基于网络药理学探讨桂枝芍药知母汤治疗痛风的作用机制

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Abstract Objective To explore the mechanism of action of Guizhi Shaoyao Zhimu Decoction in the treatment of gout based on network pharmacology. Methods The active ingredients and corresponding targets of Guizhi Shaoyao Zhimu Decoction were screened by traditional Chinese medicine systems pharmacology database and analysis platform and literature. Gout related targets were searched by GeneCards, OMIM, DisGeNET and TTD databases, and the intersection of drugs and disease targets was obtained. Cytoscape 3.7.2 software was used to construct the disease-drug-target-component network and protein-protein interaction network, and R 4.0.3 software was used for GO enrichment analysis and KEGG pathway enrichment analysis. Results A total of 125 active components of Guizhi Shaoyao Zhimu Decoction and 60 drug-disease common targets were predicted. GO functional enrichment analysis mainly involved molecular functions such as phosphatase binding, metallopeptidase activity, MAPK activity, transcription factor binding, and oxidation-reduction enzyme activity. KEGG enrichment analysis showed that TNF signaling pathway, TLR signaling pathway, IL-17 signaling pathway, Th17 cell differentiation, CLR signaling pathway, NF-κB signaling pathway were closely related to gout. Conclusion Guizhi Shaoyao Zhimu Decoction plays a significant role in the treatment of gout inflammation, uric acid metabolism disorder and bone destruction, and so on, providing theoretical basis for future clinical trials and experimental studies.

Key words： Guizhi Shaoyao Zhimu Decoction Network pharmacology Gout Mechanism of action

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	HE Jiaying1 LIU Mingling2 LI Shuyao1 WANG Xinyu1 GUAN Tong2

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HE Jiaying1 LIU Mingling2 LI Shuyao1 WANG Xinyu1 GUAN Tong2. Study on the mechanism of action of Guizhi Shaoyao Zhimu Decoction in the treatment of gout based on network pharmacology#br#[J]. 中国医药导报, 2022, 19(1): 145-149.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I1/145

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