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| Study of curcumin-loaded targeted liposomes in the treatment of myocardial infarction#br# |
| HU Dandan YANG Zhihao GAO Yali JIANG Lei WANG Na LIU Xiaoying |
| Department of Pharmaceutics, Daqing Campus, Harbin Medical University, Heilongjiang Province, Daqing 163319, China |
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Abstract Objective To construction of curcumin-loaded myocardial infarction targeted liposomes (cT-Cur-LIP) modified with anti-cTnI antibody to improve the therapeutic effect of myocardial infarction. Methods The film dispersion method was used to prepare cT-Cur-LIP; the Malvern laser particle size analyzer was used for preparation characterization; the in vitro experiment verified the uptake of cT-Cur-LIP, and the in vivo experiment verified the therapeutic effect of cT-Cur-LIP on myocardial infarction. Results The surface of the prepared cT-Cur-LIP was round and oval. In vitro results showed that the uptake of cT-Cur-LIP was higher than that of Cur and Cur-LIP, and the difference was statistically significant (P ＜ 0.05). In vivo results proved that in the cT-Cur-LIP group, the fibers of cardiomyocytes were arranged uniformly, and the horizontal cytoplasmic stripes were clear, but the local horizontal stripes disappeared. Conclusion cT-Cur-LIP nano-targeted liposomes can effectively target hypoxic myocardium and provide new ideas for the treatment of myocardial infarction.
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