|
|
|
| Influencing factors of metabolic syndrome and application value of neutrophil / lymphocyte ratio in metabolic syndrome#br# |
| DING Leilei1 JIA Chengpu2 FU Li1 LI Li1 WANG Tingting1▲ |
1.International Medical Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China;
2.Department of Orthopedic and General Surgery, Nanyuan Hospital of Beijing Fengtai District, Beijing 100076, China |
|
|
|
Abstract Objective To investigate the influencing factors of metabolic syndrome (MS) and application value of neutrophil/lymphocyte ratio (NLR) in MS. Methods A total of 968 physical examination subjects in Beijing Friendship Hospital, Capital Medical University from January 2018 to January 2019 were selected as the subjects. They were divided into MS group (241 cases) and non-MS group (727 cases) according to whether they had MS. The differences of clinical data and laboratory indicators between the two groups were observed, the correlation between NLR and MS metabolic indicators was analyzed by Pearson correlation coefficient, the influencing factors of MS were analyzed by logistic regression model, and the diagnostic efficacy of NLR for MS was evaluated by receiver operating characteristic (ROC) curve. Results In MS group, age, male proportion, smoking proportion, alcohol consumption proportion, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), uric acid (UA), hypersensitive C-reactive protein (hs-CRP), NLR were higher than those of non-MS group, and high density lipoprotein cholesterol (HDL-C) was lower than that in non-MS group, and the differences were statistically significant (P ＜ 0.05). Correlation analysis showed that NLR was positively correlated with metabolic indicators of MS patients including BMI, SBP, DBP, FBG, HbA1c, TG, UA, and hs-CRP (r ＞ 0, P ＜ 0.05), and negatively correlated with HDL-C (r ＜ 0, P ＜ 0.05), after adjusting for gender, age, smoking history, and alcohol history, the above correlation still existed (adjusted P ＜ 0.05). Analysis of influencing factors showed that advanced age, high BMI, high SBP, high DBP, high TG, high FBG, and high NLR were independent risk factors for MS (OR ＞ 1, P ＜ 0.05), while female and high HDL-C were protective factors (OR ＜ 1, P ＜ 0.05). ROC curve showed that the area under the curve of NLR for diagnostic MS was 0.745 (P ＜ 0.05). Conclusion The occurrence of MS is affected by age, gender, and a variety of metabolic factors. NLR is closely related to MS, which has certain diagnostic value for MS.
|
|
|
|
|
|
[1] 中华医学会糖尿病学分会代谢综合征研究协作组.中华医学会糖尿病学分会关于代谢综合征的建议[J].中华糖尿病杂志，2004，12（3）：156-161.
[2] Gu DF，Reynolds K，Wu XG，et al. Prevalence of the metabolic syndrome and overweight among adults in China [J]. Lancet，365（9468）：1398-1405.
[3] Balta S，Demirkol S，Unlu M，et al. Neutrophil to lymphocyte ratio may be predict of mortality in all conditions [J]. Br J Cancer，2013，109（12）：3125-3126.
[4] Jiang H，Zhang J，Wu J，et al. Neutrophil-to-lymphocyte ratio correlates with severity of extracranial carotid stenosis-a study using digital subtraction angiography [J]. J Stroke Cerebrovasc，2017，26（6）：1182-1190.
[5] 张娟，张春梅，陈伟男.急性脑梗死患者外周血中性粒细胞/淋巴细胞比值与颈动脉易损斑块的关系[J].中国现代医学杂志，2021，31（2）：67-71.
[6] 冯洁渊.中性粒细胞/淋巴细胞比值和血小板/淋巴细胞比值与急性冠脉综合征的关系研究进展[J].心血管病学进展，2020，41（12）：1276-1280.
[7] 王亚柱，马珂琳，祝丽丽，等.中性粒细胞/淋巴细胞比值、单核细胞/淋巴细胞比值与2型糖尿病合并冠心病的相关性研究[J].临床误诊误治，2021，34（2）：44-48.
[8] 马彦鹏，彭瑜，吴增颖，等.中性粒细胞/淋巴细胞比值与PCI术后AMI患者死亡的关系及其预测价值[J].心血管康复医学杂志，2021，30（1）：1-5.
[9] 王凯莉，孙子淇，吴伟华.中性粒细胞/淋巴细胞比值在糖尿病及其并发症中作用研究的进展[J].心血管康复医学杂志，2021，30（1）：88-91.
[10] 吴苏，戴雅丽，王阳阳，等.中性粒细胞/淋巴细胞比值和血小板/淋巴细胞比值与2型糖尿病患者肾小管损伤的相关性研究[J].中华糖尿病杂志，2021，13（1）：66-72.
[11] 邱丽，谭翠莲，刘华.术前NLR、PLR联合血清肿瘤标志物评估结直肠癌患者预后的临床价值[J].中国普通外科杂志，2020，29（12）：1533-1538.
[12] Yasui S，Takata T，Kamitani Y，et al. Neutrophil-to-Lymphocyte Ratio Is a Useful Marker for Predicting Histological Types of Early Gastric Cancer [J]. J Clin Med，2021，10（4）：791.
[13] 何立香，周宇，王美清，等.术前和术后中性粒细胞与淋巴细胞比值变化预测结直肠癌病人预后的研究[J].安徽医药，2021，25（1）：84-88.
[14] Levey AS，Stevens LA，Schmid CH，et al. A new equation to estimate glomerular filtration rate [J]. Ann Intern Med，2009，150（9）：604-612.
[15] Li R，Li WC，Lun ZJ，et al. Prevalence of metabolic syndrome in Mainland China：a meta-analysis of published studies [J]. BMC Public Health，2016，16：296-305.
[16] Romeo GR，Lee J，Shoelson SE. Metabolic syndrome，insulin resistance，and roles of inflammation——mechanisms and therapeutic targets [J]. Arterioscler Thromb Vasc Biol，2012，32（8）：1771-1776.
[17] Kawamoto R，Tabara Y，Kohara K，et al. Usefulness of combining serum uric acid and high-sensitivity C-reactive protein for risk stratification of patients with metabolic syndrome in community-dwelling women [J]. Endocrine，2013，44（1）：132-139.
[18] Kang DH，Park SK，Lee IK，et al. Uric acid-induced C-reactive protein expression：implication on cell proliferation and nitric oxide production of human vascular cells [J]. J Am Soc Nephrol，2005，16（12）：3553-3562.
[19] Welty FK，Alfaddagh A，Elajami TK，et al. Targeting inflammation in metabolic syndrome [J]. Transl Res，2016， 167（1）：257-280.
[20] 朱晖，季禹乔，季建伟，等.中性粒细胞/淋巴细胞比值与代谢综合征及其组分的关系[J].江苏大学学报：医学版，2018，28（1）：79-81，85.
[21] Liu X，Zhang Q，Wu HM，et al. Blood Neutrophil to Lymphocyte Ratio as a Predictor of Hypertension [J]. Am J Hypertens，2015，28（11）：1339-1346.
[22] Mertoglu C，Gunay M. Neutrophil-Lymphocyte ratio and Platelet-Lymphocyte ratio as useful predictive markers of prediabetes and diabetes mellitus [J]. Diabetes Metab Syndr，2017，11（Suppl 1）：S127-S131.
[23] Buyukkaya E，Karakas MF，Karakas E，et al. Correlation of neutrophil to lymphocyte ratio with the presence and severity of metabolic syndrome [J]. Clin Appl Thromb Hemost，2014，20（2）：159-163.
[24] 汤莎莎，李旭晴，张毅.2型糖尿病患者NLR、PLR与代谢综合征相关分析[J].医药论坛杂志，2017，38（11）：18-21.
[25] 侯丹丹.中性粒细胞/淋巴细胞比值与代谢综合征的相关性分析[D].银川：宁夏医科大学，2019.
[26] 吴跃跃，徐炯，刘军，等.老年人代谢综合征与血细胞计数比值及白细胞计数的相关性研究[J].中华老年医学杂志，2016，35（5）：498-502. |
|
|
|
