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| Research progress on the correlation between tumor stem cells and EGFR-TKI resistance mechanism of lung adenocarcinoma#br# |
| CHEN Yu1 CHEN Jie2 LI Yajun1▲ |
1.Department of Oncology, the Third Affiliated Hospital of Zunyi Medical University the First People’s Hospital of Zunyi, Guizhou Province, Zunyi 563000, China;
2.Department of Urology Surgery, the Third Affiliated Hospital of Zunyi Medical University the First People’s Hospital of Zunyi, Guizhou Province, Zunyi 563000, China |
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Abstract Lung cancer is currently the malignant tumor with the fastest increase in morbidity and mortality. Among them, the epidermal growth factor receptor (EGFR) mutation rate of adenocarcinoma accounts for the highest proportion of lung cancer patients. For such patients, epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) targeted therapy is its main treatment method, which can effectively inhibit the growth of tumor cells with EGFR sensitive mutations. However, acquired drug resistance severely restricts the use of such drugs. Cancer stem cells (CSC) are small part of cells that exist in tumor tissues, which can promote tumor cell growth, invasion and migration, multidirectional differentiation, and resistance to radiotherapy and chemotherapy. The specific targeting of CSC combined with conventional chemotherapy may achieve the goal of stabilizing remission or curing tumors. Therefore, this article reviews recent research progress in the mechanism of acquired drug resistance of CSC and lung adenocarcinoma EGFR-TKI, and provides new strategies and directions for future research.
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