子痫前期患者分娩前后血清中血管紧张素原水平变化及意义

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Abstract Objective To observe changes and significance of serum angiotensinogen (AGT) levels in patients with preeclampsia before and after delivery. Methods Ninety-five preeclampsia patients hospitalized in Obstetrics Department of Tangshan Maternal and Child Health Hospital in Hebei Province (hereinafter referred to as “our hospital”) from March 2018 to January 2019 were selected as case group. Sixty cases of normal late pregnancy women hospitalized in Obstetrics Department of our hospital at the same time without indications for cesarean section were randomly selected as control group. The serum AGT levels between two groups were detected by enzyme linked immunosor-bent assay before and 72 h after delivery. Results There were no significant differences in age and gestational age between two groups (P > 0.05). The body mass index, systolic blood pressure and diastolic blood pressure in case group were higher than those in control group (P < 0.05). The serum AGT level of case group before delivery was higher than that after delivery and control group, the differences were statistically significant (P < 0.05). The proportion of abnormal serum AGT level in case group was higher than that in control group (P < 0.05). The risk of abnormal AGT level in case group was 35.538 times the control group, and 95%CI was 14.422-100.235. Conclusion The level of serum AGT in patients with preeclampsia increased singnificantly, fell rapidly to normal standard after childbirth, AGT maybe plays an important role in the preeclampsia.

Key words： Pregnancy complication Preeclampsia Angiotensinogen Hypertensive disorder complicating pregnancy

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	LI Jing ZUO Jinling ZHANG Xiaoyu WANG Chunshuang CHEN Baoli YI Jianping

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LI Jing ZUO Jinling ZHANG Xiaoyu WANG Chunshuang CHEN Baoli YI Jianping. Changes and significance of serum angiotensinogen levels in patients with preeclampsia before and after delivery[J]. 中国医药导报, 2020, 17(27): 108-111,119.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I27/108

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