KRAS基因突变的非小细胞肺癌靶向治疗进展

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Abstract Lung cancer is one of the most deadly malignancies, ranking the first in global cancer-related death. With the development of multidisciplinary comprehensive treatment, the mortality rate of patients with lung cancer is still high. KRAS gene mutations are the most common type of mutations in non-small cell lung. At present, the targeted therapy of KRAS gene mutation mainly through the direct inhibition of KRAS gene, change the KRAS membrane localization, inhibition of KRAS downstream effector molecules, inhibition of KRAS mutant synergistic lethal genes and other aspects of research. In this review, the status and progress of KRAS mutations in non-small cell lung cancer targeted therapy are briefly reviewed.

Key words： Non-small cell lung cancer KRAS gene mutation Inhibition of KRAS downstream effector molecule Targeting therapy

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	ZHANG Yukun GE Wei▲

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ZHANG Yukun GE Wei▲. Progress in targeted therapy of KRAS mutations in non-small cell lung cancer[J]. 中国医药导报, 2017, 14(16): 32-35.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I16/32

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