve the learning efficiency of training residents and improve the teaching effect of training.
		2022 Vol. 19 (1): 68-71,84 [Abstract] ( 125 ) HTML (1 KB) PDF (673 KB) ( 52 )

	72	Construction and exploration of virtual simulation experiment teaching of chronic disease health management under the background of new medical science#br#
		LUO Guihua BAI Simin ZHANG Yuan ZHAO Shengjie FENG Jian’an OUYANG Jing
		Chronic diseases health management is an important part in the practice teaching of health service and management professional courses. Based on the teaching concept of “new medical science”, a virtual simulation experimental teaching platform for chronic diseases health management is built by using virtual simulation, multimedia, human-computer interaction, database and network communication technologies, the virtual simulation experiment teaching platform of chronic disease health management is constructed. The platform integrates health information collection, health risk assessment, health intervention and follow-up services into the virtual simulation experiment scene of chronic diseases health management (hypertension, diabetes and dyslipidemia), so that the students can have a comprehensive and systematic understanding of health management service process. Virtual simulation experiment teaching not only expands the traditional teaching mode, and greatly improves the teaching effect, strengthens the professional literacy education and enhances the sense of professional identity.
		2022 Vol. 19 (1): 72-75 [Abstract] ( 96 ) HTML (1 KB) PDF (808 KB) ( 170 )

	76	Exploration of curricular ideology construction of “college students career planning” in medical colleges#br#
		GUO Qian LI Baoqin ZENG Xuelu LIU Yang
		The proposal of curricular ideology plays an important role in improving and strengthening the ideological and political work in medical colleges. Medical colleges should integrate profound medical humanistic quality and ideological and political quality construction into the normal teaching, and fully realize the fundamental task of establishing morality and cultivating people. This paper expounds the significance and current situation of curricular ideology construction of career planning in medical colleges, and puts forward relevant suggestions in view of the existing problems, through establishing “three-in-one” education model, exploring native ideological and political resources, applying diversified teaching methods, establishing multi-dimensional evaluation system, and cultivating high-quality teaching staff to achieve the teaching goal better, tamp the professional belief of medical students, improve the humanistic quality of medical students and set up the professional ideal of medical students.
		2022 Vol. 19 (1): 76-79,101 [Abstract] ( 85 ) HTML (1 KB) PDF (1187 KB) ( 72 )

	80	Application of the teaching mode of mind mapping combined with clinical case study in 5-year undergraduate interns teaching in the department of respiratory medicine#br#
		CUI Xiaoxia1 ZHAO Le1▲ ZHANG Ning1 SUN Lei2
		Objective To explore the application effect of the teaching mode of the mind mapping combined with clinical case study in 5-year undergraduate interns teaching in the department of respiratory medicine. Methods Sixty undergraduate clinical medicine interns of Beijing University of Chinese Medicine from September to October 2020 were selected as the research subjects, and they were divided into control group and observation group by random number table method, 30 cases in each group. All interns practiced in the department of respiratory medicine for four weeks. Observation group was taught by the teaching mode of mind mapping combined with clinical case study, control group was taught by traditional cilinical practice teaching mode. The grades of the entrance department examination and leave department examination of interns in both groups were compared, and the basic knowledge learning effect, and clinical operational ability of interns in the both groups were analyzed, questionnaire survey was used to evaluate students’ evaluation of the teaching method. Results After leave department, the average scores of basic knowledge examination and clinical skill examination in the observation group were higher than those in the control group (P < 0.05); the substandard proportion in inquiry, physical examination, mastery of illness, medical record writing, thoracic puncture, sputum aspiration, arteriovenous blood collection, and cardiopulmonary resuscitation in the observation group were lower than those in the control group (P < 0.05); the qualified number of aseptic concept, health education, operation ability (puncture, catheterization, etc.), independent learning and communication in the observation group were higher than those in the control group (P ＜ 0.05), there was no significant difference in the qualified number of innovative thinking between the two groups (P ＞ 0.05). The questionnaire results showed that mind mapping combined with clinical case study was helpful to improve the quality and effect of clinical teaching. Students had a positive attitude towards this teaching method. Conclusion In the teaching of undergraduate interns in the department of respiratory medicine, the teaching mode of mind mapping combined with clinical case study is conducive to stimulate students’ interest in learning, improve learning efficiency, and help students to master clinical knowledge and skills, which should be vigorously promoted in clinical practice.
		2022 Vol. 19 (1): 80-84 [Abstract] ( 120 ) HTML (1 KB) PDF (778 KB) ( 48 )

	85	Summary of the best evidences for the evaluation and management of post-stroke urinary incontinence#br#
		YANG Jie1,2 XIE Xiaohua1,2 OU Jiexia3,4 YANG Huafeng2,4 YANG Mei2
		Objective To evaluate and summarize the best evidences for relevant literature on the assessment and management of post-stroke urinary incontinence by searching the database. Methods Up To Date, BMJ Best Practice, International Guideline Collaboration network, National Institute for Health and Care Excellence, National Guideline Clearinghouse, Registered Nurses’ Association of Ontario, Evidence-based Health Care Center database, American Heart Association Guideline network, American Stroke Society Guideline network, Embase, PubMed, CINAHL, CNKI, Wanfang Data, Medive Guide network, and CBMD were searched for the assessment and management of post-stroke urinary incontinence from inception to January 2021, included clinical decision making, clinical guidelines, systematic evaluation, evidence summary, and quasi-experimental studies. The literatures were evaluated and extracted by two researchers who had received systematic evidence-based training, and the literatures that met the quality standards were collected. Results After screening, 14 literatures were included, including four clinical decisions, five guidelines, three systematic evaluation, one evidence summary, and one quasi-experimental study, respectively. A total of 23 best evidences were collected from four aspects of post-stroke urinary incontinence assessment, health guidance, treatment measures, and follow-up, of which eight were strongly recommended and 15 were weakly recommended. Conclusion This study summarizes the best evidence for the assessment and management of urinary incontinence after stroke can provide evidence-based guidance for clinical practice. By applying the best evidence to clinical practice, the assessment and management of post-stroke urinary incontinence in different genders and degrees can be satisfied.
		2022 Vol. 19 (1): 85-88，113 [Abstract] ( 66 ) HTML (1 KB) PDF (677 KB) ( 53 )

	89	Influencing factors analysis of sedative tolerance in ICU patients on mechanical ventilation#br#
		HUANG Bing1 TANG Zhihong2 TANG Li1
		Objective To investigate the influencing factors of sedative tolerance in ICU patients, so as to provide reference for formulating corresponding medical care measures. Methods Electronic medical records of 372 patients undergoing sedative and analgesic mechanical ventilation in West China Hospital, Sichuan University from February 2017 to March 2021 were retrospectively collected, and they were divided into the tolerant group (60 cases) and the non-tolerant group (312 cases) according to the incidence of sedative tolerance. Univariate analysis and logistic regression model were used to explore the factors associated with sedative tolerance in patients. Results The age, scores of acute physiology and chronic health evaluationⅡ (APACHE Ⅱ) in the tolerant group were lower than those in the non-tolerant group, the body mass index, proportion of patients with drinking history and repeated intermitten push injection were higher than those in the non-tolerant group, the use time of sedative was longer than that of non-tolerant group, and the differences were statistically significant (P ＜ 0.05). Multivariate analysis showed that age, APACHE Ⅱ score, alcohol consumption, duration of sedative use, and repeated intermitten push injection were independent influencing factors of sedative tolerance (P ＜ 0.05). Conclusion For patients who are prone to sedative tolerance after sedative and analgesic mechanical ventilation, clinical attention should be paid to the use of sedative drugs in severe patients and management standards should be formulated, and measures should be actively taken to reduce the occurrence of sedative tolerance and protect the safety of patients.
		2022 Vol. 19 (1): 89-92 [Abstract] ( 35 ) HTML (1 KB) PDF (657 KB) ( 44 )

	93	Influencing factors of metabolic syndrome and application value of neutrophil / lymphocyte ratio in metabolic syndrome#br#
		DING Leilei1 JIA Chengpu2 FU Li1 LI Li1 WANG Tingting1▲
		Objective To investigate the influencing factors of metabolic syndrome (MS) and application value of neutrophil/lymphocyte ratio (NLR) in MS. Methods A total of 968 physical examination subjects in Beijing Friendship Hospital, Capital Medical University from January 2018 to January 2019 were selected as the subjects. They were divided into MS group (241 cases) and non-MS group (727 cases) according to whether they had MS. The differences of clinical data and laboratory indicators between the two groups were observed, the correlation between NLR and MS metabolic indicators was analyzed by Pearson correlation coefficient, the influencing factors of MS were analyzed by logistic regression model, and the diagnostic efficacy of NLR for MS was evaluated by receiver operating characteristic (ROC) curve. Results In MS group, age, male proportion, smoking proportion, alcohol consumption proportion, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), uric acid (UA), hypersensitive C-reactive protein (hs-CRP), NLR were higher than those of non-MS group, and high density lipoprotein cholesterol (HDL-C) was lower than that in non-MS group, and the differences were statistically significant (P ＜ 0.05). Correlation analysis showed that NLR was positively correlated with metabolic indicators of MS patients including BMI, SBP, DBP, FBG, HbA1c, TG, UA, and hs-CRP (r ＞ 0, P ＜ 0.05), and negatively correlated with HDL-C (r ＜ 0, P ＜ 0.05), after adjusting for gender, age, smoking history, and alcohol history, the above correlation still existed (adjusted P ＜ 0.05). Analysis of influencing factors showed that advanced age, high BMI, high SBP, high DBP, high TG, high FBG, and high NLR were independent risk factors for MS (OR ＞ 1, P ＜ 0.05), while female and high HDL-C were protective factors (OR ＜ 1, P ＜ 0.05). ROC curve showed that the area under the curve of NLR for diagnostic MS was 0.745 (P ＜ 0.05). Conclusion The occurrence of MS is affected by age, gender, and a variety of metabolic factors. NLR is closely related to MS, which has certain diagnostic value for MS.
		2022 Vol. 19 (1): 93-96 [Abstract] ( 74 ) HTML (1 KB) PDF (662 KB) ( 44 )

	97	Meta analysis of aminophylline and doxofylline in the treatment of bronchial asthma#br#
		GAO Qinfeng
		Objective To systematically evaluate the therapeutic effect of aminophylline and doxofylline on bronchial asthma. Methods China National Knowledge Infrastructure, WangFang Data, VIP, Chinese Biomedical Literature, and Pubmed were searched, and the randomized controlled trials of aminophylline and doxofylline in the treatment of bronchial asthma from the establishment of the database to July 2021 were collected, the literatures were sorted out and the qualities were evaluated, and Review Manager 5.3 software was used for statistical analysis. Results 11 literatures were included, including 1160 patients. Clinical effect [RR = 1.19, 95%CI (1.13，1.25), P ＜ 0.000 01], forced vital capacity [WMD = 0.43, 95%CI (0.06，0.79), P = 0.02], forced expiratory volume in the first second [WMD = 0.24, 95%CI (0.18，0.31), P ＜ 0.000 01] of doxofylline group were higher than those of aminophylline group. Conclusion The clinical effect of doxofylline in the treatment of bronchial asthma is better than that of aminophylline, but it still needs to be verified by multicenter and large-sample clinical trials.
		2022 Vol. 19 (1): 97-101 [Abstract] ( 126 ) HTML (1 KB) PDF (1441 KB) ( 92 )

	102	Clinical significance and changes of microinflammatory factor, calcium and phosphorus metabolism levels in patients with chronic kidney disease and cardiac insufficiency#br#
		SHEN Yuxin WANG Yangyang DENG Wenyan ZHANG Jing▲
		Objective To study the clinical significance and changes of microinflammatory factor, calcium and phosphorus metabolism levels in patients with chronic kidney disease and cardiac insufficiency, and to provide guidance for clinical research. Methods A total of 85 patients with chronic kidney disease and cardiac insufficiency admitted to the Fourth Affiliated Hospital of Anhui Medical University from March 2018 to March 2020 were selected, according to the estimated glomerular filtration rate level of patients, they were divided into chronic kidney disease stage 1-2 group (14 cases), chronic kidney disease stage 3 group (22 cases), chronic kidney disease stage 4 group (23 cases), and chronic kidney disease stage 5 group (26 cases), and 30 healthy subjects were selected as control group during the same period. Serum fibrinogen (FIB), procalcitonin (PCT), and hypersensitive C-reactive protein (hs-CRP) were detected by enzyme-linked immunosorbent assay (ELISA) and immunoturbidimetry. Blood phosphorus (P), blood calcium (Ca) and parathyroid hormone (PTH) were detected by automatic biochemical analyzer. The correlation between microinflammatory state and calcium and phosphorus metabolism was analyzed. Results The levels of FIB, PCT, and hs-CRP in the groups of chronic kidney disease stage 1-2, 3, 4, and 5 groups were significantly higher than those in the control group, the differences were statistically significant (P ＜ 0.05). The level of PCT in chronic kidney disease stage 4 group was significantly higher than that in the chronic kidney disease stage 1-2 group and 3 group, the levels of PCT and hs-CRP in the chronic kidney disease stage 5 group were significantly higher than those in chronic kidney disease stage 1-2 group, 3 group and 4 group, the differences were statistically significant (P ＜ 0.05). The levels of P and PTH in chronic kidney disease stage 1-2 group, 3 group, 4 group, and 5 group were higher than those in control group, the levels of Ca in chronic kidney disease stage 1-2 group and 3 group were lower than those in control group, and the level of PTH in chronic kidney disease 3 group was significantly higher than those in chronic kidney disease stage 1 group and 2 group. The levels of PTH and Ca in chronic kidney disease stage 4 group were significantly higher than those of chronic kidney disease stage 1-2 group, and 3 group, the levels of P and PTH in chronic kidney disease stage 5 group were higher than those in the chronic kidney disease stage 1-2 group, 3 group, and 4 group, level of Ca in chronic kidney disease stage 5 group was significantly higher than those of chronic kidney disease stage 3 group and 4 group, the differences were statistically significant (P ＜ 0.05). There was significant positive correlation between PCT level and P, PTH level, and significant negative correlation between PCT levels and Ca level (r = 0.614, 0.502, -0.551, P ＜ 0.001). hs-CRP was positively correlated with P and PTH levels, and negatively correlated with Ca level (r = 0.521, 0.518, -0.426, P ＜ 0.001). Conclusion Patients with chronic kidney disease and cardiac insufficiency have a micro-inflammatory state, abnormal calcium, and phosphorus metabolism levels, and their micro-inflammatory state may be related to calcium and phosphorus metabolism.
		2022 Vol. 19 (1): 102-105 [Abstract] ( 163 ) HTML (1 KB) PDF (620 KB) ( 45 )

	106	Effect of Theophylline Sodium Glycinate Sustained Release Tablets in the treatment of bronchial asthma#br#
		ZHAO Hai ZHAO Juan
		Objective To observe the clinical efficacy of Theophylline Sodium Glycinate Sustained Release Tablets in the treatment of bronchial asthma and the impacts on oxidative stress. Methods A total of 105 cases with bronchial asthma admitted to Sinopharm Tongmei General Hospital from November 2018 to September 2020 were selected as the research objects, and they were divided into control group (52 cases) and study group (53 cases) according to the random number table method. The control group received conventional treatment, the study group received Theophylline Sodium Glycinate Sustained Release Tablets additionally, the treatment course was three months. The clinical efficacy, disappearing time of main clinical symptoms (cough, breathe heavily, lung moist rale, and lung wheezing), pulmonary function (forced expiratory volume in one second [FEV1], FEV1/FVC, peak expiratory flow [PEF]), and oxidative stress indexes (malondialdehyde [MDA], lipid peroxide [LPO], reduced glutathione [GSH], and superoxide dismutase [SOD]) were compared, the adverse reactions were recorded. Results There was no significant difference in the total effective rate between the two groups (P ＞ 0.05). The disappearance time of cough, breathe heavily, lung moist rale, and lung wheezing in the observation group were shorter than those in the control group, and the differences were statistically significant (P ＜ 0.05). After treatment, FEV1, FEV1/FVC, PEF, GSH, and SOD increased, while MDA and LPO decreased compared with before treatment in two groups (P ＜ 0.05). FEV1, FEV1/FVC, PEF, and SOD in the observation group were higher than those in the control group, while MDA and LPO were lower than those in the control group, the differences were statistically significant (P ＜ 0.05), while GSH between the two groups showed no significant difference (P ＞ 0.05). There were no obvious adverse reactions in both groups. Conclusion Theophylline Sodium Glycinate Sustained Release Tablets combined with conventional treatment are effective and safe for patients with bronchial asthma, and could decrease the oxidative stress injury.
		2022 Vol. 19 (1): 106-109 [Abstract] ( 148 ) HTML (1 KB) PDF (617 KB) ( 182 )

	110	Effect analysis of different approaches to explore recurrent laryngeal nerve in radical operation of thyroid cancer#br#
		HU Yong WU Guohui ZHANG Rui▲
		Objective To investigate the curative effect of different approaches to explore recurrent laryngeal nerve in radical operation of thyroid cancer and to provide reference for clinical treatment of patients. Methods A total of 154 patients with unilateral thyroid cancer who received diagnosis and treatment in Huangshan People’s Hospital of Anhui Province from March 2018 to March 2021 were selected as the research subjects, and all of them received radical resection of unilateral thyroid cancer (resection of thyroid lobe and isthmus on the affected side + dissection of central lymph nodes on the affected side + exploration of recurrent laryngeal nerve on the affected side). According to the random odd and even number method, they were divided into the control group and the study group, with 77 cases in each group. In the control group, the recurrent laryngeal nerve was explored through the upper subthyroid angle approach, while in the study group, the recurrent laryngeal nerve was explored through the lower inferior thyroid artery approach. At discharge, the operation-related indexes, parathyroid gland protection, and recurrent laryngeal nerve injury were compared between the two groups. Results The operation time of the study group was shorter than that of the control group, and the intraoperative blood loss, total amount of drainage fluid were lass than those of the control group, and drainage days was shorter than that of the control group, with statistical significances (P ＜ 0.05); there were no statistical significances in the rate of temporary parathyroid injury and recurrent laryngeal nerve injury between the two groups (P ＞ 0.05). Conclusion During the radical operation of thyroid cancer, the inferior approach via the inferior thyroid artery to explore the recurrent laryngeal nerve has a significant effect, which promotes the significant improvement of patients’ operation-related indicators, better protection of patients’ parathyroid gland, and reduces the injury to the recurrent laryngeal nerve in patients, which is worthy of promotion.
		2022 Vol. 19 (1): 110-113 [Abstract] ( 119 ) HTML (1 KB) PDF (615 KB) ( 46 )

	114	Efficacy and safety of Dexmedetomidine combined with Butorphanol for postoperative analgesia in patients with microvascular decompression#br#
		CAI Botao TANG Ting LIAO Sha ZHANG Baiyin TANG Jiwei
		Objective To investigate the efficacy and safety of Dexmedetomidine combined with Butorphanol for postoperative analgesia in patients with microvascular decompression. Methods A total of 40 patients scheduled for microvascular decompression in Hunan Brain Hospital from January 2019 to December 2020 were selected, they were divided into Butorphanol group (group C) and Butorphanol combined with Dexmedetomidine group (Group D) according to the random number table method, with 20 cases in each group. Patient controlled intravenous analgesia was performed after operation. Group C received Butorphanol 10 mg + Tropisetron 5 mg, and group D received Butorphanol 10 mg + Dexmedetomidine 200 μg + Tropisetron 5 mg, diluted to 100 ml with normal saline. The mean arterial pressure (MAP) and heart rate (HR) of both groups were recorded before operation (T0) and after operation at 4 h (T1), 12 h (T2), 24 h (T3), and 48 h (T4); visual analogue scale (VAS) score and Ramsay sedation score were recorded after T1-T4 in both groups; adverse reactions and sleep quality scores were recorded. Results In group C, MAP values at T1-T2 were higher than those at T0, and MAP values at T3-T4 were lower than those at T1-T2, and the differences were statistically significant (P < 0.05). MAP values of group D at T2-T4 were lower than those at T1, and the differences were statistically significant (P < 0.05). MAP values of group D at T1-T4 were lower than those of group C, and the differences were statistically significant (P < 0.05). In group C, HR values at T2-T4 were lower than those at T0 and T1, and the differences were statistically significant (P < 0.05). In group D, HR values at T2-T4 were lower than those at T0 and T1, while HR value at T4 was higher than that at T3, and the differences were statistically significant (P < 0.05). HR values of group D at T1-T4 were lower than those of group C, and the differences were statistically significant (P < 0.05). There were statistically significant differences in the resting and active VAS scores in group C at each time points (P < 0.05). In group D, the resting VAS scores at T2-T3 were lower than those at T1, and the resting VAS score at T4 was lower than that at T1-T3, and the differences were statistically significant (P < 0.05); there were statistical significances in active VAS score in group D at each time points (P < 0.05). The resting and active VAS scores of group D at T1-T4 were lower than those of group C, and the differences were statistically significant (P < 0.05). Ramsay sedation scores in group D at T1-T4 were higher than those in group C, and the differences were statistically significant (P < 0.05). The total incidence of adverse reactions in group D was lower than that in group C, and the difference was statistically significant (P < 0.05). There was no significant difference in sleep quality before and after operation in group C (P > 0.05); the sleep quality of group D after operation was better than that before operation, and the difference was statistically significant (P < 0.05). Sleep quality of group D after operation was better than that of group C, and the difference was statistically significant (P < 0.05). Conclusion Dexmedetomidine combined with Butorphanol for postoperative analgesia after microvascular decompression is safe and effective. It can provide good sedative and analgesic effect, improve sleep quality and reduce adverse reactions.
		2022 Vol. 19 (1): 114-118 [Abstract] ( 91 ) HTML (1 KB) PDF (444 KB) ( 24 )

	119	Clinical effect of Hydromorphone Hydrochloride in the treatment of patients with bone cancer pain and its influence on pain related mediators and hormone levels#br#
		ZHANG Shengmao1 LI Na2 BAO Narisu1 SU Nan1 YUN Letian1 ZHAO Zhihui1
		Objective To investigate the analgesic effect and mechanism of Hydromorphone Hydrochloride in patients with bone cancer pain. Methods A total of 50 patients with bone cancer pain admitted to Inner Mongolia People’s Hospital from January 2017 to March 2020 were collected. They were divided into control group and observation group by random envelope method, with 25 cases in each group. The control group was treated with Disodium Pamidronate by intravenous analgesia pump, and the observation group was treated with Hydromorphone Hydrochloride by intravenous analgesia pump. Visual analogue scale (VAS) score and Karnofsky performance status (KPS) score were compared between two groups; the expression levels of pain mediators (5-hydroxytryptamine [5-HT], nitric oxide [NO], prostagrandin E2 [PGE2]) and stress hormones (cortisol [Cor], growth hormone [GH], prolactin [PRL]) were detected before treatment and 1, 2, and 3 months after treatment; the correlation between analgesic effect of Hydromorphone Hydrochloride and the levels of serum pain mediators and stress hormones in patients with bone cancer pain were analyzed. Results The analgesic effect of observation group was better than control group (P < 0.05). After 1 month of treatment, the levels of 5-HT, NO, PGE2, Cor, GH, and PRL in both groups were lower than those before treatment (P < 0.05); after 2 and 3 months of treatment, the levels of 5-HT, NO, PGE2, Cor, GH, and PRL in both groups were lower than those after 1 month of treatment (P < 0.05). After 1, 2, and 3 months of treatment, the levels of 5-HT, NO, PGE2, Cor, GH, and PRL in observation group were lower than those in control group (P < 0.05). VAS score was negatively correlated with the levels of serum 5-HT, NO, PGE2, Cor, GH, and PRL (r = -0.903, -0.675, -0.748, -0.706, -0.901, -0.621, P < 0.05); KPS score was negatively correlated with the levels of serum 5-HT, NO, PGE2, Cor, GH, and PRL (r = -0.801, -0.696, -0.738, -0.629, -0.752, -0.763, P < 0.05). Conclusion The therapeutic effect of Hydromorphone Hydrochloride on patients with bone cancer pain is better than that of traditional analgesics. The analgesic mechanism is related to inhibit the pain mediators and stress hormone levels.
		2022 Vol. 19 (1): 119-122,127 [Abstract] ( 119 ) HTML (1 KB) PDF (1018 KB) ( 81 )

	123	Overview of definition, diagnosis and treatment about head sore in ancient Chinese medicine literature#br#
		JIANG Lan1,2 SUN Liyun2
		The name of head sore in ancient books has a complicated evolution. With head sore as the key word, we systematically sort out it from ancient traditional Chinese medicine literatures, including the interpretation of definition, etiology and pathogenesis, clinical symptoms, differential diagnosis, treatment, prevention and outcome. The disease is generally divided into white ringworm and fat sore. It is a superficial fungal skin disease that occurs on the scalp, mostly occurs in children and is contagious. The pathogenesis is mostly related to the dampness and heat of the meridians and viscera, exogenous wind-heat and insects. As for treatment, it is suitable for clearing heat and removing dampness, killing insects and relieving itching. It is characterized by external treatment and there are many types of external preparations. After illness, it is necessary to prevent infection and get early diagnose and treat.
		2022 Vol. 19 (1): 123-127 [Abstract] ( 31 ) HTML (1 KB) PDF (831 KB) ( 52 )

	128	Experience summary of Professor Yu Chenghui in treating hypertensive nephropathy#br#
		LIU Qiong1，2 JIANG Yan1，2 WANG Xufang1，2
		Hypertensive nephropathy is a common cause of end-stage chronic kidney disease. Professor Yu Chenghui is a famous expert of integrated traditional Chinese and western medicine in Jiangsu Province, who has rich experience in the treatment of kidney diseases. Firstly, he puts forward the “damp heat theory” of chronic nephritis, combines disease differentiation with syndrome differentiation, and believes that hypertensive nephropathy is the syndrome of deficiency in origin and excess in superficislity. The location of the disease is initially in the liver and kidney, and finally in the heart, spleen and lung. The basic pathogenesis is deficiency of liver and kidney, dampness and turbidity, phlegm and blood stasis obstructing collaterals. It can be divided into four types: yin deficiency of liver and kidney, spleen deficiency and phlegm dampness, qi deficiency and blood stasis and turbid toxin accumulation. The main treatment is nourishing yin and suppressing yang, eliminating dampness and resolving phlegm, promoting blood circulation and removing blood stasis. Giving consideration to both the specimen and the body, strengthening the healthy and eliminating the evil. Daily emotional conditioning and diet conditioning also play an important role in the control of disease development.
		2022 Vol. 19 (1): 128-131,135 [Abstract] ( 96 ) HTML (1 KB) PDF (800 KB) ( 45 )

	132	Clinical experience of Zhang Minghe in the treatment of renal damage in systemic lupus erythematosus#br#
		HAO Jinqiu1 XU Yunsheng2 FU Xinli3
		This paper summarizes Professor Zhang Minghe’s clinical experience in the treatment of renal damage in systemic lupus erythematosus, and introduces the academic idea of treating renal damage in systemic lupus erythematosus by stages and syndrome differentiation. Professor Zhang believes that the main cause of the disease is the deficiency in origin and excess in superficiality, congenital deficiency, external heat toxin or internal heat accumulation, blood heat removing blood stasis, blood stasis and heat beating, and lying in the renal collaterals. Treatment should distinguish the primary and secondary of deficiency and excess according to syndrome differentiation, flexible selection of prescription and medication at different stages of course evolution around “deficiency of origin, blood stasis and heat toxin”. At the same time, we should pay attention to the combined treatment with Western medicine and take the advantages of the two to improve the prognosis.
		2022 Vol. 19 (1): 132-135 [Abstract] ( 92 ) HTML (1 KB) PDF (809 KB) ( 38 )

	136	Visual analysis on research hotspot and trend of primary liver cancer in the field of traditional Chinese medicine based on CiteSpace#br#
		YU Huibo1，2 HU Jiaqi1，2 CHEN Shuntai1，2 CHEN Xin1 ZHENG Honggang1
		Objective To analyze the research hotspot and trend of primary liver cancer in the field of Chinese medicine in recent 20 years by using visualization. Methods With “traditional Chinese medicine” and “primary liver cancer” as the research topics, Chinese literatures were searched from CNKI database from January 2000 to October 2020. The authors, institutions and keywords of these literatures were visually analyzed by CiteSpace. Results A total of 2488 Chinese literatures were included, the annual published articles showed a gradually increasing trend. Ling Changquan was the most prolific author, forming teams with Ling Changquan, Fang Zhaoqin and Chen Chuang as the core. Shanghai University of Traditional Chinese Medicine was the most prolific institutions, and the cooperation between different institutions was quite different. Removing subject words relevant keywords, the top three keywords were “review”, “Compound Kushen Injection” and “intervention therapy”, the top three centrality keywords were “apoptosis”, “mouse” and “Compound Kushen Injection”. A total of 13 clusters and 24 emergent words were appeared. Conclusion In recent 20 years, the research content of primary liver cancer in the field of traditional Chinese medicine in China is rich. At present, the hotspots are summarizing clinical experience and the molecular biological mechanism of traditional Chinese medicine improving liver function, immune function and cancer pain in patients with liver cancer.
		2022 Vol. 19 (1): 136-140 [Abstract] ( 145 ) HTML (1 KB) PDF (1567 KB) ( 74 )

	141	Professor Yang Suqing’s clinical experience in the treatment of oral sore with traditional Chinese medicine#br#
		ZHANG Yanhong1 AN Yuepeng2 ZHANG Qing2
		Oral sore is a common disease of oral mucous membrane in clinic. In this paper, the etiology and pathogenesis of oral sore are taken as the entry point, and the rise and fall of qi and blood of zang-fu viscera are taken as the root point. It is believed that the onset of oral sore is rooted in fire, derived from dampness, heat, poison, and stasis, and closely related to heart, spleen and kidney. Its treatment will treat fire throughout, pay attention to spleen and stomach treatment, pay attention to harmonize qi and blood, compatible with convergence and promoting granulation of oral sore medicine in order to achieve internal and external treatment, and strike a balance between manifestation and root cause. This article summarizes professor Yang Suqing’s clinical experience in the treatment of oral sore with traditional Chinese medicine, promotes work in all areas by drawing upon the experience gained on key points, sees big things through small ones, seeks the good strategy, and facilitates the treatment.
		2022 Vol. 19 (1): 141-144 [Abstract] ( 141 ) HTML (1 KB) PDF (773 KB) ( 74 )

	145	Study on the mechanism of action of Guizhi Shaoyao Zhimu Decoction in the treatment of gout based on network pharmacology#br#
		HE Jiaying1 LIU Mingling2 LI Shuyao1 WANG Xinyu1 GUAN Tong2
		Objective To explore the mechanism of action of Guizhi Shaoyao Zhimu Decoction in the treatment of gout based on network pharmacology. Methods The active ingredients and corresponding targets of Guizhi Shaoyao Zhimu Decoction were screened by traditional Chinese medicine systems pharmacology database and analysis platform and literature. Gout related targets were searched by GeneCards, OMIM, DisGeNET and TTD databases, and the intersection of drugs and disease targets was obtained. Cytoscape 3.7.2 software was used to construct the disease-drug-target-component network and protein-protein interaction network, and R 4.0.3 software was used for GO enrichment analysis and KEGG pathway enrichment analysis. Results A total of 125 active components of Guizhi Shaoyao Zhimu Decoction and 60 drug-disease common targets were predicted. GO functional enrichment analysis mainly involved molecular functions such as phosphatase binding, metallopeptidase activity, MAPK activity, transcription factor binding, and oxidation-reduction enzyme activity. KEGG enrichment analysis showed that TNF signaling pathway, TLR signaling pathway, IL-17 signaling pathway, Th17 cell differentiation, CLR signaling pathway, NF-κB signaling pathway were closely related to gout. Conclusion Guizhi Shaoyao Zhimu Decoction plays a significant role in the treatment of gout inflammation, uric acid metabolism disorder and bone destruction, and so on, providing theoretical basis for future clinical trials and experimental studies.
		2022 Vol. 19 (1): 145-149 [Abstract] ( 176 ) HTML (1 KB) PDF (1450 KB) ( 140 )

	150	Clinical experience of Wuzhuyu Decoction in treating headache#br#
		WANG Jiandong HUANG Xiaobo
		Wuzhuyu Decoction, first seen in Shanghan Lun, is a representative prescription for jueyin disease with headache. The author thinks that jueyin disease with headache should not be limited to parietal headache. Some migraines and eye distending pain can also be classified as jueyin disease with headache. The person must be accompanied by afraid of cold and fond of warm, which is especially true for the head afraid of cold and wind, pale tongue, white fur, stringy pulse, or accompanied by digestive system symptoms, such as nausea and vomiting, salivation, epigastric fullness, etc. The pathogenesis is deficiency cold of liver and stomach, upward counterflowing of turbid yin, add and subtract Wuzhuyu Decoction was used as the prescription. In addition, Wuzhuyu Decoction can also treat headache with phlegm-fluid retention and some chronic headache, which expands the application of Wuzhuyu Decoction in the treatment of headache. As for the dosage of medicinal evodia fruit, the author thinks that the dosage should be increased or decreased according to the severity of the disease and the patient’s constitution, 3 g-6 g-9 g. The dosage of medicinal evodia fruit should not be copied from the ancient prescription, and it should not be too rigidly adhered to the pharmacopoeia, otherwise, the drug dose used for serious diseases is low, making the treatment effect is not good. On this basis, it is the premise of safe use of Wuzhuyu Decoction to pay attention to the quality of Wuzhuyu Decoction Pieces and decocting method.
		2022 Vol. 19 (1): 150-153 [Abstract] ( 77 ) HTML (1 KB) PDF (767 KB) ( 210 )

	154	Effects of acupuncture combined with rehabilitation therapy on nerve, motor function and quality of life in patients with hemiplegia after stroke#br#
		GAO Yuan YU Qingpeng▲
		Objective To investigate the effects of acupuncture combined with rehabilitation therapy on nerve, motor function and quality of life in patients with hemiplegia after stroke. Methods A total of 90 patients with hemiplegia after stroke treated in Maanshan Hospital of Traditional Chinese Medicine, Anhui Province from February 2018 to February 2020 were selected as the research subjects, and they were divided into control group and combined group according to random number table method, with 45 patients in each group. The control group was treated with rehabilitation therapy and the combined group was treated with acupuncture on the basis of the control group. After 30 days of treatment, the clinical efficacy, compopsites spasticity scale (CSS) score, Fugl-Meyer motor function (FMA) score, activity of daily living scale (ADL) score, hand function, and traditional Chinese medicine syndrome score were compared between the two groups. Results The total effective rate of combined group was significantly higher than that of control group, the difference was statistically significant (P ＜ 0.05). CSS score after treatment was significantly lower than before treatment, FMA and ADL scores were significantly higher than before treatment, and the differences were statistically significant (P ＜ 0.05). After treatment, the CSS score of the combined group was significantly lower than that of the control group, while FMA and ADL scores were significantly higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). The maximum extension angle, maximum buckling angle and active range of motion in combined group were significantly higher than those in control group, and the differences were statistically significant (P ＜ 0.05). After treatment, the scores of blood stasis syndrome and qi deficiency syndrome in two groups were significantly lower than before treatment, and the combined group was significantly lower than the control group, the differences were statistically significant (P ＜ 0.05). Conclusion Acupuncture combined with rehabilitation therapy can significantly improve nerve, motor function and quality of life in patients with hemiplegia after stroke, which is worth promoting.
		2022 Vol. 19 (1): 154-157 [Abstract] ( 149 ) HTML (1 KB) PDF (774 KB) ( 58 )

	158	Application of transvaginal ultrasound combined with VCI-C plane technology and TUI technology in the diagnosis of ectopic pregnancy#br#
		XIA Qun HU Jinhua XIE Hongjuan YU Yi YANG Yan
		Objective To study the application of transvaginal ultrasound combined with volume contrast imaging (VCI)-C plane technology and tomographic ultrasound imaging (TUI) technology in the diagnosis ectopic pregnancy. Methods Eighty patients with ectopic pregnancy diagnosed by pathology in Anqing First People’s Hospital of Anhui Medical University from January 2018 to May 2020 were selected as the study subjects. Transvaginal ultrasound combined with VCI-C plane examination and transvaginal ultrasound combined with VCI-C plane and TUI examination were respectively performed to analyze the situation of the two examinations and the diagnosis rates of the two examinations was compared. Results The results of transvaginal ultrasonography combined with VCI-C plane examination were consistent with pathological results in 62 cases, including tubal pregnancy in 54 cases, cesarean scar pregnancy in six cases, and angular pregnancy in two cases. The results of transvaginal ultrasonography combined with VCI-C plane and TUI were consistent with pathological results in 72 cases, including tubal pregnancy in 59 cases, cesarean scar pregnancy in ten cases, angular pregnancy in three cases. The diagnostic rate of transvaginal ultrasonography combined with VCI-C plane and TUI was higher than that of transvaginal ultrasonography combined with VCI-C plane, the difference was statistically significant (P ＜ 0.05). Conclusion Transvaginal ultrasound combined with VCI-C plane and TUI technology in the diagnosis of ectopic pregnancy showed more clear ultrasound images, which has certain diagnostic value for early ectopic pregnancy and can improve the diagnostic rate.
		2022 Vol. 19 (1): 158-161,165 [Abstract] ( 32 ) HTML (1 KB) PDF (929 KB) ( 23 )

	162	Analysis of influencing factors of contrast medium leakage after CT enhanced scan#br#
		GU Wencui1 LIN Hongxia2
		Objective To analyze the influencing factors of contrast medium leakage after CT enhanced scan. Methods Data of 51 patients with contrast medium leakage after CT enhanced scan in Jiangsu Provincial People’s Hospital (hereinafter referred to as “our hospital”) from January 2019 to May 2021 were retrospectively collected and included in the occurrence group. Data of 51 patients without contrast medium leakage after CT enhanced scan in our hospital during the same period were collected and included in the non-occurrence group. Baseline data of the two groups were recorded and analyzed, scanning sites, injection sites, and contrast medium injection rates of the two groups were statistically analyzed, and logistic regression model was used to analyze the influencing factors of contrast medium leakage after CT enhanced scan. Results The proportion of patients with combined hypertension or diabetes mellitus or malignant tumor, forearm vena injection, and contrast medium injection rate were higher than those in the non-occurrence group, and the differences were statistically significant (P ＜ 0.05). Multivariate analysis showed that hypertension, diabetes mellitus, malignant tumor, forearm vena injection and rapid injection rate were independent risk factors for contrast medium leakage after CT enhanced scan (OR ＞ 1, P ＜ 0.05). Conclusion The contrast medium leakage after CT enhanced scan may be affected by a variety of factors, and the injection rate should be strictly controlled according to the specific situation of patients. For patients with the above risks, the contrast medium leakage should be closely observed and treated in time to ensure the quality of CT enhanced scan and the safety of patients’ lives.
		2022 Vol. 19 (1): 162-165 [Abstract] ( 31 ) HTML (1 KB) PDF (450 KB) ( 72 )

	166	Application effect of physical restraint management based on quantitative assessment strategy in ICU patients#br#
		ZHAO Wei1 LI Huifen2▲ LIAN Bin1 JIA Yan1 CHENG Jingjuan1 NI Chunyan1 LU Xiaoliang1 DU Qiuyue1
		Objective To explore the application effect of physical restraint management based on quantitative assessment strategy in intensive care unit (ICU) patients. Methods A total of 83 patients admitted to the ICU of Suzhou Municipal Hospital from May 2019 to September 2020 were selected. Using random number table method, they were divided into 42 cases in the treatment group and 41 cases in the control group. At the same time, a total of 30 ICU nurses were selected and divided into the treatment group and the control group with 15 nurses in each group by random number table method. The control group was given empirical physical restraint management for patients, while the treatment group was based on physical restraint management under the quantitative assessment strategy. The physical restraint management knowledge, beliefs, and practice (KBP) of two groups of the nurses, the physical restraint situation, and family members’ physical restraint satisfaction of the patients were compared. Results After the management, the total scores of the two groups of nurses’ of restraint knowledge, restraint attitude, restraint behavior, and restraint knowledge, belief, and practice were higher than those before management, while the test group was higher than the control group, and the differences were statistically significant (P ＜ 0.05). The physical restraint rate and restraint-related complications of the test groups were lower than those of the control group; the restraint time of the test group was shorter than that of the control group, and the differences were statistically significant (P ＜ 0.05). The satisfaction rate of family members in the experimental group was higher than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Physical restraint management based on quantitative assessment strategies can help enhance ICU nurses’ knowledge, beliefs, and practice of physical restraint, reduce the rate of physical restraint and related complications of ICU patients, and improve family satisfaction.
		2022 Vol. 19 (1): 166-169 [Abstract] ( 126 ) HTML (1 KB) PDF (628 KB) ( 42 )

	170	Application of nursing path in operating room in general surgery laparoscopic operation nursing#br#
		JIANG Weiwei1 XIE Ruhui2
		Objective To explore the value of nursing path in operating room in general surgery laparoscopic surgery. Methods From January 2018 to December 2019, a total of 200 patients who underwent laparoscopic treatment in the department of general surgery admitted to the operating room of the Affiliated Huaian No.1 People’ Hospital of Nanjing Medical University were selected as the research objects. They were divided into study group and control group by number random grouping method, with 100 cases in each group. The control group received routine care in the operating room, and the study group received intervention in the operating room nursing path. The surgical indicators and the incidence of postoperative adverse reactions were compared between the two groups. Results Intraoperative blood loss in the study group was lower than that in the control group, while the recovery time, extubation time, and operation time in the study group were shorter than those in the control group, and the differences were statistically significant (P ＜ 0.05). The total incidence rate of abdominal pain, bloating, vomiting, pressure sores, and emotional irritability in the study group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion In general surgical laparoscopic surgical nursing, intervention in the nursing path of the operating room is provided to ensure the safety of the patients’ surgical process and the effectiveness of the treatment, and promote the recovery of various body functions, which is worthy of clinical promotion.
		2022 Vol. 19 (1): 170-172,176 [Abstract] ( 156 ) HTML (1 KB) PDF (681 KB) ( 81 )

	173	Application of nursing intervention based on self-efficacy theory in patients with heart failure in vulnerable period#br#
		JIA Xia1 LIU Jingyue1 LI Yuanfei2▲
		Objective To explore the application effect of nursing intervention based on self-efficacy theory in the vulnerable period of heart failure patients. Methods A total of 91 patients with heart failure at the vulnerable stage who were admitted to the Yantai Affiliated Hospital of Binzhou Medical College from October 2019 to December 2020 were selected as the research objects. They were divided into control group (45 cases) and observation group (46 cases) by random number table method. The control group was treated with routine nursing, while the observation group was treated with 5A mode nursing intervention based on self-efficacy theory. The cardiac function indexes, referral rate, rehospitalization rate, and mortality rate were compared between the two groups. Results After nursing, the left ventricular ejection fraction (LVEF) of the observation group was higher than that of the control group, while the left ventricular end systolic volume (LVESV), left ventricular end diastolic volume (LVEDV), and left ventricular end diastolic diameter (LVEDD) were lower than those of the control group, and the differences were statistically significant (P ＜ 0.05). The LVEF of the two groups after nursing was higher than that before nursing, while LVESV, LVEDV, and LVEDD were lower than before nursing, and the differences were statistically significant (P ＜ 0.05). The referral rate of the observation group was higher than that of the control group, while the rate of rehospitalization was lower than that of the control group, and the difference was statistically significant (P ＜ 0.05). There was no statistically significant difference in mortality between the two groups (P ＞ 0.05). Conclusion The implementation of nursing intervention under the theory of self-efficacy has obvious advantages in improving the prognosis of patients in the vulnerable stage of the disease.
		2022 Vol. 19 (1): 173-176 [Abstract] ( 116 ) HTML (1 KB) PDF (629 KB) ( 74 )

	177	Application of motivational nursing combined with mindfulness decompr-ession training in postoperative patients with colorectal cancer#br#
		XUE Yuping XU Wei▲
		Objective To observe the application effect of incentive nursing combined with mindfulness decompression training in patients with colorectal cancer (CRC) after operation. Methods A retrospectively analysis was conducted on the data of 50 patients with CRC who underwent incentive nursing combined with mindfulness decompression training in Nanjing First Hospital, Nanjing Medical University from May 2020 to May 2021 and included in the observation group; the data of 50 patients with CRC treated with routine intervention in the hospital during the same period were collected and included in the control group. The data of patients were reviewed, the psychological status (self-rating anxiety scale [SAS], self-rating depression scale [SDS]), quality of life (WHO quality of life brief form) of the two groups were compared before and two weeks after intervention. Results After two weeks of intervention, the SAS and SDS scores of the two groups were lower than before the intervention, while the observation group was lower than the control group, and the differences were statistically significant (P ＜ 0.05). After two weeks of intervention, the environmental, social, psychological, and physiological scores of the two groups were higher than before the intervention, while the observation group was higher than the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Incentive nursing combined with mindfulness decompression training can alleviate the negative emotions of patients after CRC and is beneficial to improve their quality of life.
		2022 Vol. 19 (1): 177-180 [Abstract] ( 96 ) HTML (1 KB) PDF (666 KB) ( 36 )

	181	Influence of extended rehabilitation nursing based on family on psychological status and compliance with medical behavior of patients with coronary heart disease complicated with heart failure#br#
		SUN Jing XUE Fenfei WANG Shizhan
		Objective To explore the influence of extended rehabilitation nursing based on family on psychological status and compliance with medical behavior of patients with coronary heart disease complicated with heart failure. Methods A total of 100 patients with coronary heart disease complicated with heart failure admitted to Liaoning Provincial People’s Hospital from June to December 2020 were selected as the research object, and they were divided into control group and observation group by random number table method, with 50 cases in each group. The control group was treated with conventional nursing, and the observation group was treated with family-based extended rehabilitation nursing on the basis of the control group. The mental status scale in non-psychiatric settings (MSSNS) score, mini-mental state examination (MMSE) score, compliance with medical behavior, and complication rate were compared between the two groups. Results After nursing, MSSNS score of two groups was lower than before nursing, MMSE score was higher than before nursing, MSSNS score of observation group was lower than control group, MMSE score was higher than control group (P ＜ 0.05). The compliance of medication, diet, exercise, self-blood pressure monitoring, and regular review in the observation group was higher than that in the control group (P ＜ 0.05). The complication rate of the observation group was lower than the control group (P ＜ 0.05). Conclusion Family-based extended rehabilitation nursing can improve the psychological status of patients with coronary heart disease complicated with heart failure, enhance patients’ compliance with medical behavior, reduce the complication rate in the process of rehabilitation.
		2022 Vol. 19 (1): 181-184 [Abstract] ( 206 ) HTML (1 KB) PDF (626 KB) ( 45 )

	185	Effect of life hope intervention combined with respiratory function exercise on hope level and living quality of the patients with lung adenocarcinoma#br#
		YANG Ying
		Objective To explore the effects of life hope intervention combined with respiratory function exercise in improving hope level and living quality of patients with lung adenocarcinoma. Methods Seventy-two patients with lung adenocarcinoma admitted to the First Affiliated Hospital of Zhengzhou University from January to July 2019 were selected as the study subjects. They were divided into control group and intervention group, with 36 cases in each group. The control group were given the respiratory function exercise, the intervention group were given life hope intervention combined with respiratory function exercise. The hope level and living quality of the two groups were evaluated before intervention and after three months of intervention. Results After three months of intervention, the positive attitude, positive action, intimate relationship, and total score of the intervention group were higher than before intervention (P ＜ 0.05). Positive attitude, positive action, and total score of control group were higher than before intervention (P ＜ 0.05). The improvement of positive attitude, positive action, intimate relationship, and total score in the intervention group was higher than that in the control group (P ＜ 0.05). The scores of living quality of both groups were higher than before intervention, and the intervention group was higher than the control group (P ＜ 0.05). Conclusion Life hope intervention combined with respiratory function exercise can improve the hope level and the living quality of patients with lung adenocarcinoma.
		2022 Vol. 19 (1): 185-188 [Abstract] ( 111 ) HTML (1 KB) PDF (627 KB) ( 58 )

	189	Application value of information-based continuous nursing based on situational leadership theory in patients with high risk of VTE after cesarean section#br#
		Xiatiguli·aini
		Objective To explore the application value of information-based continuous nursing based on situational leadership theory in high-risk patients of venous thromboembolism (VTE) after cesarean section. Methods A total of 160 patients with high risk of VTE were selected and randomly divided into control group and observation group according to convenience sampling method, with 80 cases in each group. The control group received conventional nursing, and on the basis of the control group, the observation group was given information continuing care based on situational leadership theory, then the knowledge and practice, incidence of venous thrombosis, quality of life score and nursing satisfaction were recorded and analyzed. Results The scores of knowledge and practice in observation group were higher than those in control group, the differences were statistically significant (P ＜ 0.05), and the incidence of deep venous thrombosis of lower extremities in lower extremity was lower than that in control group, the difference was statistically significant (P ＜ 0.05). The observational group were higher than the control group in quality of life score, the difference was statistically significant (P ＜ 0.05), and the nursing satisfaction of observational group was higher than that of the control group, the difference was statistically significant (P ＜ 0.05). Conclusion Informational continuous nursing based on situational leadership theory can improve the knowledge and practice level of puerpera with high-risk VTE, reduce the incidence of VTE, improve the life quality, and improve nursing satisfaction, which is worthy of clinical promotion.
		2022 Vol. 19 (1): 189-192 [Abstract] ( 104 ) HTML (1 KB) PDF (666 KB) ( 118 )

	193	Influence of repeated first aid drill on the comprehensive first aid ability of nurses#br#
		ZOU Xin1 LIN Lin1▲ SUN Lei1 LIU Ling1 LI Xin2
		Objective To explore the influence of repeated first aid drill on the comprehensive first aid ability of nurses. Methods Twenty-one nurses from Ward Four, Department of Cardiovascular Medicine, Dalian Central Hospital of Liaoning Province from December 2019 to December 2020 were selected as the research subjects. Combat and emergency drill training teams were established. Nurses in the department carry out actual combat and emergency plan learning, including determining contents, making plans, drawing up actual combat and drill plans, role configuration, on-site actual combat and real scene simulation of first-aid implementation. After the training, review, analysis and summary were carried out, 24 actual combat and retelling simulation first aid drills were carried out, each session continuous 90 minutes. The first aid practice ability and preparation time of first aid materials of nurses after training were compared with those before training. Results After the training, the theoretical knowledge and practical ability of first aid were higher than before, the preparation time of emergency supplies was shorter than that before the training, and the differences were statistically significant (P ＜ 0.05). After the training, the scores of cardiopulmonary resuscitation, electrocardiogram monitoring, use of defibrillator, oxygen inhalation of nasal obstruction, sputum aspiration technique, and venous puncture were all higher than before, the differences were statistically significant (P ＜ 0.05). Conclusion The comprehensive ability of first aid of nurses can be improved through the drill of repeated first aid technique.
		2022 Vol. 19 (1): 193-196 [Abstract] ( 34 ) HTML (1 KB) PDF (662 KB) ( 35 )

Copyright © Editorial Board of 中国医药导报
Supported by:Beijing Magtech