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| Relationship between serum GGT level with inflammatory factors and lung function in patients with acute exacerbation of chronic obstructive pulmonary disease |
| LI Rui CHEN Chuanguo ZHU Maozhi |
| Department of Emergency Medicine, the Second People′s Hospital of Wuhu City, Anhui Province, Wuhu 241000, China |
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Abstract Objective To investigate the relationship between serum levels of γ-glutamyl transferase (GGT) with inflammatory factors and lung function in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods One hundred and three patients with AECOPD were followed up in the Second People′s Hospital of Wuhu City in Anhui Province (“our hospital” for short) from January 2017 to December 2019 were selected as AECOPD group, they were divided into high GGT group (＞ 63.59 U/L, 41 cases) and low GGT group (≤ 63.59 U/L, 62 cases) according to the average GGT at admission. In addition, 92 patients with stable of chronic obstructive pulmonary disease (SCOPD) patients (SCOPD group) and 80 healthy people (CON group) were selected as control. The differences of general clinical data, GGT, inflammatory factors and lung function between AECOPD group, SCOPD group and CON group were analyzed, and the differences of inflammatory factors and lung function in AECOPD patients with different GGT levels were compared, and the correlation between serum GGT level and inflammatory factors and lung function in AECOPD patients was analyzed. Results The levels of serum procalcitonin (PCT), C-reactive protein (CRP）, interleukin-6 (IL-6) and GGT in AECOPD group and SCOPD group were higher than those in CON group, FVC, FEV1 and FEV1/FVC in AECOPD group and SCOPD group were lower than those in CON group (P ＜ 0.05). The levels of PCT, CRP, IL-6 and GGT in AECOPD group were higher than those in SCOPD group, and FVC, FEV1, FEV1/FVC in AECOPD group were lower than those in SCOPD group (P ＜ 0.05). The levels of PCT, CRP and IL-6 in high GGT group were higher than those in low GGT group, while FVC, FEV1 and FEV1/FVC in high GGT group were lower than those in low GGT group (P < 0.05). The level of serum GGT was positively correlated with PCT, CRP and IL-6 (r = 0.706, 0.802, 0.589, P < 0.001), and negatively correlated with FEV1, FVC and FEV1/FVC (r = -0.562, - 0.657, - 0.734, P < 0.001). Conclusion The serum GGT level in AECOPD patients is significantly increased, which has a good correlation with inflammatory factors and lung function, and can provide help for the evaluation of inflammatory response and lung function in patients.
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