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2017 Vol. 14, No. 16 Published: 2017-06-05

	4	Study on the antiviral activity of ethanol extract and water extract of Paeoniae Radix Rubra
		LIU Xiangwen HOU Lin ZHANG Chenghua SUN Chunyong LIU Jin′an TIAN Jingzhen
		Objective To investigate the antiviral activity of ethanol extract and water extract of Paeoniae Radix Rubra. Methods Combining with cytopathic effect (CPE) method and CCK-8, taking therapeutic index (TI) as index, the prevention, direct killing and penetration inhibition effects of ethanol extract and water extract of Paeoniae Radix Rubra for respiratory syncytial virus (RSV), herpes simplex virus (HSV-1), Coxsackie virus (COX-B5), hand, foot and mouth virus (EV71) were researched. Results The ethanol extract and water extract of Paeoniae Radix Rubra had no prevention and penetration inhibition effects for RSV, HSV-1, COX-B5, EV71, which had no direct killing effects for EV71 and had direct killing effects for RSV, HSV-1, COX-B5, among which, the water extract had better direct killing effects for RSV and COX-B5, the TI value was 15.034 and 13.076 respectively. 75% ethanol extract of Paeoniae Radix Rubra had good direct killing effect for HSV-1, the TI value was 10.944, all positive control drugs had effects for the four kinds of virus, among which, the TI values of Ribavirin for the direct killing, prevention and penetration inhibition effects of RSV were 19.760, 16.760, 18.028 respectively, which were 17.482, 15.516, 16.568 for COX-B5, 43.158, 24.296, 22.162 for EV71. The TI values of Acyclovir for the direct killing, prevention and penetration inhibition effects of HSV-1 were 23.432, 10.922, 23.417 respectively. Conclusion The ethanol extract and water extract of Paeoniae Radix Rubra has direct killing effects for RSV, HSV-1, COX-B5, has no direct killing effects for EV71, has no prevention and penetration inhibition effects for four kinds of virus, while the positive control drugs have direct killing, prevention and penetration inhibition effects for the four kinds of virus.
		2017 Vol. 14 (16): 4-7 [Abstract] ( 155 ) HTML (1 KB) PDF (624 KB) ( 91 )

	8	Study on the intestinal absorption characteristics of deoxydeoxyandrographolide in rats
		WU Zhizhong1 YE Ling2
		Objective To measure and analyze the oil-water partition coefficients and intestinal absorption characteristics of deoxyandrographolide in rats. Methods The shaking method and rat intestinal perfusion model in vivo was used. Oil-water partition coefficient, chemical and biological stability were measured by UPLC, and contents in intestinal perfusate and bile were determined. Results Oil water partition coefficient Log P=1.45±0.12 of deoxyandrographolide in the HBSS (pH 6.5), and its chemical and biological stability were well. In the perfusion model, the absorption of deoxyandrographolide in duodenum, jejunum, ileum and colon were 30.29%, 28.39%, 22.04% and 34.63%. On the other hand, deoxyandrographolide was excreted by bile with 0.146% of total prefused amount of deoxyandrographolide. Conclusion Deoxyandrographolide in various intestinal segments of rats are absorbed, but there is no significant difference on absorption rate in different intestinal segments.
		2017 Vol. 14 (16): 8-11 [Abstract] ( 181 ) HTML (1 KB) PDF (906 KB) ( 87 )

	12	Chemical constituents analysis of the drug pair of "Cinnamomum cassia Presl and Paeoniae Radix Alba" by UPLC-Q/TOF-MS
		CHEN Yongcai1 QIAN Jianghui2，3 WANG Binhui4 SHA Xianyi2，3
		Objective To develop an ultra-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometric (UPLC-Q/TOF-MS) method to analyze the chemical constituents in the drug pair of "Cinnamomum cassia Presl and Paeoniae Radix Alba". Methods Agilent 1290 UPLC machine and YMC-Triart C18 column (100 mm × 2.1 mm, 1.9 μm) were adopted to separate ingredients; the mobile phase was acetonitrile (A)-0.1% acetic acid solution (B) with gradient elution; the column temperature was 30℃; the inject volume was 5 μL; the detection wavelength was set at 254 nm; the flow rate was 0.3 mL/min; the mass spectrometer AB 5600 with an electrospray ionization (ESI) interface was under positive or negative mode for data collection. Results 8 compounds were identified by reference substance, 13 compounds were qualitative identified according to the MS/MS information, and the belonging of the main constituents had been confirmed. These compounds included six kinds of organic acid such as gallic acid and protocatechuic acid, tentotal paeoniflorin monoterpenes like paeoniflorin and albiflorin, and coumarins. Conclusion Determination of chemical composition of "Cinnamomum cassia Presl and Paeoniae Radix Alba" by UPLC-Q/TOF-MS in order to clarify the "Cinnamomum cassia Presl and Paeoniae Radix Alba" drug on the basis of the material to provide strong evidence.
		2017 Vol. 14 (16): 12-15,23 [Abstract] ( 180 ) HTML (1 KB) PDF (833 KB) ( 45 )

	16	Effects of Sodium Cantharidate and vitamin B6 on apoptosis and survivin expression in human osteosarcoma cells
		KANG Xiao1 HU Wenhai2 PEI Shishen1 WANG Qinghe1 LIU Pu1 LI Shixue1
		Objective To study the mechanism of Sodium Cantharidate and vitamin B6 inducing apoptosis of MG-63 cells. Methods The different concentrations of Sodium Cantharidinate and vitamin B6 were applied in MG-63 cells, the anti-proliferative effect of drug for cells was detected by MTT colorimetry; reverse transcription polymerase chain reaction (RT-PCR) was used to detect the expression of survivin messenger RNA. Results Sodium Cantharidate and vitamin B6 could inhibit the proliferation of MG-63 cells in a time and dose-dependent manner, and the inhibition rate could be as high as (68.56±5.21)%. RT-PCR showed downregulation of survivin gene expression. Conclusion The inhibitory effect of Sodium Cantharidate and vitamin B6 on the proliferation of MG-63 cells is obvious, and the mechanism may be related to down regulation of the expression of survivin.
		2017 Vol. 14 (16): 16-19 [Abstract] ( 175 ) HTML (1 KB) PDF (743 KB) ( 45 )

	20	Study on chemical constituents and their inhibition of anthropogenic colon cancer cells bioactivity from ethnic medicine Pteris dispar
		SUN Dan ZHANG Yan SUN Qiang PENG Yubo WANG Lei
		Objective To study the inhibition of anthropogenic colon cancer cells activity constituents of Pteris dispar. Methods The medicinal materials were extracted by 95% ETOH. Compounds were obtained by kinds of chromatographies including polyamide, Sephadex LH-20 and pre-HPLC and the structures identified by NMR. In vitro antitumor activity was tested by SRB methods. Results 5 compounds were obtained from the plant and their structures were established as geopyxin A (1), geopyxin C (2), ent-11β-acetoxykaur-16-en-18-ol (3), 7β, 16α, 17-trihydroxy-ent-kauran-19-oic acid (4) and neolaxiflorin K (5). Compounds 1, 2 and 5 showed strong in vitro antitumor activity against HCT-116, with IC50 values of 1.20, 2.45 and 3.26 μmol/L respectively. Conclusion Compounds 1-5 are obtained from Pteris dispar for the first time.
		2017 Vol. 14 (16): 20-23 [Abstract] ( 172 ) HTML (1 KB) PDF (704 KB) ( 46 )

	24	The relationship between the expression of brain amyloid beta protein along with neural behavior in rats with hypercholesterolemia level
		LIANG Qian1 TANG Wei2 LIU Wenbo1 WANG Wei1
		Objective To research the relationship between the expression of brain amyloid beta (Aβ) protein along with neural behavior in rats with hypercholesterolemia level, in order to clarify the preventive effect of simvastatin on Alzheimer's disease. Methods The 32 Wistar rats were divided into normal group and high cholesterol group according to random number table, with 16 rats in each group. After two weeks, the rats in the normal group were randomly divided into normal drug group and normal placebo group, with 8 rats in each group; and the rats in the high cholesterol group were randomly divided into high fat drug group and high fat placebo group, with 8 rats in each group. And then simvastatin were filled into the stomach of the 16 drug group rats, the same volume placebo (distilled water) were filled into the stomach of placebo group. Immunohistochemical method was used to determine the expression of Aβ protein in brain, Morris water maze was used to test the cognitive and memory abilities in rats. Results Aβ1-42 protein expression of the prefrontal cortex in the high fat drug group was less than that of high fat placebo group (P < 0.05); and there was no significant difference in the high fat drug group, normal placebo group and normal drug group (P > 0.05). In the high fat drug group, the escape latency was decreased than that of high fat placebo group (P < 0.05), times of crossing platform was increased (P < 0.05); and there was no significant difference in the high fat drug group, normal placebo group and normal drug group (P > 0.05). Conclusion Simvastatin has some effects on the expression of Aβ1-42 protein in prefrontal cortex of hypercholesterolemic rats, and accompanied by neurobehavioral changes in rats.
		2017 Vol. 14 (16): 24-27 [Abstract] ( 168 ) HTML (1 KB) PDF (729 KB) ( 75 )

	28	Effect of pigment epithelium derived factor on ultra structure of acute optic nerve injury in rats
		ZHAO Junbo1 WANG Bin2▲ YAN Xiaoxiao1 CUI Cui1
		Objective To investigate the protective effect of pigment epithelium derived factor (PEDF) on mitochondria axon ultra structure of retinal ganglion cells (RGCs) in rats after acute optic nerve injury. Methods 60 SD rats were randomly divided into 3 groups: blank group, model group and experiment group, each group included 20 rats. The blank group was not given any disposal, rats in model group and experiment group were treated with forceps clamping left eye optic nerve to cause incomplete injury of optic nerve, the right eye was not given any disposal. The model group and experiment group, the left eyes models successfully made immediately, at 1 week and 2 weeks, the rats was injected balanced salt solution 5 μL and PEDF 1 μg into vitreous cavity respectively. Rats of three groups were harvested at the third week, 10 rats left eyeball were taken out to make specimens in each group, changes of retinal ultra structure was observed by the electron microscopy; the remaining rats were prepared to make 5 μm retinal slices, the retinal ganglion cells were counted by routine HE staining. Results Mitochondria edema, cytoplasm condensed axon swelling existed in model group and experiment group, compared with the blank group by observing with the electron microscopy. Compared with model group, the degree of cytoplasm condensed axon swelling was lesser, and structure was more completely in the experiment group. HE staining showed ganglion cells in the experiment group and model group were less (P < 0.05), cell morphology of ganglion cells were better and the number of RGCs were more in experiment group. The number of ganglion cell counts in model group and experiment group decreased by 73.3% and 53.3% respectively, the difference was statistically significant (P < 0.05). Conclusion Incomplete injury of optic nerve can cause obvious damage to the ultra structure of the optic nerve, and PEDF can relieve the damage of the ultra structure of the optic nerve., also can weaken the apoptosis of RGCs.
		2017 Vol. 14 (16): 28-31 [Abstract] ( 195 ) HTML (1 KB) PDF (887 KB) ( 44 )

	32	Progress in targeted therapy of KRAS mutations in non-small cell lung cancer
		ZHANG Yukun GE Wei▲
		Lung cancer is one of the most deadly malignancies, ranking the first in global cancer-related death. With the development of multidisciplinary comprehensive treatment, the mortality rate of patients with lung cancer is still high. KRAS gene mutations are the most common type of mutations in non-small cell lung. At present, the targeted therapy of KRAS gene mutation mainly through the direct inhibition of KRAS gene, change the KRAS membrane localization, inhibition of KRAS downstream effector molecules, inhibition of KRAS mutant synergistic lethal genes and other aspects of research. In this review, the status and progress of KRAS mutations in non-small cell lung cancer targeted therapy are briefly reviewed.
		2017 Vol. 14 (16): 32-35 [Abstract] ( 221 ) HTML (1 KB) PDF (419 KB) ( 66 )

	36	Progress of manlnutrion treatment for dialysis patients
		LIU Yangyan1 XIONG Mingxia2 YANG Junwei1，2
		Malnutrition of dialysis patients, also known as protein-energy wasting malnutrition, is one of the common complications of patients with maintenance hemodialysis, and is associated with high hospitalization rates, mortality/morbidity and adverse clinical outcomes. The pathogenesis of malnutrition of dialysis patients in order to get the full research, inclouding inadequate nutrient intake, metabolic and hormonal disorders and inadequate dialysis and so on. But at the moment, treatment strategy of malnutrition is still lack of attention and not reached a consensus. This article aimes at summarizing the progress of the evaluation and treatment of malnutrition in the dialysis patients.
		2017 Vol. 14 (16): 36-39 [Abstract] ( 140 ) HTML (1 KB) PDF (438 KB) ( 94 )

	40	Advances research of microRNA-21 in esophageal cancer
		YANG Jingrong1 WU Bo2▲
		Esophageal cancer is one of the most common digestive system neoplasms in China. The mechanism of esophageal cancer is still unclear. microRNA is a kind of endogenous non-coding short RNA, which regulates many tumor biological behaviors,such as cell multiplication, differentiation, apoptosis, drug resistance and invasion. miR-21 is valued highly in miRNA. It express highly in esophageal cancer cell and tissue. miR-21 participates in esophageal cancer cell multiplication, differentiation, apoptosis, drug resistance and metastasis via regulating gene expression. This review summarizes the advances in research on miR-21 in esophageal cancer .
		2017 Vol. 14 (16): 40-43 [Abstract] ( 186 ) HTML (1 KB) PDF (410 KB) ( 102 )

	44	Level and significance of serum hyaluronic acid and laminin in patients with idiopathic pulmonary fibrosis
		CHEN Xueyuan LI Yaqian FENG Zhemin HE Wenbo SUN Yibo
		Objective To explore the level and significance of serum hyaluronic acid (HA) and laminin (LN) in patients with idiopathic pulmonary fibrosis (IPF). Methods From June 2014 to June 2016 , in Department of Respiratory Diseases, Affiliated Hospital of Hangzhou Normal University, 38 patients with IPF were selected as control group, and 30 healthy persons without smoking at same time were selected as control group. The levels of serum HA and LN in IPF patients and cotrol group were detected by radioimmunoassay. And the correlation between serum HA, LN with lung function, 6-minute walk test (6MWT) and dyspnea score was evaluated. Results Compared with the control group, the levels of serum HA and LN of patients in IPF group were significantly higher (P < 0.05). The levels of serum HA and LN in patients with IPF were negatively correlated with FVC, FEV1 and DLCO (all r < 0, P < 0.05 or P < 0.01); HA and LN were negatively correlated with 6MWT (r = -0.637, -0.705, P < 0.01); the levels of serum HA and LN in IPF patients were positively correlated with mMRC score (r = 0.618, 0.552, P < 0.05). Conclusion These data suggest that serum HA and LN may be useful biomarkers to estimate the severity and treatment effect of patients with IPF.
		2017 Vol. 14 (16): 44-46 [Abstract] ( 193 ) HTML (1 KB) PDF (492 KB) ( 91 )

	47	Effect of optimized postoperative urinary catheterization after total knee arthroplasty based on fast track theory
		YOU Tian1 WANG Shuang1 WEN Qinqin1 HU Huiying2 XIAO Yingui1 LI Jiuqun1
		Objective To discuss the effect of optimized postoperative urinary catheterization after total knee arthroplasty (TKA) based on fast track theory. Methods From January to June 2015, in Peking University Shenzhen Hospital, 100 patients underwent TKA were selected, according to random number table, they were divided into control group (all indwelling catheter) and trial group (catheterization threshold of 500 mL), with 50 cases in each group. The time and volume of first voluntary micturition, urinary tract infection, urination comfort index were observed and compared. Results The first urination time of trial group were shorter than control group, the difference was statistically significant (P < 0.05). the difference was statistically significant (P < 0.05). The first urination volume of trial group were more than control group, the difference was statistically significant (P < 0.05). The comfort index of trial group were better than control group, the difference was statistically significant (P < 0.05). The urinary tract infection rate of two groups were compared, the difference was not statistically significant (P > 0.05). Conclusion In fast-track TKA, a bladder volume of 500 mL is reasonable and safe catheterization threshold, which can relieve the discomfort effectively, and speed the recovery postoperatively.
		2017 Vol. 14 (16): 47-50 [Abstract] ( 179 ) HTML (1 KB) PDF (535 KB) ( 93 )

	51	Clinical effect of Holigic vacuum microrotatotomy in treatment of complications and prognosis of nonpalpable breast nodules
		ZHAO Na1 CHEN Shibin2▲ LIU Cuizhu2 LIU Baojun2 GE Shaojuan3 LI Jinmin4 LI Xianliang5
		Objective To investigate the clinical effect of Holigic vacuum microrotatotomy in the treatment of complications and prognosis of nonpalpable breast nodules. Methods From February 2015 to October 2016, in Seventh People's Hospital of Hebei Province, 154 patients with nonpalpable breast nodules were selected, they were divided into two groups by random number table, with 77 cases in each group. The control group was treated with traditional small incision surgery, the experiment group was treated with Holigic vacuum microrotatotomy surgery. Operation related index, postoperative complication rate, recurrence, cosmetic effect and treatment satisfaction of two groups were compared. Results The intraoperative blood loss, operative time, incision healing time in the experiment group were less than those in control group, scar length in the experiment group were lower than those in control group, the differences were statistically significant (P < 0.05), the incidence rate of incision infection, incision dehiscence, local hematoma, breast collapse, postoperative pain in the experiment group were lower than those in control group, the differences were statistically significant (P < 0.05). All patients were followed up for 6 months, and no recurrence occurred in the two groups, the rate of excellent and good cosmetic effect in the control group was lower than the experiment group, the difference was statistically significant (P < 0.05). The treatment satisfaction rate in the control group was lower than the experiment group, the difference was statistically significant (P < 0.05). Conclusion Holigic vacuum microrotatotomy can significantly reduce the amount of intraoperative bleeding in the treatment of patients with nonpalpable breast nodules, shorten the operation time and wound healing time, reduce the incidence of postoperative complications.
		2017 Vol. 14 (16): 51-54 [Abstract] ( 166 ) HTML (1 KB) PDF (528 KB) ( 31 )

	55	Evaluation on the cognitive function of patients with chronic obstructive pulmonary disease and analysis on its influencing factors
		CHEN Xiaoyan1 LI Xiao2▲
		Objective To evaluate the cognitive function of patients with chronic obstructive pulmonary disease (COPD), and to analyze its influencing factors. Methods From February 2015 to July 2016, 68 patients with COPD admitted to Xinqiao Hospital, Third Military Medical University ("our hospital" for short) were selected as COPD group, and they were divided into mild-moderate group (37 cases) and severe group (31 cases) according to the severity of illness, 28 healthy persons in our hospital at the same time were selected as normal control group. The cognitive function of subjects were evaluated by mini-mental state examination (MMSE), the indexes of pulmonary function and arterial blood gas were detected respectively by pulmonary function detector and automatic blood gas analyzer. Results Compared with normal control group, the scores of MMSE and the indexes of pulmonary function in mild-moderate group and severe group decreased, the differences were all highly statistically significant (P < 0.01). The indexes of arterial blood gas PaO2, SaO2 in mild-moderate group were all lower than those of normal control group, the differences were all highly statistically significant (P < 0.01), while there was no significant difference of PaCO2 between mild-moderate group and normal control group (P > 0.05). The indexes of arterial blood gas PaO2, SaO2 in severe group were all lower than those of normal control group (P < 0.01), and PaCO2 was higher than that of normal control group, the difference was highly statistically significant (P < 0.01). Compared with mild-moderate group, the scores of MMSE and the indexes of pulmonary function in severe group decreased, the PaCO2 increased, the differences were all highly statistically significant (P < 0.01), there were no statistically significant differences of PaO2 and SaO2 between the two groups (P > 0.05). Pearson analysis showed that, the scores of MMSE in mild-moderate group were significantly positively correlated with PaO2 (r = 0.46, P < 0.05), the scores of MMSE in severe group were significantly positively correlated with FEV1 and PaO2 (r = 0.45, 0.40, P < 0.05). Conclusion The patients with COPD has obvious cognitive impairment, and the degree of cognitive impairment is correlated with severity of illness, among which, FEV1 and PaO2 are the important influencing factors of the occurrence of cognitive impairment in patients with COPD.
		2017 Vol. 14 (16): 55-58 [Abstract] ( 190 ) HTML (1 KB) PDF (533 KB) ( 75 )

	59	Effects of different anesthesia methods on immune function in patients with gynecological surgery
		CHEN Xinyan WANG Lei NIU Shikun FANG Xianjie
		Objective To observe and analyze the effects of different anesthesia methods on immune function in patients with gynecological surgery. Methods From February 2014 to December 2015, in Shiyan Maternal and Child Health-Care Hospital, 156 patients underwent gynecological surgery were selected, they were divided into three groups by the anesthesia method, group A was given Dexmedetomidine intravenous infusion combined with Sevoflurane inhalation anesthesia, group B was given Sevoflurane inhalation anesthesia, group C was given Propofol combined with Sufentanil anesthesia. The changes of SBP, DBP, HR, RR, SpO2, peripheral blood T lymphocyte subsets and inflammatory cytokines of all patients were observed at before anesthesia (T0), after surgrey 2 h (T1),after surgrey 6 h (T2), after surgrey 12 h (T3), after surgrey 1 d (T4), after surgrey 3 d (T5), after surgrey 7 h (T6). Results The levels of SBP at T1, T2, T3, DBP, RR at T1, T2, TNF-α at T1, T6, IL-6, IL-8 at T1-T6, CD3+ at T1, CD4+ at T1, T2 of group A were compared with those at T0, the differences were statistically significant (P < 0.05). The levels of SBP at T1, T2, T3, RR at T1, T2, TNF-α at T1, T2, T5, T6, IL-6, IL-8 at T1-T6, CD3+ at T1, CD4+ at T1, T2, T3 of group B were compared with those at T0, the differences were statistically significant (P < 0.05). The levels of SBP at T1, T2, T3, TNF-α at T1, T4-T6, IL-1β at T6, IL-6, IL-8 at T1-T6, CD3+, CD4+ at T1 of group C were compared with those at T0, the differences were statistically significant (P < 0.05). The levels of IL-6 at T1-T6, IL-8 at T1, T5, T6 of group B, the levels of TNF-α at T5, IL-6，IL-8 at T1-T6 of group C were compared with those at the same time points of group A, the differences were statistically significant (P < 0.05). The levels of IL-6, IL-8 at T1-T6 of group C were compared with those at the same time points of group B, the differences were statistically significant (P < 0.05). Conclusion The combination of Dexmedetomidine and Sevoflurane inhalation has a transient inhibitory effect on the immune function of gynecological patients. Compared with other anesthesia methods, the immune function recovered more quickly after surgery, which is anesthesia for gynecological patients ideal method, it is worth to popularize and apply in clinic.
		2017 Vol. 14 (16): 59-62 [Abstract] ( 177 ) HTML (1 KB) PDF (475 KB) ( 158 )

	63	Analgesic effect of Ketorolac Tromethamin combined with Pentazocine after general anesthesia
		YIN Fang LIU Aihua TIAN Lichuan ZHANG Huimin
		Objective To analyze analgesic effect of Ketorolac Tromethamin combined with Pentazocine after general anesthesia. Methods From February 2015 to February 2016, in Cangzhou People's Hospital, 200 patients treated with open surgery under general anesthesia in were selected, and they were divided into experiment group and control group according to the random number table method, 100 cases in each group. Patients in two groups were given PCIA after surgery, the experiment group was given Ketorolac Tromethamin 60 mg intramuscular at 30 min before surgery, control group was given equivalent normal saline. The degree of pain (VAS), the degree of sedation (Ramsay score) and the average pulse pressure (MAP), HR, SpO2 after operation of 1, 2, 4, 6, 8, 12, 24 h were observed, and PCIA pressing times and drug dosage after surgery 24 h were analyzed, and adverse reaction rates in the two groups were compared. Results VAS scores of two groups gradually decreased significantly at postoperative 1, 2, 4, 6, 8 h, and VAS scores of the experiment group were significantly lower than those in the control group (P < 0.05), and there were no statistically significant differences at postoperative 12, 24 h between the two groups (P > 0.05). There were no significant differences in Ramsay scores at postoperative 1, 2, 4, 6, 24 h between the two groups (P > 0.05), Ramsay scores at postoperative 8, 12 h in the experiment group were significantly higher than those in the control group (P < 0.05). PCIA pressing times and the dosage at postoperative 24 h in the experiment group were significantly lower than those in the control group (P < 0.05). MAP, HR at postoperative 2, 4 h in the experiment group were significantly higher than those at postoperative 1 h (P < 0.05), and MAP, HR at postoperative 2, 4, 6, 8 h in the control group were significantly higher than those at postoperative 1 h (P < 0.05). MAP, HR at postoperative 6, 8 h in the experiment group were significantly higher than those in the control group (P < 0.05), and there were no statistically significant differences in SpO2 at postoperative 1, 2, 4, 6, 8, 12, 24 h in the two groups (P > 0.05). Conclusion Ketorolac Tromethamin combined with Pentazocine can effectively reduce postoperative pain of patients with general anesthesia, with less adverse reactions and high safety.
		2017 Vol. 14 (16): 63-67 [Abstract] ( 171 ) HTML (1 KB) PDF (470 KB) ( 32 )

	67	A randomised controlled trial of intravenous Dexamethasone combined with interscalene brachial plexus blockade guided by ultrasound in shoulder surgery
		LIN Lei1 CHEN Chun1 HOU Jun2 YANG Ping2
		Objective To investigate the effects of intravenous injection of different doses of Dexamethasone combined with ultrasound-guided interscalene bronchial plexus block on postoperative analgesia in patients underwent shoulder surgery. Methods 80 cases of patients underwent shoulder arthroscopy under interscalene brachial plexus blockade in Yichang Central People's Hospital from June 2014 to October 2015 were chosen and randomly divided into four groups: intravenous injection of saline (group A, n=20), 0.025 mg/kg Dexamethasone (group B, n=20), 0.05 mg/kg Dexamethasone (group C, n=20), 0.1 mg/kg Dexamethasone (group D, n=20) before blockade, respectively. Outcomes for 48 h were recorded. Primary endpoint was the time to first postoperative analgesic required. No or mild pain at 24 h and 48 h, weakness at 24 h, cumulative analgesic consumption, sleep disturbance, nausea and vomiting, and satisfaction were considered as secondary outcomes. Results The median time to first postoperative analgesic required was significantly longer in group C and group D than that in group A (P < 0.01), but there was no significant difference between group C and group D (P > 0.05). Among the four groups, no or mild pain at 24 h and 48 h, weakness at 24 h, no analgesia required, the amount of Tramadol and Dolantin required were compared, there were no significant differences (P > 0.05), but the amount of Diclofenac Sodium Suppository was lower in group D than that in group A (P < 0.05). The incidence of sleep disturbance in group C and group D was less than that in group A (P < 0.05), and patients' anesthesia satisfaction rate in group D was higher than that in group A (P < 0.05). Conclusion Intravenous injection of 0.05 mg/kg or 0.1 mg/kg Dexamethasone can extend the duration of postoperative analgesia provided by interscalene brachial plexus block, patients' satisfaction with anesthesia by using 0.1 mg/kg Dexamethasone is higher.
		2017 Vol. 14 (16): 67-70 [Abstract] ( 172 ) HTML (1 KB) PDF (504 KB) ( 38 )

	71	Textual research of common yam rhizome's name
		GE Chengcheng1 CHEN Guihua2 ZHENG Xiajing3 ZHUANG Jinyuan4 CHEN Yingwen2
		In order to help college students know more about Chinese herbal medicine, understand more about traditional Chinese medicine culture, increase interest of learning Chinese herbal medicine, this paper uses literature research method and analytical research method, studies common yam rhizome's name, through referring to Compendium of Materia Medica, Shi Ming, and newspapers, thesis, and so on. The results show that the name after color, homophonic, place of production, growth environment, form, texture, taboo, and so on.
		2017 Vol. 14 (16): 71-73 [Abstract] ( 184 ) HTML (1 KB) PDF (718 KB) ( 186 )

	74	Effect of Tongmai Huazhuo Decoction in the treatment of hypertension patients with syndrome of intermin-gled phlegm and blood stasis and its influence on transforming growth factor-β1, vascular endothelial growth factor, soluble intercellular adhesion molecule-1
		RUAN Lin JIAO Xiaomin▲ LI Jia WANG Chunlin LI Ting
		Objective To investigate the effect of Tongmai Huazhuo Decoction in the treatment of hypertension patients with syndrome of intermin-gled phlegm and blood stasis and its influence on transforming growth factor-β1 (TGF-β1), vascular endothelial growth factor (VEGF), soluble intercellular adhesion molecule-1 (sICAM-1). Methods Seventy hypertension patients with syndrome of intermin-gled phlegm and blood stasis admitted to the Second Department of Cardiology, the Second Hospital Affiliated to Liaoning University of Traditional Chinese Medicine from August 2013 to July 2016 were selected and randomly divided into experimental group and control group, with 35 cases in each group. The control group was treated with Amlodipine Besylate 5 mg, one agent every day. On basis of control group, the experimental group was treated with Chinese medicine Tongmai Huazhuo Decoction, once a day. The course of the two groups was 8 weeks. The clinical efficacy and levels of blood pressure, TGF-β1, VEGF, sICAM-1 before and after treatment between the two groups were compared. Results The total effective rate in the experimental group was higher than that of control group, the difference was statistically significant (P ＜ 0.05). After treatment, the levels of systolic blood pressure and diastolic blood pressure in the two groups were all lower than those before treatment, and the levels of systolic blood pressure and diastolic blood pressure in the experimental group after treatment were lower than those of control group, the differences were statistically significant (P ＜ 0.05). After treatment, the levels of TGF-β1, VEGF and sICAM-1 in the two groups were all lower than those before treatment, and the levels of TGF-β1, VEGF and sICAM-1 in the experimental group after treatment were lower than those of control group, the differences were statistically significant (P ＜ 0.05). Conclusion Tongmai Huazhuo Decoction in the treatment of hypertension patients with syndrome of intermin-gled phlegm and blood stasis has significant curative effects, which can down-regulate the levels of TGF-β1, VEGF and sICAM-1, it is suitable for clinical promotion and application.
		2017 Vol. 14 (16): 74-77 [Abstract] ( 170 ) HTML (1 KB) PDF (766 KB) ( 49 )

	78	Effects of Chaishi Tuire Granules on epidemic encephalitis B virus CQ11-66
		LIU Zhiyong1 MENG Yi1 CHANG Xuehui1 GUO Jian1 QIAO Mingliang1 ZHAO Li'na2
		Objective To investigate the effects of Chaishi Tuire Granules on epidemic encephalitis B virus CQ11-66. Methods One hundred and fifty patients with epidemic encephalitis B hospitalized in He'nan Traditional Chinese Medicine Hospital from May 2015 to December 2016 were selected and divided into two groups by random number table method, with 75 cases in each group. The control group was treated with routine comprehensive treatment, on basis of control group, the observation group was added with Chaishi Tuire Granules. Both groups were treated for 15 days. After treatment, the clinical efficacy and symptom improvement time of the two groups were observed, the hospital stay and the contents of serum neuron-specific enolase (NSE), lipid peroxidase (LPO), interleukin-2 (IL-2) before and after treatment between the two groups were compared. Results The cure rate in the observation group was significantly higher than that in the control group, the difference was statistically significant (P ＜ 0.05), the total effective rate in the observation group was higher than that in the control group, but the difference was not statistically significant (P ＞ 0.05). The time of body temperature returned to normal, time of intelligence returned to normal, and the relief time of headache, vomiting, convulsions in the observation group was all shorter than those of control group, the differences were all statistically significant (P ＜ 0.05). The average hospital stay of observation group was shorter than that of control group, the difference was statistically significant (P ＜ 0.05). After treatment, the contents of serum NSE, LPO in the two groups were all lower than those before treatment, the contents of IL-2 were higher than those before treatment, the differences were all statistically significant (P ＜ 0.05). But there were no statistically significant differences of the contents of serum NSE, LPO, IL-2 after treatment between the two groups (P ＞ 0.05). Conclusion Chaishi Tuire Granules has obvious therapeutic effect for epidemic encephalitis B virus CQ11-66, which can obviously shorten hospital stay, speed up the improvement of symptoms, relieve the pain of patients effectively, it is worthy of extensive promotion.
		2017 Vol. 14 (16): 78-81 [Abstract] ( 161 ) HTML (1 KB) PDF (757 KB) ( 101 )

	82	Curative effect of "Changqi Tongluo" manipulation combined with acupuncture in Bǎihuì acupoint in the treatment of cervical spondylosis and its influence on the blood flow velocity
		LING Yaoquan1 YANG Renxuan1 DENG Cong1 LIAO Xinglong2 GAO Jie2 GUO Chengxiang3 YU Baonan1 WANG Weicong1
		Objective To investigate the effect of "Changqi Tongluo" manipulation combined with acupuncture in Bǎihuì acupoint in the treatment of vertebral artery type of cervical spondylosis and its influence on the blood flow velocity. Methods Ninety patients with vertebral artery type of cervical spondylosis admitted to Department of Rehabilitation, Zhuhai Branch of Guangdong Provincial Hospital of Traditional Chinese Medicine from October 2014 to October 2016 were selected as research objects, and they were randomly divided into experimental group and control group by draw method, with 45 cases in each group. The experimental group was given "Changqi Tongluo" manipulation combined with acupuncture in Bǎihuì acupoint, the control group was given basic western medicine. The symptom scores, cervical range of motion, and mean flow velocity (Vm) of left vertebroarterial artery, right vertebroarterial artery, basilar artery before and after treatment between the two groups were compared. Results After treatment, the symptom scores of headache, dizziness, tinnitus, blurred vision, neck pain in the two groups were all significantly lower than those before treatment (P ＜ 0.05), and the symptom scores of headache, dizziness, tinnitus, blurred vision, neck pain in the experimental group after treatment were significantly lower than those of the control group, the differences were statistically significant (P ＜ 0.05). After treatment, the cervical ranges of motion in the two groups were higher than those before treatment (P ＜ 0.05), and the cervical range of motion in the experimental group after treatment was significantly higher than that of the control group, the difference was statistically significant (P ＜ 0.05). After treatment, the Vm of left vertebroarterial artery, right vertebroarterial artery, basilar artery in the two groups were higher than those before treatment (P ＜ 0.05), and the Vm of left vertebroarterial artery, right vertebroarterial artery, basilar artery in the experimental group after treatment were significantly higher than those of the control group, the differences were statistically significant (P ＜ 0.05). Conclusion "Changqi Tongluo" manipulation combined with acupuncture in Bǎihuì acupoint in the treatment of vertebral artery type of cervical spondylosis has obvious curative effect, which can significantly improve the cervical range of motion, relieve the clinical symptoms, its main mechanism may be associated with the improvement of Vm of vertebroarterial artery and basilar artery.
		2017 Vol. 14 (16): 82-85,113 [Abstract] ( 170 ) HTML (1 KB) PDF (1079 KB) ( 92 )

	86	Clinical effect of Bushen Shugan Prescription in the treatment of recurrent spontaneous abortion with syndrome of kidney deficiency and liver depression
		QIAN Yanqing MA Dazheng SUN Yun
		Objective To explore the clinical effect of Bushen Shugan Prescription in the treatment of recurrent spontaneous abortion with syndrome of kidney deficiency and liver depression. Methods The recurrent spontaneous abortion patients with syndrome of kidney deficiency and liver depression in Traditional Chinese Medicine Hospital of Wenzhou City from July 2015 to November 2016 were selected as research objects, and they were randomly divided into control group and treatment group. The control group received Progesterone Injection alone, the treatment group received Progesterone Injection combined with traditional Chinese medicine. The clinical comprehensive therapeutic effect, TCM symptom score, the max diameter line of gestational sac, self-rating anxiety scale (SAS), and the levels of serum human chorionic gonadotropin (β-HCG), progesterone in the two groups were observed. Results The total effective rate in the treatment group was 88.0%, which was significantly higher than that of control group (72.0%), there was statistically significant difference (P ＜ 0.05). TCM syndrome score of treatment group after treatment was lower than that before treatment and that of control group after treatment, the differences were statistically significant (P ＜ 0.05). After treatment, the max diameter line of gestational sac of the two groups was both higher than those before treatment, and the max diameter line of gestational sac in the treatment group after treatment was higher than that of control group, the differences were statistically significant (P ＜ 0.05). After treatment, the SAS score of treatment group was lower than that before treatment, the SAS score of control group was higher than that before treatment, the differences were statistically significant (P ＜ 0.05), the SAS score of treatment group after treatment was lower than that of control group, the difference was statistically significant (P ＜ 0.05). After pregnancy for 5, 6 weeks, the levels of serum progesterone in the treatment group were lower than those of control group, the levels of β-HCG were higher than those of control group, the differences were statistically significant (P ＜ 0.05), while there were no statistically significant differences of serum progesterone, β-HCG between the two groups after pregnancy for 8, 10 weeks (P ＞ 0.05). Conclusion Bushen Shugan Prescription can increase the success rate of preventing miscarriages of recurrent spontaneous abortion patients with syndrome of kidney deficiency and liver depression, improve anxiety state, which is safe and effective in clinic.
		2017 Vol. 14 (16): 86-89 [Abstract] ( 178 ) HTML (1 KB) PDF (728 KB) ( 153 )

	90	Clinical study of Yangyin Xifeng Fumai Decoction in the treatment of premature ventricular contraction with syndrome of insufficiency of heart Yin and wind-driven heart collaterals
		ZHANG Limei1 HU Yuanhui1 CHEN Jin2
		Objective To observe the curative effect of Yangyin Xifeng Fumai Decoction on premature ventricular contraction with the syndrome of insufficiency of heart Yin and wind-driven heart collaterals. Methods The patients with premature ventricular contraction who were diagnosed as insufficiency of heart Yin and wind-driven heart collaterals syndrome admitted to Guang'anmen Hospital, China Academy of Chinese Medical Sciences and its south area from November 2011 to August 2016 were randomly divided into treatment group and control group by random number table method, with 70 cases in each group. The treatment group was given Yangyin Xifeng Fumai Decoction, while the control group received the treatment of Metoprolol. The course of both groups were (28±2) days. The differences of clinical curative effect, the curative effect of 24 hours dynamic electrocardiogram and the heart rate variability (HRV) between two groups were compared. Results At the end of treatment, 1 case of treatment group and 2 cases of control group were lost. The total effective rate of Chinese medicine syndrome was 89.9% in the treatment group, 72.1% in the control group, the treatment group was superior to the control group (P ＜ 0.05); the total effective rate of 24 hours dynamic electrocardiogram was 73.9% in the treatment group, 67.6% in the control group, the difference between the two groups was not statistically significant (P ＞ 0.05). After treatment, both groups were significantly higher than before treatment in SDNN, SDANN, PNN50, RMSSD indexes (P ＜ 0.05), and the treatment group was significantly better than the control group in SDNN, SDANN and RMSSD indexes (P ＜ 0.05). Conclusion Yangyin Xifeng Fumai Decoction can effectively improve the symptom, the number of premature ventricular contraction and the HRV in patients with premature ventricular contraction diagnosed as insufficiency of heart Yin and wind-driven heart collaterals syndrome, the security is good.
		2017 Vol. 14 (16): 90-93 [Abstract] ( 153 ) HTML (1 KB) PDF (763 KB) ( 121 )

	94	Development present situation and policy suggestion on old-age service of Beijing traditional Chinese medicine
		HU Lingjuan WU Xin LI Ruifeng MENG Haoting CUI Yuanyue
		Beijing has entered the aging society, the situation of providing for the aged is very serious. The development of old-age service task is pressing, traditional Chinese medicine (TCM) has a unique advantage in the old-age health services. It is necessary to promote combination of Chinese medicine health services and social services during the development process of old-age service system. This paper explains the reason about development difficulties and its countermeasures of old-age health service industry proceed from the current situation of old-age service, and old-age care institutions should enhance nursing of TCM function, impel innovation of old-age care service mode, let TCM service for old-age go into communities and residents families, build TCM old-age service model areas, upgrade intelligentization and informatization of TCM old-age service, support and development conducive medical health products and measures for elderly group.
		2017 Vol. 14 (16): 94-97 [Abstract] ( 172 ) HTML (1 KB) PDF (720 KB) ( 77 )

	98	Clinical effect of Bushen Huoxue Prescription cooperated with core decompression and internal support bone grafting in the treatment of early necrosis of the femoral head
		XU Xinghui
		Objective To observe the clinical effect of Bushen Huoxue Prescription cooperated with core decompression and internal support bone grafting in the treatment of early necrosis of the femoral head. Methods Eighty-three cases of patients with early necrosis of the femoral head treated in Baoji Hospital of Traditional Chinese Medicine from April 2012 to April 2015 were selected as research objects, and they were randomly divided into study group (41 cases, 53 hip)and control group (42 cases, 57 hip) by random number table method. The control group was given core decompression and internal support bone grafting, the study group was given Bushen Huoxue Prescription on the second day after core decompression and internal support bone grafting, treating for 3 months continuously. The imageology efficacy of the two groups was observed, and the changes of hip joint function in the two groups before and after treatment were evaluated by Harris scoring method. Results After treatment for 3 months, the total effective rate of imageology efficacy in the study group (92.68%) was obviously higher than that of control group (80.95%), there was statistically significant difference (P ＜ 0.05). There were no statistically significant differences of total scores of Harris and scores of pain, function, malformation, joint range of motion between the two groups before treatment (P ＞ 0.05). Compared with before treatment, the total scores of Harris and scores of pain, function, malformation, joint range of motion in the two groups after treatment were obviously increased, the differences were all statistically significant (P ＜ 0.05), and the scores above in the study group after treatment were all significantly higher than those of control group (P ＜ 0.05). Conclusion Bushen Huoxue Prescription cooperated with core decompression and internal support bone grafting can prevent and treat the early necrosis of the femoral head effectively, which can relieve pain, improve the hip joint function, increase the joint range of motion, it is worthy of clinical promotion.
		2017 Vol. 14 (16): 98-101 [Abstract] ( 178 ) HTML (1 KB) PDF (726 KB) ( 98 )

	102	The FDG uptake of the normal prostate gland with 18F-FDG PET/CT imaging
		CHEN Wen ZHANG Jianfei LIU Xiuqin
		Objective To determine the FDG uptake of the normal prostate gland with 18F-FDG PET/CT imaging and its influence factors. Methods The normal prostates in 83 men detected by 18F-FDG PET/CT imaging in Beijing Hospital from November 2014 to January 2016 were analyzed retrospectively, aged 20-91, average of (60±18) years. Their PET/CT imaging characteristics were analyzed. ROI technology was used for getting the SUVmax and SUVavg, and the diameters of prostate gland were detected in the maximum shear plane. Correlations among the SUV, prostate size and age were analyzed by Pearson correlation analysis with SPSS 17.0. Results The average of SUV maximum and mean was (2.3±0.4) and (1.6±0.3) respectively. The average of normal prostate gland size was (4.4±0.7) cm. There was positive correlation between prostate size and age (r=0.365, P < 0.05), but there was no statistically significant relationship between the SUV (SUVmax and SUVavg) and the size of normal prostate gland (P > 0.05), the SUV (SUVmax and SUVavg) of the prostate gland was not significantly related with age also (P > 0.05). Conclusion The prostate gland size get larger as age increased, but the age and the size are not influence the FDG uptake of the prostate gland with 18F-FDG PET/CT imaging.
		2017 Vol. 14 (16): 102-105 [Abstract] ( 202 ) HTML (1 KB) PDF (510 KB) ( 66 )

	106	Evaluation of left ventricular function of hypertrophic cardiomyopathy paients by two dimentional speckle tracking echocardiography
		Muhetajiang·Wubulihasimu1 LIU Huan2
		Objective To discuss clinical feasibility of two dimentional speckle tracking echocardiography (2DSTE) by application for evaluation of left ventricular function of hypertrophic cardiomyopathy (HCM) paients. Methods 60 cases of patients with HCM in the First People's Hospital of Kashi in Xinjiang Uygur Autonomous Region ("our hospial" for short) from July 2015 to June 2016 were selected as case gorup, while 40 healthy volunteers during the same time were selected as the control gorup. All of them were given two-dimensional echocardiography (2DE), 2DSTE and cardiac magnetic resonance (CMR) detection. The levels of LVESV, LVEDV and LVEF were compared, and the correlation among the three detection methods were analyzed. Results In the case gorup, 3 patients had poor image quality, 57 patients included in the case gorup ultimately. Compared with CMR, 2DE and 2DSTE had shorter image acquisition time (P < 0.05), while image analysis time comparison, the three groups had statistically significant (P < 0.05). Results of between-group comparison showed that, in the case gorup, the levels of LVEDV and LVESV were significantly lower than those of the control group (P < 0.05). Results of intra-group comparison showed that, in the case gorup, the LVEDV level by 2DE detection was significantly lower than CMR and 2DSTE detection (P < 0.05), the LVESV level had statistically significant differences among the three detection methods (P < 0.05), the LVEF level by 2DSTE detection was significantly lower than CMR and 2DE detection (P < 0.05). There were positive correlation among 2DSTE, 2DE and CMR detection in the two gorups (P < 0.05). Conclusion The left ventricular volumes of HCM patients are significantly lower than normal, the parameter values by 2DSTE detecion have high correlation with CMR, with simple operation and shorter time. 2DSTE has unique advantage for heart function detection in HCM paients, which has preferable clinical application prospects.
		2017 Vol. 14 (16): 106-109 [Abstract] ( 149 ) HTML (1 KB) PDF (431 KB) ( 94 )

	110	Analysis on distribution, drug resistance, and influence factors of fungal infection after colorectal cancer operation
		SHEN Bingzheng1 CHEN Zhiming1 LI Hua1 PEI Xiaoping1 GAO Xiang2 YU Yan3▲
		Objective To explore the distribution of pathogenic fungus, drug resistance, and influence factors of fungal infection after colorectal cancer operation. Methods 46 cases of fungal infection patients in Department of Gastrointestinal Surgery after colorectal cancer operation from January 2014 to June 2016 were selected. The identification, distribution, drug resistance and influence factors of pathogenic fungus isolated form patients' blood, urine, sputum and secretions in the surgical site were analyzed. Results Pathogenic fungus isolated mainly from the secretion of surgical site and blood. The isolation rates of Candida albicans, Candida parapsilosis, Candida glabrata and Candida krusei were high, the isolation rate was 28.3%, 21.7%, 13.0% and 10.9% respectively. The results of antifungal-drug sensitive experiment showed that the pathogenic fungus displayed different degrees of resistance against antifungal drugs. Pathogenic fungus presented higher resistant rates against Fluconazole, Ketoconazole and Econazole (resistant rate more than 20%), but sensitive against 5-fluorine cytosine, Amphotericin B and Voriconazole (sensitive rate more than 90%). The results of single factor χ2 test showed that operation time, age, and basal metabolic disorder were the important influence factors of fungal infection after colorectal cancer operation (P < 0.05). Conclusion Clinical medical staff should pay much more attention to patients with related influence factors and prevent fungal infection after colorectal cancer operation. If fungal infection has occurred, appropriate antifungal drugs should be selected according to the results of drug sensitive experiment.
		2017 Vol. 14 (16): 110-113 [Abstract] ( 159 ) HTML (1 KB) PDF (480 KB) ( 94 )

	114	Investigation on the normal reference range of healthy children serum Vitamin B12 in Guangzhou
		HUANG Yujun1 WU Shaoguo2 QIU Yuanyuan3 CAI Minmin4 CHEN Huimin5 LI Yanyou6
		Objective To establish the normal reference range of healthy children serum Vitamin B12 (VB12) in Guangzhou. Methods Levels of serum VB12 of 2065 healthy children (1208 boys and 857 girls) and 129 adults (52 male and 77 female) living in Guangzhou Region were examined by LK3000V Vitamin Analyzer from September 2015 to December 2016. The results were analyzed statistically. Results There were no statistical differences in levels of serum VB12 between boys and girls in 11 age groups (aged less than 11) and 11-17 age group (P > 0.05). The median (P2.5, P97.5) levels of serum VB12 defined by age were 252.4 (192.3, 338.0) pg/mL of 0-2 years-old group, 253.1 (192.5, 359.5) pg/mL of >2-5 years-old group as well as >7-17 years-old group, 262.7 (194.8, 374.9) pg/mL of >5-7 years-old group, 297.5 (233.7, 383.1) pg/mL of ＞17 years-old group, there were statistically significant differences between any two groups (P < 0.05). Positive correlation was found between age and level of serum VB12 (r=0.228, P=0.000). Conclusion Reference ranges of healthy children serum VB12 in Guangzhou Region are showed as follows: 192.3-338.0 pg/mL of 0-2 years-old children, 192.5-359.5 pg/mL of >2-5 years-old as well as >7-17 years-old children, and 194.80-374.9 pg/mL of >5-7 years-old children.
		2017 Vol. 14 (16): 114-118 [Abstract] ( 173 ) HTML (1 KB) PDF (593 KB) ( 95 )

	119	Application value of different testing methods in the diagnosis of tuberculous meningitis
		WANG Juanjuan MA Li▲
		Objective To explore the application value of peripheral blood T-SPOT.TB, cerebrospinal fluid mycobacterium tuberculosis culture and tuberculin test (PPD test) in the diagnosis of tuberculous meningitis. Methods 65 cases of patients suspected tuberculous meningitis from January 2015 to December 2016 in Yan 'an University Affiliated Hospital were chosen as the research objects. All patients were given the test of peripheral blood T-SPOT.TB, cerebrospinal fluid mycobacterium tuberculosis culture and PPD test. The sensitivity, specificity in the diagnosis of tuberculous meningitis were compared among the three testing methods. Results Among 65 patients, there were 35 cases with tuberculous meningitis and 30 cases with non-tuberculous meningitis. In patients with tuberculous meningitis, the positive rate of T-SPOT.TB test was 74.29%, and it was significantly higher than that of mycobacterium tuberculosis cultivate and PPD test (40.00%, 57.14%), and the positive rate of the PPD test was higher than that of mycobacterium tuberculosis culture, with statistically significant differences (P < 0.05). In patients with non-tuberculous meningitis, the positive rate of PPD test was 26.27%, which was significantly higher than that of T-SPOT.TB and mycobacterium tuberculosis culture (10.00%, 0.00%), with statistically significant differences (P < 0.05). In the diagnosis of tuberculous meningitis, the sensitivity, specificity, positive predictive value, negative predictive value of T-SPOT.TB was 89.66%, 75.00%, 74.29%, 90.00% respectively, which were significantly higher than 71.43%, 59.46%, 57.14%, 73.33% of PPD test, with statistically significant differences (P < 0.05); the specificity and positive predictive value of T-SPOT. TB were higher than those of the mycobacterium tuberculosis culture (52.63%, 40.00%), with statistically significant differences (P < 0.05). Conclusion Peripheral blood T-SPOT.TB test in the diagnosis of tuberculous meningitis has high sensitivity and specificity, which is helpful for the rapidly diagnosing tuberculous meningitis. It is worthy of clinical promotion.
		2017 Vol. 14 (16): 119-122 [Abstract] ( 157 ) HTML (1 KB) PDF (515 KB) ( 86 )

	123	Analysis on the effect of disaster rescue training for college nursing students
		DAI Yue WANG Ling▲
		Objective To explore the effect of disaster rescue ability training for nursing students. Methods From September 2015 to September 2016, 244 nursing students in grade three in the four Jiangxi Medical Colleges were selected by convenience sampling method, and they were carried out the disaster rescue ability training. Before and after the training, the self-made disaster relief papers and rescue practice projects were evaluated by self-control method, and the training effects of nursing students were evaluated by self-made questionnair. Results After training, the scores of disaster management theory and rescue practice of college nursing students were significantly higher than those before training, with statistically significant difference (P < 0.05). The eight dimensions of the training effectiveness evaluation scale were 4.0 or higher, and more than 85% students were satisfied with the training effect. Conclusion It can improve the disaster rescue training system and the protection of disaster response capability that carrying out the disaster rescue ability training.
		2017 Vol. 14 (16): 123-125 [Abstract] ( 141 ) HTML (1 KB) PDF (580 KB) ( 75 )

	126	Applied research of OSCE-based teaching methods in surgical residents training
		LIU Diangang1 CAO Zhanyu2 CHU Changbiao3 LI Fei1
		Objective To study the application significance of objective structured clinical examination (OSCE) teaching method in surgical resident training program (the first phase). Methods Eighty surgical training residents (accessed September, 2014) from Xuan Wu Hospital and Beijing Tian Tan Hospital of Capital Medical University were enrolled in this study. All residents were divided into observation group and control group according to random number table , with 40 residents in each group. All the residents were trained by traditional teaching method, moreover the residents in observation group were trained by OSCE teaching method. Then at the end of three-year-training program, the skills in clinical theory, clinical practice and doctor-patient communication in two groups were compared. A questionnaire survey was conducted in observation group. Results Compared to control group, the skills of clinical practice in observation group were significantly improved (P < 0.01), whereas their clinical theory skills were no significant difference (P > 0.05). Specifically, the doctor-patient communication skill was improved after the training program within each group (P < 0.01), and the improvement in the observation group was much more significantly (P < 0.01). Conclusion Compared to the traditional training method, the OSCE teaching method is significantly better in improving the clinical practice and doctor-patient communication skills of the trained residents.
		2017 Vol. 14 (16): 126-129 [Abstract] ( 178 ) HTML (1 KB) PDF (593 KB) ( 76 )

	130	Teaching reform of comprehensive experiment of biopharmaceutics and pharmacokinetics based on constructivism theory
		DENG Youcai LIU Hongmei JIA Yi ZHANG Jianxiang LI Xiaohui TANG Yuan
		Biopharmaceutics and pharmacokinetics is one of the core curricula of pharmacy students and its experimental teaching can enable students to consolidate and expand theoretical teaching content, cultivate students' autonomous learning and the ability of original innovation. Constructivism is a theory to explain how knowledge is constructed in the human being when information comes into contact with existing knowledge by special circumstances, cooperation, conversation and meaning construction. Department of Pharmaceutics, College of Pharmacy, Third Military Medical University carried out the teaching reform of comprehensive experiment of biopharmaceutics and pharmacokinetics based on constructivism theory, used clinical practical problems as the cases in teaching situation, and carried out three aspects of cooperation and conversation between teachers and students. The teaching reform of comprehensive experiment helps students solve problems independently and achieve the ultimate goal of the construction of meaning.
		2017 Vol. 14 (16): 130-133 [Abstract] ( 183 ) HTML (1 KB) PDF (553 KB) ( 133 )

	134	A preliminary exploration on the teaching plan of "Chinese medicine internal medicine - edema disease"
		MENG Yuan WANG Yuefen▲ WANG Yu ZHAO Wenjing ZHANG Binghou
		This paper hierarchically describes the teaching content, train of method and matters needing attention in the five-year system of " Chinese medicine internal medicine - edema disease", to analyze the current situation of teaching preparation, conception, etiology, pathogenesis, diagnosis and syndrome differentiation and treatment based on differentiation of symptoms and signs. According to the syllabus, the teaching contents, emphasizing the key points and difficulties, and putting forward the teaching ideas and methods were expanded, to complement the physiological mechanism of Chinese medicine water metabolism, expand contemporary medical clinical experience, form a strong practical, prominent characteristics of traditional Chinese medicine. Teaching activities can closely combine with classical theory and echo with clinical practice, which can effectively mobilize the enthusiasm of students, contribute to the training of clinical practical talents, in order to realize the sustainable development of teaching activities of traditional Chinese medicine.
		2017 Vol. 14 (16): 134-137 [Abstract] ( 194 ) HTML (1 KB) PDF (593 KB) ( 94 )

	138	Analysis on the prediction of per capita medical expenses of general hospitals in Jiangsu Province
		CUI Tingting XIONG Jixia
		Objective To establish a model based on the per capita medical expenses of general hospitals in Jiangsu Province from 2004 to 2015, and to forecast it from 2016 to 2020. Methods Per capita medical expenses of general hospitals in Jiangsu Province from 2016 to 2020 was calculated and predicted based on GM(1, 1) model, Excel and GTMS 3.0. Results Each model′s accuracy level of prediction was rather high and fitting effect was qualified. The results indicated that the outpatient per capita medical expenses, outpatient drug fee, inpatient per capita medical expenses and inpatient drug fee will show an increasing trend, while the proportion of drug fee in medical expenses will show a declining trend from 2016 to 2020. Conclusion This theory suggests establishing the long-term effective compensation mechanism, the dynamic adjustment mechanism of medical service price and the national health insurance system.
		2017 Vol. 14 (16): 138-141 [Abstract] ( 185 ) HTML (1 KB) PDF (805 KB) ( 80 )

	142	Analysis on factors influencing development of hospital and improvement measures from perspective of organizational health
		SUN Zengyan1 WEI Suli2
		Since the establishment of Beijing Xiaotangshan Hospital ("our hospital" for short) in 1958, it has been developed for more than 50 years. These developments reflect the importance of healthy state of organization to the organization's management and operation, to adapt to the changes of the internal and external environment, and to achieve long-term growth and sustained prosperity. The article analyzes the factors that affect the development of our hospital from the perspective of organizational health. This paper discusses the influence of external factors such as policy environment and leadership structure on hospital development, decision-making and operation, And analyzes the influence of the internal factors such as the stability of the leadership team, the hospital incentive mechanism, the cultural construction, the individual factors of the staff and the lack of organizational repair ability on the sustained growth and development ability of the hospital. And to improve the organization's cohesion and improve the adaptability of the organization by optimizing the leadership structure, changing the communication style and power mode of the core leadership, strengthening the individual training of the staff and paying attention to the individual's health and so on. This fully proved that the organization and organization of health is the fundamental guarantee for the development of our hospital.
		2017 Vol. 14 (16): 142-145,158 [Abstract] ( 149 ) HTML (1 KB) PDF (644 KB) ( 102 )

	146	Influence of infection control in hospital operation room and nursing work quality by evidence-based management
		LUO Xianhui
		Objective To approach the influence of infection control in the hospital operation room and nursing work quality by evidence-based management. Methods From May 2012 to May 2016, in Traditional Chinese Medicine Hospital of Suining City, the clinical data of 4020 operations were analyzed, they were divided into two groups by different time quantum, the 2000 operations from May 2012 to May 2014 were selected as management group, the 2020 operations from June 2014 to May 2016 were selected as evidence-based management group. The sampling results qualified rate, nursing work quality score, risk event rate of two groups were detected, the satisfaction of two groups patients were detected. Results The sampling results qualified rate of operation room air, body surface, medical and nursing staffs hands, ultraviolet radiator, aseptic materials of evidence-based management group were higher than those of routine management group, the differences were statistically significant (P < 0.05); the operation environmental management, nursing staff training, nursing safety, disinfection and isolation, nursing quality control, humanistic care and nursing documents management score of evidence-based management group were higher than those of routine management group, the differences were statistically significant (P < 0.05); the operation sequencing errors, surgical instruments no complete, histopathological specimens pollution, disinfection quality rate no qualified in operation room of evidence-based management group were lower than those of routine management group, the differences were statistically significant (P < 0.05); the satisfaction rate of operation patients in evidence-based management group was higher than that of routine management group, the difference was statistically significant (P < 0.05). Conclusion The application of infection control in the hospital operation room by evidence-based management can improve sampling results qualified level and nursing work quality, decrease risk event rate, increase satisfaction of patients.
		2017 Vol. 14 (16): 146-149 [Abstract] ( 127 ) HTML (1 KB) PDF (625 KB) ( 148 )

	150	The practice of standardizing the management of standby drugs based on the hospital accreditation standards
		LAN Hong1 CHEN Hongmei2
		Objective To standardize the management of standby drugs based on the accreditation standards for class Ⅲ comprehensive hospital. Methods Three rounds of PDCA cycle management was applied to constantly improve drug classification, identification, storage, usage, record and claim of standby drugs among 83 departments of Shiyan Taihe Hospital under the instruction of the Pharmaceutical Affairs Board from March to December in 2015. Results The types, amounts and storage positions of the first-aid medicine were unified. The types was decreased by 54.63%; the storage was significantly reduced, among which the injection was reduced by 65.42%; and the inspection time of standby drugs by the medical staffs was reduced by 63.28%. During the third round of PDCA evaluation, the eligible rate of standby drugs was 100%, which was highly praised by the evaluation experts in the hospital accreditation. Conclusion It has been proved that by applying PDCA cycle management under the safety guidance of hospital accreditation can help to improve the management efficiency and guarantee the safety and speediness of standby drugs, reduce the management cost of hospital. Therefore, in clinical practice PDCA cycle management is highly recommended.
		2017 Vol. 14 (16): 150-153 [Abstract] ( 200 ) HTML (1 KB) PDF (627 KB) ( 108 )

	154	Current situation and strategy of two-way referral implementation in integrated delivery system of China
		ZHONG Yanyu1，2 CHEN Juan1▲
		China′s two-way referral system has developed rapidly, and it has made a certain achievements in the number of referrals, referral quality, improvement of hospitals′ comprehensive performance, chronic disease management and so on. But still there are many problems that need to be solved. In this article, through the literature analysis, two-way referral is found to have a certain effect in improving the medical services, but there are some problems, which need hospitals, patients and the government to work together to improve the assessment tools and systems of the effectiveness of two-way referral, cultivate general practitioners to improve primary health care, improve the referral process and convenience, implement supporting policies and clear the labor division all levels of medical institutions to strengthen cooperation, in order to promote the smooth implementation of medical treatment associations and two-way referral system.
		2017 Vol. 14 (16): 154-158 [Abstract] ( 177 ) HTML (1 KB) PDF (634 KB) ( 65 )

	159	Predictive care and outcomes in patients with early hairstyle severe preeclampsia and the influence of the quality of life
		ZHU Hong MENG Tao LIU Peiyan
		Objective To explore and analyze the influence about the life quality and mother and fetus outcome of the predictive care treated in patients with early onset severe pre-eclampsia. Methods From June 2014 to June 2016, 90 cases with early onset severe pre-eclampsia treated in the First Hospital of China Medical University were selected. All the patients divided into the observational group and the control group according to the random number table, with 45 cases in each group. The control group was given to routine care, the observation group was implemented predictive care based on the control group. The maternal and infant outcomes and life quality of two groups were compared. Results The incidence rates disseminated intravascular coagulation, postpartum hemorrhage, liver and kidney function damage, heart failure, placental abruption of the observation group were decreased than those of the control group, with statistically significant difference (P < 0.05). The eutocia rate and 1 min neonatal Apgar score in the observation group were increased, the cesarean delivery rate, delivery time and neonatal asphyxia incidence in the observation group were decreased, compared with the control group (P < 0.05). The overall health, physiological function, physiological function, the body pain, vitality, social function, emotional function and emotional health score in the observation group were higher than those in the control group, with statistically significant difference (P < 0.05). Conclusion The predictive care applied to early hairstyle severe preeclampsia patients can promote outcomes and improve the quality of survival.
		2017 Vol. 14 (16): 159-162 [Abstract] ( 177 ) HTML (1 KB) PDF (566 KB) ( 38 )

	163	Influence on negative emotions and adherence of psychological nursing for the patients with pituitary adenoma after trans-sphenoid operation
		JIA Xueqian1 ZHAO Xu1 CHEN Qingbo1 YU Changjiang2 CHENG Yu1
		Objective To explore and analyze the influence about negative emotions and adherence of psychological nursing for the patients with pituitary adenoma after trans-sphenoid operation. Methods From October 2014 to October 2016, 90 cases with pituitary adenoma after trans-sphenoid operation treated in the First Affiliated Hospital of Harbin Medical University were selected. All the patients divided into routine nursing and psychological care group according to the random number table, with 45 cases in each group. The negative emotions, compliance and nursing satisfaction and adverse reactions of the two groups were compared. Results The SAS and SDS scores of two groups were decreased after nursing, and the effects of the psychological care group were better than those of the routine nursing group, with statistically significant difference (P < 0.05). The treatment adherence, nursing satisfaction in the psychological nursing group were higher than those in the routine nursing group, with statistically significant difference (P < 0.05). The overall incidence of disturbance of consciousness, cerebrospinal fluid leak, diabetes insipidus and decreased pituitary function of two groups had no significant difference (P > 0.05). Conclusion The application of psychological nursing based on the routine nursing for the patients with pituitary adenoma after trans-sphenoid operation can obviously alleviate patients' negative mood, improve the treatment compliance and patient satisfaction and reduce the incidence of adverse reactions.
		2017 Vol. 14 (16): 163-165,169 [Abstract] ( 142 ) HTML (1 KB) PDF (580 KB) ( 76 )

	166	Rapid rehabilitation nursing on preventing the application of the femur fractures of postoperative deep vein thrombosis
		WU Lingling1 CHEN Jin1 ZHANG Muchun1 CHEN Fang2 DENG Eryi3 CHEN Yuting1 LI Xiaoyan4
		Objective To explore and analyze the application of rapid rehabilitation nursing on preventing the deep vein thrombosis after femoral fracture operation. Methods From May 2014 to May 2016, 90 cases with femoral fracture treated in Central People's Hospital of Zhanjiang were selected. All the patients divided into the control group and observation group according to the random number table, with 45 cases in each group. The control group was given to routine nursing only, the observation group was given to rapid rehabilitation nursing, all the patients were treated for one month. The postoperative deep vein thrombosis rate, length of hospital stay, hospital expenses, postoperative pain score, the nursing satisfaction and functional independence evaluation questionnaire (FIM) scores of two groups were compared. Results The postoperative deep vein thrombosis rate, the hospitalization expense and postoperative pain score in the observation group were lower, the hospitalization time in the observation group was shorter, and the nursing satisfaction of observation group was higher, compared with the control group (P < 0.05). The FIM scores of two groups at 2 weeks, 1, 3 months after surgery were higher than those before surgery, and the increase of above index of observation group was more remarkable than that of the control group at the same time (P < 0.05). Conclusion The rapid rehabilitation nursing can effectively prevent the formation of postoperative deep vein thrombosis after femoral fractures operation, and can shorten the healing time, improve nursing satisfaction, promote the prognosis.
		2017 Vol. 14 (16): 166-169 [Abstract] ( 168 ) HTML (1 KB) PDF (571 KB) ( 84 )

	170	The application value of knowledge, attitude, practice model in patients with spinal cord injury care research
		CHEN Ming QIAO Lei▲
		Objective To explore and analyze the application effect of knowledge, attitude, practice model in nursing of patients with radiation and chemotherapy of spinal cord injury. Methods From June 2014 to June 2016, 90 cases with radiation and chemotherapy of spinal cord injury treated in Shengjing Hospital of China Medical University were selected. All the patients divided into the control group and observation group according to the random number table, with 45 cases in each group. The patients in the control group were given to routine nursing only, and the patients in the observation group were given to knowledge, attitude, practice model based on the control group. All the patients were treated for one month. The pain score, functional independence evaluation questionnaire score, anxiety, depression and quality of life of two groups were compared. Results The NRS score of two groups after nursing were lower than before, and FIM score was increased, the improvement of observation group was more significant than that of the control group after nursing nursing, with statistically significant difference (P < 0.05). The SAS and SDS scores of the two groups after nursing were significantly lower than before, the decrease of scores in observation group were more remarkable than that in the control group after nursing, with statistically significant difference (P < 0.05). The physical function, role function, cognitive function, emotional function and social function score of the two groups after nursing were increased, and the improvement of observation group was more significant than that of the control group, with statistically significant difference (P < 0.05). Conclusion The application of knowledge, attitude, practice model treated in the patients with radiation and chemotherapy of spinal cord injury based on nursing can improve pain relief, promote the functional recovery, reduce anxiety depression, and improve the quality of life.
		2017 Vol. 14 (16): 170-173 [Abstract] ( 169 ) HTML (1 KB) PDF (565 KB) ( 78 )

	174	Application effect of fine nursing intervention in patients with coronary artery CT imaging
		CHEN Yi XIE Juan
		Objective To investigate the effect of fine nursing intervention in patients with coronary artery CT imaging examination. Methods From March 2014 to March 2016, 158 patients who recieved coronary CT imaging by Difinition FLASH，sinmens CT angiographyin department of Radiology, West China Hospital, Sichuan University were selected, they were randomly divided into the intervention group (80 cases) and control group (78 cases) according to random number table. The control group was given to conventional nursing scheme, while the intervention group was given to intensive nursing based on the control group. The image quality, SAS score, heart rate control breathing time and cooperating with the incidence of training time, fluctuation of heart rate >10 bpm were compared. Results The quality of the images in the intervention group was significantly better than that of the control group, with statistically significant difference (P < 0.05). Before intervention, the SAS scores in two groups were not significant difference (P > 0.05); after intervention, the SAS score in the intervention group was significantly lower than that before intervention (P < 0.05), while SAS score in the control group before and after intervention had no significant difference (P > 0.05); after intervention, the SAS score in intervention group was significantly lower than that in the control group (P < 0.05). The heart rate control time and breathing training time of the intervention group were significantly shorter than those of the control group (P < 0.05), the incidence of heart rate fluctuation in >10 bpm of the intervention group was significantly lower than that of the control group (P < 0.05). Conclusion Using intensive nursing intervention in patients with CT imaging of the coronary arteries, can reduce the patients psychological anxiety in patients with heart rate and stable, improve the quality of imaging, which is helpful to clinical diagnosis. It is worthy of clinical application
		2017 Vol. 14 (16): 174-177 [Abstract] ( 154 ) HTML (1 KB) PDF (567 KB) ( 31 )

	178	Influence of humanistic solicitude on the mental health of nurses in geriatrics
		ZHAO Jianjun
		Objective To understand the mental health of nurses with humanistic care ability. Methods 117 female nurses from the First Affiliated Hospital of Chengdu Medical College were selected. The nurses from Department of Geriatrics (22 cases) were divided into treatment group, which were received humane care service (from June 2016). And the nurses from other departments (95 cases) were divided into control group, which were received no intervention. SCL-90 and SCSQ were respectively used to evaluate the nurses in the two groups in May 2016 and November 2016. Results Before intervention, the scores of SCL-90 and SCSQ in the two groups had no difference (P > 0.05). After Intervention, the scores of somatization, depression and anxiety of SCL-90 and SCSQ in the treatment group were decreased (P <0.05); and those scores of the treatment group were lower than those in the control group after intervention, with statistically significant difference (P < 0.05). Conclusion Nurses with humanistic care can improve the nurse-patient relationship, obtain a sense of accomplishment and happiness from the work, which can contribute to alleviate the work of nurses pressure and promote their mental health.
		2017 Vol. 14 (16): 178-180 [Abstract] ( 165 ) HTML (1 KB) PDF (558 KB) ( 106 )

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