去氧穿心莲内酯的大鼠肠吸收特征研究

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Abstract Objective To measure and analyze the oil-water partition coefficients and intestinal absorption characteristics of deoxyandrographolide in rats. Methods The shaking method and rat intestinal perfusion model in vivo was used. Oil-water partition coefficient, chemical and biological stability were measured by UPLC, and contents in intestinal perfusate and bile were determined. Results Oil water partition coefficient Log P=1.45±0.12 of deoxyandrographolide in the HBSS (pH 6.5), and its chemical and biological stability were well. In the perfusion model, the absorption of deoxyandrographolide in duodenum, jejunum, ileum and colon were 30.29%, 28.39%, 22.04% and 34.63%. On the other hand, deoxyandrographolide was excreted by bile with 0.146% of total prefused amount of deoxyandrographolide. Conclusion Deoxyandrographolide in various intestinal segments of rats are absorbed, but there is no significant difference on absorption rate in different intestinal segments.

Key words： Deoxydeoxyandrographolide Rat intestinal perfusion Absorption

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	WU Zhizhong1 YE Ling2

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WU Zhizhong1 YE Ling2. Study on the intestinal absorption characteristics of deoxydeoxyandrographolide in rats[J]. 中国医药导报, 2017, 14(16): 8-11.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I16/8

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