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2020 Vol. 17, No. 27
Published: 2020-09-25
 
 
4 Effect of CXCL-13 on human bone marrow mesenchymal mtem cell migration by activating PI3K-Akt signaling pathway
SHEN Lei LI Yongtao SUN Shizhu YAO Lijie WANG Lulu LIU Danyang JIN Haifeng ZHANG Shanqiang
Objective To verify C-X-C motif chemokine ligand-13 (CXCL-13) effect on human bone marrow mesenchymal stem cells (hBMSC) migration by activating PI3K-Akt signaling pathway. Methods hBMSC without stimulation was control group. hBMSCs were stimulated with 80 μmol/L CXCL-13 as CXCL-13 group. hBMSCs were first cultured with 25 nmol/L LY294002 for 40 min, and then 80 μmol/L CXCL-13 were added as PI3K inhibitor group. hBMSCs were cultured with 50 μmol/L Triciribine for 30 min in advance and then 80 μmol/L CXCL-13 were added as Akt inhibitor group. Cell wound scratch assay and Transwell cell migration assay were used to detect the scratch area closure rate and cell migration rate of hBMSCs in four groups. The expression of human PI3K, Akt and P-Akt proteins in hBMSCs of four groups were detected by enzyme linked immunosorbent assay. Results The hBMSCs scratch area closure rate and cell migration rate in CXCL-13 group were higher than those in control group, the hBMSCs scratch area closure rate and cell migration rate in PI3K inhibitor group and Akt inhibitor group were lower than those in CXCL-13 group (P ＜ 0.05 or P ＜ 0.01). The protein contents of human PI3K, Akt and P-Akt in CXCL-13 group were higher than those in control group, the protein contents of human PI3K, Akt and P-Akt in PI3K inhibitor group and Akt inhibitor group were lower than those in CXCL-13 group(all P ＜ 0.01). Conclusion CXCL-13 activates the PI3K-Akt signaling pathway to promote the migration of hBMSCs.
2020 Vol. 17 (27): 4-7 [Abstract] ( 726 ) HTML (1 KB)  PDF (1245 KB)  ( 347 )
8 Exploration of a new hybrid design sequence in drug interchangeability
LING Jia1 LIU Shengjie2 YAN Fangrong2▲
Objective To propose a new hybrid design sequence (TTRR, RRTT, RTTR, TRRT) to explore its application in drug interchangeability. Methods Based on criterion for drug interchangeability (SCDI) scaled by Chow, etc. as evaluation criteria, the application of the new sequence in drug interchangeability was explored by considering the variation among drug individuals, and was compared with the common sequence (TRTR, RTRT). Results Through computer simulation of different situations, it was found that the new sequence presented a consistent trend. In addition, the new sequence presented in this study was more sensitive than the common sequence when the key parts σWR, σD of drug interchangeability were changed. Conclusion Although the new sequences are more sensitive to variation than the common sequence in drug interchangeability, the additional two sequences make it less effective in sample size.
2020 Vol. 17 (27): 8-11,32 [Abstract] ( 116 ) HTML (1 KB)  PDF (825 KB)  ( 232 )
12 Study on the dietary habits and the risk of type 2 diabetes among ZhuangZú residents in Nanning City, Guangxi Zhuang Autonomous Region
ZHONG Xin DAI Xia MA Cui HUANG Yanfeng HUANG Shan ZHANG Qiu ZHAI Lu LIU Yuhua
Objective To explore the relationship between the dietary habits of ZhuangZú residents in Nanning City, Guangxi Zhuang Autonomous Region and the prevalence of type 2 diabetes (T2DM), and to provide a scientific basis for reducing the risk of T2DM in the ZhuangZú. Methods From January to March 2017, a cluster sampling method was used to select 900 urban ZhuangZú residents and 900 rural ZhuangZú residents in Nanning City, Guangxi Zhuang Autonomous Region for questionnaire surveys. A two-class logistic regression model was used to analyze the relationship between T2DM and tea types, tea drinking frequency, cooking methods, and diet tastes. Results The results of univariate analysis showed that there were highly statistically significant difference between the two groups in terms of gender, age, smoking, drinking, and family history (P ＜ 0.01). There were highly statistically significant difference in dietary rules, tastes, cooking methods, types of tea, frequency of drinking tea, and frequency of intake of fried food between the two groups (P ＜ 0.01). Multivariate logistic regression analysis showed that females and high frequency of tea drinking were protective factors for diabetes in ZhuangZú (OR ＜ 1, P ＜ 0.05); age, family history, irregular diet, saltiness, and cooking were the ZhuangZú risk factors for diabetes (OR ＞ 1, P ＜ 0.05). Conclusion Eating behaviors such as eating taste, eating regularity, tea drinking type, tea drinking frequency, cooking style may be the influencing factors of T2DM in ZhuangZú, and dietary health education and life guidance should be given to T2DM patients in ZhuangZú.
2020 Vol. 17 (27): 12-15 [Abstract] ( 135 ) HTML (1 KB)  PDF (629 KB)  ( 210 )
16 Effects of Butylphthalide on the expression of GSK-3β and p-Tau proteins in CA1 region of hippocampal of Alzheimer′s disease rats
DENG Chunying1 LI haibin2 MAO Wenjing1 LI Shiying1
Objetive To observe the effects of Butylphthalide (NBP) on the expression of glycogen synthase kinase-3β (GSK-3β) protein and p-Tau protein in CA1 region of hippocampus of Alzheimer′s disease rats, and to explore the mechanism of brain protection by butylphthalide. Method Seventy-two male SD rats were randomly divided into sham operation group (24 rats), AD model group (24 rats) and NBP treatment group (24 rats). Aβ-amyloid 1-42 (Aβ1-42) was used to make AD model. The sham operation group was injected with 5 μL saline. Four weeks after successful modeling, NBP treatment group was given NBP mixed solution made of NBP and edible oil by gavage. The sham operation group and the AD model group were given the same dose of edible oil. Morris water maze experiment was used to compare the number of times the rats crossed the platform. Western blot was used to detect the expression of GSK-3β and p-Tau proteins in the hippocampal CA1 region at one, two, four and eight weeks after administration. Results Compared with the sham operation group, the number of rat crossing the platform at each time point in AD model group was significantly reduced (all P ＜ 0.05). Compared with AD model group, the number of rats crossing the platform increased at each time point in the NBP treatment group (all P ＜ 0.05). Compared with the sham operation group in the same period, the relative expression levels of p-Tau and GSK-3β proteins in the hippocampal CA1 area of the AD model group were increased, and the differences were highly statistically significant (P ＜ 0.01). Compared with the AD model group in the same period, the relative expression levels of p-Tau and GSK-3β proteins in the hippocampal CA1 area of rats in the NBP treatment group were decreased, and the differences were highly statistically significant (P ＜ 0.01). Compared with the sham operation group in the same period, the relative expression levels of p-Tau and GSK-3β proteins in the hippocampal CA1 area of rats in the NBP treatment group were increased, and the difference was statistically significant (P ＜ 0.01). Conclusion NBP can play a protective role on the brain of AD model rats by down-regulating the expression of GSK-3β and p-Tau protein.
2020 Vol. 17 (27): 16-19 [Abstract] ( 132 ) HTML (1 KB)  PDF (745 KB)  ( 90 )
20 The correlation between the number of acute attacks in bronchial asthma and children′s behavior abnormality
LI Yingxia1 TIAN Tian1 GAO Songyi1 FAN Fang2
Objective To analyze the correlation between the number of acute attacks in bronchial asthma and children′s behavior abnormality. Methods One hundred and two children with bronchial asthma admitted to Xi′an Central Hospital from January 2016 to October 2018 were selected as the research objects. According to whether the annual attack times of asthma were ≥ five times, they were divided into frequent group (n = 69) and non frequent group (n = 33). The basic data of the children were collected. The children′s social behavior ability was assessed by Achenbach children′s behavior rating scale. The scores of behavior problems of children in two groups were compared. The scores of behavior problems of children with different gender and parents with the highest education level in frequent group were compared. The correlation between the number of acute attacks of bronchial asthma and behavioral abnormalities was analyzed. Results The scores of behavior problems and total scores of frequent group were significantly higher than those of non frequent group (P < 0.05). The score of aggressive behavior in boys was significantly higher than that in girls of frequent group (P < 0.05). There were no significant differences in the scores of other behavior problems and the total scores in children of different genders between two groups (P > 0.05). The anxiety/depression scores of the parents with the highest education level of senior high school or below were higher than those of the junior college or above, and the differences were statistically significant (P < 0.05). There were no significant differences in the scores of other behavior problems and total scores between the children with different parents with the highest education level in the frequent occurrence group (P > 0.05). There was a significant positive correlation between the number of acute asthma attacks and the total score of behavioral problems (r = 0.522, P < 0.05). Conclusion There is a positive correlation between the degree of behavioral abnormality and the number of acute attacks in children with bronchial asthma. The gender of children and the education level of their parents has a certain impact on their behavioral abnormality. Targeted behavioral correction and psychological intervention will be helpful to reduce the number of attacks.
2020 Vol. 17 (27): 20-23 [Abstract] ( 141 ) HTML (1 KB)  PDF (671 KB)  ( 110 )
24 Analysis on the status and influencing factors of unexpected pregnancy in adolescents
YUAN Xiaowei DENG Jihong ZHANG Wen
Objective To understand the status of adolescent reproductive health, the status of unwanted pregnancy and its influencing factors, so as to provide the basis for sex education and clinical diagnosis and treatment of adolescent female clinic. Methods From June 2017 to June 2019, a total of 500 adolescent patients were randomly selected from Kunming Maternal and Child Health Hospital to conduct a questionnaire survey. The survey included two parts: the status of reproductive health and the knowledge of family planning. According to whether they had accidental pregnancy experience or not, 500 cases were divided into accidental pregnancy experience group (106 cases) and no accidental pregnancy experience group (394 cases). The related factors of unexpected pregnancy were analyzed. Results The age of menarche, the age of beginning sexual life, the experience of menstrual disorder, the experience of taking emergency contraceptives, the need to take contraceptive measures and the correct use of condoms were related to the occurrence of unexpected pregnancy, and the differences were statistically significant (P < 0.05). There was no significant relationship between the age of breast development, reproductive tract infection, the risk of induced abortion and the occurrence of unexpected pregnancy (P > 0.05). Experience of taking emergency contraceptives, understanding the need to take contraceptive measures when having sex and understanding the correct use of condom were the protective factors of accidental pregnancy (OR = 0.581, 0.459, 0.511), while menstrual disorder was the risk factor of unexpected pregnancy (OR = 1.903). Conclusion According to the development characteristics and reproductive health status of adolescent women, the knowledge of reproductive health and contraception should be publicized to reduce the occurrence of unwanted pregnancy.
2020 Vol. 17 (27): 24-27 [Abstract] ( 143 ) HTML (1 KB)  PDF (624 KB)  ( 88 )
28 Expression of UBQLN-1 and RUNX3 in rectal cancer tissues and their clinical significance
SUN Guangyuan1 GUO Shengchao2 WU Xueliang1 XUE Jun1 QU Ming1 GUO Fei1 HAN Lei1 HAN Jie3
Objective To explore the expression of UBQLN-1 and RUNX3 in rectal cancer tissues and clinical significance. Methods From June 2017 to June 2019, 85 cases of rectal cancer tissues and adjacent normal tissues were selected from the First Affiliated Hospital of Hebei North University were selected. The mRNA and protein levels of UBQLN-1 and RUNX3 were detected by reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemistry and the relationship between UBQLN-1, RUNX3 and the clinicopathological characteristics of tumors and the correlation between their expressions were analyzed. Results The expression of UBQLN-1 mRNA in rectal cancer tissues was higher than that in adjacent normal tissues; and the expression of RUNX3 mRNA in rectal cancer tissues was lower than that in adjacent normal tissues，and the differences were highly statistically significant (P ＜ 0.01). The positive expression rate of UBQLN-1 in rectal cancer tissues was higher than that in adjacent normal tissues and the positive expression rate of RUNX3 was lower than that of adjacent normal tissues, with highly statistically significant differences (P < 0.01). UBQLN-1 was negatively correlated with RUNX3 expression in rectal cancer tissues（r = -0.225, P = 0.038）. Conclusion The abnormal expressions of UBQLN-1 and RUNX3 in the rectal cancer tissues are closely related to their development and evolution, and rectal cancer tissues and adjacent normal tissues are significantly negatively correlated, which can be used as potential molecular biological indicators for the diagnosis, treatment and prognosis assessment of rectal cancer.
2020 Vol. 17 (27): 28-32 [Abstract] ( 118 ) HTML (1 KB)  PDF (742 KB)  ( 120 )
33 Research progress of non-coding RNA in the development of atrial fibrillation
ZHENG Jie CHENG Yu CHEN Can
Atria fibrillation (AF) is one of the most common supraventricular arrhythmias the global, and its morbidity and mortality rates are gradually on the rise. Non-coding RNA are rnas that are transcribed from the genome and do not have the ability to translate into proteins RNA. It is widely involved in biological physiological and pathological processes. It is found that it is closely related to the occurrence and development of AF. Therefore, this paper describes the research progress of the role of non-coding RNA (miRNA, LncRNA and circRNA) in AF, which can provide the theoretical basis for the clinical prevention and treatment of AF.
2020 Vol. 17 (27): 33-36 [Abstract] ( 209 ) HTML (1 KB)  PDF (652 KB)  ( 56 )
37 Advances in the treatment of AIDS complicated with tuberculosis
WEI Huaying YANG Yang ZENG Jing WU Yongfeng HUA Wei GUO Caiping ZHANG Yulin▲
Tuberculosis (TB) is one of the leading opportunistic infections and causes of death among people infected with the human immunodeficiency virus. The treatment of AIDS patients with tuberculosis (AIDS) is complicated by the fact that antiretroviral (ART) drugs and anti-TB drugs may have similar metabolic and elimination pathways. Therefore, the choice of treatment drugs for coinfected persons is very important. This article will briefly describe the progress of treatment regimens, drug interactions and drug hepatotoxicity in AIDS patients with TB.
2020 Vol. 17 (27): 37-39 [Abstract] ( 156 ) HTML (1 KB)  PDF (615 KB)  ( 55 )
40 Advanced mechanisms and potential clinical application value of monocrotaline-induced pulmonary artery hypertension animal model
CHENG Xiaohan1 QI Jing2 BAI Yuhua1 ZHENG Xiaodong2
Pulmonary artery hypertension (PAH) is a fatal cardiovascular disease characterized by increases in pulmonary artery pressure and pulmonary vascular resistance. The pathological features of PAH induced by monocrotaline (MCT) are similar to those of clinical patients. MCT-induced PAH through multiple factors including inflammatory response, endothelium pathway, and regulation of pulmonary artery smooth muscle cells proliferation, et al. Therefore, this article briefly reviews the advances molecular mechanism of the MCT-induced PAH and the exploration in the novel therapeutic targets by using this animal model in recent years.
2020 Vol. 17 (27): 40-43 [Abstract] ( 312 ) HTML (1 KB)  PDF (626 KB)  ( 104 )
44 Research progress on the treatment of arteriosclerosis obliterans of limbs with traditional Chinese medicine
YE Xuejin1 LI Zhihong1 DENG Baiyang2
With the rapid development of social economy, changes in diet and lifestyle of huge, lead to obesity is on the rise, the incidence of arteriosclerosis obliterans (ASO) increased year by year, when ASO develops to the middle and late stages, most patients lose the ability to walk normally due to insufficient blood supply to the limbs, and eventually face the choice of high paraplegia. At present, there are no effective methods and drugs, and both surgery and interventional therapy have high costs and the possibility of recurrence is 30%-50%. Therefore, seeking for effective treatment measures is a key problem that needs to be solved urgently. Traditional Chinese medicine has unique advantages in the treatment of limb ischemic vascular diseases, so it is particularly urgent to strengthen the research on the treatment of ASO by traditional Chinese medicine, especially in the field of surgery of traditional Chinese medicine, and to find a research that can effectively treat ASO by utilizing modern research and traditional Chinese medicine technology. This paper aims to comprehensively summarize the current situation and treatment prospect in this field, so as to provide theoretical basis for the future surgical treatment of ASO in traditional Chinese medicine, so as to better improve the clinical effect.
2020 Vol. 17 (27): 44-47 [Abstract] ( 135 ) HTML (1 KB)  PDF (620 KB)  ( 84 )
48 Advances in the pharmacological action and clinical application of Kunxian Capsules in the treatment of immunological kidney diseases
DENG Yi1* ZHU Dekang1,2* TAO Xia1 ZHANG Feng1 CHEN Wansheng1,3
Kunxian Capsules is composed of tripterygium hypoglaucum, epimedium herb, barbary wolfberry fruit and dodder seed, has the effect of tonifying kidney and dredging channels, dispelling wind and eliminating dampness, and also has anti-inflammatory, immunosuppressive and improving kidney function. It is a commonly used drug in clinical treatment of rheumatoid arthritis and other immune diseases. The study of Kunxian Capsules in immunological kidney diseases has attracted increasing attention, focusing on the combination of Kunxian Capsules with hormones and immunosuppressive/cytotoxic drugs to protect kidney function and reduce adverse reactions. In this paper, the pharmacological action and clinical research progress of Kunxian Capsules in the treatment of immunological kidney diseases are reviewed in order to provide references for rational clinical use of drugs.
2020 Vol. 17 (27): 48-50,61 [Abstract] ( 384 ) HTML (1 KB)  PDF (636 KB)  ( 327 )
51 Research progress of the pathogenesis and intervention effect of traditional Chinese medicine on irritable bowel syndrome
WANG Song CAO Yiyuan HUANG Sijie XI Qing LI Guowen
 Irritable bowel syndrome is a common gastrointestinal disease. Its pathogenesis is complex and still unclear, which may be related to visceral hypersensitivity, gut-brain axis abnormal interaction, intestinal flora, psychology, genetics and other factors. At present, conventional treatment is mainly used to improve the quality of life, and its effect is limited. In recent years, traditional Chinese medicine has played a unique advantage in improving clinical symptoms, reducing adverse reactions, controlling recurrence rate and so on, and has achieved good curative effect. Two aspects of pathogenesis and intervention effect of traditional Chinese medicine on irritable bowel syndrome is summarized in this article.
2020 Vol. 17 (27): 51-54 [Abstract] ( 121 ) HTML (1 KB)  PDF (624 KB)  ( 119 )
55 Research progress of the expression and clinical significance for the miRNA in cervical cancer tissue
XU Jiehuan1 LIAN Ping1 LI Yaojun1 YE Feng1 DENG Yuping2
The pathogenesis of cervical cancer is very complex, so it is very important to find reliable tumor markers.
miRNA is an important regulatory factor. In recent years, the exploration of the regulatory mechanism of miRNA has become a hot spot. This paper will discuss the related research progress in the expression and clinical significance of miRNA in cervical cancer.
2020 Vol. 17 (27): 55-57 [Abstract] ( 199 ) HTML (1 KB)  PDF (620 KB)  ( 63 )
58 Advancements of microRNA in diabetic nephropathy
TIAN Shasha1 YANG Xiaopeng1 GUO Hui1,2
Diabetic nephropathy (DN) is one of the main complications of diabetic microangiopathy and has been the leading cause of chronic kidney disease in China. It′s important to understand the pathogenesis and find new diagnostic and therapeutic targets of DN. MicroRNA (miRNA), as a ubiquitous non-coding small molecular RNA, is widely involved in gene post-transcriptional and epigenetic regulations. The expression or abnormal function play an important role in the occurrence and development of DN, mediating the pathophysiological changes such as the pathophysiological changes of renal tissue fibrosis, inflammation, podocyte apoptosis in DN. Recently, the value of miRNA in the early diagnosis and prognosis judgment of DN has been confirmed and it has been gradually used in clinical treatment as a therapeutic target for DN by inhibiting or reconstructing miRNA. However, there are great challenges of miRNA in the pathogenesis and clinical application for DN in the future.
2020 Vol. 17 (27): 58-61 [Abstract] ( 144 ) HTML (1 KB)  PDF (626 KB)  ( 40 )
62 Analysis of the status quo and influencing factors of the core competence of obstetric specialist nurses in Xinjiang Uygur Autonomous Region′s top three hospitals
FU Liping LU Huimin NIE Yuqin
Objective To understand the status quo of the core competence of obstetric specialist nurses in Xinjiang Uygur Autonomous Region′s top three hospitals, and to analyze the factors which affected the core competence of obstetric specialist nurses. Methods Using the cluster sampling method, the general information questionnaire and the “core competence evaluation index scale for obstetric specialist nurses”, a total of 469 registered nurses in the obstetrics department of Xinjiang Uygur Autonomous Region′s top three hospitals were selected as the research subjects, and the questionnaire survey was conducted from June to August 2019. Results A total of 480 questionnaires were issued, 480 questionnaires were returned, and 469 questionnaires were valid, with an effective response rate of 97.7%. The core competency score of obstetric specialist nurses was (83.66±21.84) points. The core competence scores of nurses of different ages, marital status, education background, and ability levels were compared, and the differences were statistically significant (P ＜ 0.05). Multiple linear regression analysis showed that marital status and energy level were entered the multivariate regression equation, and the differences were statistically significant (P ＜ 0.05). Conclusion The core competence of obstetric nurses in Xinjiang Uygur Autonomous Region′s top three hospitals are at an intermediate level. Nursing managers should conduct hierarchical training and assessment based on the comprehensive competence of nurses to comprehensively improve the core competence of obstetric nurses.
2020 Vol. 17 (27): 62-65,77 [Abstract] ( 145 ) HTML (1 KB)  PDF (544 KB)  ( 140 )
66 Analysis of health behaviors and influencing factors in stroke survivors after discharge
DENG Liping1 XIE Xiaohua2 PAN Lu3 MA Jiahui1 XIAO Jingyi4 YANG Jie1 XIONG Xiaoyun5
Objective To explore the current status of health behaviors of stroke patients after discharge for one year, and to analyze the influencing factors. Methods A self-designed general information questionnaire and a stroke patient health behavior scale were used to conduct a questionnaire on a total of 106 stroke patients who were discharged from the hospital for more than one year in the stroke nursing clinic of the Second People′s Hospital of Shenzhen in Guangdong Province from August to December 2019. Results One year after discharge from the hospital, the overall health behaviors of stroke patients were at an upper-moderate level. In univariate analysis, the differences in health behavior scores of stroke patients with different gender, education level, marital status, monthly income, and types of combined chronic diseases were statistically significant (P ＜ 0.05). The results of multiple linear regression analysis showed that gender, education level, and marital status were the influencing factors of healthy behavior (P ＜ 0.05), which could explain 30.8% of the variance of healthy behavior. Conclusion The overall level of healthy behaviors of stroke patients one year after discharge from the hospital is relatively high, but exercise and responsibility need to be improved. In health education, we should be paid attention to men, people with low education levels, and divorced or widowed people, to help establish healthy behaviors, to reduce recurrence of diseases, and to improve the quality of life.
2020 Vol. 17 (27): 66-69 [Abstract] ( 145 ) HTML (1 KB)  PDF (537 KB)  ( 90 )
70 Status and correlation of malnutrition and psychological distress in patients with malignant tumors
ZHANG Ping1 ZHAO Yun1▲ MENG Aifeng2 WANG Yeping1 WANG Meixiang2 WU Bing1 YANG Bo1
Objective To investigate the status quo of malnutrition and psychological pain in patients with malignant tumors, and to analyze the correlation between them. Methods The convenience sampling method was used to select a total of 352 malignant tumor patients who were hospitalized in Jiangsu Cancer Hospital from April 2018 to January 2019 as the research objects. The general situation questionnaire, psychological distress thermometer (DT), patient subjective overall assessment scale (PG-SGA) and nutritional risk screening tool 2002 (NRS 2002) were used to investigate the correlation between malnutrition and psychological distress. Results A total of 352 questionnaires were issued in this survey, and a total of 345 valid questionnaires were returned. The effective response rate was 98.01%. The detection rate of patients with significant psychological pain was 41.45%. The incidence of malnutrition screened by PG-SGA and NRS 2002 were 55.36% and 48.99%, respectively. The scores of PG-SGA and NRS 2002 were significantly positively correlated with DT scores (P ＜ 0.05). Parallel trials showed that there was a significant correlation between them (P ＜ 0.01), however in continuous trials, the difference was not statistically significant (P ＞ 0.05). Conclusion The malnutrition of patients with malignant tumors is positively correlated with the level of psychological pain. In the future, food-based nutritional interventions can be considered to improve the psychological state of patients.
2020 Vol. 17 (27): 70-73 [Abstract] ( 126 ) HTML (1 KB)  PDF (533 KB)  ( 4668 )
74 Survey on satisfaction of bonus distribution and influencing factors of health personnel in public hospitals of Chinese medicine in Shaanxi Province
QI Baoning1,2 MIAO Jing2▲ LI Juan2 XU Shouzhu2 SHI Chuandao2 JI Mingrui2 WANG Jiaxin2
Objective To understand the satisfaction of health personnel in Shaanxi public hospitals of traditional Chinese medicine with the hospital′s existing bonus distribution system and the main influencing factors. Methods From January 2016 to January 2018, a multi-stage stratified cluster random sampling method was adopted to evaluate the basic situation of health personnel, job satisfaction, bonus distribution satisfaction, hospital welfare project satisfaction, and non-economic compensation satisfaction and work environment satisfaction. Results A total of 2695 questionnaires were distributed in this survey, and a total of 2131 valid questionnaires were returned. Among the hospitals sampled, only 2.82% and 1.50% of the health personnel were “very satisfied” with their current work and the hospital′s bonus distribution. Among them, there were statistically significant differences in the satisfaction of bonus distribution among health personnel with different professional types, working years, job positions, positions and professional titles (P ＜ 0.05). The professional type, working years, job title and annual income of health personnel all had impact on the satisfaction of health personnel′s bonus distribution (P ＜ 0.05). Conclusion The overall job satisfaction and bonus distribution satisfaction of health personnel in public hospitals of Chinese medicine in Shaanxi Province are generally low. It is recommended that relevant departments and hospital managers adopt corresponding incentive measures to improve the bonus distribution plan and improve the job satisfaction of health personnel.
2020 Vol. 17 (27): 74-77 [Abstract] ( 121 ) HTML (1 KB)  PDF (603 KB)  ( 42 )
78 Effects of total parathyroidectomy on clinical symptoms, depression and anxiety and quality of life in patients with secondary hyperparathyroidism
QI Na1 FENG Xiaodong2 XU Tianchao1 BI Ting2 TANG Yufu2
Objective To explore the effect of total parathyroidectomy on clinical symptoms, depression and anxiety and quality of life in patients with secondary hyperparathyroidism (SHPT). Methods A total of 160 patients with SHPT secondary to chronic kidney disease who underwent total parathyroid resection admitted to the Department of Hepatobiliary Surgery of the General Hospital of Northern Theater Command from June 2016 to December 2018 were selected. Serum levels of calcium, phosphorus, alkaline phosphatase (ALP) and parathyroid hormone (iPTH) were measured before and Six months after operation. Pasieka parathyroid symptom score (PAS) was performed in all patients. Hamilton depression scale (HAMD) and hamilton anxiety scale (HAMA) were used to evaluate patients′ negative emotions. Summary of health survey (SF-36) was used to evaluation of patient quality of life. Results Compared with preoperative, the blood calcium, blood phosphorus, ALP, and iPTH of the patients were significantly reduced at six months after operation (P ＜ 0.05). The scores and total scores of 13 symptom items in PAS decreased significantly (P ＜ 0.05). Postoperative HAMD and HAMA scores were significantly decreased (P ＜ 0.05). SF-36 physical health score and mental health score were significantly increased (P < 0.05). PAS total score minus points were positively correlated with HAMD and HAMA scores (r = 0.501, 0.358, all P ＜ 0.05), and negatively correlated with SF-36 physiological health scores and mental health scores (r = -0.567, -0.428, all P ＜ 0.05). All HAMD and HAMA minus points were negatively correlated with SF-36 physiological health score and mental health score (r = -0.368, -0.317, -0.433, -0.394, all P ＜ 0.05). Conclusion Parathyroidectomy can alleviate the clinical symptoms, improve the depression and anxiety, and improve the quality of life of SHTP patients.
2020 Vol. 17 (27): 78-81 [Abstract] ( 148 ) HTML (1 KB)  PDF (437 KB)  ( 110 )
82 Effect of Insulin Glargine combined with Atorvastatin on vascular endothelial function and oxidative stress in patients with type 2 diabetes mellitus
CHEN Ping CHEN Weihong
Objective To investigate the regulation effect of Glargine combined with Atorvastatin on vascular endothelial function and oxidative stress in patients with type 2 diabetes mellitus. Methods A total of 100 patients with type 2 diabetes mellitus who treated in Ma′anshan People′s Hospital, Anhui Province from January 2017 to January 2019 were selected, they were divided into the control group (50 cases, Insulin Glargine treatment) and the observation group (50 cases, Insulin Glargine combined with Atorvastatin treatment) by random number table method. The blood glucose control, vascular endothelial function (carotid artery intima-media thickness [IMT], serum nitric oxide [NO], plasma endothelin [ET-1]), oxidative stress response (malondialdehyde [MDA], glutathione peroxidase [GSH-PX], superoxide dismutase [SOD]) were compared between the two groups. Results After 12 weeks of treatment, the blood glucose levels of the two groups before breakfast and 2 h after breakfast were decreased, and the observation group was lower than the control group, the differences were statistically significant (P ＜ 0.05); the levels of IMT, ET-1, and MDA in the two groups were decreased, and the observation group was lower than the control group, the differences were statistically significant (P ＜ 0.05); the levels of NO, GSH-PX and SOD in the two groups were increased, and the observation group was higher than the control group, the differences were statistically significant (P ＜ 0.05). Conclusion Insulin Glargine combined with Atorvastatin in treatment of patients with type 2 diabetes mellitus can improve vascular endothelial function and oxidative stress response, and promote the stability of disease.
2020 Vol. 17 (27): 82-85 [Abstract] ( 168 ) HTML (1 KB)  PDF (431 KB)  ( 163 )
86 Meta analysis of retrograde intrarenal surgery and percutaneous nephrolithotomy for the treatment of 2-3 cm renal calculi
LI Jinze PENG Lei WEI Tangqiang XIA Zhongyou LI Yunxiang
Objective To systematically review the efficacy and safety of retrograde intrarenal surgery (RIRS) versus percutaneous nephrolithotomy (PCNL) in kidney stones of 2-3 cm. Methods PubMed, EMBASE, Science, WanFang, VIP and CNKI databases were electronically searched to identify all eligible comparative studies from inception of the database to October 2019. Then meta-analysis was performed by using RevMan 5.3 software. Results A total of 10 studies involving 1597 patients were included. Among them, there were 778 patients in the RIRS group and 819 patients in the PCNL group. The results of meta-analysis showed that: compared with PCNL, RIRS had lower stone-free rate (OR = 0.47, 95%CI [0.34, 0.66], P ＜ 0.000 01), shorter hospital stay (MD = -2.45, 95%CI[-2.96, -1.94], P ＜ 0.000 01), less decrease in haemoglobin (MD = -6.43, 95%CI[-9.05, -3.82], P ＜ 0.000 01), and lower complication rate (OR = 0.69, 95%CI [0.51, 0.93], P = 0.02), but no difference was found in operation time between the two groups (MD = 6.27, 95%CI[-3.51, 16.05], P = 0.21). Conclusion Compared with PCNL, RIRS has a lower SFR, but it has advantages in terms of hospital stay, decrease in haemoglobin, and complication rate. Therefore, for patients with kidney stones of 2-3 cm, RIRS is a safe and effective alternative to PCNL.
2020 Vol. 17 (27): 86-91 [Abstract] ( 148 ) HTML (1 KB)  PDF (1306 KB)  ( 152 )
92 Finite element analysis of proximal femoral nail anti-rotation with different length in the treatment of type A3.3 femoral intertrochanteric fracture in elderly
CHEN Xinmin1 JIANG Teng1 YANG Wei1 ZHENG Liqin2 LIN Ziling2 TU Shijie1
Objective To investigate the optimal length of proximal femoral nail anti-rotation for the treatment of type A3.3 femoral intertrochanteric fracture in elderly by using finite element method. Methods Based on one patient volunteer′s hip CT data in Fengcheng Hospital of Traditional Chinese Medicine, Jiangxi Province imported into Mimics 19.0 and Geomagic 2017 softwares and obtained proximal femur model after processed. Then the model was imported into Solidworks 2017 software to simulate A3.3 type fracture and assembled with different length of proximal femoral nail anti-rotation getting model A (short nail), B (middle nail), and C (long nail)  respectively. The models were imported into Abaqus 2016 software one by one in step format to set material parameters and boundary conditions, etc. and then the calculation was carried out. The Von Mises cloud pictures were checked and the whole femur stress, internal fixation stress, fracture gap size and inversion angle of head-neck bone fragment were observed. Results The overall stress of femur in model B was the minimum, that in model C was the maximum, and that in model A was the center. Proximal femoral nail anti-rotation was the main supporting structure of head and neck bone fracture, and beared most of the stress. The stress peak was located at the connection between spiral blade and main nail, and the secondary peak was located at the entry point of external femoral wall. The fracture gap size and inversion angle of head-neck bone fragment were inversely proportional to the length of the main nail, model A had the smallest fracture gap size and inversion angle of head-neck bone fragment, model C had the largest, and model B had the middle. Conclusion The application of the short length proximal femoral nail anti-rotation in the treatment of type A3.3 femoral intertrochanteric fracture in the elderly has a smaller fracture gap size, a more stable fracture end and a better biomechanical effect.
2020 Vol. 17 (27): 92-95 [Abstract] ( 124 ) HTML (1 KB)  PDF (694 KB)  ( 81 )
96 Experience of Zang Fuke proved recipe Xiaojiye Decoction in the treatment of synovitis of knee osteoarthritis
GUO Hongyu WANG Bin YUAN Yi FAN Xiran LI Duoduo ZANG Fuke
This paper summarizes the experience of professor Zang Fuke on the treatment of synovitis of knee osteoarthritis, comprehensive the four diagnosis of traditional Chinese medicine and pathological anatomy of western medicine, emphasize on the combination of overall syndrome differentiation and local disease differentiation combined with each other in dialectics. The overall concept of syndrome differentiation and treatment is to protect the spleen and stomach and prevent recurrence, and local differentiation of disease is reflected in the principle of three stages of bone injury treatment, that is, “promoting blood circulation for removing blood stasis for the first-stage, regulating the motion of Yingqi for the mid-stage, strengthening the function of kidney and bone for the last-stage”. In the early stage, traditional Chinese medicine orthopedic diseases must injure qi and blood, damage bones and muscles, and involve liver and kidney more in the middle and late stage. Therefore, spleen, liver and kidney deficiency and wet stasis mutual junction are established as the core pathogenesis of this disease. Through the clinical diagnosis and treatment approach of “making the etiology and disease name consistent, identifying the diseased nature and position, making it disease correlated with syndrome”, the diagnosis and treatment of the disease and syndrome are divided into two types of clinical staging: “qi stagnation, blood stasis, and water accumulation type” (swelling phase) and “yang deficiency type of spleen and kidney” (non-swelling phase). In the swelling stage, the method of “soothing the liver, activating the blood and benefiting the water” should be adopted; in the remission stage, the method of “strengthening the spleen and benefiting the kidney” should be adopted; the prescription of “Xiaojiye Decoction” should be adopted to add or decrease the dosage and apply, both samples should be taken into consideration, and the curative effect is confirmed.
2020 Vol. 17 (27): 96-99,103 [Abstract] ( 170 ) HTML (1 KB)  PDF (593 KB)  ( 103 )
100 Clinical Study of Changqi Tongluo manipulation in treatment of pain after anterior cervical discectomy and fusion
CHEN Maoshui WU Yongsheng ZENG Haobin ZHANG Bo YANG Renxuan
Objective To observe the clinical effect of Changqi Tongluo manipulation in the treatment of cervical back pain after anterior cervical discectomy and fusion (ACDF). Methods A total of 64 patients with cervical back pain after ACDF in Zhuhai Hospital, Guangdong Hospital of Traditional Chinese Medicine from July 2016 to July 2019 were selected and they were divided into experimental group and control group by simple random grouping method, with 32 patients in each group. The experimental group was treated with Changqi Tongluo manipulation plus oral Celecoxib Capsules, while the control group was treated with oral Celecoxib Capsules. Visual analogue scale (VAS), cervical spine dysfunction index (NDI), hospital stays after neck drainage tube extraction were compared between the two groups before and after treatment, and adverse events were observed. Results VAS and NDI scores of the two groups after treatment were lower than those before treatment, and VAS and NDI scores of the experimental group were lower than those of the control group, with statistically significant differences (all P ＜ 0.05). The hospital stays after neck drainage tube extraction in the experimental group was shorter than that in the control group (P ＜ 0.05). No adverse events occurred during the study. Conclusion Changqi Tongluo manipulation is effective in the treatment of postoperative cervical back pain after ACDF. It can effectively improve the pain symptoms, promote the recovery of neck function after ACDF, shorten the postoperative hospital stays, and achieve the purpose of accelerating rehabilitation. Changqi Tongluo manipulation has positive clinical significance in accelerating recovery after ACDF, which is worthy of further exploration and promotion.
2020 Vol. 17 (27): 100-103 [Abstract] ( 129 ) HTML (1 KB)  PDF (570 KB)  ( 132 )
104 Expression and clinical significance of heat shock protein 27 in maternal and fetal serum and placenta of patients with hypertensive disorder complicating pregnancy
LI Renren1 ZHU Jinming2 WANG Fengzhen3
Objective To investigate the expression and clinical significance of heat shock protein 27 (HSP27) in maternal and fetal serum and placental of patients with hypertensive disorders of pregnancy (HDP). Methods Ninety pregnant women with gestational hypertension delivered in Xuzhou Maternal and Child Health Hospital in Jiangsu Province from June 2018 to June 2019 were selected (including 30 cases of gestational hypertension group, 30 cases of non severe preeclampsia group and 30 cases of severe preeclampsia group). Another 30 healthy pregnant women were selected as control group. The levels of HSP27 in venous blood and cord blood of pregnant women were detected by enzyme linked immunosorbent assay, and the expressions of HSP27 mRNA and protein in placenta were detected by RT-PCR and immunohistochemistry. Results The levels of HSP27 in venous blood and cord blood of pregnant women in control group, gestational hypertension group, preeclampsia (non severe) group and severe preeclampsia group showed an increasing trend, and the differences among all groups were highly statistically significant (P < 0.01). The expression of HSP27 mRNA in placental tissues of control group, pregnancy induced hypertension group, preeclampsia (non severe) group and severe preeclampsia group showed an increasing trend, and the differences among all groups were statistically significant (P < 0.05). The expression of HSP27 protein in placental tissues of control group, pregnancy induced hypertension group, preeclampsia (non severe) group and severe preeclampsia group showed an increasing trend, and the differences among all groups were statistically significant (P < 0.05). Conclusion HSP27 is highly expressed in venous blood, umbilical blood and placental of pregnant women with HDP, and the expression of HSP27 is correlated with the severity of HDP, suggesting that HSP27 may play a role in the development of HDP.
2020 Vol. 17 (27): 104-107 [Abstract] ( 94 ) HTML (1 KB)  PDF (596 KB)  ( 68 )
108 Changes and significance of serum angiotensinogen levels in patients with preeclampsia before and after delivery
LI Jing ZUO Jinling ZHANG Xiaoyu WANG Chunshuang CHEN Baoli YI Jianping
Objective To observe changes and significance of serum angiotensinogen (AGT) levels in patients with preeclampsia before and after delivery. Methods Ninety-five preeclampsia patients hospitalized in Obstetrics Department of Tangshan Maternal and Child Health Hospital in Hebei Province (hereinafter referred to as “our hospital”) from March 2018 to January 2019 were selected as case group. Sixty cases of normal late pregnancy women hospitalized in Obstetrics Department of our hospital at the same time without indications for cesarean section were randomly selected as control group. The serum AGT levels between two groups were detected by enzyme linked immunosor-bent assay before and 72 h after delivery. Results There were no significant differences in age and gestational age between two groups (P > 0.05). The body mass index, systolic blood pressure and diastolic blood pressure in case group were higher than those in control group (P < 0.05). The serum AGT level of case group before delivery was higher than that after delivery and control group, the differences were statistically significant (P < 0.05). The proportion of abnormal serum AGT level in case group was higher than that in control group (P < 0.05). The risk of abnormal AGT level in case group was 35.538 times the control group, and 95%CI was 14.422-100.235. Conclusion The level of serum AGT in patients with preeclampsia increased singnificantly, fell rapidly to normal standard after childbirth, AGT maybe plays an important role in the preeclampsia.
2020 Vol. 17 (27): 108-111,119 [Abstract] ( 100 ) HTML (1 KB)  PDF (743 KB)  ( 135 )
112 Effect study of low-dose Progesterone Injection combined with Baotai Wuyou Capsules on serum P, E2, β-hCG in pregnant women with threatened abortion
ZHANG Qi1 ZENG Qingdong2 YIN Qingyun1
Objective To analyze the therapeutic effect of low-dose Progesterone Injection combined with Baotai Wuyou Capsules on patients with threatened abortion, and serum progesterone (P), estradiol (E2), β-human chorionic gonadotropin (β-hCG) levels. Methods The women with threatened abortion treated in Dandong Women and Children′s Hospital of Liaoning Province from October 2016 to October 2018 were selected as research subjects, and they were divided into control group and observation group according to the random number table method, with 80 cases in each group. Patients of both groups were given low-dose Progesterone Injection, and observation group was given Baotai Wuyou Capsules. Treatment effect of two groups was observed. Serum P, E2, β-hCG, immune indicators levels and incidence of adverse reactions before and after treatment of two groups were compared. Results Treatment success rate in observation group was significantly higher than that in control group (P < 0.05). There were no significant differences in the levels of β-hCG, P and E2 between two groups before treatment (P > 0.05). After treatment, the levels of β-hCG, P and E2 in two groups were higher than those before treatment, and observation group was higher than that control group, the differences were statistically significant (P < 0.05). There were no significant differences in the levels of IgG, IgA and IgM between two groups before treatment (P > 0.05). After treatment, the levels of IgG, IgA and IgM in two groups were higher than those before treatment, and observation group was higher than that control group, the differences were statistically significant (P < 0.05). There were no significant differences in the total incidence of dizziness, vomiting, breast pain and other adverse reactions between two groups (P > 0.05). Conclusion Low-dose Progesterone Injection combined with Baotai Wuyou Capsules has a good therapeutic effect on women with threatened abortion. It can obviously improve the hormone level of patients and increase the success rate of fertility protection. It has good clinical application value.
2020 Vol. 17 (27): 112-115 [Abstract] ( 125 ) HTML (1 KB)  PDF (481 KB)  ( 132 )
116 Effect of vitrectomy combined with internal limiting membrane peeling on macular structure and function in high myopia patients with MHRD and analysis of the influencing factors of macular hole closure after operation
SHI Wei JIANG Na
Objective To investigate the effect of vitrectomy combined with internal limiting membrane peeling (ILMP) on macular structure and function in high myopia patients with macular hole retinal detachment (MHRD) and analysis of the influencing factors of macular hole closure after operation. Methods Clinical data of 69 patients with MHRD with high myopia treated with vitrectomy and ILMP in Hebei Handan Eye Hospital from February 2016 to August 2018 were retrospectively analyzed. According to the follow-up results of macular hole closure at three months after operation, they were divided into closed group (57 cases) and unclosed group (12 cases). All patients underwent optical coherence tomography, slit lamp microscopy and best corrected visual acuity before and after surgery. The changes of foveal retinal thickness (FRT), sub foveal choroidal thickness (SFCT), and the parameters and index of macular hole before and after operation were measured. Combined with clinical data of the patients, univariate and multivariate logistic regression models were used to analyze the influencing factors of macular hole closure. Results There were no significant differences in FRT and SFCT between two groups before operation (P > 0.05). After operation, FRT and SFCT of two groups were thinner than those before operation, and closed group was thinner than that unclosed group, the differences were statistically significant (P < 0.05). There were significant differences in MD, MHI and THI between two groups (P < 0.05). Multivariate logistic regression analysis showed that MD (OR = 1.003, 95%CI: 1.000-1.005, P = 0.048), MHI (OR = 108.369, 95%CI: 5.047-2326.771, P = 0.003) and THI (OR = 215.263, 95%CI: 2.248-20 609.444, P = 0.021) were independent risk factors for macular hole closure. Conclusion Vitrectomy combined with ILMP can significantly improve the macular structure and function in MHRD patients with high myopia. MD, MHI and THI are risk factors for macular hole closure.
2020 Vol. 17 (27): 116-119 [Abstract] ( 146 ) HTML (1 KB)  PDF (387 KB)  ( 110 )
120 A comparative study of ferulic acid content in taproot and rootlet of Radix Angelicae Sinensis from different regions
CHAO Lei1 CAO Yudan2 YAN Hui2 CHEN Peidong2
Objective To compare the content of ferulic acid in taproot and rootlet of Radix Angelicae Sinensis from different regions. Methods The content of ferulic acid was measured by high performance liquid chromatography. Kromasil C18 column (250 mm×4.6 mm, 5 μm) was used in this study. The mobile phase was acetonitrile and 0.085% phosphoric acid (17∶83), the detection wavelength was set at 316 nm, the flow rate was set at 1.0 mL/min, the column temperature was 35℃, and the sample size was 20 μL. Results The ferulic acid showed a good linear relationship in the range of 19.52-31.20 μg/mL (r = 0.9999), and the average recovery was 99.70%, RSD was 2.40%. Conclusion The method is simple and reproducible. The content of ferulic acid sample from Heqing County of Yunnan Province is higher than those in other regions, and the content in the rootlet of Radix Angelicae Sinensis is higher than that in taproot of the plant.
2020 Vol. 17 (27): 120-122 [Abstract] ( 128 ) HTML (1 KB)  PDF (463 KB)  ( 114 )
123 Influence of Ivabradine combined with Levosimendan on ventricular remodeling in senile patients with chronic heart failure
LU Yaohua1 SHEN Weihua2▲
Objective To observe the benefit of Iavbredine combined with Levosimendan in the treatment of senile patients with chronic heart failure (CHF) and to analyze the effect of drugs on ventricular remodeling in patients. Methods From July 2018 to July 2019, 70 cases with senile patients with CHF who treated in Affiliated Sixth People′s Hospital of Shanghai Jiaotong University were selected as the study subjects. They were divided into the observation group and the control group according to the random table number method, with 35 cases in each group. Two groups were given routine treatment, and the control group was treated with Levosimendan on this basis, and the observation group was treated with Ivabradine on this basis of the control group, with two weeks of continuous treatment. The myocardial fibrosis indexes (Ⅰ collagen crosslinked carboxy terminal peptide [ⅠCTP], hyaluronic acid [HA], connective tissue growth factor [CTGF], laminin [LN], procollagen Ⅲ N-terminal propeptide [PⅢNP]) and ventricular remodeling indexes (left ventricular mass index [LVMI], left ventricular fraction shortening [LVFS], inter-ventricular septum end-stolic thickness [IVSS], left ventricular posterior wall thickness [LVPWT]) of the patients were detected before treatment and after treatment for two weeks. The adverse reactions during the treatment were recorded. Results There were no statistically differences in ⅠCTP, HA, CTGF, LN, PⅢNP, LVMI, LVFS, IVSS and LVPWT between the two groups before treatment (P > 0.05). The levels of ⅠCTP, HA, CTGF, LN, PⅢNP, LVMI, IVSS and LVPWT after treatment for two weeks were lower than those before treatment, and the observation group was lower than the control group; the level of LVFS was higher than that before treatment, and the observation group was higher than the control group, and the differences were statistically significant (all P < 0.05). There were no statisticaliy differences in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion Ivabradine combined with Levosimendan in treatment of senile patients with CHF can delay the the further development of myocardial fibrosis and ventricular remodeling, and the drug combination will not increase the adverse reactions, which have good safety and high application value.
2020 Vol. 17 (27): 123-126,130 [Abstract] ( 195 ) HTML (1 KB)  PDF (634 KB)  ( 116 )
127 Discussion on research ideas of early identification of metabolic syndrome prone population by integrated traditional Chinese and western medicine
WANG Daohong1 HUA Rong2 LIU Zhenjie2
Prevention of the metabolic syndrome is the disease prevention and control of aging society first line of defense, this paper discusses is used to discuss the necessity and feasibility of the metabolic syndrome early identification combined with traditional Chinese and western medicine. The research train is roughly summed up as: selecting feasible criteria for the diagnosis of metabolic syndrome; quantitative collection of traditional Chinese medicine dialectical information; application of large data screening of risk factors of Chinese and Western medicine, multicenter prospectie cohort analysis, and finally determine the early identification of risk prediction model.
2020 Vol. 17 (27): 127-130 [Abstract] ( 121 ) HTML (1 KB)  PDF (396 KB)  ( 91 )
131 Analysis on the law of tongue and pulse manifestation and syndrome types of clinical diabetes mellitus based on data mining
GUAN Yuanyuan1 TIAN Chunying1 SUN Xuan1 WANG Dongjun1 ZHU Qingqing1 ZHOU Zonghui1 WANG Hongwu2
Objective To study the distribution and correlation of tongue, pulse manifestation and syndrome types in clinical diabetes research. Methods CNKI, VIP and Wanfang Data were collected to study the clinical journals, conferences and dissertations on tongue, pulse manifestation and syndrome types of diabetes mellitus from the establishment of the database to December 2019. The search strategy was “diabetes” and “tongue manifestation” “pulse manifestation” “syndrome type”. The database of diabetes tongue and pulse manifestation and syndrome types was established, and descriptive statistics, association rule analysis and cluster analysis on the data were performed. Results The tongue and pulse manifestation and syndrome types with the highest frequency in the clinical study of diabetes were dark red tongue, greasy fur, deep pulse, stringy pulse, syndrome of endogenous heat due to yin deficiency. The most relevant combination of tongue and pulse manifestation were red tongue-deep pulse + stringy pulse, greasy fur-deep pulse + stringy pulse, greasy fur-slippery pulse + stringy pulse. In the results of the fourth-order association rules, the first four items with the highest degree were tongue and pulse transformations on the basis of syndrome of deficiency of both qi and yin and syndrome of endogenous heat due to yin deficiency, which were slippery pulse + stringy pulse + dark red tongue, slippery pulse + dark red tongue + greasy fur, plump tongue + deep pulse + red tongue, slippery pulse + dark red tongue + yellow fur. Conclusion The transfomation of tongue and pulse manifestation and syndrome types in clinical diabetes mellitus is complicated. The application of association rules in data mining analysis can provide theoretical guidance for clinical diagnosis and treatment of treating diabetes mellitus with traditional Chinese medicine.
2020 Vol. 17 (27): 131-134 [Abstract] ( 122 ) HTML (1 KB)  PDF (1030 KB)  ( 50 )
135 Thinking and discussion on the treatment of anxiety disorder with the theory of “Piwei Lun”
ZHAO Chunyi1 XIAO Rong1 ZHENG Zhuanfang1 ZHENG Liming2 LI Yan2
By combining the theory of “Piwei Lun” with clinical practices, this paper analyzes the etiology and pathogenesis of anxiety disorder, and points out that the main pathogenesis of such disorder lies in “spleen and stomach damage with imbalanced rising and falling of vital energy”. According to Professor Li Yan′s clinical experience in treating anxiety disorder for many years in Guangdong Provincial Hospital of Traditional Chinese Medicine, this paper summarizes different syndrome characteristics of anxiety disorder patients as followed: “deficiency heat in spleen and stomach”, “spleen deficiency and flaring-up of liver-fire”, “stagnation of liver qi and spleen deficiency”, “spleen deficiency and body-fluid consumption”, and “spleen and stomach disharmony”. In terms of treatment, effective prescriptions, such as Buzhong Yiqi Decoction, Bupiwei Xieyinhuo Shengyang Decoction, Shengyang Sanhuo Decoction, Huangqi Renshen Decoction and Modified Pingwei Powder are respectively selected based on the principle of “regulating spleen and stomach, benefiting primordial qi, purging yin fire and harmonizing qi and blood”.
2020 Vol. 17 (27): 135-137,142 [Abstract] ( 160 ) HTML (1 KB)  PDF (754 KB)  ( 154 )
138 Research on the formula features and academic thoughts of Jingyue Quanshu·Furen Gui for treating menopathy diseases
QIAN Xuwu1 JIANG Yuchen1 ZHAO Qi2 JIANG Ying2
Objective To systemically sort out the prescriptions for the treatment of menopathy diseases in “Jingmai Lei” in the Jingyue Quanshu·Furen Gui, and to explore his academic thoughts. Methods Taking the book of Jingyue Quanshu·Furen Gui published by China Medical Science Press as the retrieval source, the formulas that met the inclusion criteria were used for frequency analysis. The software of SPSS Statistic 23.0 and SPSS Modeler 14.1 were used for cluster analysis and association analysis of the high frequency drugs. Results Finally, 97 prescriptions were obtained, of which, the tonifying array was the most. A total of 100 Chinese herbs were obtained, among which, the high frequency drugs included Radix Angelicae Sinensis, Radix Glycyrrhizae, Radix Rehmanniae Preparata, and so on. Five core drug groups were obtained by cluster analysis, which were Radix Ginseng and Radix Glycyrrhizae, Rhizoma Ligustici Chuanxiong and Chinese peony, Cortex Moutan Radicis and Rhizoma Alismatis, Radix Bupleuri and Pericarpium Citri Reticulatae, Rhizoma Dioscoreae and Fructus Corni. Through correlation analysis, four drug combinations with strong correlation were obtained, which were Radix Glycyrrhizae and Radix Ginseng, Radix Angelicae Sinensis and Radix Glycyrrhizae, Radix Angelicae Sinensis and Chinese peony, Radix Angelicae Sinensis and Radix Rehmanniae Preparata. According to Apriori correlation analysis model, eight groups of traditional Chinese medicine with potential association rules, which were Radix Glycyrrhizae and Radix Ginseng, Radix Glycyrrhizae and Rhizoma Atractylodis Macrocephalae, Radix Rehmanniae Preparata and Rhizoma Dioscoreae, Radix Angelicae Sinensis and Rhizoma Ligustici Chuanxion, Radix Glycyrrhizae and Radix Bupleuri, Rhizoma Dioscoreae and Fructus Corni, Radix Rehmanniae Preparata and Fructus Corni, Radix Glycyrrhizae and Rhizoma Zingiberis. Conclusion The results of data mining show that Zhang Jingyue is good at replenishing qi and nourishing blood, especially in invigorating spleen and tonifying kidney, and strengthening vital qi and eliminating pathogen in the same time, and paying attention in warming up but not eliminating heat. The result of data mining is consistent with the traditional theory, which is reasonable and effective.
2020 Vol. 17 (27): 138-142 [Abstract] ( 150 ) HTML (1 KB)  PDF (1008 KB)  ( 31 )
143 Effect of self-made Gujing Yishen Decoction in the treatment of nephrotic syndrome and its influence on immune function
LIU Shifu LI Fangxia LIU Wenjun LING Xiaosan LYU Wei
Objective To explore the effect of self-made Gujing Yishen Decoction in the treatment of nephrotic syndrome (NS) and its influence on immune function. Methods A total of 82 cases of NS patients who were treated in Wuhu Traditional Chinese Medicine Hospital from February 2016 to December 2019 were selected. According to the random number table, the above patients were divided into the control group (41 cases) and the study group (41 cases). The control group was treated with conventional Western medicine, while the study group was treated with self-made Gujing Yishen Decoction on the basis of the control group. The curative effect, traditional Chinese medicine (TCM) syndrome score, renal function (24-hour urinary protein quantitative [24hPro], blood urea nitrogen [BUN], creatinine [Scr]),immune function (immunoglobulin A [IgA], immunoglobulin M [IgM], immunoglobulin G [IgG]) and adverse reactions were compared between the two groups. Results The total clinical effective rate of the study group was higher than the control group (P ＜ 0.05). After treatment, the symptom scores of the two groups were lower than that before treatment, and the study group was lower than the control group (P ＜ 0.05). After treatment, 24hPro, BUN and Scr levels were decreased in the two groups, and the study group was lower than those of the control group (P ＜ 0.05). After treatment, the IgA level decreased in the two groups, and the study group was lower than the control group (P ＜ 0.05), IgM and IgG increased in the two groups, and the study group was higher than those of the control group (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Self-made Gujing Yishen Decoction has a significant effect on NS patients. It can effectively improve renal function and immune function without increasing the incidence of adverse reactions, with good clinical application value.
2020 Vol. 17 (27): 143-146 [Abstract] ( 127 ) HTML (1 KB)  PDF (746 KB)  ( 105 )
147 Professor Li Yanning′s experience in treating children’s chronic persistent of asthma from the homology of phlegm and blood stasisWANG Ying1   LI Yanning2
WANG Ying1 LI Yanning2
Professor Li Yanning believes that “intermingled phlegm and blood stasis” is the key to the pathogenesis of children′s chronic persistent of asthma, and the physiological relationship of “homogeny of clear fluid and blood” must be accompanied by the pathological relationship of “intermingled phlegm and blood stasis”. “Phlegm” is the “root” of the onset of asthma and throughout the whole process of asthma. The chronic persistent of asthma is mainly intangible phlegm, which should be treated by “clearing phlegm”. However, “homogeny of clear fluid and blood”, “chronic disease and blood stasis”, phlegm turbid for a long time, blocking the vein and blocked can cause “blood stasis”. “Blood stasis” is an important pathological factor of chronic persistent of asthma. From the perspective of homology of phlegm and blood stasis, the author summarizes Professor Li Yanning′s experience in the treatment of children′s chronic persistent of asthma, discusses its unique etiology, pathogenesis, syndrome differentiation and treatment, enriches the theoretical basis of asthma treatment, and provides new ideas for clinical diagnosis and treatment.
2020 Vol. 17 (27): 147-151 [Abstract] ( 213 ) HTML (1 KB)  PDF (744 KB)  ( 208 )
151 Effect of resolving turbidity and removing toxicity comprehensive treatment on patients with stage 2-3 of chronic kidney disease
YAO Shuoshuo1 WEI Xiaona2 JI Dawei1 ZHENG Linlin1 FENG Cun2
Objective To observe the effect of resolving turbidity and removing toxicity comprehensive treatment on patients with stage 2-3 of chronic kidney disease (CKD). Methods A total of 160 patients with stage 2-3 of CKD in Nephrology Outpatient and Ward Department of Hebei Hospital of Traditional Chinese Medicine were selected from October 2017 to March 2019. Stratified by age, the patients were randomly divided into two groups, 78 cases in the treatment group and 82 cases in the control group. The treatment group was treated with resolving turbidity and removing toxicity comprehensive treatment plan, and the control group was treated with Niaoduqing Granules orally. Three months was a course of treatment. The overall efficacy, traditional Chinese medicine (TCM) syndrome score, renal function index (blood creatinine [Scr], blood urea nitrogen [BUN], uric acid [UA]), hemoglobin (HGB) and serum transforming growth factor-β1 (TGF-β1) levels before and after treatment were observed. Results The total effective rate in the treatment group was higher than that in the control group. After treatment, the TCM symptom score, Scr, BUN, and TGF-β1 levels were reduced in both groups, and the TCM symptom score, Scr, BUN, UA, and TGF-β1 levels in the treatment group were lower than those in the control group (P ＜ 0.05). After treatment, the HGB level was reduced in both groups, and the treatment group was higher than that in the control group (P ＜ 0.05). Conclusion Resolving turbidity and removing toxicity comprehensive treatment can regulate cytokines and effectively delay the progression of CKD.
2020 Vol. 17 (27): 151-154 [Abstract] ( 166 ) HTML (1 KB)  PDF (741 KB)  ( 71 )
155 The ancient and modern research of improving sleep by Zhuyou therapy
SUN Qiaosi HU Jingqing
“Zhuyou” originated from Neijing, which is to say the cause of illness to patients, or cooperate with the technique of incantation and forbidding evil, so as to eliminate the anxiety and depression of patients, so as to treat diseases related to emotion or caused by obvious mental factors. On the basis of consulting the papers and medical records, the origins and derived meaning of “Zhuyou” are analyzed. The principle of treating diseases is emotion-restricting, empathize, eliminating pathogen and strengthening vital qi, suggestion and solving puzzles, making use of other methods to treat diseases and pretending the name of Zhuyou. Zhuyou can improve sleeping quality through adjusting the state of mind, tranquilizing the mind, clearing up the nightmare and hypnotize the patients. So rational use of Zhuyou method can improve sleep quality effectively and it is worth further study.
2020 Vol. 17 (27): 155-158,167 [Abstract] ( 223 ) HTML (1 KB)  PDF (1051 KB)  ( 49 )
159 Effect of implanting catgut in abdominal acupoint combined with Heye Jiangzhi Decoction on glucose and lipid metabolism in obese type 2 diabetes mellitus
TIAN Feng1 PAN Hong2▲
Objective To investigate the effect of implanting catgut in abdominal acupoint combined with Heye Jiangzhi Decoction on glucose and lipid metabolism in obese type 2 diabetes mellitus patients. Methods A total of 155 obese type 2 diabetes mellitus patients admitted to Qianjiang Central Hospital of Chongqing City from February 2016 to March 2018 were prospectively selected as the research objects. The patients were divided into control group (77 cases) and observation group (78 cases) according to the random number table method. The control group was treated with Heye Jiangzhi Decoction, and the observation group was added with implanting catgut in abdominal acupoint on the basis of the control group. The clinical effect after treatment and the level of fasting blood glucose (FBG) at different time were observed. The levels of blood lipid indexes (total cholesterol [TC], triacylglycerol [TG], low density lipoprotein-cholesterol [LDL-C], high density lipoprotein-cholesterol [HDL-C]), nesfatin-1 and apelin were recorded before and after treatment. Obesity was recorded before and after treatment. Results After treatment, the total effective rate in the observation group was higher than that in the control group, and the difference was statistically significant (P ＜ 0.05). After treatment, the levels of obesity, TC, TG, LDL-C, nesfatin-1 and apelin in the two groups decreased, while the level of HDL-C increased, and the differences were statistically significant (P ＜ 0.05). After treatment, the levels of obesity, TC, TG, LDL-C, nesfatin-1 and apelin in the observation group were lower than those in the control group, and the HDL-C was higher than that in the control group, and the differences were statistically significant (P ＜ 0.05). The FBG level of the two groups showed a decreasing trend with time, and the FBG level at 30 and 60 d after treatment of the observation group were lower than those of the control group respectively, and the differences were statistically significant (P ＜ 0.05). Conclusion Implanting catgut in abdominal acupoint combined with Heye Jiangzhi Decoction is effective in the treatment of obese type 2 diabetes mellitus, which can significantly reduce blood glucose and lipid levels, and the mechanism may be related to the regulation of nesfatin-1 and apelin.
2020 Vol. 17 (27): 159-162 [Abstract] ( 125 ) HTML (1 KB)  PDF (744 KB)  ( 167 )
163 Meta analysis on clinical effect of acupotomy therapy on calcaneodynia
RUAN Anmin1 CHEN Pu1 ZHOU Jun1 ZHANG Xiaozhe1 ZONG Chenzhong1 SHEN Jiahao1 WANG Qingfu2
Objective To systematically evaluate the clinical effect of acupotomy therapy on calcaneodynia and provide evidence-based evidence for acupotomy therapy on calcaneodynia. Methods China National Knowledge Infrastructure, VIP, Wanfang, PubMed and Cochrane Library databases were searched by computer, and the retrieval time was from the establishment of the library to December 5, 2019. A clinical randomized controlled trials of acupotomy therapy on calcaneodynia were searched according to inclusion and exclusion criteria. The quality of the literature was evaluated according to the Cochrane 5.3 systematic evaluation manual, and the outcome indicators were meta-analyzed with RevMan5.3 software. Results A total of 11 clinical randomized controlled trials were included, involving 1010 patients. Meta-analysis showed that the effective rate of experimental group was higher than that of control goup (RR = 1.21, 95%CI：1.10, 1.32, P < 0.0001). Visual analogue scale scores in experimental group were lower than those in control group (MD = -1.48, 95%CI：-1.97, -0.99, P < 0.000 01). The ankle function scores in experimental group were higher than those in control group (MD = 11.68, 95%CI：6.97, 16.39, P < 0.000 01). Conclusion Acupotomy therapy has a good clinical effect on the treatment of calcaneodynia, which can significantly relieve pain and improve patients′ quality of life.
2020 Vol. 17 (27): 163-167 [Abstract] ( 186 ) HTML (1 KB)  PDF (1205 KB)  ( 87 )
168 Treatment of osteonecrosis of the femoral head from the theory of tendon by acupotomy
LIU Daobing1 CHEN Zhiwei2 WANG Rongtian3 LI Yan1 ZHOU Yu1 WANG Junyu1 CHEN Weiheng3
Osteonecrosis of the femoral head is a common hip disease in and thopedics department of traditional Chinese medicine. Hip pain and joint dysfunction are the main clinical manifestations and factors affecting the quality of life of patients. This paper first discusses the relationship between the loss of the tendon and the pain and dysfunction of the hip from the physiological function and pathological changes of tendon, and then combined with the function and characteristics of acupotomy therapy, forms the treatment plan of the osteonecrosis of the femoral head based on the tendon theory, and observed its curative effect. The result showed that acupotomy therapy can significantly improve the function of the hip in all directions of the patients, and it can relieve the pain around the hip and improve the quality of life. It provides an effective treatment for osteonecrosis of the femoral head.
2020 Vol. 17 (27): 168-170,174 [Abstract] ( 126 ) HTML (1 KB)  PDF (677 KB)  ( 80 )
171 A case of bronchial lipoma treated by bronchoscope high frequency electrical snare combined with cryotherapy
WANG Baoming1 LI Zhihao2 XING Xiqian3,4▲
Tracheobronchial lipoma is a rare disease, mostly seen in middle-aged and elderly men. Its etiology has not been determined yet, and its clinical symptoms are not specific, so it is easy to be misdiagnosed. A patient with broncholipoma who was admitted to the Department of Respiratory and Critical Care Medicine, Yan′an Hospital, Kunming City, Yunnan Province in 2016 was selected. Describe the diagnosis and treatment process and summarize the experience. The patient, female, 46 years old, was admitted for “cough and sputum for 3 weeks”. After admission, she was examined by high-resolution chest CT and bronchoscopy, and the neoplasm in the bronchial lumen was removed by high frequency electrical entrapment under the tracheoscope combined with cryotherapy, and the neoplasm was removed to reveal lipoma with saliary gland hyperplasia. Postoperative symptoms of cough and sputum were alleviated. Chest CT reexamination showed that the right middle bronchial lumen was unobtrusive and the right middle and lower lungs exudated and absorbed. Through case review and literature review, the epidemiology, clinical symptoms, imaging characteristics, and treatment selection of tracheobronchial lipoma were reviewed. Improve the level of diagnosis and treatment of tracheobronchial lipoma, reduce missed diagnosis and misdiagnosis.
2020 Vol. 17 (27): 171-174 [Abstract] ( 128 ) HTML (1 KB)  PDF (579 KB)  ( 122 )
175 Relationship between serum GGT level with inflammatory factors and lung function in patients with acute exacerbation of chronic obstructive pulmonary disease
LI Rui CHEN Chuanguo ZHU Maozhi
Objective To investigate the relationship between serum levels of γ-glutamyl transferase (GGT) with inflammatory factors and lung function in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods One hundred and three patients with AECOPD were followed up in the Second People′s Hospital of Wuhu City in Anhui Province (“our hospital” for short) from January 2017 to December 2019 were selected as AECOPD group, they were divided into high GGT group (＞ 63.59 U/L, 41 cases) and low GGT group (≤ 63.59 U/L, 62 cases) according to the average GGT at admission. In addition, 92 patients with stable of chronic obstructive pulmonary disease (SCOPD) patients (SCOPD group) and 80 healthy people (CON group) were selected as control. The differences of general clinical data, GGT, inflammatory factors and lung function between AECOPD group, SCOPD group and CON group were analyzed, and the differences of inflammatory factors and lung function in AECOPD patients with different GGT levels were compared, and the correlation between serum GGT level and inflammatory factors and lung function in AECOPD patients was analyzed. Results The levels of serum procalcitonin (PCT), C-reactive protein (CRP）, interleukin-6 (IL-6) and GGT in AECOPD group and SCOPD group were higher than those in CON group, FVC, FEV1 and FEV1/FVC in AECOPD group and SCOPD group were lower than those in CON group (P ＜ 0.05). The levels of PCT, CRP, IL-6 and GGT in AECOPD group were higher than those in SCOPD group, and FVC, FEV1, FEV1/FVC in AECOPD group were lower than those in SCOPD group (P ＜ 0.05). The levels of PCT, CRP and IL-6 in high GGT group were higher than those in low GGT group, while FVC, FEV1 and FEV1/FVC in high GGT group were lower than those in low GGT group (P < 0.05). The level of serum GGT was positively correlated with PCT, CRP and IL-6 (r = 0.706, 0.802, 0.589, P < 0.001), and negatively correlated with FEV1, FVC and FEV1/FVC (r = -0.562, - 0.657, - 0.734, P < 0.001). Conclusion The serum GGT level in AECOPD patients is significantly increased, which has a good correlation with inflammatory factors and lung function, and can provide help for the evaluation of inflammatory response and lung function in patients.
2020 Vol. 17 (27): 175-178,182 [Abstract] ( 168 ) HTML (1 KB)  PDF (686 KB)  ( 111 )
179 Comparison and suggestion on resident training system of cancer radiotherapy between China and the United States
LIN Dandan CHEN Biao LI Yue XU Ximing
The standardized residency training system for oncology radiation physicians is critical for improving the treatment of cancer patients and constitutes. After tens years of practice, the United States has established a relatively well-performing residency training system for oncology radiation physicians. The application and admission match process for oncology radiation physicians is very strict, emphasizes training on clinical practice and basic scientific research, student should learn by themselves. The assessment system after graduation consists of mutual evaluation, elimination system. In contrast, the oncology radiation residency training system in China is not mature and needs to be improved. According to my own training experience in UT Southwestern Medical Center, by comparison of the radiation residency training systems between China and the United States, this paper put forward some thinking and suggestions.
2020 Vol. 17 (27): 179-182 [Abstract] ( 151 ) HTML (1 KB)  PDF (577 KB)  ( 34 )
183 The translator′s subjectivity research of Neonatal and Pediatric Respiratory Therapy and its enlightenment to medical translation team
CHEN Chen1 CHEN Lin2▲ GUO Zikai1 LIU Boyuan1 LIU Manlin1▲
Since the 1980′s, translation subjectivity has remained a heated topic, resulting in the deep exploration into translator′s subjectivity. Translation is undertaken by translators whose principal role should be well recognized. This paper based on the study of the translation process of Neonatal and Pediatric Respiratory Therapy, gives a systematic analysis of translators′ initiative to ensure translation quality throughout the translation process. In the meantime, the author is inspired by Lefevere′s “rewriting theory” to recognize that the publication of a medical book is closely related to its translation quality, which requires the medical translation team to cater to the sponsor′s request. The medical translation team should not only meet the requirements of medical book translation project, but also follow the codes and norms of the target language.
2020 Vol. 17 (27): 183-185 [Abstract] ( 116 ) HTML (1 KB)  PDF (611 KB)  ( 101 )
186 Analysis of the humanistic spirit cultivation path of medical students under the concept of “big ideological and political ”
SHI Chen
The cultivation of medical students′ humanistic spirit is an important part of contemporary medical education, especially in the context of healthy China. As an open, dynamic and inclusive educational concept, the “big ideological and political” educational concept provides a new idea for the development of medical humanistic education. This paper elaborate the connotation and features of “big education” education, based on the analysis of the medical humanities education, on the basis of unique advantages, put forward from the establishment of new educational idea, construction of “medical humanities” course system, strengthening practice, build network and campus humanities environment four dimensions, and cultivate medical students humanistic spirit path optimization and innovation.
2020 Vol. 17 (27): 186-189 [Abstract] ( 163 ) HTML (1 KB)  PDF (578 KB)  ( 110 )
190 Research on high-quality development strategy and countermeasure of nursing talents in the third-level general hospital of Hebei Province
ZHANG Jiaqi1 JING Chao2
Since the 19th CPC national congress, the development mode of Hebei Province has shifted to high-quality development, and accordingly, the development of nursing talents in tertiary general hospitals in Hebei Province has also shifted to high-quality development stage. In the tertiary general hospital, nursing staff is the largest number and also a very critical professional and technical group. Among the medical staff supporting Wuhan in China, nursing staff is nearly three times that of doctors, playing a decisive role in epidemic prevention and resistance. This paper expounds the present situation and existing problems of high-quality development of nursing talents in tertiary general hospitals in Hebei Province, and puts forward a series of countermeasures on how to use policy advantages to optimize the development strategy of nursing talents, which has strong guiding value and practical significance.
2020 Vol. 17 (27): 190-192,196 [Abstract] ( 250 ) HTML (1 KB)  PDF (460 KB)  ( 100 )
193 Reform and exploration of innovation and entrepreneurship education system in the higher school of Chinese medicine under the background of new medicine
LIU Yang LI Baoqin
With the arrival of a new round of scientific and technological revolution, medical education is deeply integrated with the internet, big data, artificial intelligence and other modern information technologies. In order to meet the realistic demand of healthy China strategy and the social demand for compound medical talents, new medical science was born. Under the background of new medicine, in order to promote the implementation of the healthy China strategy and accelerate the development of traditional Chinese medicine health industry, the higher school of Chinese medicine which is the cradle of cultivating high-quality talents with innovative consciousness and spirit, should conform to the trend of the times and reform the education system for innovation and entrepreneurship. They should focus on changing the concept of education, improving practice platform and the security system to optimize the education system for innovation and entrepreneurship in the higher school of Chinese medicine. In this way, it can provide beneficial guidance for training top-notch innovative talents in traditional Chinese medicine industry that meet the requirements of medical development in the new era.
2020 Vol. 17 (27): 193-196 [Abstract] ( 155 ) HTML (1 KB)  PDF (450 KB)  ( 46 )
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