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| Advances research of microRNA-21 in esophageal cancer |
| YANG Jingrong1 WU Bo2▲ |
| 1.Department of Thoracic and Cardiovascular Surgery, Fuzhou General Hospital of Nanjing Military Command, Fujian Province, Fuzhou 350025, China; 2.Department of Emergency, Fuzhou General Hospital of Nanjing Military Command, Fujian Province, Fuzhou 350025, China |
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Abstract Esophageal cancer is one of the most common digestive system neoplasms in China. The mechanism of esophageal cancer is still unclear. microRNA is a kind of endogenous non-coding short RNA, which regulates many tumor biological behaviors,such as cell multiplication, differentiation, apoptosis, drug resistance and invasion. miR-21 is valued highly in miRNA. It express highly in esophageal cancer cell and tissue. miR-21 participates in esophageal cancer cell multiplication, differentiation, apoptosis, drug resistance and metastasis via regulating gene expression. This review summarizes the advances in research on miR-21 in esophageal cancer .
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