甲状旁腺全切术对继发性甲旁亢患者临床症状、抑郁焦虑情绪和生活质量的影响

Abstract
Figure/Table
References (23)
Related Citation (15)

Download: PDF (437 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To explore the effect of total parathyroidectomy on clinical symptoms, depression and anxiety and quality of life in patients with secondary hyperparathyroidism (SHPT). Methods A total of 160 patients with SHPT secondary to chronic kidney disease who underwent total parathyroid resection admitted to the Department of Hepatobiliary Surgery of the General Hospital of Northern Theater Command from June 2016 to December 2018 were selected. Serum levels of calcium, phosphorus, alkaline phosphatase (ALP) and parathyroid hormone (iPTH) were measured before and Six months after operation. Pasieka parathyroid symptom score (PAS) was performed in all patients. Hamilton depression scale (HAMD) and hamilton anxiety scale (HAMA) were used to evaluate patients′ negative emotions. Summary of health survey (SF-36) was used to evaluation of patient quality of life. Results Compared with preoperative, the blood calcium, blood phosphorus, ALP, and iPTH of the patients were significantly reduced at six months after operation (P ＜ 0.05). The scores and total scores of 13 symptom items in PAS decreased significantly (P ＜ 0.05). Postoperative HAMD and HAMA scores were significantly decreased (P ＜ 0.05). SF-36 physical health score and mental health score were significantly increased (P < 0.05). PAS total score minus points were positively correlated with HAMD and HAMA scores (r = 0.501, 0.358, all P ＜ 0.05), and negatively correlated with SF-36 physiological health scores and mental health scores (r = -0.567, -0.428, all P ＜ 0.05). All HAMD and HAMA minus points were negatively correlated with SF-36 physiological health score and mental health score (r = -0.368, -0.317, -0.433, -0.394, all P ＜ 0.05). Conclusion Parathyroidectomy can alleviate the clinical symptoms, improve the depression and anxiety, and improve the quality of life of SHTP patients.

Key words： Total parathyroidectomy Secondary hyperparathyroidism Depression Anxiety Quality of life

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	QI Na1 FENG Xiaodong2 XU Tianchao1 BI Ting2 TANG Yufu2

Cite this article:

QI Na1 FENG Xiaodong2 XU Tianchao1 BI Ting2 TANG Yufu2. Effects of total parathyroidectomy on clinical symptoms, depression and anxiety and quality of life in patients with secondary hyperparathyroidism[J]. 中国医药导报, 2020, 17(27): 78-81.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I27/78

[1] Guideline Working Group，Japanese Society for Dialysis Therapy. Clinical practice guideline for the management of secondary hyperparathyroidism in chronic dialysis patients [J]. Ther Apher Dial，2008，12（6）：514-525.
[2] 安宏，庞毅，徐辉.慢性肾脏病继发甲状旁腺功能亢进的手术治疗[J].天津医药，2019，46（12）：1357-1362.
[3] 王俊霞，肖雄木，李国辉.阿法骨化醇冲击治疗对继发性甲状旁腺功能亢进症患者生活质量的影响[J].中华骨质疏松和骨矿盐疾病杂志，2012，5（4）：259-263.
[4] Hampl R，Bi■íková M，Sosvorová L. Hormones and the blood-brain barrier [J]. Horm Mol Biolo Clin Investig，2015，21（3）：159-164.
[5] 许楠，刘新杰，周冬仙，等.甲状旁腺全切术治疗继发性甲状旁腺功能亢进症35例[J].暨南大学学报：自然科学与医学版，2014，35（2）：182-185.
[6] Lau WL，Obi Y. Parathyroidectomy in the management of secondary hyperparathyroidism [J]. Clin J Am Soc Nephrol，2018，13（6）：952-961.
[7] 施俊义.继发性甲状旁腺功能亢进的诊断与治疗[J].中国实用外科杂志，2008，28（3）：185-186.
[8] Greutelaers B，Kullen K，Kollias J，et al. Pasieka Illness Questionnaire：Its value in primary hyperparathyroidism [J]. ANZ J Surg，2004，74（3）：112-115.
[9] Bech P，Allerup P，Gram LF，et al. The hamilton depression scale [J]. Acta Psychiatr Scand，2007，63（3）：290-299.
[10] Maier W，Buller R，Philipp M，et al. The Hamilton Anxiety Scale：reliability，validity and sensitivity to change in anxiety and depressive disorders [J]. J Affect Disord，1998，14（1）：61-68.
[11] Larson JS. The MOS 36-Item Short form Health Survey：A Conceptual Analysis[J]. Eval Health Prof，1997，20（1）：14-27.
[12] 赖贻旺.甲状旁腺切除术联合西那卡塞治疗继发性甲状旁腺功能亢进疗效分析[J].临床军医杂志，2018，46（12）：97-98.
[13] 王海峰，张凌，姚力，等.三种不同甲状旁腺切除术治疗继发性甲状旁腺功能亢进425例疗效比较[J].中国血液净化，2016，15（9）：455-458.
[14] Sari R，Yabanoglu H，Hargura AS，et al. Outcomes of total parathyroidectomy with autotransplantation versus subtotal parathyroidectomy techniques for secondary hyperparathyroidism in chronic renal failure [J]. J Coll Physicians Surg Pak，2020，30（1）：18-22.
[15] 朱旻婷，刘建民.原发性甲状旁腺功能亢进症神经心理改变及可能机制[J].中华骨质疏松和骨矿盐疾病杂志，2018，11（5）：86-91.
[16] Sauerland S，Hensler T，Bouillon B，et al. Plasma levels of procalcitonin and neopterin in multiple trauma patients with or without brain injury [J]. J Neurotrauma，2003，20（10）：953-960.
[17] Kearns AE，Espiritu RP，Vickers Douglass K，et al. Clinical characteristics and depression score response after parathyroidectomy in primary hyperparathyroidism [J]. Clin Endocrinol，2019，91（3）：464-470.
[18] 张小桐，肖枫林，玄方，等.维持性血液透析患者骨骼肌减少与生活质量和心理状况的关系[J].第二军医大学学报，2019，40（5）：577-582.
[19] 刘惠军，郭海玲，韩元媛.护理干预对维持性血液透析患者抑郁症的影响[J].中国医药导报，2011，8（14）：125-126.
[20] 帕热旦木·托乎提，李玉芳，张丽，等.维持性血液透析患者蛋白质-能量消耗现况及对生活质量的影响[J].中国医药导报，2019，16（29）：141-144.
[21] 廖淑媚，朱丽芳，周珍俐，等.中医饮食调护对维持性血液透析患者营养状况及生活质量的研究分析[J].中国医药科学，2020，10（5）：40-42.
[22] 袁仲飞，刘先燕.早期营养支持对维持性血液透析患者氧化应激状态和生活质量的影响[J].中国现代医生，2020，58（6）：97-100.
[23] Bratucu MN，Garofil ND，Radu PA，et al. Measurement of quality of life after total parathyroidectomy in patients with secondary hyperparathyroidism and end stage renal disease [J]. Chirurgia，2015，110（6）：511-517.